Article
Radiology, Nuclear Medicine & Medical Imaging
Felix Thiele, Franziska Schau, Julian M. M. Rogasch, Christoph Wetz, Stephanie Bluemel, Winfried Brenner, Holger Amthauer, Catharina Lange, Imke Schatka
Summary: The study aimed to establish a normal database for semiquantification of DAT SPECT using [I-123]FP-CIT on a CZT camera, compare it with the preexisting NaI-derived database, and evaluate its diagnostic findings. The results showed that semiquantification based on the CZT NDB led to fewer discordant ratings compared to the GE NDB in CZT scans, improving agreement between semiquantification and visual assessment.
Article
Clinical Neurology
Hiroo Terashi, Takeshi Taguchi, Yuki Ueta, Hiroshi Mitoma, Hitoshi Aizawa
Summary: The results of this study showed that I-123-FP-CIT-SPECT findings were significantly associated with motor severity and gait severity in drug-naive patients with Parkinson's disease (PD), particularly the mean specific binding ratios of the striatum and anterior putamen.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Psychiatry
Ivan Milenkovic, Lucie Bartova, Konstantinos Papageorgiou, Siegfried Kasper, Tatjana Traub-Weidinger, Dietmar Winkler
Summary: Diagnosing parkinsonian syndromes in patients with severe depression can be challenging due to overlapping clinical phenomena. [I-123]FP-CIT-SPECT is a useful method for detecting degenerative parkinsonian disorders but drugs may influence the results. Consultation with a movement disorder specialist prior to dopamine transporter imaging is recommended.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yoshinori Ito, Naotoshi Fujita, Kazuhiro Hara, Tomohiro Tada, Shinji Abe, Masahisa Katsuno, Shinji Naganawa, Katsuhiko Kato
Summary: This study proposed a novel semi-quantitative approach to accurately evaluate the accumulation of tracers in the caudate and putamen. By examining the approximate image, the proposed method could calculate accurate accumulation amounts. Compared to conventional methods, the correlation of the proposed method was higher.
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2022)
Article
Multidisciplinary Sciences
Minyoung Oh, Seung Jun Oh, Sang Ju Lee, Jungsu S. Oh, Sun Ju Chung, Jae Seung Kim
Summary: This study aims to evaluate the diagnostic accuracy of F-18-FP-CIT PET in patients with clinically uncertain Parkinsonism. The results show that compared to baseline clinical diagnosis, F-18-FP-CIT PET is more accurate in diagnosing CUPS, reducing the false-negative and inconclusive diagnosis rates at baseline.
SCIENTIFIC REPORTS
(2023)
Article
Psychiatry
Hans-Christoph Aster, Marcel Romanos, Susanne Walitza, Manfred Gerlach, Andreas Muehlberger, Albert Rizzo, Marta Andreatta, Natalie Hasenauer, Philipp E. Hartrampf, Kai Nerlich, Christoph Reiners, Reinhard Lorenz, Andreas K. Buck, Lorenz Deserno
Summary: The study found that methylphenidate (MPH) can alter the availability of striatal dopamine transporters (DAT), and higher off-MPH DAT levels may reflect lower baseline dopamine levels and indicate symptom severity.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Minyoung Oh, Narae Lee, Chanwoo Kim, Hye Joo Son, Changhwan Sung, Seung Jun Oh, Sang Ju Lee, Sun Ju Chung, Chong Sik Lee, Jae Seung Kim
Summary: Dual phase F-18-FP-CIT PET and F-18-FDG PET can aid in the differential diagnosis of degenerative parkinsonism and other parkinsonian disorders, showing a high concordance rate with clinical diagnosis.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Jihye Yoo, In Kook Chun
Summary: F-18-FP-CIT PET/CT is a useful diagnostic tool that can differentiate between idiopathic Parkinson disease and atypical Parkinson syndrome by visualizing the striatum, where the nigrostriatal dopaminergic neurons' nerve endings are located. We present a case of an 83-year-old man with an unusual accumulation of F-18-FP-CIT in the infarct and peri-infarct brain area, who was referred for suspected cerebral infarction management due to sudden dysarthria and delirium.
