Editorial Material
Clinical Neurology
Jonathan K. Kleen, Kathryn A. Davis
Summary: Do transient bursts of interictal epileptiform activity have a clinically relevant effect on cognition? This study examines the impact of such bursts on cognitive impairment and reaction times. Scalp EEG has demonstrated focal effects of discharges within a particular hemisphere or lobe, while recent intracranial work has provided more functional-anatomic detail and mechanistic studies. However, most clinicians still hesitate to treat the interictal EEG without clear quantitative guidance.
Article
Clinical Neurology
Jennifer A. Kim, Wei-Long Zheng, Jonathan Elmer, Jin Jing, Sahar F. Zafar, Manohar Ghanta, Valdery Moura Junior, Emily J. Gilmore, Lawrence J. Hirsch, Aman Patel, Eric Rosenthal, Brandon M. Westover
Summary: This study aims to investigate whether epileptiform discharge burden can identify individuals at risk for delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH). A retrospective analysis was conducted on 113 SAH patients with moderate to severe grade who had continuous EEG (cEEG) recordings during hospitalization. The burden of epileptiform discharges (ED), measured as the number of ED per hour, was calculated. The results indicate that ED burden is a useful parameter for identifying individuals at higher risk of developing DCI after SAH, and specific trends of ED burden over time can help stratify DCI risk.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Clinical Neurology
Mengrong Miao, Yaqian Han, Ying Zhang, Yuehua Xu, Liyuan Zhang, Yitian Yang, Mingyang Sun, Jiaqiang Zhang
Summary: The study found that the incidence of epileptiform EEG events in children during sevoflurane anesthesia varied from 19.1% to 59.2%. Using a low initial concentration of sevoflurane induction can reduce the incidence of these epileptiform discharges, while longer exposure to high concentration sevoflurane may increase the rate of epileptiform discharges.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Clinical Neurology
Fabio A. Nascimento, Jaden D. Barfuss, Alex Jaffe, M. Brandon Westover, Jin Jing
Summary: This study designed an algorithm to quantify the six IFCN criteria for identifying interictal epileptiform discharges (IEDs) and estimate the likelihood of a candidate IED being epileptiform. The model's performance was excellent but lower than human experts or a deep neural-network model. The six features of candidate IEDs were of different importance in determining their epileptiform nature, with waveform asymmetry being the most important and duration being the least discriminative. This model may assist clinical electroencephalographers in decision-making and trainees in learning to identify IEDs.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Neurosciences
Christian Sandoe Musaeus, Kristian Steen Frederiksen, Birgitte Bo Andersen, Peter Hogh, Preben Kidmose, Martin Fabricius, Melita Cacic Hribljan, Martin Christian Hemmsen, Mike Lind Rank, Gunhild Waldemar, Troels Wesenberg Kjaer
Summary: In this study, it was found that most patients with Alzheimer's disease (AD) had epileptiform discharges, with a three-fold higher frequency compared to healthy elderly controls (HC), which most likely originated from the temporal lobes. This result suggests that elevated spike frequency should be considered a marker of hyperexcitability in AD.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Clinical Neurology
Christian Sandoe Musaeus, Troels Wesenberg Kjaer, Melita Cacic Hribljan, Birgitte Bo Andersen, Peter Hogh, Preben Kidmose, Martin Fabricius, Martin Christian Hemmsen, Mike Lind Rank, Gunhild Waldemar, Kristian Steen Frederiksen
Summary: Patients with DLB have a higher occurrence of interictal epileptiform discharges (IED) compared to healthy controls. These findings suggest that IED may be a consequence of neurodegeneration in patients with DLB.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Anca A. Arbune, Pirgit Meritam Larsen, Stephan Wustenhagen, Daniella Terney, Elena Gardella, Sandor Beniczky
Summary: The study found that more than one third of epileptiform EEG discharges showed a decrease in spiking patterns during seizures, suggesting a potential anticonvulsive function, while the majority of discharges increased in association with seizures.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Jan Pyrzowski, Jean- Eudes Le Douget, Amal Fouad, Mariusz Sieminski, Joanna Jedrzejczak, Michel Le Van Quyen
Summary: The clinical diagnosis of epilepsy heavily relies on detecting interictal epileptiform discharges (IEDs) from scalp EEG signals, which is challenging by visual means. This study introduces a simple signal analysis method based on scalp EEG zero-crossing patterns to extract the spatiotemporal structure of scalp voltage fluctuations. The analysis revealed the effectiveness of this method in detecting intracranial IEDs, including those that do not propagate to the neocortex, and accurately discriminating between patients with epilepsy and normal subjects.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Simon Henin, Anita Shankar, Helen Borges, Adeen Flinker, Werner Doyle, Daniel Friedman, Orrin Devinsky, Gyorgy Buzsaki, Anli Liu
Summary: The spatiotemporal characteristics of cortical high-gamma activity, hippocampal ripple activity, and interictal epileptiform discharges have a significant impact on memory performance during an associative memory task, particularly in the hippocampal region. Interictal epileptiform discharges may impair associative memory by disrupting physiological activity, making them a promising therapeutic target for memory remediation in patients with epilepsy.
