Journal
NEUROLOGICAL SCIENCES
Volume 32, Issue 1, Pages 59-65Publisher
SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s10072-010-0393-3
Keywords
Hypoxic ischemia neonatal; Uric acid; Myeloperoxidase; Urinary lipid peroxidation
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Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq-PIBIC)
- Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul (FAPERGS)
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The aim of this study was to evaluate urinary uric acid (UA) and lipid peroxidation levels, plasma myeloperoxidase (MPO) and adenosine deaminase (ADA) activities, and serum UA in neonatal rats subjected to hypoxia-ischemia neonatal HI model. The relevance of the findings is the fact that urinary lipid peroxidation and UA levels were significantly higher in 8 days in HI group when compared with the control, returning to baseline levels 60 days after HI. Hence, being an indication of purinic degradation during these first days post-HI. Furthermore, the higher levels of malondialdehyde (MDA) in urine in this period may be related to inadequate scavenging abilities of the immature nervous system and being noninvasive it may suggest the use of urinary MDA measurement as a marker for lipid peroxidation after HI insult. In application terms, these findings can help develop therapeutic interventions as soon as 8 days after HI.
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