CLINICAL NUCLEAR MEDICINE
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Youssef Chahid, Zulfiqar H. Sheikh, Max Mitropoulos, Jan Booij
Summary: This study aims to update the research on the effects of medications and drugs of abuse on dopamine transporter (DAT) binding in the brain. Through a systematic literature review, we found that certain medications may influence DAT binding, and therefore should be withdrawn before DAT imaging. These findings can help reduce the occurrence of false-positive results.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Neurosciences
Jamie van Son, Katy A. van Galen, Anne Marijn Bruijn, Karin E. Koopman, Ruth I. Versteeg, Susanne E. la Fleur, Mireille J. Serlie, Jan Booij
Summary: Food craving is increased in obesity, but the scores for food craving are not significantly related to changes in striatal DAT availability.
Article
Radiology, Nuclear Medicine & Medical Imaging
Elon Wallert, Erwann Letort, Friso van der Zant, Ania Winogrodzka, Henk Berendse, Martijn Beudel, Rob de Bie, Jan Booij, Pieter Raijmakers, Elsmarieke van de Giessen
Summary: This study compared the results of FDOPA-PET and DAT-SPECT in patients with parkinsonian syndromes and found that DAT-SPECT was more often abnormal than FDOPA-PET in early disease stages, indicating a greater loss of DAT binding in CUPS patients.
Article
Neurosciences
Lars Frings, Franziska Henninger, Martin Treppner, Goran Koeber, Martin Boeker, Philipp T. Meyer
Summary: DAT SPECT, commonly used in dementia diagnostics, has been found to provide valuable prognostic information. Patients with nigrostriatal degeneration (NSD) detected by DAT SPECT have a significantly higher mortality risk compared to those without NSD, with lower striatal DAT binding associated with increased mortality risk.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Computer Science, Artificial Intelligence
Diego Castillo-Barnes, Carmen Jimenez-Mesa, Francisco J. Martinez-Murcia, Diego Salas-Gonzalez, Javier Ramirez, Juan M. Gorriz
Summary: Spatial normalization allows quantitative comparison of brain scans and the quantification of bias introduced by nonlinear transformations is important for studying neurological disorders. Nonlinear transformations can alter diagnosis outcomes and introduce artificial information.
INTERNATIONAL JOURNAL OF NEURAL SYSTEMS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Miguel A. Labrador-Espinosa, Michel J. Grothe, Daniel Macias-Garcia, Silvia Jesus, Astrid Adarmes-Gomez, Laura Munoz-Delgado, Paula Fernandez-Rodriguez, Juan Francisco Martin-Rodriguez, Ismael Huertas, David Garcia-Solis, Pablo Mir
Summary: The study found that reductions in DAT levels in the sensorimotor striatal subregion were most pronounced in PD patients who developed LID, providing a potentially sensitive tool for early detection and improved prognosis of this common complication in PD.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuliya Piatkova, Pierre Payoux, Caroline Boursier, Manon Bordonne, Veronique Roch, Pierre-Yves Marie, Gabriela Hossu, Laetitia Imbert, Antoine Verger
Summary: This study compared I-123-FP-CIT SPECT imaging obtained from a 360 degrees CZT camera with different focus configurations to that from a conventional Anger camera. The results showed that the 360 degrees CZT camera provided higher image quality, shorter acquisition times, and fewer discordant cases compared to the conventional camera, possibly due to its higher spatial resolution.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Clinical Neurology
Jeff Zarp Petersen, Cristina Varo, Cecilie F. Skovsen, Caroline V. Ott, Hanne L. Kjaerstad, Eduard Vieta, Catherine J. Harmer, Gitte M. Knudsen, Lars V. Kessing, Julian Macoveanu, Kamilla W. Miskowiak
Summary: Cognitive impairment in bipolar disorder originates from the failure to recruit key regions in the cognitive control network (CCN) and to suppress task-irrelevant default mode network (DMN) activity during cognitive performance.
