Article
Medical Laboratory Technology
Jaroslav A. Hubacek, Ladislav Dusek, Ondrej Majek, Vaclav Adamek, Tereza Cervinkova, Dana Dlouha, Vera Adamkova
Summary: This study found that ACE I/D polymorphism has the potential to predict the severity of COVID-19, with I/I homozygotes being at increased risk of symptomatic COVID-19.
CLINICA CHIMICA ACTA
(2021)
Review
Oncology
Junjian Chen, Mao Sun, Min Zhou, Renfu Lu
Summary: The meta-analysis showed no significant association between the ACE I/D polymorphism and lung cancer risk, and subgroup analysis by ethnicity did not yield significant results.
Article
Medicine, General & Internal
Cecilia Calabrese, Anna Annunziata, Antonietta Coppola, Pia Clara Pafundi, Salvatore Guarino, Valentina Di Spirito, Valeria Maddaloni, Nicola Pepe, Giuseppe Fiorentino
Summary: Recent studies suggest a high risk of thromboembolism in patients with severe COVID-19 pneumonia, with a potential link to ACE gene polymorphisms. In this pilot study, researchers found a significant difference in ACE I/D polymorphisms between COVID-19 patients with and without pulmonary embolism, indicating a possible genetic susceptibility to thromboembolism in COVID-19.
FRONTIERS IN MEDICINE
(2021)
Correction
Oncology
Junjian Chen, Mao Sun, Min Zhou, Renfu Lu
Summary: An amendment to this paper has been published and can be accessed via the original article.
Article
Genetics & Heredity
Kathleen Y. de Almeida, Tiago Cetolin, Andrea Rita Marrero, Aderbal Silva Aguiar Junior, Pedro Mohr, Naoki Kikuchi
Summary: This study examines the associations between the ACTN3 R577X and ACE I/D gene polymorphisms and the incidence and severity of muscle injury in professional soccer athletes from Brazil. The findings suggest that individuals with the ACTN3 XX genotype are more susceptible to severe injuries, and those with the ACE II genotype have a higher number of injuries per season. Additionally, the combination of the ACTN3 577X allele and the ACE II genotype is associated with an increased number of injuries per season.
Article
Genetics & Heredity
Arezoo Faridzadeh, Mahmoud Mahmoudi, Sara Ghaffarpour, Mohammad Saber Zamani, Akram Hoseinzadeh, Mohammad Mehdi Naghizadeh, Tooba Ghazanfari
Summary: This study aimed to evaluate the association of ACE1 and ACE2 gene polymorphisms with the severity of COVID-19. The findings suggest that the ACE1 DD genotype is inversely correlated with intubation risk and mortality in COVID-19 patients. Additionally, the ACE2 rs1978124 CT and TT genotypes have a positive role in susceptibility to COVID-19 in females, but a protective effect against the severity of the disease.
FRONTIERS IN GENETICS
(2022)
Article
Cardiac & Cardiovascular Systems
Duy Cong Tran, Linh Hoang Gia Le, Truc Thanh Thai, Sy Van Hoang, Minh Duc Do, Binh Quang Truong
Summary: This study aimed to investigate the association between ACE I/D genotypes and the severity of coronary artery disease in patients with acute myocardial infarction. The study found that the DD genotype of the ACE I/D polymorphism was independently associated with a higher severity of coronary artery disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Amrit Sudershan, Agar Chander Pushap, Hardeep Kumar, Parvinder Kumar
Summary: The present meta-analysis found that MTHFR-C677T is significantly associated with an increased risk of migraine and its clinical subtype. ACE I/D also significantly increases the risk of overall migraine and both clinical subtypes. MTHFR A1289C only increases the risk of migraine in certain genetic models.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Neha Kumari, Rajeev Ahirwar, Amarjeet Yadav, Lakshmy Ramakrishnan, Surender Kumar Sagar, Prakash Ranjan Mondal
Summary: The ACE gene I/D polymorphism has been found to be associated with cardiovascular disease, and recent research suggests an increasing prevalence of metabolic disorders in rural areas of developing nations. This study aimed to assess the prevalence of the ACE gene I/D polymorphism in the Yadav population of India and explore its link with cardiovascular risk factors. The findings showed a significant association between the DD genotype of ACE polymorphism and high TC, high TG, and low non-HDL levels, indicating a correlation with cardiovascular disease risk factors in this population.
