Article
Clinical Neurology
Milja Kivela, Markus Paananen, Eero Kajantie, Marja Ojaniemi, Rozenn Nedelec, Harri Rusanen, Jouko Miettunen, Ina Rissanen
Summary: This study found that females with low weight and height during early childhood, as well as females with high BMI during BMI rebound, have an increased risk of developing ischemic cerebrovascular diseases in adulthood.
Article
Clinical Neurology
Masahiro Uemura, Yuya Hatano, Hiroaki Nozaki, Shoichiro Ando, Hajime Kondo, Akira Hanazono, Akira Iwanaga, Hiroyuki Murota, Yosuke Osakada, Masato Osaki, Masato Kanazawa, Mitsuyasu Kanai, Yoko Shibata, Reiko Saika, Tadashi Miyatake, Hitoshi Aizawa, Takeshi Ikeuchi, Hidekazu Tomimoto, Ikuko Mizuta, Toshiki Mizuno, Tomohiko Ishihara, Osamu Onodera
Summary: This study aimed to clarify the frequency and clinical features of monogenic cerebral small vessel disease (mgCSVD) among patients with adult-onset severe CSVD in Japan. The study found that over 90% of mgCSVD can be diagnosed by screening for NOTCH3, HTRA1, and ABCC6 mutations.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Medicine, General & Internal
Nicholas S. Phillips, Kayla L. Stratton, AnnaLynn M. Williams, Tim Ahles, Kirsten K. Ness, Harvey Jay Cohen, Kim Edelstein, Yutaka Yasui, Kevin Oeffinger, Eric J. Chow, Rebecca M. Howell, Leslie L. Robison, Gregory T. Armstrong, Wendy M. Leisenring, Kevin R. Krull
Summary: Adult survivors of childhood cancer may have an elevated risk for late-onset neurocognitive impairments. Modifiable risk factors identified in early survivorship are associated with the increased risk.
Review
Pediatrics
Dorota M. Marchel, Debbie S. Gipson
Summary: Patients with iCONS may continue to experience effects of the disease and treatment into adulthood, including issues related to kidney health, cardiovascular disease, and reproductive health. Long-term studies and interventions are necessary to address these late effects.
PEDIATRIC NEPHROLOGY
(2021)
Article
Clinical Neurology
Stefanie C. Vuotto, Mingjuan Wang, M. Fatih Okcu, Daniel C. Bowers, Nicole J. Ullrich, Kirsten K. Ness, Chenghong Li, Deo Kumar Srivastava, Rebecca M. Howell, Todd M. Gibson, Wendy M. Leisenring, Kevin C. Oeffinger, Leslie L. Robison, Gregory T. Armstrong, Kevin R. Kull, Tara M. Brinkman
Summary: This study examined the impact of central nervous system (CNS)-directed therapies on the independence of adult survivors of childhood cancer. The study found that CNS-treated survivors had difficulty achieving full independence compared to non-CNS-treated survivors or siblings. Interventions to promote independence may be beneficial for survivors with treatment-related neurological issues.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Elizabeth L. Tung, Kristen E. Wroblewski, Jennifer A. Makelarski, Nathaniel J. Glasser, Stacy Tessler Lindau
Summary: Parental incarceration is associated with an increased risk of hypertension and high-risk hsCRP in adulthood, suggesting possible transgenerational health consequences of mass incarceration.
Article
Clinical Neurology
Gian Marco De Marchis, David J. Seiffge, Sabine Schaedelin, Duncan Wilson, Valeria Caso, Monica Acciarresi, Georgios Tsivgoulis, Masatoshi Koga, Sohei Yoshimura, Kazunori Toyoda, Manuel Cappellari, Bruno Bonetti, Kosmas Macha, Bernd Kallmuenzer, Carlo W. Cereda, Philippe Lyrer, Leo H. Bonati, Maurizio Paciaroni, Stefan T. Engelter, David J. Werring
Summary: This study compared the optimal timing of starting direct oral anticoagulants (DOACs) after acute ischemic stroke (AIS) related to atrial fibrillation (AF) and found no significant difference in the risk of recurrent AIS and intracranial hemorrhage between early versus late DOAC-start groups. The sevenfold higher risk of recurrent AIS than intracranial hemorrhage suggests that an early DOAC-start might be reasonable, supporting enrollment into randomized trials comparing an early versus late DOAC-start.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Yadav Sapkota, Weiyu Qiu, Stephanie B. Dixon, Carmen L. Wilson, Zhaoming Wang, Jinghui Zhang, Wendy Leisenring, Eric J. Chow, Smita Bhatia, Gregory T. Armstrong, Leslie L. Robison, Melissa M. Hudson, Angela Delaney, Yutaka Yasui
Summary: A report from large cohorts of adult survivors of childhood cancer demonstrates that genetic risk scores improve the risk prediction of developing severe obesity, providing opportunities for surveillance and mitigation interventions.
