Article
Neurosciences
Damien Dupont, Jian-Sheng Lin, Francois Peyron, Hideo Akaoka, Martine Wallon
Summary: The study demonstrated that Toxoplasma gondii infection can lead to chronic alterations in sleep-wake states in mice, characterized by increased time spent awake, increased cortical EEG theta power density, and decreased slow-wave sleep. These effects can be alleviated by anti-inflammatory treatment with corticosteroid dexamethasone, shedding light on the neurodegenerative and neuropsychiatric disorders reported in infected patients.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Rajib Acharjee, Keith K. Talaam, Endah D. Hartuti, Yuichi Matsuo, Takaya Sakura, Bundutidi M. Gloria, Shinya Hidano, Yasutoshi Kido, Mihoko Mori, Kazuro Shiomi, Masakazu Sekijima, Tomoyoshi Nozaki, Kousuke Umeda, Yoshifumi Nishikawa, Shinjiro Hamano, Kiyoshi Kita, Daniel K. Inaoka
Summary: Toxoplasma gondii is a protozoan parasite that infects a large portion of the global human population. A new potential drug target, TgMQO, has been identified in this study, and a novel expression system was developed to study its characteristics. Ferulenol, an MQO inhibitor, showed promising inhibitory effects on TgMQO, with distinct binding sites from other known inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Marjan Enshaeieh, Geita Saadatnia, Jalal Babaie, Majid Golkar, Samira Choopani, Mohammad Sayyah
Summary: The study showed that valproic acid can inhibit chronic Toxoplasma infection and reduce the copy numbers of specific proteins and DNA in the brains of mice, comparable to the common medication TMP-SMZ.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Review
Parasitology
Alia Maisarah, Suharni Mohamad, Maruzairi Husain, Sarimah Abdullah, Rahmah Noordin
Summary: Toxoplasmosis is a prevalent zoonotic disease caused by the parasite Toxoplasma gondii. Transmission can occur through close contact with pets/cats, ingestion of undercooked meat or food/water contaminated by cat feces. Recent studies have shown an association between T. gondii infection and psychiatric disorders, particularly schizophrenia, depressive disorders, and bipolar disorders.
FOLIA PARASITOLOGICA
(2022)
Article
Veterinary Sciences
Roberto Condoleo, Pasquale Rombola, Roberta Palumbo, Davide Santori, Salvatore Serra, Sara Tonon, Antonio Bosco, Erminia Sezzi
Summary: Toxoplasmosis is a parasitic disease that affects a wide range of species, including humans, and can lead to important clinical manifestations. This study examines the seroprevalence and potential risk factors for ovine infection with Toxoplasma gondii, the causative agent of toxoplasmosis. The findings highlight the influence of environmental and climatic variables on the spread of the disease.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Immunology
Kun Yin, Chao Xu, Guihua Zhao, Huanhuan Xie
Summary: Toxoplasma gondii has a complex life cycle and can infect a wide range of warm-blooded animals globally. Infection by this parasite has been linked to various psychiatric disorders, such as schizophrenia and suicide. The mechanism behind the parasite's manipulation effects has not been fully elucidated. Recent research suggests that neuroendocrine programs and neurotransmitter imbalance may play a key role in this process. Additionally, studying the expression patterns of host genes, long noncoding RNAs (lncRNAs), and mRNAs provides new insights into understanding the neurotransmitter dysfunction induced by parasite manipulation.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Min Chen, Pei Yang, Zixuan Xin, Jiating Chen, Weihao Zou, Lijuan Zhou, Lili Yang, Jiao Peng, Hongjuan Peng
Summary: Toxoplasma gondii is a pathogen causing toxoplasmosis and has similarities with immunotherapy for cancers. The knockout of GRA5 gene in T. gondii resulted in an avirulent strain that stimulated immune responses. ME49 & UDelta;gra5 vaccination provided protection against T. gondii infection and breast cancer by boosting anti-tumor responses. The vaccine upregulated Th1 cytokines and tumor-infiltrating T cells, and increased the number of immune cells in the spleen.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
James M. Hodge, Anna E. Coghill, Youngchul Kim, Noemi Bender, Stephanie A. Smith-Warner, Susan Gapstur, Lauren R. Teras, Tom K. Grimsrud, Tim Waterboer, Kathleen M. Egan
Summary: Two prospective cohort studies suggest a potential association between T gondii infection and increased risk of glioma, especially among participants with high antibody titers specific to the sag-1 antigen. Further studies with larger case numbers are needed to confirm this etiologic role for T gondii in glioma.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Veterinary Sciences
Raul Munoz, Ezequiel Hidalgo-Hermoso, Fernando Fredes, Raul Alegria-Moran, Sebastian Celis, Carolina Ortiz-Tacci, Ignacio Kemec, Myra Mansell, Juan Verasay, Galia Ramirez-Toloza
Summary: Toxoplasma gondii is prevalent in zoo mammals in Chile, with higher seroprevalence in felids. Different taxonomic groups of animals have varying risks of T. gondii infection. Contact and transmission of the parasite within zoos may pose health risks for susceptible animals.
