Article
Immunology
Hang Zhou, Libin Hu, Jianru Li, Wu Ruan, Yang Cao, Jianfeng Zhuang, Hangzhe Xu, Yucong Peng, Zhongyuan Zhang, Chaoran Xu, Qian Yu, Yin Li, Zhangqi Dou, Junwen Hu, Xinyan Wu, Xiaobo Yu, Chi Gu, Shenglong Cao, Feng Yan, Gao Chen
Summary: The study demonstrates the role of AXL in transforming astrocytes into a phagocytic phenotype after TBI through the AXL/STAT1/ABCA1 pathway, which helps limit neuroinflammation and improve neurological impairments. The findings provide a potential therapeutic target for TBI.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Neurosciences
Yitong Liu, Wentong Hong, Pifang Gong, Guibo Qi, Xiaoxuan Wang, Siying Kang, Han Tang, Song Qin
Summary: This study found that the expression level of Sox2 transcription factor in astrocytes increased significantly after traumatic brain injury during early postnatal period. Specific knockout of Sox2 in astrocytes inhibited the proliferation of reactive astrocytes and promoted tissue recovery.
Article
Multidisciplinary Sciences
Zhaohua Tang, Gang Yang, Zhengbu Liao, Feilan Chen, Song Chen, Wentao Wang, Gang Huo, Xiaochuan Sun, Xiaoshu Wang
Summary: This study found that TSO IIA can alleviate astrocytic swelling caused by ischemia-reperfusion-like injury in an in vitro model. The protective mechanism may involve the activation of the HMGB1/RAGE/NF-kappa B/IL-6 pro-inflammatory axis.
SCIENTIFIC REPORTS
(2022)
Article
Critical Care Medicine
Benjamin E. E. Zusman, Yijen Wu, Patrick M. M. Kochanek, Vincent E. E. Vagni, Keri Janesko-Feldman, Volodymyr Gerzanich, J. Marc Simard, Katherine Karahalios, Sandra Mihaljevic, Sudhanshu Raikwar, Anupama Rani, Jarrod Rulney, Shashvat M. M. Desai, Joshua Catapano, Ruchira M. M. Jha
Summary: This study evaluated the differential effects of glibenclamide on dose, TBI type, and imaging endophenotype. High-dose glibenclamide showed benefits in reducing hematoma volume, vasogenic edema, cytotoxic edema, and maintaining blood-brain barrier integrity after isolated brain contusion. However, its anti-edema effects were not robust in the presence of concomitant hemorrhagic shock.
CRITICAL CARE MEDICINE
(2023)
Article
Immunology
Jianqin Xue, Yu Zhang, Junhua Zhang, Zhujun Zhu, Qi Lv, Jianhua Su
Summary: This study revealed the important role of astrocyte-derived CCL7 in promoting microglia-mediated inflammation after TBI, suggesting CCL7 could serve as a potential therapeutic strategy for attenuating TBI by inhibiting microglial activation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Physiology
Rodrigo G. Mira, Matias Lira, Waldo Cerpa
Summary: Traumatic brain injury (TBI) is a heterogeneous disorder that causes brain damage due to external forces, leading to CNS damage under various mechanisms. Glial cells such as astrocytes, microglia, and oligodendrocytes play crucial roles in response to TBI, affecting neuronal damage and pathophysiology.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Neurosciences
Mengqi Yuan, Haitao Wu
Summary: Astrocytes play a crucial role in controlling processes in the nervous system after brain injury, producing neuroprotective factors while also potentially hindering CNS repair. Understanding the dual role of astrocytes may improve post-brain injury recovery and lead to the development of novel therapeutic strategies for TBI.
EXPERIMENTAL NEUROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Shotaro Michinaga, Yutaka Koyama
Summary: Traumatic brain injury (TBI) is immediate damage to the brain caused by a blow to the head, resulting in death or serious disabilities. Astrocytes play a key role in the pathogenesis of TBI, with both beneficial and detrimental effects. They are attractive targets for novel therapeutic drugs for TBI, although such drugs have not yet been developed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Critical Care Medicine
Daniel Agustin Godoy, Francisco Murillo-Cabezas, Jose Ignacio Suarez, Rafael Badenes, Paolo Pelosi, Chiara Robba
Summary: To ensure neuronal survival after severe traumatic brain injury, sufficient oxygen supply is crucial. Cerebral tissue oxygenation, which is determined by multiple physiological parameters, reflects the adequacy of cerebral perfusion. Brain tissue hypoxia occurs when oxygen supply is inadequate or cannot be utilized at the cellular level. Precision medicine and multimodal monitoring are important in individualized therapeutic interventions for specific brain damage.
Article
Health Care Sciences & Services
Wilmer Danilo Esparza, Arian Ramon Aladro-Gonzalvo, Antonio Ruiz-Hontangas, Daniela Celi, Maria Belen Aguirre
Summary: This study aimed to explore the effect of craniofacial MLD in combination with pharmacological treatment for improving cranial pain intensity, vital signs, and cerebral edema in moderate traumatic brain injury (mTBI) patients. The results showed that patients who received both pharmacological and MLD treatment experienced decreased cranial pain intensity, reduced systolic blood pressure, and decreased cerebral edema.
Review
Neurosciences
Baoman Li, Dianjun Zhang, Alexei Verkhratsky
Summary: This review summarizes the roles of astrocytes in posttraumatic stress disorder (PTSD) and highlights the potential therapeutic targets in the impairment of astrocytic functions.
