☆ 4.5 Article

Cerebrospinal fluid cathepsin B and S

NEUROLOGICAL SCIENCES (2013)

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Journal

NEUROLOGICAL SCIENCES
Volume 34, Issue 4, Pages 445-448

Publisher

SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s10072-012-1022-0

Keywords

Cathepsin B; Cathepsin S; Cerebrospinal fluid; Age

Categories

Clinical Neurology Neurosciences

Funding

  1. Uppsala University Hospital Research Fund
  2. Uppsala Berzelii center

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Cathepsins are increased in the brain of elderly animals. We investigate the presence of cathepsin B and S in human cerebrospinal fluid (CSF) plasma and the associations with cystatin C, age and sex. We measured cathepsin B and S concentrations in CSFs from 118 persons, undergoing elective surgical procedures, with ELISA. Both cathepsin B and cathepsin S were positively correlated with age. No correlation was observed between cathepsin B or S and length, height or body mass index. Both cathepsin B and S were positively correlated to the cystatin C concentration in CSF. Calculated reference intervals were 4,893-17,636 pg/mL for cathepsin B and 2,681-11,459 pg/mL for cathepsin S. Elderly individuals had significantly higher levels of both cathepsin B (r (s) = 0.38, p = 0.00002) and cathepsin S (r (s) = 0.35, p = 0.0001) in CSF.

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