Journal
NEUROLOGIC CLINICS
Volume 27, Issue 4, Pages 865-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ncl.2009.08.002
Keywords
Major depressive disorder; Hippocampal atrophy; Temporal lobe epilepsy; Frontal lobe epilepsy; Anxiety disorders
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Depressive disorders are the most frequent psychiatric comorbidity in patients with epilepsy (PWE). Although they are typically considered a psychiatric disorder, ample data suggest that depressive disorders are a neurologic disorder with psychiatric clinical manifestations. Patients with epilepsy whose seizures originate in temporal and frontal lobes have the highest prevalence of comorbid depressive disorders. Not only are patients with epilepsy at higher risk of developing depression but also patients with depression are at higher risk of developing epilepsy. This article reviews these data, the clinical manifestations of depressive disorders in PWE, and their significant impact on the suicidal risk and quality of life.
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