Article
Clinical Neurology
Jose Fidel Baizabal-Carvallo, Joseph Jankovic
Summary: This study aimed to characterize the frequency and features of blocking tics in patients with Tourette syndrome (TS). The results showed that approximately 6% of patients had blocking phenomena, with phonic tic intrusion causing speech arrest being the most common. Variables such as shoulder tics, leg tics, copropraxia, dystonic tics, simple phonic tics, and number of phonic tics per patient were statistically related to blocking phenomena. The presence of dystonic tics and a higher number of phonic tics were associated with blocking phenomena.
JOURNAL OF MOVEMENT DISORDERS
(2023)
Review
Clinical Neurology
James Peters, Nirosen Vijiaratnam, Heather Angus-Leppan
Summary: This study reviewed the clinical spectrum of tic disorders induced by AED, including the types of AED implicated and the characteristics of the symptoms. The analysis revealed that multiple AEDs can induce tic disorders, suggesting that the cause is unlikely to be solely related to alterations in a single neurotransmitter, but rather a network imbalance influenced by various factors.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Karla Claudio-Campos, Daniel Stevens, Sang-Wahn Koo, Alexa Valko, Oscar Joseph Bienvenu, Cathy B. Budman, Danielle C. Cath, Sabrina Darrow, Daniel Geller, Fernando S. Goes, Marco A. Grados, Benjamin D. Greenberg, Erica Greenberg, Matthew E. Hirschtritt, Cornelia Illmann, Franjo Ivankovic, Robert A. King, James A. Knowles, Janice Krasnow, Paul C. Lee, Gholson J. Lyon, James T. McCracken, Mary M. Robertson, Lisa Osiecki, Mark A. Riddle, Guy Rouleau, Paul Sandor, Gerald Nestadt, Jack Samuels, Jeremiah M. Scharf, Carol A. Mathews
Summary: In individuals with Persistent motor or vocal tic disorder (PMVT) and Tourette syndrome (TS), there are differences in comorbid psychiatric disorders, age of tic onset, and tic severity. ADHD and OCD increase the odds of other psychiatric disorders, contributing to the observed differences between PMVT and TS. First-degree relatives of TS patients have elevated rates of TS, PMVT, OCD, and ADHD compared to the general population.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Tamara Pringsheim, Christos Ganos, Christelle Nilles, Andrea E. E. Cavanna, Donald L. L. Gilbert, Erica Greenberg, Andreas Hartmann, Tammy Hedderly, Isobel Heyman, Holan Liang, Irene Malaty, Osman Malik, Nanette Mol Debes, Kirsten Muller Vahl, Alexander Munchau, Tara Murphy, Peter Nagy, Tamsin Owen, Renata Rizzo, Liselotte Skov, Jeremy Stern, Natalia Szejko, Yulia Worbe, Davide Martino
Summary: In 2020, there was a significant increase in referrals for young people with rapid onset of severe tic-like behaviors. A working group was formed to develop clinical criteria for the diagnosis of functional tic-like behaviors (FTLBs) to aid in recognition and diagnosis by healthcare professionals.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Justyna Kaczynska, Piotr Janik
Summary: This study evaluated the prevalence, age of onset, and clinical correlates of blocking tics (BTs) in patients with Gilles de la Tourette syndrome (GTS). BTs represent early and common symptoms of GTS, associated with a more severe form of the syndrome.
FRONTIERS IN NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Payton Beeler, Nicholas O. Jensen, Soyoung Kim, Amy Robichaux-Viehoever, Bradley L. Schlaggar, Deanna J. Greene, Kevin J. Black, Rajan K. Chakrabarty
Summary: The study confirms the fractal nature of tics, indicating correlation between neighboring time scales. The fractal dimension is correlated with tic severity and serves as a sensitive parameter for examining the effects of tic suppression conditions. This finding opens up new possibilities for utilizing the fractal nature of tics as a tool for assessing and treating tic disorders.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2022)
Article
Nutrition & Dietetics
Chang-Chun Wu, Lee-Chin Wong, Chia-Jui Hsu, Chianne-Wen Yang, Ying-Chieh Tsai, Feng-Shiang Cheng, Hsiao-Yun Hu, Wang-Tso Lee
Summary: The study suggests that probiotics may not reduce tics in children with Tourette syndrome, but they may benefit comorbidities such as attention deficit and hyperactivity disorder. Further research is needed to clarify the effects of probiotics on the comorbidities of Tourette syndrome children.
