Review
Pathology
Joon Hyuk Choi, Jae Y. Ro
Summary: Soft tissue tumors are rare and diagnostically challenging neoplasms that require accurate diagnosis for proper treatment and prognosis. The 5th Edition of the 2020 WHO classification of tumors of soft tissue and bone incorporates significant advances in molecular biology and diagnostic criteria, emphasizing the increasing reliance on molecular characteristics for tumor classification.
ADVANCES IN ANATOMIC PATHOLOGY
(2021)
Review
Pharmacology & Pharmacy
Monika Kaurav, Sakina Ruhi, Husni Ahmed Al-Goshae, Ashok Kumar Jeppu, Dhani Ramachandran, Ram Kumar Sahu, Ashish Kumar Sarkar, Jiyauddin Khan, Abu Md Ashif Ikbal
Summary: A brain tumor is an uncontrolled cell proliferation that grows and divides abnormally. Approximately 25,690 primary malignant brain tumors are discovered each year, with 70% originating in glial cells. Nanocarriers have shown significant therapeutic efficacy in various brain diseases.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pathology
Kiril Trpkov, Ondrej Hes, Sean R. Williamson, Adebowale J. Adeniran, Abbas Agaimy, Reza Alaghehbandan, Mahul B. Amin, Pedram Argani, Ying-Bei Chen, Liang Cheng, Jonathan I. Epstein, John C. Cheville, Eva Comperat, Isabela Werneck da Cunha, Jennifer B. Gordetsky, Sounak Gupta, Huiying He, Michelle S. Hirsch, Peter A. Humphrey, Payal Kapur, Fumiyoshi Kojima, Jose I. Lopez, Fiona Maclean, Cristina Magi-Galluzzi, Jesse K. McKenney, Rohit Mehra, Santosh Menon, George J. Netto, Christopher G. Przybycin, Priya Rao, Qiu Rao, Victor E. Reuter, Rola M. Saleeb, Rajal B. Shah, Steven C. Smith, Satish Tickoo, Maria S. Tretiakova, Lawrence True, Virginie Verkarre, Sara E. Wobker, Ming Zhou, Anthony J. Gill
Summary: The Genitourinary Pathology Society (GUPS) reviewed recent advances in renal neoplasia, emphasizing the diagnostic criteria and key prognostic features for different types of renal tumors. They also proposed new nomenclature and classification recommendations for some novel variants.
Review
Pathology
Yoh Zen
Summary: Pathologists play a pivotal role in the diagnosis and classification of intrahepatic cholangio-carcinoma (iCCA). iCCA can be divided into small-duct and large-duct types, each with distinct characteristics and molecular features. Chronic liver diseases are associated with small-duct iCCA, while chronic cholangiopathies increase the risk of large-duct iCCA.
Review
Oncology
Ruolan Xia, Yuwen Zhou, Yuqing Wang, Jiaming Yuan, Xuelei Ma
Summary: HAS is a rare malignant tumor, often diagnosed at an advanced stage with symptoms similar to CGC. It has similar morphology and immunophenotype to HCC and generally has a worse prognosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Antje Chang, Lisa Jeske, Sandra Ulbrich, Julia Hofmann, Julia Koblitz, Ida Schomburg, Meina Neumann-Schaal, Dieter Jahn, Dietmar Schomburg
Summary: The BRENDA enzyme database is a comprehensive collection of enzyme and metabolism data, providing reliable information and easy access to users. The database has been continuously updated and improved to enhance usability and connectivity with other resources.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Multidisciplinary Sciences
Wei-Wen Hsu, Jing-Ming Guo, Linmin Pei, Ling-An Chiang, Yao-Feng Li, Jui-Chien Hsiao, Rivka Colen, Peizhong Liu
Summary: Accurate glioma subtype classification is critical for the treatment management of patients with brain tumors. In this study, a novel hybrid CNN-based method using whole slide imaging (WSI) and multiparametric magnetic resonance imaging (mpMRI) is proposed for glioma subtype classification. The method overcomes the label constraint issue and enhances the robustness of predictions by fusing results from both modalities.