Article
Oncology
Bryan Dieffenbach, Qi Liu, Andrew J. Murphy, Deborah R. Stein, Natalie Wu, Arin L. Madenci, Wendy M. Leisenring, Nina S. Kadan-Lottick, Emily R. Christison-Lagay, Robert E. Goldsby, Rebecca M. Howell, Susan A. Smith, Kevin C. Oeffinger, Yutaka Yasui, Gregory T. Armstrong, Christopher B. Weldon, Eric J. Chow, Brent R. Weil
Summary: This study investigated the incidence of late-onset kidney failure among childhood cancer survivors and found that factors such as high kidney dose from radiotherapy, high-dose anthracycline, any ifosfamide chemotherapy, and nephrectomy were associated with an increased risk. Successfully managing modifiable risk factors like diabetes and hypertension could help reduce the risk of late-onset kidney failure. The association of late-onset kidney failure with anthracycline chemotherapy is a novel finding that requires further study.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Oncology
Trausti Oskarsson, Anne Katrine Duun-Henriksen, Andrea Bautz, Scott Montgomery, Arja Harila-Saari, Cecilia Petersen, Riitta Niinimaki, Laura Madanat-Harjuoja, Laufey Tryggvadottir, Anna Sallfors Holmqvist, Henrik Hasle, Mats Heyman, Jeanette Falck Winther
Summary: The study identified 26,334 childhood cancer survivors diagnosed before the age of 20, and found a higher risk of hospital admissions for skeletal adverse events in these survivors. The risks of osteonecrosis, osteoporosis, fractures, osteochondropathies, and osteoarthrosis were all increased among the survivors. Understanding the different lifetime patterns of skeletal adverse events and identifying high-risk groups is crucial for optimizing skeletal health in childhood cancer survivors.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Engineering, Biomedical
I-Ling Yeh, Jessica Holst-Wolf, Naveen Elangovan, Anna Vera Cuppone, Kamakshi Lakshminarayan, Leonardo Capello, Lorenzo Masia, Juergen Konczak
Summary: This study provides evidence that non-visual proprioceptive training can lead to rapid improvements in proprioceptive function in chronic stroke survivors. However, it remains inconclusive whether such training transfers to untrained motor tasks.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2021)
Article
Oncology
L. M. E. van Erp, H. Maurice-Stam, L. C. M. Kremer, W. J. E. Tissing, H. J. H. van der Pal, L. Beek, A. C. H. de Vries, M. M. van den Heuvel-Eibrink, B. A. B. Versluys, M. van der Heiden-van der Loo, M. van Gorp, G. A. Huizinga, M. A. Grootenhuis
Summary: This study examined the support needs and associated factors of young adult childhood cancer survivors (YACCS) in the Netherlands. The results showed that YACCS had the strongest need for concrete information in the domains of lifestyle, fertility, and physical consequences of childhood cancer. The associated factors were mainly socioeconomic and psychosocial in nature. The study suggests that psychosocial care should be integrated into survivorship care for YACCS.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Cardiac & Cardiovascular Systems
Jessica Bengtsson, Leonie K. Elsenburg, Gregers Stig Andersen, Mogens Lytken Larsen, Andreas Rieckmann, Naja Hulvej Rod
Summary: The study found that childhood adversity is associated with the development of cardiovascular disease in young adulthood. Individuals who experienced severe somatic illness and death in the family, as well as those who experienced high rates of adversity during childhood and adolescence, had a higher risk of developing cardiovascular disease.
EUROPEAN HEART JOURNAL
(2023)
Review
Clinical Neurology
Gargi Banerjee, John Collinge, Nick C. Fox, Tammaryn Lashley, Simon Mead, Jonathan M. Schott, David J. Werring, Natalie S. Ryan
Summary: Cerebral amyloid angiopathy (CAA) is a significant cerebral small vessel disease that is associated with brain haemorrhage and cognitive change. While the common form affects individuals in mid- to later life, rare early-onset forms are increasingly recognized and may be caused by genetic or iatrogenic factors. This review provides an overview of the causes of early-onset CAA and proposes a structured approach for investigation and management, aiming to raise awareness among healthcare professionals.
Article
Oncology
Heleen Maurice-Stam, Loes M. E. van Erp, Anne Maas, Hedy A. van Oers, Leontien C. M. Kremer, Eline Van Dulmen-den Broeder, Wim J. E. Tissing, Jacqueline J. Loonen, Helena J. H. van der Pal, Laura R. Beek, Andrica C. H. de Vries, Marry M. Van den Heuvel-Eibrink, Cecile M. Ronckers, Dorine Bresters, Marloes Louwerens, Margriet Van der Heiden-van der Loo, Gea A. Huizinga, Martha A. Grootenhuis
Summary: This study aimed to compare the psychosocial development of young adult survivors of childhood cancer with a norm group of young adults from the general population. The results showed that the overall psychosocial development of the young adult survivors of childhood cancer was as favorable as the norm group, but survivors of central nervous system cancer were at risk of an unfavorable psychosocial development in all domains.
SUPPORTIVE CARE IN CANCER
(2022)
