Review
Biochemistry & Molecular Biology
Alexander N. Rodichkin, Tomas R. Guilarte
Summary: Clinical reports on childhood-onset manganese-induced dystonia-parkinsonism have provided valuable insights, but our understanding of the underlying neuropathophysiology remains limited. The availability of Slc39a14 knockout animal models offers a powerful platform for further research into the neurological effects of elevated manganese concentrations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Eun-Young Lee, Michael R. Flynn, Guangwei Du, Mechelle M. Lewis, Michael Goldenberg, Lan Kong, Richard B. Mailman, Young-Seoub Hong, Xuemei Huang
Summary: This study examined asymptomatic welders to assess differences in the substantia nigra (SN), a key pathological locus of Parkinson's disease (PD). The results revealed that chronic, low-level manganese exposure in welders was associated with decreased fractional anisotropy (FA) in the globus pallidus (GP), suggesting neurotoxic processes may differ from PD at relatively low exposure levels. Additionally, higher welding duration and levels were linked to FA differences in the SN and GP, indicating potential neurotoxic effects with prolonged or higher levels of welding exposure.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Nutrition & Dietetics
Boguslaw Habrat, Andrzej Silczuk, Anna Klimkiewicz
Summary: Manganese encephalopathy is a recognized disorder in occupational medicine, and there has been an increase in cases among intravenous users of homemade methcathinone. A survey conducted in Polish rehabilitation centers revealed that over 4% of individuals being treated displayed symptoms of manganese encephalopathy, with a lack of knowledge on the subject in more than 70% of surveyed institutions. There is an urgent need for personnel training and dissemination of information on this emerging issue.
Review
Biochemistry & Molecular Biology
Roberto Lucchini, Kim Tieu
Summary: Manganese exposure has shifted from acute to chronic, resulting in investigations of the long-term impact on Parkinson's disease and parkinsonism. Experimental research has explored the pathogenic mechanisms and genetic susceptibility associated with manganese. This review aims to link epidemiological data with potential mechanistic interpretations.
Article
Public, Environmental & Occupational Health
Nur Safak Alici, Turkan Nadir Ozis, Gulay Celiker, Tulin Birlik Akturk
Summary: This study is the first to evaluate blood manganese levels in welders and their correlation with pulmonary and neurological effects. The study found that poor working conditions and exposure to fibrogenic fumes in manganese-exposed welders are associated with chronic lung diseases and the accumulation of manganese, as evidenced by hyperintensity in brain MRI.
MEDICINA DEL LAVORO
(2022)
Article
Neurosciences
Alexander N. Rodichkin, Melissa K. Edler, Jennifer L. McGlothan, Tomas R. Guilarte
Summary: The study found that aging Slc39a14-KO mice exhibit behavioral and neurofunctional deficits similar to early-onset cases, along with elevated levels of manganese in the blood and brain. There were no neurodegenerative changes in the dopamine system of the basal ganglia, but a marked inhibition of dopamine release in the striatum compared to wildtype mice.
Article
Medicine, General & Internal
Mohiudeen Alikunju, Nafeesathu Misiriyyah, Shaikh Sayeed Iqbal, Maria Khan
Summary: Manganese-induced cerebral toxicity is a rare neurological condition that can mimic stroke symptoms. We present a case of a 40-year-old male with occupational exposure to manganese who presented with slurred speech and facial weakness. Imaging studies revealed manganese deposition in the brain, confirming the diagnosis. The patient was managed conservatively and advised on workplace safety measures.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Endocrinology & Metabolism
I. S. Ivleva, A. P. Ivlev, N. S. Pestereva, T. Tyutyunnik, M. N. Karpenko
Summary: Manganism, a complication of manganese exposure, is characterized by neurological dysfunction linked to metal accumulation in the brain. Current therapies fail to prevent disease progression. In this study, inhibition of calpains, a family of proteases, was found to alleviate Mn-induced neurological symptoms in a rodent model, suggesting that calpain inhibitors may be a promising therapeutic agent against manganism.
METABOLIC BRAIN DISEASE
(2022)
Article
Environmental Sciences
Muxue Lu, Ping Deng, Lingling Yang, Xue Wang, Xiang Mei, Chao Zhou, Mengyan Chen, Zhou Zhou, Huifeng Pi, Lichuan Wu, Zhengping Yu
Summary: This study investigates the pathogenesis of manganese-induced parkinsonism in C57BL/6 J mice. The results show that manganese overexposure alters the lipidome profiles, leading to lipid metabolism disorders, oxidative stress, and dopaminergic neuron injury, which may play important roles in the development of Parkinson-like symptoms.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Gastroenterology & Hepatology
Kerem C. Gurol, Michael Aschner, Donald R. Smith, Somshuvra Mukhopadhyay
Summary: Manganese induces neurotoxicity, but its excretion and its role in regulating manganese homeostasis and neurotoxicity have received less attention. Recent studies have found that mutations in SLC30A10 and SLC39A14 cause hereditary manganese neurotoxicity, reigniting interest in manganese excretion.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jiayu Wu, Qiaoying Zhang, Pengfeng Sun, Hong Zhang, Ming Gao, Mingyue Ma, Yan Dong, Peng Liu, Xiaoping Wu
Summary: This study found that chronic occupational manganese (Mn) exposure resulted in changes in gray matter volume and structural covariance patterns in certain brain regions of welders. These regions are involved in motivational response, cognitive control, and emotional regulation. The findings provide preliminary evidence for understanding the pathophysiology of Mn overexposure.
EUROPEAN RADIOLOGY
(2022)
Article
Environmental Sciences
Jairo Buitrago Cortes, Philippe Sarazin, Denis Dieme, Jonathan Cote, Capucine Ouellet, Naima El Majidi, Michele Bouchard
Summary: This research aimed to assess the actual dose of metal components absorbed by apprentice welders in a learning environment and establish the nature and level of exposure to welding fumes and their metallic components. The study found higher levels of manganese, iron, and nickel in urine and manganese in hair during the Shielded Metal Arc Welding (SMAW) module, while there was no significant difference for the other elements.
ENVIRONMENTAL RESEARCH
(2023)
Article
Engineering, Environmental
Zhipeng Qi, Shuang Wang, Jiashuo Li, Yi Wen, Rong Cui, Ke Zhang, Yanan Liu, Xinxin Yang, Lei Zhang, Bin Xu, Wei Liu, Zhaofa Xu, Yu Deng
Summary: Manganese exposure leads to abnormal dopaminergic neurons projection and reduced levels of FTO and ephrin-B2 through upregulation of Foxo3a. FTO can counteract manganese-induced down-regulation of axon guidance molecule ephrin-B2, ultimately affecting motor function.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Neurosciences
Praneet Kaur Marwah, Gijong Paik, Christopher J. Issa, Christopher C. Jemison, Muhammad B. Qureshi, Tareq M. Hanna, Eduardo Palomino, Krishna Rao Maddipati, David Njus
Summary: Chronic exposure to high levels of manganese causes a condition called manganism, which selectively affects the dopamine-rich basal ganglia and leads to movement disorders similar to Parkinson's disease. The specific targeting mechanism is not yet known, but it is hypothesized that complexation of manganese with dopamine derivatives may play a role.
Article
Public, Environmental & Occupational Health
Lilian Lourenco, Silvia Luis
Summary: The study found that welders have a higher incidence of musculoskeletal disorders compared to non-welders, particularly in the cervical, dorsal, lumbar, wrists, and hands. The presence of these disorders was associated with increased bodily pain and decreased health-related quality of life.
FRONTIERS IN PUBLIC HEALTH
(2021)