SCIENTIFIC REPORTS
(2022)
Review
Cell Biology
James G. Kench, Mahul B. Amin, Daniel M. Berney, Eva M. Comperat, Ian A. Cree, Anthony J. Gill, Arndt Hartmann, Santosh Menon, Holger Moch, George J. Netto, Maria R. Raspollini, Mark A. Rubin, Puay Hoon Tan, Toyonori Tsuzuki, Samra Turjalic, Theo H. van Der Kwast, Ming Zhou, John R. Srigley
Summary: The fifth edition of the WHO Classification of Tumours of the Urinary and Male Genital Systems provides updates on the classification and prognosis assessment of prostatic carcinoma, including recognizing PIN-like carcinoma as a subtype of acinar adenocarcinoma, renaming basal cell carcinoma as adenoid cystic (basal cell) cell carcinoma, discussing grading issues in acinar adenocarcinoma, and providing more detailed coverage of intraductal carcinoma of prostate.
Review
Neurosciences
Mingguo Xie, Xiongfei Wang, Zejun Duan, Guoming Luan
Summary: Brain tumors involving cortical neurons can often lead to seizures, especially intractable focal seizures. Low-grade epilepsy-associated neuroepithelial tumors (LEATs), such as ganglioglioma (GG) and dysembryoplastic neuroepithelial tumor (DNET), have common clinicopathological features including seizure onsets at a young age, involvement of the temporal lobe, and a slow growth pattern. Surgical treatments with complete resection of tumors and epileptogenic zones offer the best chance for seizure control and recurrence-free survival in patients with LEATs. However, there is ongoing debate among experts regarding the classification and diagnosis of LEAT entities.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Oncology
Evan H. Einstein, Faina Ablyazova, Ashley Rosenberg, Manju Harshan, Samuel Wahl, Gady Har-El, Peter D. Constantino, Jason A. Ellis, John A. Boockvar, David J. Langer, Randy S. D'Amico
Summary: This study demonstrates that stimulated Raman histology (SRH) is non-inferior to frozen sectioning in terms of diagnostic capability and the quality and condition of tissue after analysis. It is the first study to provide evidence of SRH accuracy using one-to-one tissue analysis in neuropathological specimens.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Oncology
Cecilia Taverna, Abbas Agaimy, Alessandro Franchi
Summary: In recent years, molecular analysis has made significant progress in the diagnosis and treatment of sinonasal carcinomas, allowing for the classification of different subtypes and the identification of potential therapeutic targets.
Article
Medical Laboratory Technology
Farshid Siadat, Mehdi Mansoor, Ondrej Hes, Kiril Trpkov
Summary: This article provides an overview of new and emerging renal entities, with their key features summarized in Table 1. Awareness of these renal neoplasms is crucial for practicing pathologists, as navigating this evolving field can be challenging, even in regions with a high volume of renal tumors. General pathologists must have diagnostic awareness to correctly classify these cases, as they can often be diagnosed or at least suspected based on morphological findings combined with immunohistochemistry. Recognizing these novel renal entities will guide pathologists and clinicians in translating developments into more accurate diagnoses and improved patient management.
CLINICS IN LABORATORY MEDICINE
(2023)
Review
Clinical Neurology
Pouya Jamshidi, Daniel J. J. Brat
Summary: The recently published WHO Classification of Tumours, Central Nervous System Tumours, Fifth Edition introduces significant clinical changes based on improved understanding of the molecular basis of brain tumor types. These changes provide neurologists with opportunities for individualized treatment options and the discovery of novel therapeutics.
CURRENT OPINION IN NEUROLOGY
(2022)
Review
Oncology
Alexander Marx, John K. C. Chan, Lara Chalabreysse, Sanja Dacic, Frank Detterbeck, Christopher A. French, Jason L. Hornick, Hiroshi Inagaki, Deepali Jain, Alexander J. Lazar, Mirella Marino, Edith M. Marom, Andre L. Moreira, Andrew G. Nicholson, Masayuki Noguchi, Daisuke Nonaka, Mauro G. Papotti, Stefan Porubsky, Lynette M. Sholl, Hisashi Tateyama, Vincent Thomas de Montpreville, William D. Travis, Arun Rajan, Anja C. Roden, Philipp Stroebel
Summary: This article provides an overview of the new developments in the fifth edition of the WHO classification of thymic epithelial tumors, mediastinal germ cell tumors, and mesenchymal neoplasms, focusing on diagnostic, molecular, and conceptual advances. Diagnostic advances include immunohistochemical characterization and the identification of genetic translocations. Molecular and tumor biological advancements include the finding that thymomas and most thymic carcinomas lack currently targetable mutations, but typically have a PD-L1(high) phenotype. Additionally, conceptual advancements for the classification of thymic NETs are discussed.