Article
Health Care Sciences & Services
Jesjeet Singh Gill
Summary: This case report describes a young male with Tourette syndrome and comorbid major depressive disorder and ADHD who experienced troublesome side effects due to his existing medications. The patient's symptoms were effectively controlled and improved by switching risperidone to cariprazine and increasing the antidepressant dose.
Article
Behavioral Sciences
Lina Schubert, Julius Verrel, Amelie Behm, Tobias Baeumer, Christian Beste, Alexander Muenchau
Summary: The study found that associations between urges and tics in patients with Gilles de la Tourette syndrome are complex and heterogeneous, with some individuals not showing the expected positive correlation, and even displaying negative associations. While most patients demonstrated a positive relationship between urges and tics, there were substantial inter-individual differences in these associations.
Article
Clinical Neurology
Kirsten R. Muller-Vahl, Carolin Fremer, Chan Beals, Jelena Ivkovic, Henrik Loft, Christoph Schindler
Summary: Lu AG06466 did not show efficacy in reducing tics and premonitory urges in patients with Tourette syndrome, but the treatment was generally safe.
MOVEMENT DISORDERS
(2021)
Article
Psychology, Clinical
Joey K. -Y. Essoe, Emily J. Ricketts, Kesley A. Ramsey, John Piacentini, Douglas W. Woods, Alan L. Peterson, Lawrence Scahill, Sabine Wilhelm, John T. Walkup, Joseph F. McGuire
Summary: The study demonstrated that homework adherence is crucial in behavior therapy for Tourette's Disorder, with higher adherence predicting reductions in tic severity and treatment response. Early adherence predicted therapeutic improvement in youth, while late adherence predicted improvement in adults. Adherence in youth was influenced by hyperactivity/impulsivity and caregiver strain, while in adults, predictors included younger age, hyperactivity/impulsivity, obsessive-compulsive severity, anger, and work-related disability.
BEHAVIOUR RESEARCH AND THERAPY
(2021)
Review
Clinical Neurology
Aribert Rothenberger, Hartmut Heinrich
Summary: This article discusses how to use electrophysiological methods to study the development of brain dynamics in TS patients, and points out its potential application in tic treatment. Studies have shown that the brain dynamics parameters of TS patients evolve concurrently with clinical characteristics, including a delay in motor inhibition maturation and specific sleep parameters and perception-action binding.
FRONTIERS IN NEUROLOGY
(2021)
Article
Psychiatry
Cyril Atkinson-Clement, Astrid de Liege, Yanica Klein, Benoit Beranger, Romain Valabregue, Cecile Delorme, Emmanuel Roze, Emilio Fernandez-Egea, Andreas Hartmann, Trevor W. Robbins, Yulia Worbe
Summary: Reward sensitivity is suggested as a central mechanism in Tourette disorder. This study found that delay discounting behavior is present in patients with Tourette disorder, indicating higher impulsivity and more severe tics. Brain functional imaging revealed that reward discounting is associated with connectivity of the pre-supplementary motor area, playing a key role in delay discounting, impulsivity, and tic severity.
