Review
Biochemistry & Molecular Biology
Beniamina Mercante, Paolo Enrico, Franca Deriu
Summary: In recent years, there has been a significant scientific effort to find effective and safe treatments for cognitive decline. Non-invasive neuromodulation, particularly trigeminal nerve stimulation (TNS), has gained attention for its potential cognitive effects. However, the use of TNS for cognitive enhancement and treatment of cognitive decline still faces challenges due to the lack of standardization in stimulation protocols.
Article
Clinical Neurology
Aurelie Leplus, Denys Fontaine, Anne Donnet, Jean Regis, Christian Lucas, Nadia Buisset, Serge Blond, Sylvie Raoul, Evelyne Guegan-Massardier, Stephane Derrey, Bechir Jarraya, Bich Dang-Vu, Frederic Bourdain, Dominique Valade, Caroline Roos, Christelle Creach, Stephan Chabardes, Pierric Giraud, Jimmy Voirin, Jocelyne Bloch, Sophie Colnat-Coulbois, Francois Caire, Philippe Rigoard, Laurie Tran, Coralie Cruzel, Michel Lanteri-Minet
Summary: This study evaluated the long-term efficacy of occipital nerve stimulation (ONS) in treating refractory chronic cluster headache (rCCH) and found that ONS can significantly reduce attack frequency, improve quality of life, and emotional impacts in patients. In responders, ONS led to a major reduction of functional and emotional headache-related impacts and a dramatic improvement of quality of life.
Article
Clinical Neurology
Daniel H. Lench, Travis H. Turner, Colin McLeod, Heather A. Boger, Lilia Lovera, Lisa Heidelberg, Jordan Elm, Anh Phan, Bashar W. Badran, Vanessa K. Hinson
Summary: This study evaluated the feasibility, safety, and efficacy of transcutaneous auricular vagus nerve stimulation (taVNS) in participants with mild to moderate Parkinson's disease. The results showed that taVNS treatment was safe and well-tolerated, but daily in-office visits were burdensome for participants. Although there were no significant differences in MDS-UPDRS scores or self-reported measures, verbal fluency decreased in the taVNS group. Future studies should explore at-home stimulation devices and optimize stimulation parameters.
FRONTIERS IN NEUROLOGY
(2023)
Article
Biophysics
Rongyu Tang, Chenglin Zhang, Bingxin Liu, Chanyuan Jiang, Lei Wang, Xuerui Zhang, Qiang Huang, Jing Liu, Lei Li
Summary: A fluidic cuff electrode using gallium-based liquid metal conductor has been developed as an artificial peripheral nerve device. The LM cuff electrode has high flexibility and conductivity. It has been shown to maintain long-term effectiveness in transmitting nerve signals and triggering event-related potentials.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Clinical Neurology
Ryan P. Verner, Jerzy B. Szaflarski, Jane Allendorfer, Kristl Vonck, Gaia Giannicola
Summary: This study aims to evaluate the impact of high frequency bursts of stimulation, called Microburst VNS, on patients with refractory epilepsy, as well as its application in standard anti-seizure medication treatment. The study used a novel stimulaion pattern and an fMRI-guided titration protocol for personalized dosing. The study began in 2018 and final results are expected in 2023.
FRONTIERS IN NEUROLOGY
(2023)
Review
Clinical Neurology
Catherine Veilleux, Devon Khousakoun, Churl-Su Kwon, Farnaz Amoozegar, Fady Girgis
Summary: Occipital nerve stimulation (ONS) may be an effective surgical treatment for approximately two thirds of patients with medically refractory trigeminal autonomic cephalalgias (TACs).
Article
Clinical Neurology
Lin Zhao, Tao Song
Summary: Short-term high cervical spinal cord stimulation combined with peripheral nerve stimulation has shown promising results in treating trigeminal postherpetic neuralgia affecting the V2 and V3 divisions. A novel PNS approach to the maxillary nerve has also been demonstrated, providing potential new options for TPHN therapy.
