Article
Immunology
Jianxun Han, Juan Carlos Zuniga-Pflucker
Summary: Research shows that in high oxygen submersion cultures, FOXN1 expression in thymic epithelial cells (TECs) is restored, promoting the expression of important FOXN1 target genes and maintaining high levels of MHCII expression in TECs. High oxygen submersion cultures facilitate the self-renewal of CD4(-)CD8(-)CD44(-)CD25(+) cells, allowing for the continuous generation of later stage thymocytes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Kazuki Kurihara, Hajime Moteki, Mitsutoshi Kimura, Masahiko Ogihara
Summary: The mechanism of GH-induced hepatocyte DNA synthesis and proliferation is mainly mediated through the JAK2/PLC pathway leading to autocrine secretion of IGF-I, which then activates the IGF-I receptor tyrosine kinase signaling pathway. Blocking antibodies to IGF-I, but not transforming growth factor alpha, inhibit GH-induced hepatocyte DNA synthesis and proliferation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Immunology
Maria Danielma Santos dos Reis, Luciana Peixoto Veneziani, Felipe Lima Porto, Marvin Paulo Lins, Daniella Areas Mendes-da-Cruz, Wilson Savino
Summary: Growth hormone (GH) is a crucial hormone for body growth and metabolism, its secretion is regulated by GH-releasing hormone and somatostatin. GH can act directly on target cells or indirectly by stimulating the production of insulin-like growth factors (IGFs). Clinical trials have shown that treatment with GH can successfully recover thymic function in immunocompromised patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Endocrinology & Metabolism
Mengyang Li
Summary: The GH/IGF system plays a role in growth regulation in the body. By studying the basal chordate amphioxus, it was discovered that most members of the GH/IGF system are present in amphioxus, providing strong evidence for the origin of this system in amphioxus.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Layla Damen, Melitza S. M. Elizabeth, Stephany H. Donze, Sjoerd A. A. van den Berg, Laura C. G. de Graaff, Anita C. S. Hokken-Koelega
Summary: In children with Prader-Willi syndrome receiving GH treatment, high immunoreactive IGF-I levels are often observed, while free IGF-I levels are low, indicating a significant discrepancy between the two.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Microbiology
Helene Michaux, Aymen Halouani, Charlotte Trussart, Chantal Renard, Hela Jaidane, Henri Martens, Vincent Geenen, Didier Hober
Summary: CV-B4 infection in murine TEC cells reduces the activity of the Igf2 P3 promoter and decreases STAT3 phosphorylation. Mice infected with CV-B4 show altered expression of Igf2 isoforms and a decrease in pro-IGF2 precursor in the thymus, indicating disruption of central self-tolerance to insulin by viral infection.
Review
Endocrinology & Metabolism
Haim Werner, Zvi Laron
Summary: The GH-IGF1 signaling pathway plays a key role in aging and longevity. Patients with LS, a congenital IGF1 deficiency, seem to be protected from cancer. Aging and cancer may be different manifestations of the same underlying processes. Genome-wide screenings have identified genes associated with aging and longevity in LS patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kangkang Chen, Xiaoyi Dou, Jai Hoon Eum, Ruby E. Harrison, Mark R. Brown, Michael R. Strand
Summary: This study assessed the expression of insulin-like peptides (ILPs) and ovary ecdysteroidogenic hormone (OEH) in Aedes aegypti during a gonadotrophic cycle and further functionally characterized these peptides to understand their roles in regulating egg formation. The results showed that all ILPs and OEH were expressed during the cycle, and there were differences in their biological activities and insulin- insulin growth factor signaling (IIS) phosphorylation levels.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Article
Obstetrics & Gynecology
Dilek Menekse Beser, Deniz Oluklu, Derya Uyan Hendem, Muradiye Yildirim, Atakan Tanacan, Dilek Sahin
Summary: Objective of this study was to investigate the thymic-thoracic ratio (TTR) in fetuses of pregnant women with familial Mediterranean fever (FMF). The study found that TTR was significantly lower in the FMF group compared to the control group, and TTR was associated with various blood markers. The study suggests that TTR can be used as an easily applicable method to evaluate fetal inflammation.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rosario Baltazar-Lara, Jose Avila-Mendoza, Carlos G. Martinez-Moreno, Martha Carranza, Santiago Pech-Pool, Olivia Vazquez-Martinez, Mauricio Diaz-Munoz, Maricela Luna, Carlos Aramburo
Summary: GH and IGF-1 have been shown to have protective effects against neural damage, leading to increased cell viability and decreased apoptosis and necrosis in embryonic chicken cerebellar cell cultures exposed to acute HI injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
In-Ho Jung, Seonah Choi, Cheol Ryong Ku, Sang-Guk Lee, Eun Jig Lee, Sun Ho Kim, Eui Hyun Kim
Summary: This study evaluated the reliability of IGF-1 levels as an alternative for disease monitoring after surgical treatment of acromegaly. The results showed that IGF-1 levels can serve as a reliable alternative to OGTT and play a valuable role in monitoring acromegaly status.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Genetics & Heredity
Rui-Lin Xie, Rui Liang, Yuan-Yuan Luo, Zhuo-Hao Ruan, Yi-Fu Li, Wen-Sheng Liu
Summary: This study investigates the effects of growth hormone changes on the genes and regulatory roles of the turtle. The results show that the injection of recombinant human growth hormone promotes the growth of the turtle by affecting the expression of SS, GHR, and IGF-1 genes.