BIOCHEMICAL GENETICS
(2023)
Review
Nutrition & Dietetics
Ana Karina Zambrano, Santiago Cadena-Ullauri, Patricia Guevara-Ramirez, Viviana A. Ruiz-Pozo, Rafael Tamayo-Trujillo, Elius Paz-Cruz, Adriana Alexandra Ibarra-Rodriguez, Nieves Domenech
Summary: Hypertension is a major risk factor for cardiovascular diseases worldwide, and its prevalence is increasing in Latin America due to various factors including age, adoption of Westernized diets, and potential genetic predisposition. Genetic diversity in Latin America can influence disease susceptibility and treatment effectiveness. The spread of Western dietary patterns and excessive sodium consumption contribute to the rising prevalence of hypertension.
FRONTIERS IN NUTRITION
(2023)
Review
Health Care Sciences & Services
Aline Ruilowa de Pinho Coelho, Luciana Carvalho Silveira, Kamilla de Faria Santos, Rodrigo da Silva Santos, Angela Adamski da Silva Reis
Summary: This study used a systematic review and meta-analysis to investigate the relationship between the ACE gene (I/D) polymorphism and the development and progression of DR in type 2 diabetic patients. The results showed no significant association between the polymorphism and DR risk, indicating that the I/D polymorphism is not involved in the susceptibility to and progression of DR in type 2 diabetic patients.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Genetics & Heredity
Hendri Susilo, Budi Susetyo Pikir, Mochammad Thaha, Mochamad Yusuf Alsagaff, Satriyo Dwi Suryantoro, Citrawati Dyah Kencono Wungu, Ifan Ali Wafa, Cennikon Pakpahan, Delvac Oceandy
Summary: In Javanese CKD patients, the association between ACE I/D polymorphism and high plasma ACE levels indirectly contributes to the increased risk of ASCVD and cardiovascular mortality.
Article
Medicine, General & Internal
Duy Cong Tran, Minh Duc Do, Linh Hoang Gia Le, Truc Thanh Thai, Sy Van Hoang, Binh Quang Truong
Summary: The prognostic role of the ACE I/D genetic polymorphism in patients with AMI is evaluated in a study with Vietnamese patients. The study finds that the ACE I/D genetic polymorphism is not associated with 12-month all-cause mortality in Vietnamese patients with AMI. However, it is associated with mortality in patients who do not use ACEI/ARB and have lower GRACE scores.
Article
Clinical Neurology
Hendrikus J. A. van Os, Jos P. Kanning, Michel D. Ferrari, Tobias N. Bonten, Janet M. Kist, Hedwig M. M. Vos, Rimke C. Vos, Hein Putter, Rolf H. H. Groenwold, Marieke J. H. Wermer
Summary: The addition of female-specific factors and psychosocial risk factors improves the discriminatory performance of prediction models for stroke in women younger than 50 years.
Article
Endocrinology & Metabolism
Yawa Abouleka, Kamel Mohammedi, Charlyne Carpentier, Severine Dubois, Pierre Gourdy, Jean-Francois Gautier, Ronan Roussel, Andre Scheen, Francois Alhenc-Gelas, Samy Hadjadj, Gilberto Velho, Michel Marre
Summary: The deletion (D) allele of the ACE insertion/deletion (I/D) polymorphism is associated with an increased risk of major kidney events and all-cause death in patients with long-standing type 1 diabetes.