PREVENTIVE VETERINARY MEDICINE
(2021)
Article
Multidisciplinary Sciences
Taixiu Liu, Peng Gao, Deyun Bu, Dong Liu
Summary: This study investigates the current situation of Toxoplasma gondii infection in psychiatric patients and finds an association between T. gondii infection and mania, schizophrenia, depression, recurrent depressive disorder, and bipolar disorder.
SCIENTIFIC REPORTS
(2022)
Article
Microbiology
Amani Babekir, Sayed Mostafa, Emmanuel Obeng-Gyasi
Summary: This study found an association between T. gondii exposure and chronic kidney disease (CKD). Participants with positive T. gondii IgG antibody had higher levels of CKD biomarkers, and age was positively associated with CKD. Further investigations are needed to examine these findings in different geographical locations and differentially exposed populations.
Article
Multidisciplinary Sciences
Tooran Nayeri, Mahmood Moosazadeh, Abdolhossein Dalimi Asl, Fatemeh Ghaffarifar, Shahabeddin Sarvi, Ahmad Daryani
Summary: This systematic review and meta-analysis found that toxoplasmosis is common in both Rh-negative and Rh-positive blood groups. However, no significant association was found between toxoplasmosis and the Rh factor. More research is recommended to determine the exact relationship between toxoplasmosis and the Rh factor, due to the limited number of studies in this field.
Article
Multidisciplinary Sciences
Iti Saraav, Luisa Cervantes-Barragan, Philipp Olias, Yong Fu, Qiuling Wang, Leran Wang, Yi Wang, Matthias Mack, Megan T. Baldridge, Thaddeus Stappenbeck, Marco Colonna, L. David Sibley
Summary: Oral infection with Toxoplasma gondii exacerbates damage to the colon caused by chemical irritant and impairs wound healing by suppressing stem cell regeneration. Enhanced tissue damage is due to inflammatory monocytes releasing inflammatory mediators.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Public, Environmental & Occupational Health
Chin-Wei Hsu, Pao-Jung Wang, Pei-Yun Huang, Chen-Yeh Lien, Li-Hsin Wu, Yen-Hsueh Lai, Jun-Cheng Guo, Yen-Chen Chang, Chiu-Hung Cheng, Hui-Wen Chang
Summary: Toxoplasma gondii infection in mammals in Taipei Zoo is influenced by diet, presence of stray cats, and preventive measures like feeding frozen meat to carnivores and restricting access to stray cats can reduce the risk of T. gondii exposure.
ZOONOSES AND PUBLIC HEALTH
(2022)
Article
Parasitology
Junior Mario Baltazar de Oliveira, Bruno Pajeu e Silva, Muller Ribeiro-Andrade, Wagnner Jose Nascimento Porto, Renata Pimentel Bandeira de Melo, Jose Wilton Pinheiro Junior, Andrea Alice da Fonseca Oliveira, Rinaldo Aparecido Mota
Summary: This study evaluated Toxoplasma gondii infection in pregnant goats and found that it significantly affected reproductive health, leading to estrus recurrence, embryonic death, and abortion. The presence of anti-T. gondii antibodies in serum samples from goats and their offspring, along with the detection of T. gondii DNA in aborted fetuses and associated histopathological lesions, confirmed vertical transmission. In addition, the study determined that toxoplasmosis caused by genotype ToxoDB #1 resulted in severe reproductive loss in the goat flock.