Article
Endocrinology & Metabolism
Yang Xu, Chang Yong Han, Mi Jung Park, Myung Chan Gye
Summary: This study investigated the mechanism of precocious sexual maturation following prepubertal rhGH therapy. The results showed that rhGH can promote gonadal maturation by activating the steroidogenic pathway of LCs and increasing testicular IGF1 levels.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Christa C. van Bunderen, Rick I. Meijer, Paul Lips, Mark H. Kramer, Erik H. Serne, Madeleine L. Drent
Summary: The study found that increasing IGF-1 levels had a beneficial effect on body composition but was detrimental to insulin resistance. At the same time, the contribution of the neurogenic vasomotion domain also increased.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Stefan Porubsky, Zoran V. Popovic, Sunil Badve, Yara Banz, Sabina Berezowska, Dietmar Borchert, Monika Brueggemann, Timo Gaiser, Thomas Graeter, Peter Hollaus, Katrin S. Huettl, Michaela Kotrova, Andreas Kreft, Christian Kugler, Fabian Lotscher, Burkhard Moller, German Ott, Gerhard Preissler, Eric Roessner, Andreas Rosenwald, Philipp Stroebel, Alexander Marx
Summary: Thymic hyperplasia with LESA-like features (LESA-like TH) is associated with lymphomas in 14% of cases and partially overlapping autoimmune diseases in 33% of cases. A hematologic and rheumatologic workup should be standard in patients diagnosed with LESA-like TH, particularly those with autoimmune diseases. Radiologists and clinicians should consider LESA-like TH as a potential differential diagnosis for mediastinal mass lesions in patients with autoimmune diseases.
Article
Genetics & Heredity
Olivier Gaspard, Pierre Vanderzwalmen, Barbara Wirleitner, Stephanie Ravet, Frederic Wenders, Verena Eichel, Alice Mockova, Dietmar Spitzer, Caroline Jouan, Virginie Gridelet, Henri Martens, Laurie Henry, Herbert Zech, Sophie Perrier d'Hauterive, Michelle Nisolle
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2018)
Article
Endocrinology & Metabolism
Gwennaelle Bodart, Khalil Farhat, Chantal Renard-Charlet, Guillaume Becker, Alain Plenevaux, Roberto Salvatori, Vincent Geenen, Henri Martens
FRONTIERS IN ENDOCRINOLOGY
(2018)
Article
Immunology
Khalil Farhat, Gwennaelle Bodart, Chantal Charlet-Renard, Christophe J. Desmet, Michel Moutschen, Yves Beguin, Frederic Baron, Pierrette Melin, Pascale Quatresooz, Anne-Simone Parent, Daniel Desmecht, Jean-Claude Sirard, Roberto Salvatori, Henri Martens, Vincent G. Geenen
FRONTIERS IN IMMUNOLOGY
(2018)
Review
Multidisciplinary Sciences
Vincent Geenen, Charlotte Trussart, Helene Michaux, Aymen Halouani, Hela Jaidane, Caroline Collee, Chantal Renard, Marc Daukandt, Philippe Ledent, Henri Martens
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2019)
Editorial Material
Endocrinology & Metabolism
Ana Rosa Perez, Daniella Areas Mendes-da-Cruz, Vincent Geenen, Wilson Savino
FRONTIERS IN ENDOCRINOLOGY
(2019)
Article
Genetics & Heredity
Aymen Halouani, Habib Jmii, Helene Michaux, Chantal Renard, Henri Martens, Dimitri Pirottin, Maha Mastouri, Mahjoub Aouni, Vincent Geenen, Hela Jaidane
Article
Microbiology
Helene Michaux, Aymen Halouani, Charlotte Trussart, Chantal Renard, Hela Jaidane, Henri Martens, Vincent Geenen, Didier Hober
Summary: CV-B4 infection in murine TEC cells reduces the activity of the Igf2 P3 promoter and decreases STAT3 phosphorylation. Mice infected with CV-B4 show altered expression of Igf2 isoforms and a decrease in pro-IGF2 precursor in the thymus, indicating disruption of central self-tolerance to insulin by viral infection.
Article
Microbiology
Aymen Halouani, Helene Michaux, Habib Jmii, Charlotte Trussart, Ahlem Chahbi, Henri Martens, Chantal Renard, Mahjoub Aouni, Didier Hober, Vincent Geenen, Hela Jaidane
Summary: The thymus plays a crucial role in establishing central tolerance during fetal life by educating self-tolerant T cells. In utero infection of the thymus by CV-B4 virus leads to a decreased expression of autoantigens at both mRNA and protein levels, potentially increasing the risk of autoimmune diseases.
Review
Microbiology
Abdulaziz Alhazmi, Magloire Pandoua Nekoua, Helene Michaux, Famara Sane, Aymen Halouani, Ilka Engelmann, Enagnon Kazali Alidjinou, Henri Martens, Hela Jaidane, Vincent Geenen, Didier Hober
Summary: Viral infections, especially CVB4 infection, can disrupt thymic functions and may play a role in the pathogenesis of type 1 diabetes (T1D) by affecting thymic cells and functions.
Review
Biochemistry & Molecular Biology
Sophie Perrier d'Hauterive, Romann Close, Virginie Gridelet, Marie Mawet, Michelle Nisolle, Vincent Geenen
Summary: This article summarizes the different isoforms of human chorionic gonadotropin (hCG) and its effects on angiogenesis, immune response, miscarriages, and thyroid function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Vincent Geenen, Didier Hober
PEDIATRIC ENDOCRINOLOGY REVIEWS PER
(2019)
Article
Endocrinology & Metabolism
Beatriz Gonzalez-Aguilera, Daniela Betea, Laurence Lutteri, Etienne Cavalier, Vincent Geenen, Albert Beckers, Hernan Valdes-Socin
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2018)
Article
Immunology
Barbara Polese, Virginie Gridelet, Sophie Perrier d'Hauterive, Chantal Renard, Carine Munaut, Henri Martens, David Vermijlen, Irah L. King, Nathalie Jacobs, Vincent Geenen
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2018)