Article
Public, Environmental & Occupational Health
Marco Piccininni, Jessica L. Rohmann, Maximilian Wechsung, Giancarlo Logroscino, Tobias Kurth
Summary: This article discusses the impact of age and education correction on discrimination performance in cognitive screening tests and quantifies it using a causal framework. The results show that correcting test scores removes meaningful information, leading to a decrease in discrimination performance.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Clinical Neurology
Hebun Erdur, Joachim E. Weber, Anselm Angermaier, Stephan Kinze, Ali Sotoodeh, Claudia Gorski, Kerstin Bollweg, Stefanie Ernst, Farid Kandil, Janina Behrens, Ramanan Ganeshan, Anne Keysers, Malgorzata Kotlarz-Boettcher, Daniel Peters, Ludwig Schlemm, Kirsten Stangenberg-Gliss, Carl Witt, Beata Hennig, Katrin C. Reber, Udo Schneider, Christiana Franke, Ingo Schmehl, Hans-Beatus Straub, Agnes Floeel, Sarah Theen, Matthias Endres, Tobias Kurth, Heinrich J. Audebert
Summary: Implementing a multicomponent system-of-care can reduce the risk of poor outcomes in stroke patients.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
Ana Sofia Oliveira Goncalves, Jessica L. Rohmann, Marco Piccininni, Tobias Kurth, Martin Ebinger, Matthias Endres, Erik Freitag, Peter Harmel, Irina Lorenz-Meyer, Ira Rohrpasser-Napierkowski, Reinhard Busse, Heinrich J. Audebert
Summary: The study assessed the cost-utility and cost-effectiveness of additional mobile stroke unit (MSU) dispatch in ischemic stroke patients eligible for recanalizing treatments. Results showed that MSU dispatch increased costs but also improved quality-adjusted life years (QALYs), and it was considered cost-effective according to internationally accepted thresholds.
ANNALS OF NEUROLOGY
(2023)
Editorial Material
Clinical Neurology
Tobias Kurth, Jessica L. Rohmann
Review
Economics
Ana Sofia Oliveira Goncalves, Sophia Werdin, Tobias Kurth, Dimitra Panteli
Summary: This review aimed to identify how studies deal with methodological challenges of repeated measurements in mapping algorithms using patient responses to questionnaires. The inconsistent use of methods to account for interdependent observations indicates a need for mapping guidelines and journal updates.
Article
Pediatrics
Stefanie Theuring, Mascha Kern, Franziska Hommes, Marcus A. A. Mall, Joachim Seybold, Frank P. P. Mockenhaupt, Toivo Glatz, Tobias Kurth
Summary: During the COVID-19 pandemic, children and adolescents worldwide have been disproportionately affected in their psychological health and wellbeing. A cohort study in Germany found that anxiety symptoms among school children decreased from June to August 2021, but increased again in September 2021. Factors such as gender, school type, household education and income level, and COVID-19 vaccination were significantly associated with reporting anxiety symptoms.
CHILD AND ADOLESCENT PSYCHIATRY AND MENTAL HEALTH
(2023)
Article
Clinical Neurology
Jessica L. Rohmann, Rodrigo Huerta-Gutierrez, Heinrich J. Audebert, Tobias Kurth, Marco Piccininni
Summary: This study demonstrates the potential bias in using unadjusted stacked bar graphs to compare functional outcomes after stroke. By using IPT weighting to account for measured confounding, the researchers were able to present more accurate results.
EUROPEAN STROKE JOURNAL
(2023)
Article
Infectious Diseases
Annemarie Pantke, Christian Kollan, Barbara Gunsenheimer-Bartmeyer, Bjoern-Erik Ole Jensen, Christoph Stephan, Olaf Degen, Dirk Schuermann, Tobias Kurth, Viviane Bremer, Uwe Koppe
Summary: This study aimed to examine the incidence rates and predictive utility of established prognostic factors for the progression to AIDS among people living with HIV under clinical care. The study used data from two observational cohorts of people living with HIV in Germany and found that the rates of a first AIDS event have continuously declined, and health outcomes depend on CD4 count, viral load, and age but not on transmission mode.