NEUROSCIENCE BULLETIN
(2022)
Article
Immunology
Brittany P. Todd, Michael S. Chimenti, Zili Luo, Polly J. Ferguson, Alexander G. Bassuk, Elizabeth A. Newell
Summary: The study revealed sustained, lineage-specific transcriptional changes in both microglia and astrocytes following severe TBI, with microglia showing a greater transcriptional response than astrocytes at a subacute time point. Both microglia and astrocytes were enriched for genes related to type I interferon signaling and MHC class I antigen presentation. The transcriptional response of microglia and astrocytes to severe TBI was distinct from prior reports in mild TBI and other neurodegenerative and neuroinflammatory diseases.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Neurosciences
Chaonan Zhang, Chuan Liu, Fanjian Li, Mutian Zheng, Yafan Liu, Lei Li, Huaijin Yang, Shu Zhang, Chongjin Wang, Hongtao Rong, Hui Guo, Ying Li, Ying Fu, Zilong Zhao, Jianning Zhang
Summary: Traumatic brain injury (TBI) can lead to neuroinflammation, which is associated with poor outcomes and high mortality in patients. Cellular microvesicles, especially extracellular mitochondria, released from injured cells contribute to TBI-induced coagulopathy and inflammation. In addition to their procoagulant activity, extracellular mitochondria can also induce pro-inflammatory polarization of microglia, aggravating neuroinflammation and cerebral edema in a ROS-dependent manner.
NEUROTOXICITY RESEARCH
(2022)
Article
Clinical Neurology
Audrey C. Leasure, Lindsey R. Kuohn, Kevin N. Vanent, Matthew B. Bevers, W. Taylor Kimberly, Thorsten Steiner, Stephan A. Mayer, Charles C. Matouk, Lauren H. Sansing, Guido J. Falcone, Kevin N. Sheth
Summary: Higher admission IL-6 levels in patients with spontaneous intracerebral hemorrhage are associated with worse 90-day functional outcome, larger ICH volume, and larger perihematomal edema volume.
Article
Pharmacology & Pharmacy
Ping Ma, Ning Huang, Jun Tang, Zunjie Zhou, Jing Xu, Yi Chen, Maoxin Zhang, Qin Huang, Yuan Cheng
Summary: The study shows that 9-PH effectively reduces cerebral edema by inhibiting the TRPM4 channel, reducing cytotoxic edema and preventing vasogenic edema. It also alleviates secondary brain injury by reducing inflammation and apoptosis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Shuo-Yao Qu, Ya-Long He, Jian Zhang, Chang-gui Wu
Article
Oncology
Anan Yin, Amandine Etcheverry, Yalong He, Marc Aubry, Jill Barnholtz-Sloan, Luhua Zhang, Xinggang Mao, Weijun Chen, Bolin Liu, Wei Zhang, Jean Mosser, Xiang Zhang
Article
Radiology, Nuclear Medicine & Medical Imaging
Yang Liu, Xi Zhang, Na Feng, Lulu Yin, Yalong He, Xiaopan Xu, Hongbing Lu
Article
Neurosciences
An-An Yin, Nan Lu, Amandine Etcheverry, Marc Aubry, Jill Barnholtz-Sloan, Lu-Hua Zhang, Jean Mosser, Wei Zhang, Xiang Zhang, Yu-He Liu, Ya-Long He
CNS NEUROSCIENCE & THERAPEUTICS
(2018)
Article
Neurosciences
Yalong He, Shuoyao Qu, Jiang Wang, Xiaosheng He, Wei Lin, Haining Zhen, Xiang Zhang
Article
Clinical Neurology
Yalong He, Guitao Yang, Yangang Wang, Yi Ren, Xiaosheng He, Xiang Zhang, Zhou Fei
NEUROLOGICAL RESEARCH
(2013)
Article
Respiratory System
Shuo-Yao Qu, Hai-Feng Ou-Yang, Ya-Long He, Qi Wan, Jie-Ran Shi, Chang-Gui Wu
Article
Respiratory System
Shuo-Yao Qu, Hai-Feng Ou-Yang, Ya-Long He, Zhi-Kui Li, Jie-Ran Shi, Li-Qiang Song, Chang-Gui Wu
Article
Neurosciences
En-Ming Kang, An-An Yin, Ya-Long He, Wei-Jun Chen, Amandine Etcheverry, Marc Aubry, Jill Barnholtz-Sloan, Jean Mosser, Wei Zhang, Xiang Zhang
CNS NEUROSCIENCE & THERAPEUTICS
(2019)
Article
Oncology
An-An Yin, Ya-Long He, Amandine Etcheverry, Yu-He Liu, Marc Aubry, Jill Barnholtz-Sloan, Bo-Lin Liu, Jean Mosser, Zi-Fan Lu, Xiang Zhang
CLINICAL EPIGENETICS
(2019)
Article
Oncology
Weifeng Lv, Qi Li, Bo Jia, Yalong He, Yi Ru, Qingdong Guo, Xia Li, Wei Lin
Summary: The study reveals that DEC1 regulates TMZ resistance through the SP1-MGMT axis, influencing cell apoptosis in GBM. The expression levels of DEC1 are correlated with MGMT in glioma tissues, indicating its predictive value in TMZ resistance and poor prognosis.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Oncology
Anan Yin, Zhende Shang, Amandine Etcheverry, Yalong He, Marc Aubry, Nan Lu, Yuhe Liu, Jean Mosser, Wei Lin, Xiang Zhang, Yu Dong
Summary: The study identified 8 CpGs that are significantly correlated with overall survival in non-G-CIMP GBMs, independent of other clinical and molecular factors. These CpGs were used to develop a prognostic risk signature that can predict prognosis in both non-G-GIMP GBMs and IDHwt LGGs, showing good discriminating value across different cohorts. Furthermore, functional experiments indicated that one of the identified CpGs may regulate the gene S100A2, which is associated with various GBM cell activities and potential immunosuppression.