Article
Clinical Neurology
Noa Cohen, Yoram Ebrahimi, Mordekhay Medvedovsky, Guy Gurevitch, Orna Aizenstein, Talma Hendler, Firas Fahoum, Tomer Gazit
Summary: Polymicrogyria is a common brain malformation that can lead to epileptic seizures. By tracking BOLD activations over time, researchers have found that early hemodynamic activity may provide important information to help localize the source of epileptic activity in patients with PMG. The development of IEDs within a small area of the PMG lesion with subsequent wider engagement of brain structures may explain the difficulty in detecting them on scalp EEG.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Franz Furbass, Johannes Koren, Manfred Hartmann, Georg Brandmayr, Sebastian Hafner, Christoph Baumgartner
Summary: This study quantifies the effects of sleep and seizures on IED rates and classifies patients with epilepsy based on their IED activation patterns. Five sub-cohorts with distinct IED activation patterns were identified, showing associations with circadian rhythms, sleep stages, and seizure occurrence.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Lei Dong, Lin-Lin Song, Wen-jun Zhao, Ling Zhao, Lei Tian, Yu Zheng
Summary: Electromagnetic stimulation (EMS) can modulate the transition of epileptiform activity (EFA) from brief interictal discharges (IIDs) to prolonged ictal discharges (IDs). The study found that real-time magnetic fields can block the normal EFA process and this suppression effect depends on input intensities and intervention duration.
BRAIN RESEARCH BULLETIN
(2023)
Article
Clinical Neurology
Maurice Abou Jaoude, Claire S. Jacobs, Rani A. Sarkis, Jin Jing, Kyle R. Pellerin, Andrew J. Cole, Sydney S. Cash, M. Brandon Westover, Alice D. Lam
Summary: This diagnostic study aimed to develop and validate a machine learning algorithm that accurately detects hippocampal epileptiform activity (HEA) from a standard scalp EEG, providing a novel, noninvasive, quantitative, and clinically relevant biomarker of hippocampal hyperexcitability in humans.
Article
Engineering, Biomedical
Ana Maria Amaro de Sousa, Michel J. A. M. van Putten, Stephanie van den Berg, Maryam Amir Haeri
Summary: Interictal discharges are important signatures of epilepsy and their detection can assist in epilepsy diagnostics. This study explored unsupervised and semi-supervised deep learning approaches for the automatic detection of these discharges in EEG recordings. The best performance was achieved using a semi-supervised approach, with a sensitivity of 81.9% and specificity of 91.7%.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2024)
Article
Clinical Neurology
Robert J. Quon, Stephen Meisenhelter, Edward J. Camp, Markus E. Testorf, Yinchen Song, Qingyuan Song, George W. Culler, Payam Moein, Barbara C. Jobst
Summary: The study utilized an automated method combining template-matching algorithm and CNN to successfully detect intracranial IEDs with high F1 score and AUC. On the external test set, it was able to identify 100% of high-amplitude IED complexes, 96.23% of high amplitude isolated IEDs, and 66.15% of IEDs with atypical morphology.
