Article
Clinical Neurology
Femke Vanwetswinkel, Ronny Bruffaerts, Umesa Arif, Titia Hompes
Summary: Perinatal Depression (PND) is a common complication during the peri-natal period, and its clinical course and phenotypes are diverse. Pregnant women and mothers with depression are not a homogeneous clinical group, and can be categorized into low, medium, high, and episodic trajectories. Risk factors for high-symptom trajectory of depressive symptoms include history of depression and socio-demographic factors.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Benedikt Romer, Ingvild Dalen, Clive Ballard, Dag Aarsland
Summary: This study found that depressive symptoms increased continuously in patients with DLB, whereas patients with AD showed a delayed increase. The increase in depressive symptoms in DLB was mainly driven by anhedonia and retardation. Proximity to death and risk factors for depression and dementia also played a role in the course of depressive symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Hiba Bilal, Ian H. Harding, Julie C. Stout
Summary: Huntington's disease (HD) is a neurodegenerative disorder characterized by motor abnormalities, cognitive decline, and neuropsychiatric disturbances. Depression is common in HD, but the short-term dynamics of mood and its relationship with depression in HD have not been studied. This study found that depression severity was associated with average mood across 28 days, but not with day-to-day mood variability or inertia. It also revealed that female HD carriers experienced more day-to-day mood variability compared to males.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychology, Clinical
Zijuan Ma, Jingbo Zhao, Huilin Chen, Yanqiang Tao, Yifan Zhang, Fang Fan
Summary: This study examined the temporal relationships between depressive symptoms across distinct depressive trajectories from the COVID-19 outbreak period to the COVID-19 control period. The study found that the longitudinal relationships among different depressive trajectories were unique during the COVID-19 pandemic. Specifically, suicidal ideation in the chronic- and delayed-dysfunction groups at T1 was most predictive of other symptoms at T2, while sleep in the recovery group at T1 and lack of energy in the resistance group at T1 may be strongly related to the remission of other depressive symptoms at T2.
DEPRESSION AND ANXIETY
(2023)
Article
Clinical Neurology
Yang Du, Jie Yu, Manhua Liu, Qi Qiu, Yuan Fang, Lu Zhao, Wenjing Wei, Jinghua Wang, Xiang Lin, Feng Yan, Xia Li
Summary: This study investigates the relationship between depressive symptoms, cognitive function, amygdala functional connectivity, and radiomic features in patients with Alzheimer's disease (AD). The results show differences in amygdala functional connectivity between AD patients with depressive symptoms and healthy controls. Additionally, the study demonstrates that amygdala-based radiomic features and functional connectivity mediate the relationship between depressive symptoms and cognitive function in AD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Geriatrics & Gerontology
Antoinette B. Coe, Ana Montoya, Chiang-Hua Chang, Pil S. Park, Julie P. W. Bynum, Theresa I. Shireman, Tingting Zhang, Ellen M. McCreedy, Lauren B. Gerlach
Summary: The COVID-19 pandemic disrupted nursing home care and led to increased depression symptoms and CNS-active medication use among long-stay NH residents with dementia. Regular assessment of depression symptoms and appropriate medication use are necessary during periods of increased isolation.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Psychiatry
Manish Dama, Michelle Wu, Vanessa K. Tassone, Ilya Demchenko, Benicio N. Frey, Roumen Milev, Arun Ravindran, Sagar Parikh, Susan Rotzinger, Wendy Lou, Raymond W. Lam, Sidney H. Kennedy, Venkat Bhat
Summary: This study examined the changes in insomnia symptoms during the acute treatment of major depressive disorder with antidepressant medication. The results showed that monitoring subjective sleep-onset and mid-nocturnal insomnia throughout the treatment can predict acute remission of depression.
PSYCHIATRY RESEARCH
(2023)
Article
Geriatrics & Gerontology
Andres Losada-Baltar, Naoko Kishita, Lucia Jimenez-Gonzalo, Jose Fernandes-Pires, Cristina Huertas-Domingo, Milena Contreras, Elien Van Hout, Javier Olazaran, Jose Angel Martinez-Huertas, Maria Marquez-Gonzalez
Summary: This study aims to cross-culturally analyze the association between BPSD, ambivalent feelings, and depressive symptoms in family caregivers of people with dementia from Spain and the UK. The results suggest that the influence of BPSD on caregivers' depressive symptoms is indirect, through ambivalent feelings. The observed associations were equivalent between countries and explained a significant percentage of the variance of depressive symptoms.