PARASITOLOGY RESEARCH
(2022)
Review
Clinical Neurology
Silvia Fabiani, Barbara Pinto, Ugo Bonuccelli, Fabrizio Bruschi
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2015)
Article
Infectious Diseases
B. Pinto, R. Mattei, G. A. Moscato, M. Cristofano, M. Giraldi, R. Scarpato, W. Buffolano, F. Bruschi
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2017)
Review
Immunology
Silvia Fabiani, Simona Fortunato, Mario Petrini, Fabrizio Bruschi
TRANSPLANT INFECTIOUS DISEASE
(2017)
Review
Endocrinology & Metabolism
Silvia Fabiani, Poupak Fallahi, Silvia Martina Ferrari, Mario Miccoli, Alessandro Antonelli
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2018)
Review
Endocrinology & Metabolism
Poupak Fallahi, Silvia Martina Ferrari, Dilia Giuggioli, Andreina Manfredi, Caterina Mancusi, Silvia Fabiani, Marco Centanni, Santino Marchi, Clodoveo Ferri, Alessandro Antonelli
HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
(2014)
Article
Immunology
F. Bruschi, C. Bianchi, M. Fornaro, G. Naccarato, M. Menicagli, M. A. Gomez-Morales, E. Pozio, B. Pinto
PARASITE IMMUNOLOGY
(2014)
Article
Otorhinolaryngology
Luca Bruschini, Stefano Berrettini, Cambi Christina, Simone Ferranti, Silvia Fabiani, Marina Cavezza, Francesca Forli, Amelia Santoro, Enrico Tagliaferri
JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY
(2019)
Article
Immunology
Matteo Bassetti, Antonio Vena, Daniele Roberto Giacobbe, Marco Falcone, Giusy Tiseo, Maddalena Giannella, Renato Pascale, Marianna Meschiari, Margherita Digaetano, Alessandra Oliva, Cristina Rovelli, Novella Carannante, Angela Raffaella Losito, Sergio Carbonara, Michele Fabiano Mariani, Antonio Mastroianni, Gioacchino Angarano, Mario Tumbarello, Carlo Tascini, Paolo Grossi, Claudio Maria Mastroianni, Cristina Mussini, Pierluigi Viale, Francesco Menichetti, Claudio Viscoli, Alessandro Russo
OPEN FORUM INFECTIOUS DISEASES
(2020)
Article
Pharmacology & Pharmacy
Rosalinda Madonna, Silvia Fabiani, Riccardo Morganti, Arianna Forniti, Matteo Mazzola, Francesco Menichetti, Raffaele De Caterina
Summary: Isolated ExPH is associated with worse clinical status and poor immunological control in HIV patients. Assessment of ExPH by ESE may help identify subgroups of HIV patients with a propensity to develop subclinical impairment of pulmonary circulation following poor control of HIV infection.
VASCULAR PHARMACOLOGY
(2021)
Article
Parasitology
Silvia Fabiani, Claudio Caroselli, Martina Menchini, Giovanna Gabbriellini, Marco Falcone, Fabrizio Bruschi
Summary: This review explores the widespread protozoan parasite Toxoplasma gondii, particularly its impact on ocular health. The intricate relationship between the parasite and its human host, as well as the potential treatment and prevention strategies, warrant further investigation.
Review
Microbiology
Fabiani Silvia, Fortunato Simona, Bruschi Fabrizio
Article
Medicine, General & Internal
S. Fabiani
CLINICA TERAPEUTICA
(2015)
Article
Endocrinology & Metabolism
Alessandro Antonelli, Silvia Martina Ferrari, Dilia Giuggioli, Andrea Di Domenicantonio, Ilaria Ruffilli, Alda Corrado, Silvia Fabiani, Santino Marchi, Clodoveo Ferri, Ele Ferrannini, Poupak Fallahi
WORLD JOURNAL OF DIABETES
(2014)
Review
Rheumatology
S. Fabiani, F. Bruschi
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2014)