Correction
Radiology, Nuclear Medicine & Medical Imaging
Eric Guedj, Andrea Varrone, Ronald Boellaard, Nathalie L. Albert, Henryk Barthel, Bart van Berckel, Matthias Brendel, Diego Cecchin, Ozgul Ekmekcioglu, Valentina Garibotto, Adriaan A. Lammertsma, Ian Law, Ivan Penuelas, Franck Semah, Tatjana Traub-Weidinger, Elsmarieke van de Giessen, Donatienne Van Weehaeghe, Silvia Morbelli
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ivar J. H. G. Wamelink, Joost P. A. Kuijer, Beatriz E. Padrela, Yi Zhang, Frederik Barkhof, Henk J. M. M. Mutsaerts, Jan Petr, Elsmarieke van de Giessen, Vera C. Keil
Summary: This study investigates the reproducibility of cerebral APT-CEST imaging in healthy tissue and gliomas at 3 T. The results indicate that cerebral APT-CEST shows good scan-rescan reproducibility in healthy tissue and tumors, and short-term measurement effects may be the dominant components for reproducibility.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Elon D. Wallert, Elsmarieke van de Giessen, Remco J. J. Knol, Martijn Beudel, Rob M. A. de Bie, Jan Booij
Summary: Imaging of dopaminergic transmission plays a crucial role in the diagnosis and research of neurodegenerative disorders. It provides high diagnostic accuracy in detecting nigrostriatal degeneration in diseases such as Parkinson's disease and dementia with Lewy bodies. Additionally, it helps in studying the preclinical and premotor phases of these disorders and examining different subtypes of Parkinson's disease. Imaging also aids in understanding the neuronal substrates of impulse control disorders and measuring endogenous dopamine release in the treatment of Parkinson's disease.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Review
Neurosciences
Carmen F. M. van Hooijdonk, Marjan Drukker, Elsmarieke van de Giessen, Jan Booij, Jean-Paul Selten, Therese A. M. J. van Amelsvoort
Summary: Alterations in the dopaminergic system may play a role in vulnerability and transition to psychosis. Studies have shown that striatal dopamine D-2/3 receptor availability is generally unaltered in high-risk groups, while dopamine synthesis capacity varies among different high-risk groups.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Clinical Neurology
Marieke van der Pluijm, Elon D. Wallert, Bram F. Coolen, Kaithlyn T. Tjong Tjin Joe, Lieuwe de Haan, Jan Booij, Elsmarieke van de Giessen
Summary: This study compared different approaches to accelerate NM-MRI sequences and found that 2D sequences with compressed sense (CS) had the best reliability.
Article
Radiology, Nuclear Medicine & Medical Imaging
Elon Wallert, Erwann Letort, Friso van der Zant, Ania Winogrodzka, Henk Berendse, Martijn Beudel, Rob de Bie, Jan Booij, Pieter Raijmakers, Elsmarieke van de Giessen
Summary: This study compared the results of FDOPA-PET and DAT-SPECT in patients with parkinsonian syndromes and found that DAT-SPECT was more often abnormal than FDOPA-PET in early disease stages, indicating a greater loss of DAT binding in CUPS patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Denise Visser, Sander C. J. Verfaillie, Iris Bosch, Iman Brouwer, Hayel Tuncel, Emma M. Coomans, Roos M. Rikken, Sophie E. Mastenbroek, Sandeep S. V. Golla, Frederik Barkhof, Elsmarieke van de Giessen, Bart N. M. van Berckel, Wiesje M. van der Flier, Rik Ossenkoppele
Summary: The purpose of this study was to investigate the association between Tau pathology, atrophy, and cerebral blood flow (CBF) in Alzheimer's disease (AD). The results showed that increased Tau load was associated with cortical thinning, but not with decreased relative CBF. Baseline Tau PET load was a stronger predictor of cortical thinning than changes in Tau PET signal over time.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Review
Clinical Neurology
Carmen F. M. van Hoojdonk, Marieke van der Pluijm, Iris Bosch, Therese A. M. J. van Amelsvoort, Jan Booij, Lieuwe de Haan, Jean-Paul Selten, Elsmarieke van de Giessen
Summary: This study reviewed different molecular aspects of nigral functioning in patients with schizophrenia compared to healthy controls and found evidence for hyperdopaminergic functioning in the substantia nigra of patients with schizophrenia, as well as reduced GABAergic inhibition, excessive glutamatergic excitation, and several other disturbances. These results highlight the importance of the substantia nigra in schizophrenia pathology and suggest that some aspects of molecular functioning in the substantia nigra could potentially be used as treatment targets or biomarkers.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Oncology