FRONTIERS IN NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Fei Jin, Tong Li, Zhidong Wei, Ruiying Xiong, Lili Qian, Juan Ma, Tao Yuan, Qi Wu, Chengteng Lai, Xiying Ma, Fuyi Wang, Ying Zhao, Fengyu Sun, Ting Wang, Zhang-Qi Feng
Summary: Researchers have developed a wearable neural invasive electrical stimulation (iES) system that can eliminate neural stimulus-inertia and achieve nerve regeneration and functional recovery. This system provides a promising avenue for personalized treatment of nerve injuries and neurodegenerative diseases.
NATURE COMMUNICATIONS
(2022)
Article
Clinical Neurology
Mengyi Guo, Jing Wang, Chongyang Tang, Jiahui Deng, Jing Zhang, Zhonghua Xiong, Siqi Liu, Yuguang Guan, Jian Zhou, Feng Zhai, Guoming Luan, Tianfu Li
Summary: The study retrospectively collected the outcomes of VNS treatment in patients with refractory PTE, with at least a 1-year follow-up. The responder rate increased over time, and patients with focal or multifocal interictal epileptic discharges were found to have better efficacy after VNS therapy.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Eva Koritakova, Irena Dolezalova, Jan Chladek, Tereza Jurkova, Jan Chrastina, Filip Plesinger, Robert Roman, Martin Pail, Pavel Jurak, Daniel J. Shaw, Milan Brazdil
Summary: The study team developed a predictive model for therapeutic effects, which was validated using EEG data from a different recording system. By classifying patients, it was possible to accurately predict responders to treatment.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Alison M. Luckey, Katherine Adcock, Sven Vanneste
Summary: Recent technological improvements have opened up new possibilities for innovative discoveries in research. There is growing interest in peripheral nerve stimulation, particularly the vagus, trigeminal, or greater occipital nerve, due to their involvement in higher cognitive processes. This opinion piece suggests that the effects of transcutaneous electrical stimulation may be influenced by the interaction of multiple neuromodulatory networks, and calls for further consideration of these networks in future research.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Clinical Neurology
Asim Roy, Joseph Ojile, Jerrold Kram, Jonathan Olin, Russell Rosenberg, J. Douglas Hudson, Richard K. Bogan, Jonathan D. Charlesworth
Summary: This study evaluated the long-term efficacy and safety of TOMAC for treating medication-refractory moderate-to-severe primary RLS. The results showed that TOMAC remained safe and efficacious for over 24 weeks of treatment, with a partial reversion of benefits upon cessation.
Article
Medicine, General & Internal
Aleksandra Sobiborowicz, Tomasz Switaj, Pawel Teterycz, Mateusz J. Spalek, Anna Szumera-Cieckiewicz, Michal Wagrodzki, Marcin Zdzienicki, Anna M. Czarnecka, Piotr Rutkowski
Summary: PEComas are a rare family of mesenchymal tumors, some of which are malignant. Patients treated surgically in national sarcoma centers have better disease control and survival rates. Microscopically radical resection is associated with longer disease-free survival.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Tzu-Ting Liu, Andreia Morais, Tsubasa Takizawa, Inge Mulder, Bruce J. Simon, Shih-Pin Chen, Shuu-Jiun Wang, Cenk Ayata, Jiin-Cherng Yen
Summary: Our study provides insight on optimal nVNS parameters to suppress CSD and suggests its benefit on CSD-induced neuroinflammation and trigeminovascular activation in migraine treatment.
JOURNAL OF HEADACHE AND PAIN
(2022)
Article
Clinical Neurology
Can Sarica, Christian Iorio-Morin, David H. Aguirre-Padilla, Michelle Paff, Samuelle-Arianne Villeneuve, Artur Vetkas, Kazuaki Yamamoto, Nardin Samuel, Vanessa Milano, Aaron Loh, Brendan Santyr, Ajmal Zemmar, Andres M. Lozano, Mojgan Hodaie
Summary: This study systematically reviewed the literature on peripheral nerve field stimulation (PNFS) for trigeminal pain and found that PNFS can provide effective long-term pain control for patients with trigeminal pain.
JOURNAL OF NEUROSURGERY
(2022)