AGING & MENTAL HEALTH
(2023)
Review
Clinical Neurology
Meenakshi Dauwan, Marieke J. H. Begemann, Margot I. E. Slot, Edwin H. M. Lee, Philip Scheltens, Iris E. C. Sommer
Summary: Physical exercise as an add-on therapeutic intervention shows significant effects on quality of life and mood in patients with chronic brain disorders, as well as improvements in multiple cognitive domains with small but significant effects. Additionally, exercise is considered safe with a positive dose-response correlation.
JOURNAL OF NEUROLOGY
(2021)
Article
Dermatology
Sheena Chatrath, Donald Lei, Muhammad Yousaf, Rajeev Chavda, Sylvie Gabriel, Jonathan I. Silverberg
Summary: Depressive symptoms in adults with atopic dermatitis are closely related and fluctuate with the severity of the skin condition. Improved control of atopic dermatitis, particularly reducing itchiness, may indirectly improve mental health.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Clinical Neurology
Anouk F. J. Geraets, Sebastian Kohler, Jacobus F. A. Jansen, Simone J. P. M. Eussen, Coen D. A. Stehouwer, Nicolaas C. Schaper, Anke Wesselius, Frans R. J. Verhey, Miranda T. Schram
Summary: Longitudinal investigation revealed that larger white matter hyperintensity volumes were associated with incident and persistent late-life depressive symptoms, while total burden of cerebral small vessel disease was related to persistent depressive symptoms, indicating a potential target for the prevention of chronic late-life depression.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Multidisciplinary Sciences
Giulia Buzi, Francis Eustache, Arnaud D'Argembeau, Thomas Hinault
Summary: This study aims to investigate the impact of depressive symptoms on temporal processing. The results suggest that depressive symptoms play a crucial role in age-related changes in temporal processing.
SCIENTIFIC REPORTS
(2023)
Article
Environmental Sciences
Inken Hoeller, Dajana Schreiber, Fionneke Bos, Thomas Forkmann, Tobias Teismann, Jurgen Margraf
Summary: This study examined the changes in symptom interrelations of patients with depressive symptoms undergoing cognitive behavioral therapy. The results showed that the severity of depressive symptoms decreased while network connectivity increased during therapy. The associations among symptoms and their centrality also changed during the course of treatment.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Clinical Neurology
Luca Kleineidam, Michael Wagner, Jannis Guski, Steffen Wolfsgruber, Lisa Miebach, Horst Bickel, Hans-Helmut Koenig, Siegfried Weyerer, Dagmar Luehmann, Hanna Kaduszkiewicz, Melanie Luppa, Susanne Rohr, Michael Pentzek, Birgitt Wiese, Wolfgang Maier, Martin Scherer, Johannes Kornhuber, Oliver Peters, Lutz Frolich, Jens Wiltfang, Piotr Lewczuk, Michael Huell, Alfredo Ramirez, Frank Jessen, Steffi G. Riedel-Heller, Kathrin Heser
Summary: This study found that subjective cognitive decline (SCD) typically precedes depressive symptoms (DS), and individuals with SCD and high DS are at an increased risk for cognitive decline and dementia progression. Additionally, levels of CSF Ass42 can predict increasing DS.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Takae Ohno, Satoshi Fukuda, Naoyuki Murabe, Mizuho Niido, Masaki Sakurai
Summary: This study used viral tracing and slice recording techniques to investigate the development and elimination of early corticomotoneuronal connections. The findings revealed that these connections increased gradually from the second week postnatal to the twentieth week before rapidly disappearing, with the timing of elimination matching previous research results.