CLINICAL NEUROPHYSIOLOGY
(2022)
Letter
Clinical Neurology
Hiroshi Fujioka, Eiichirou Urasaki, Akifumi Izumihara, Katsuhiro Yamashita
CLINICAL NEUROPHYSIOLOGY
(2016)
Article
Psychology, Biological
Hidekazu Kaneko, Hiroto Sano, Yasuhisa Hasegawa, Hiroshi Tamura, Shinya S. Suzuki
LEARNING & BEHAVIOR
(2017)
Letter
Clinical Neurology
Hiroshi Fujioka, Eiichirou Urasaki, Katsuhiro Yamashita
CLINICAL NEUROPHYSIOLOGY
(2018)
Letter
Clinical Neurology
Hiroshi Fujioka, Eiichirou Urasaki, Akifumi Izumihara, Katsuhiro Yamashita
CLINICAL NEUROPHYSIOLOGY
(2018)
Article
Biophysics
Tetsuhiro Harimoto, Kuniharu Takei, Takeshi Kawano, Akito Ishihara, Takahiro Kawashima, Hidekazu Kaneko, Makoto Ishida, Shiro Usui
BIOSENSORS & BIOELECTRONICS
(2011)
Article
Neurosciences
Hiroshi Tamura, Yoshiya Mori, Hidekazu Kaneko
JOURNAL OF NEUROPHYSIOLOGY
(2014)
Meeting Abstract
Neurosciences
Hidekazu Kaneko, Hiroshi Tamura, Shinya S. Suzuki
NEUROSCIENCE RESEARCH
(2011)
Meeting Abstract
Neurosciences
Takeshi Kawano, Akifumi Fujishiro, Hidekazu Kaneko, Takahiro Kawashima, Makoto Ishida
NEUROSCIENCE RESEARCH
(2011)
Article
Multidisciplinary Sciences
Akifumi Fujishiro, Hidekazu Kaneko, Takahiro Kawashima, Makoto Ishida, Takeshi Kawano
SCIENTIFIC REPORTS
(2014)
Article
Critical Care Medicine
Miyuki Tauchi, Maria Mercedes Tejada de Rink, Hiroshi Fujioka, Satoko Okayama, Kei-ichiro Nakamura, Barbara Dietel, Stephan Achenbach, Rainer Kollmar, Stefan Schwab, Kazuo Ushijima, Hideki Harada
THERAPEUTIC HYPOTHERMIA AND TEMPERATURE MANAGEMENT
(2018)
Article
Food Science & Technology
Hidekazu Kaneko, Hiroshi Endo, Shuichi Ino
JOURNAL OF TEXTURE STUDIES
(2020)
Article
Multidisciplinary Sciences
Hideki Harada, Seiya Muta, Tatsuyuki Kakuma, Misa Ukeda, So Ota, Maiko Hirata, Hiroshi Fujioka, Osamu Nakashima, Barbara Dietel, Miyuki Tauchi
Summary: An investigational interface device was developed to connect needle electrodes to BIS sensors for surgeries where standard electrode placement is not feasible. Statistical analysis confirmed significant concordance between direct and indirect BIS values, providing an opportunity for intraoperative monitoring in patients with unconventional electrode placement.
Article
Medicine, General & Internal
Hiroshi Fujioka, Hideki Harada, Eiichirou Urasaki
Summary: This case report highlights the potential risk of scoliosis following intrathecal baclofen therapy in adult patients. Careful preoperative investigations and postoperative follow-up are recommended for patients receiving intrathecal baclofen therapy.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Hiroshi Fujioka, Eiichirou Urasaki, Yoshiteru Soejima, Hideki Harada, Katsuhiro Yamashita
CUREUS JOURNAL OF MEDICAL SCIENCE
(2020)
Article
Clinical Neurology
Hiroshi Fujioka, Takenori Uozumi, Yasushi Miyagi, Eiichirou Urasaki
NEUROLOGY AND CLINICAL NEUROSCIENCE
(2020)