JOURNAL OF THORACIC ONCOLOGY
(2022)
Review
Clinical Neurology
Catena Kresbach, Sina Neyazi, Ulrich Schueller
Summary: Ependymal neoplasms are a heterogeneous group of tumors that occur in different parts of the central nervous system. Recent advances in understanding the genetic and molecular characteristics of ependymal tumors have led to an improved classification system. New classification schemes based on global DNA methylation profiling have enhanced the prediction of patients' outcomes.
Article
Neurosciences
Christina M. Marra
Summary: Stroke can be a complication of CNS infections, especially caused by VZV and T pallidum. Treatment with adjunctive dexamethasone for acute pneumococcal meningitis is recommended, but it may lead to the emergence of DCV syndrome.
NEUROIMAGING CLINICS OF NORTH AMERICA
(2024)
Article
Neurosciences
Selima Siala, Nabil Rahoui, Benjamin Cho, Carlos A. Zamora
NEUROIMAGING CLINICS OF NORTH AMERICA
(2024)
Article
Neurosciences
Renato Hoffmann Nunes, Diogo Goulart Correa, Felipe Torres Pacheco, Ana Paula Alves Fonseca, Luiz Celso Hygino da Cruz Jr, Antonio Jose da Rocha
Summary: Vasculopathy is a significant consequence of various infections, and early recognition is essential as many of these diseases have poor outcomes if left untreated. Neuroimaging techniques such as MRI, CTA, and MRA can be used to visualize the complications associated with infectious vasculopathy, while high-resolution intracranial vessel wall imaging can directly assess the presence of vasculitis.
NEUROIMAGING CLINICS OF NORTH AMERICA
(2024)
Article
Neurosciences
Sheng-Che Hung, Carolina Guimaraes
NEUROIMAGING CLINICS OF NORTH AMERICA
(2024)
Article
Neurosciences
Omar Hamam, Samuel C. Cartmell, Javier M. Romero
NEUROIMAGING CLINICS OF NORTH AMERICA
(2024)
Article
Neurosciences
Manish K. Saha
NEUROIMAGING CLINICS OF NORTH AMERICA
(2024)
Article
Neurosciences
Alison M. Bays
NEUROIMAGING CLINICS OF NORTH AMERICA
(2024)
Article
Neurosciences
Carlos A. Zamora, Mahmud Mossa-Basha, Mauricio Castillo
Summary: Assessment of cerebral vasculopathies can be challenging, but a comprehensive understanding of different imaging methods can facilitate the process. There are various angiographic techniques with unique advantages and disadvantages, such as bolus-based methods that enhance arterial depiction and non-contrast techniques that show high-resolution arteries. MRI can assess vessel wall pathology and aid in diagnosing vasculitis and non-inflammatory vasculopathies.
NEUROIMAGING CLINICS OF NORTH AMERICA
(2024)
Article
Neurosciences
Paulo Puac-Polanco, Alex Rovira, Lubdha M. Shah, Richard H. Wiggins, Francisco Rivas Rodriguez, Carlos Torres
Summary: Cocaine-induced CNS vasculitis and midline destructive lesion, as well as reversible vasoconstriction syndrome triggered by substance abuse, are all important conditions that are associated with drugs and their risk factors.
NEUROIMAGING CLINICS OF NORTH AMERICA
(2024)
Article
Neurosciences
Aaron Bangad, Mehdi Abbasi, Sam Payabvash, Adam de Havenon
NEUROIMAGING CLINICS OF NORTH AMERICA
(2024)