Article
Public, Environmental & Occupational Health
Philippa J. Clarke, Jennifer Weuve, Lisa Barnes, Denis A. Evans, Carlos F. Mendes de Leon
ANNALS OF EPIDEMIOLOGY
(2015)
Article
Geriatrics & Gerontology
Kumar B. Rajan, Liesi E. Hebert, Paul A. Scherr, Carlos F. Mendes de Leon, Denis A. Evans
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2015)
Article
Neurosciences
Kumar B. Rajan, Julie A. Schneider, Neelum T. Aggarwal, Robert S. Wilson, Susan A. Everson-Rose, Denis A. Evans
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2015)
Article
Sport Sciences
Gary J. Farkas, Gregory L. Cvetanovich, Kumar B. Rajan, Alejandro A. Espinoza Orias, Shane J. Nho
SPORTS HEALTH-A MULTIDISCIPLINARY APPROACH
(2015)
Article
Public, Environmental & Occupational Health
Lindsay R. Pool, Belinda L. Needham, Sarah A. Burgard, Michael R. Elliott, Carlos F. Mendes de Leon
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2017)
Article
Public, Environmental & Occupational Health
Bart Klijs, Carlos F. Mendes de Leon, Eva U. B. Kibele, Nynke Smidt
Article
Geriatrics & Gerontology
Liming Dong, Vicki A. Freedman, Brisa N. Sanchez, Carlos F. Mendes de Leon
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2019)
Article
Psychiatry
Liming Dong, Vicki A. Freedman, Carlos F. Mendes de Leon
PSYCHOSOMATIC MEDICINE
(2020)
Article
Geriatrics & Gerontology
Talha Ali, Michael R. Elliott, Toni C. Antonucci, Belinda L. Needham, Jon Zelner, Carlos F. Mendes de Leon
Summary: This study examined the diversity and complexity of social support networks among older adults and developed a multidimensional typology of these networks. The results identified five distinct types of social networks among older adults, with membership in these types varying by age, gender, marital status, race/ethnicity, education, mental health, and birth cohort.
INNOVATION IN AGING
(2022)
Article
Gerontology
Amilcar Matos-Moreno, Ashton M. Verdery, Carlos F. Mendes de Leon, Vivianna M. De Jesus-Monge, Alexis R. Santos-Lozada
Summary: Puerto Rico is experiencing rapid population aging due to long-running fertility and mortality trends, as well as high levels of outmigration of working-age adults. Policymakers and government leaders need to plan for this unconventional population aging, taking into account its impact on government services, economic prospects, social support networks, caregiving dynamics, and public health policies.
Article
Geriatrics & Gerontology
Dana A. Glei, Carlos F. Mendes de Leon, Chioun Lee, Maxine Weinstein
Summary: The study suggests that worse cognitive function is associated with premature mortality, even at working ages. This highlights the importance of cognitive function as an early warning sign for premature death.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Pankaja Desai, Kristin R. Krueger, Carlos Mendes de Leon, Robert S. Wilson, Denis A. Evans, Kumar B. Rajan
Summary: This study investigates the impact of depressive symptoms and glial fibrillary acid protein (GFAP) concentrations on cognitive functioning. The results show that depressive symptoms and high GFAP concentrations contribute to cognitive decline, while depressive symptoms and low GFAP concentrations have a smaller effect.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Medicine, General & Internal
Boya Zhang, Kenneth M. Langa, Jennifer Weuve, Jennifer D'Souza, Adam Szpiro, Jessica Faul, Carlos Mendes de Leon, Joel D. Kaufman, Lynda Lisabeth, Richard A. Hirth, Sara D. Adar
Summary: This study investigated whether hypertension and stroke serve as mediators and modifiers of the association between PM2.5 and incident dementia. The findings suggest that although hypertension may enhance individuals' susceptibility to air pollution, hypertension and stroke do not significantly mediate or modify the association of PM2.5 with dementia.
Article
Gerontology
Talha Ali, Michael R. Elliott, Toni C. Antonucci, Belinda L. Needham, Jon Zelner, Carlos F. Mendes de Leon
Summary: Findings on the effect of network size and support on functional health are mixed. In this study, we examined the association between network types, which incorporate multiple network characteristics, and functional health in late life. Results showed that older adults in small, restricted, high contact networks had fewer disabilities but worse mobility.
JOURNAL OF AGING AND HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Farah Kader, Latifa Bazzi, Lilah Khoja, Fatima Hassan, Carlos Mendes de Leon
JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES
(2020)