Ivar J. H. G. Wamelink, Hugo L. L. Hempel, Elsmarieke van de Giessen, Mark H. M. Vries, Philip De Witt Hamer, Frederik Barkhof, Vera C. C. Keil
Summary: This study aims to understand the experiences of patients with primary brain tumors regarding MRI, follow-up protocols, and the use of gadolinium-based contrast agents (GBCAs). The analysis of patient surveys revealed that patients consistently underestimated the number of previous scans and most patients did not find MRI bothersome and would not change the frequency of follow-up MRIs. Women were found to be more uncomfortable with the MRI and receiving intravenous cannulas. Patient knowledge of GBCAs was limited.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Clinical Neurology
Massimo Filippi, Giordano Cecchetti, Annachiara Cagnin, Camillo Marra, Flavio Nobili, Lucilla Parnetti, Federica Agosta
Summary: Currently, no disease-modifying therapies are available for Alzheimer's disease (AD) in Europe. However, evidence from clinical trials suggests that anti-beta amyloid (Aβ) monoclonal antibodies (mAbs) may be authorized for marketing in the near future. A group of prominent AD clinical experts in Italy met to discuss patient selection and management strategies, recognizing the need for significant changes in dementia care to implement disease-modifying therapies. They emphasized the importance of a biological diagnosis using amyloid- and tau-related biomarkers, as well as specialized diagnostic work-up and exclusion criteria assessment by neurology specialists. The experts also proposed a reorganization of dementia and cognitive decline centers into three levels with defined tasks and requirements.
JOURNAL OF NEUROLOGY
(2023)
Review
Medicine, General & Internal
Tessa N. A. Slagboom, Dirk Jan Stenvers, Elsmarieke van de Giessen, Stefan D. D. Roosendaal, Maartje M. L. de Win, Joseph C. J. Bot, Eleonora Aronica, Rene Post, Jantien Hoogmoed, Madeleine L. L. Drent, Alberto M. M. Pereira
Summary: The study provides a structured analysis of the diagnostic accuracy and clinical use of molecular imaging in patients with ACTH-dependent Cushing's syndrome, as well as the role of multidisciplinary counseling in decision making. It proposes a complementary diagnostic algorithm for both de novo and recurrent or persistent Cushing's disease. The use of molecular imaging modalities is of added and complementary value in the detection of pituitary microadenoma in ACTH-dependent Cushing's syndrome.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Dylan Henssen, Lars Leijten, Frederick J. A. Meijer, Anja van der Kolk, Anne I. J. Arens, Mark ter Laan, Robert J. Smeenk, Anja Gijtenbeek, Elsmarieke M. van de Giessen, Nelleke Tolboom, Daniela E. Oprea-Lager, Marion Smits, James Nagarajah
Summary: Sophisticated imaging techniques have been suggested for distinguishing tumor progression (TP) from treatment-related abnormalities (TRA) in post-treatment surveillance of gliomas. However, it remains unclear if any technique holds diagnostic superiority. This meta-analysis compared the diagnostic accuracy of different imaging techniques and found no superior technique.
Article
Radiology, Nuclear Medicine & Medical Imaging
Bobby A. Runderkamp, Thomas Roos, Wietske van der Zwaag, Gustav J. Strijkers, Matthan W. A. Caan, Aart J. Nederveen
Summary: This study aimed to achieve homogeneous signal throughout the human liver at 7 T. By using subject-specific multichannel absolute B-1(+) maps and parallel-transmit k(T)-point pulses for flip angle (FA) shimming, homogeneous whole-liver images were obtained.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sofia K. Michopoulou, John C. Dickson, Glen G. Gardner, Thomas R. Gee, Andrew J. Fenwick, Timothy Melhuish, Clare A. Monaghan, Neil O'Brien, Angus M. J. Prosser, Catherine J. Scott, Roger T. Staff, Jonathan Taylor
Summary: This study evaluated the use of Brain SPECT and PET scans in the UK and explored drivers and barriers to using quantitative analysis through an online survey. The results showed variations across the UK, with high availability of DaTscan imaging and quantification and lower availability of other SPECT and PET scans.
NUCLEAR MEDICINE COMMUNICATIONS
(2023)