TRANSLATIONAL PSYCHIATRY
(2021)
Review
Clinical Neurology
Natalia Szejko, Kirsten R. Muller-Vahl
Summary: Tourette syndrome (TS) is characterized by vocal and motor tics, often accompanied by psychiatric comorbidities. Differential diagnosis between tics and OCD-related phenomena can be challenging, as some symptoms may overlap. "Just right" phenomena are common in patients with TS, showing similarities with both tics and OCD. Treatment strategies for tics and OCD in TS patients should take into consideration these complexities.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Article
Clinical Neurology
Simon Morand-Beaulieu, Michael J. Crowley, Heidi Grantz, James F. Leckman, Lawrence Scahill, Denis G. Sukhodolsky
Summary: Comprehensive Behavioral Intervention for Tics (CBIT) is an effective treatment for Tourette syndrome (TS), but its underlying brain mechanisms are not well understood. This study found no association between EEG coherence during a Go/NoGo task and CBIT outcome, suggesting that the brain processes involved in motor response inhibition may not play a role in CBIT.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Neurosciences
Giuliana Galassi, Manuela Tondelli, Alessandra Ariatti, Francesca Benuzzi, Paolo Nichelli, Franco Valzania
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2017)
Article
Neurosciences
Diana Ferraro, Veronica Galli, Anna Maria Simone, Roberta Bedin, Francesca Vitetta, Elisa Merelli, Paolo Frigio Nichelli, Patrizia Sola
JOURNAL OF NEUROVIROLOGY
(2017)
Correction
Clinical Neurology
Elisa Baldin, Stefania Testoni, Silvia de Pasqua, Salvatore Ferro, Fiorenzo Albani, Agostino Baruzzi, Roberto D'Alessandro
NEUROLOGICAL SCIENCES
(2017)
Article
Clinical Neurology
Elisa Baldin, Stefania Testoni, Silvia de Pasqua, Salvatore Ferro, Fiorenzo Albani, Agostino Baruzzi, Roberto D'Alessandro
NEUROLOGICAL SCIENCES
(2017)
Article
Neurosciences
Marco Mazzoli, Alessandra Ariatti, Franco Valzania, Shaniko Kaleci, Manuela Tondelli, Paolo F. Nichelli, Giuliana Galassi
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2018)
Letter
Clinical Neurology
Antonio Fasano, Francesco Cavallieri, Jessica Mandrioli, Annalisa Chiari, Paolo Nichelli
NEUROLOGICAL SCIENCES
(2018)
Article
Clinical Neurology
Giuliana Galassi, Marco Mazzoli, Alessandra Ariatti, Shaniko Kaleci, Franco Valzania, Paolo F. Nichelli
ACTA NEUROLOGICA BELGICA
(2018)
Editorial Material
Clinical Neurology
Diana Ferraro, Valentina Camera, Francesca Vitetta, Mauro Zennaro, Ludovico Ciolli, Paolo Frigio Nichelli, Patrizia Sola
Article
Multidisciplinary Sciences
Daniela Ballotta, Fausta Lui, Carlo Adolfo Porro, Paolo Frigio Nichelli, Francesca Benuzzi
Article
Behavioral Sciences
Manuela Tondelli, Anna M. Barbarulo, Giulia Vinceti, Chiara Vincenzi, Annalisa Chiari, Paolo F. Nichelli, Giovanna Zamboni
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2018)
Article
Behavioral Sciences
Francesca Benuzzi, Daniela Ballotta, Giacomo Handjaras, Andrea Leo, Paolo Papale, Michaela Zucchelli, Maria Angela Molinari, Fausta Lui, Luca Cecchetti, Emiliano Ricciardi, Giuseppe Sartori, Pietro Pietrini, Paolo Frigio Nichelli
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2018)
Meeting Abstract
Clinical Neurology
M. Mazzoli, A. Ariatti, M. T. Mascia, F. Valzania, P. Nichelli, G. Galassi
EUROPEAN JOURNAL OF NEUROLOGY
(2018)
Meeting Abstract
Clinical Neurology
M. Mazzoli, A. Ariatti, F. Valzania, M. Mascia, P. Nichelli, G. Galassi
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2018)
Meeting Abstract
Clinical Neurology
V. Camera, D. Ferraro, F. Vitetta, M. Zennaro, A. M. Simone, P. F. Nichelli, P. Sola
MULTIPLE SCLEROSIS JOURNAL
(2017)
Meeting Abstract
Clinical Neurology
D. Ferraro, A. M. Simone, R. Bedin, F. Vitetta, V. Camera, P. F. Nichelli, P. Sola
MULTIPLE SCLEROSIS JOURNAL
(2017)