Article
Genetics & Heredity
Corinna Grasemann, Jakob Hoppner, Peter Burgard, Michael M. Schundeln, Nora Matar, Gabriele Mueller, Heiko Krude, Reinhard Berner, Min Ae Lee-Kirsch, Fabian Hauck, Kerstin Wainwright, Sylvana Baumgarten, Janet Atinga, Jens J. Bauer, Eva Manka, Julia Korholz, Cordula Kiewert, Andre Heinen, Tanita Kretschmer, Tobias Kurth, Janna Mittnacht, Christoph Schramm, Christoph Klein, Holm Graessner, Olaf Hiort, Ania C. Muntau, Annette Grueters, Georg F. Hoffmann, Daniela Choukair
Summary: The transition process from paediatric/adolescent to adult medical care settings is crucial for the future health of adolescents with chronic diseases, especially in the context of rare diseases. This study presents a patient-focused transition pathway that can be adopted for different rare diseases, aiming to improve patients' health literacy and empower them through individualized training and counselling.
ORPHANET JOURNAL OF RARE DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Marco Piccininni, Tobias Kurth, Heinrich J. Audebert, Jessica L. Rohmann
Summary: The B_PROUD study aimed to evaluate the impact of mobile stroke unit (MSU) dispatch on ischemic stroke and transient ischemic attack (TIA) patients. However, a large proportion of patients did not receive MSU care despite being dispatched. The study found that receiving additional MSU care was associated with better functional outcomes compared to conventional care.
Article
Cardiac & Cardiovascular Systems
Pamela M. Rist, Julie E. Buring, Nancy R. Cook, Tobias Kurth
Summary: Adding information on migraine with aura (MA) to cardiovascular disease (CVD) risk prediction models can improve risk prediction accuracy, but does not significantly improve risk stratification among women.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Tobias Kurth, Pamela M. Rist
Summary: The connection between migraine and cardiovascular disease is intricate and involves overlapping mechanisms like endovascular disturbances. Challenges in measuring migraine, differentiating causation from prediction, and understanding clinical implications emphasize the importance of further research to guide treatment and cardiovascular risk assessment for migraine sufferers.
NATURE REVIEWS CARDIOLOGY
(2023)
Article
Clinical Neurology
Marco Piccininni, Ralph Brinks, Jessica L. Rohmann, Tobias Kurth
Summary: This study used modern epidemiological methods to estimate the prevalence of never, active, and inactive migraine. The transition rate from active to inactive migraine increased after age 22.5 for women and 27.5 for men in Germany. The estimated prevalence of inactive migraine at age 60 was 25.7% for women in Germany and 16.5% globally, and 10.4% for men in Germany and 7.1% globally.
JOURNAL OF HEADACHE AND PAIN
(2023)
Article
Health Care Sciences & Services
Vanessa Voelskow, Claudia Messner, Tobias Kurth, Amelie Busam, Toivo Glatz, Natalie Ebert
Summary: During the COVID-19 pandemic in Germany, telephone hotlines of local health authorities were overwhelmed with information requests. This study evaluated the use of a COVID-19-specific voicebot (CovBot) in these authorities and found that while it provided some relief to staff, it could not fully replace human assistance.
Article
Clinical Neurology
Eugen Schwabauer, Marco Piccininni, Erik Freitag, Martin Ebinger, Frederik Geisler, Peter Harmel, Annegret Hille, Irina Lorenz-Meyer, Ira Rohrpasser-Napierkowski, Tobias Kurth, Jessica L. Rohmann, Matthias Endres, Frieder Schlunk, Joachim Weber, Matthias Wendt, Heinrich J. Audebert
Summary: The study found that dispatching Mobile Stroke Units (MSUs) led to a reduction in systolic blood pressure (sBP) and shorter dispatch-to-imaging time compared to conventional ambulance care for patients with acute intracerebral haemorrhage (ICH). However, there was no significant difference in other outcomes, including 7-day mortality and favorable outcome.
EUROPEAN STROKE JOURNAL
(2023)