Article
Neurosciences
Michael H. Parrish, Janine M. Dutcher, Keely A. Muscatell, Tristen K. Inagaki, Mona Moieni, Michael R. Irwin, Naomi Eisenberger
Summary: This study used fMRI to investigate the relationship between self-enhancement and emotion regulation in social evaluation tasks. The results showed that stable state self-esteem and higher trait self-esteem were associated with increased functional connectivity between RVLPFC and VS during positive evaluation. Additionally, participants with stable-state self-esteem showed stronger RVLPFC activation during all types of feedback processing and left VS activation during negative feedback processing.
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2022)
Article
Neurosciences
Jana Lieberz, Simone G. Shamay-Tsoory, Nira Saporta, Alisa Kanterman, Jessica Gorni, Timo Esser, Ekaterina Kuskova, Johannes Schultz, Rene Hurlemann, Dirk Scheele
Summary: This study aimed to investigate the behavioral and neural correlates of social avoidance in loneliness, revealing that lonely individuals show a distinct pattern of behavioral and neural responsiveness to social decision-making and social feedback compared to social anxiety.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Margaret Prenger, Madeline Gilchrist, Kathryne Van Hedger, Ken N. Seergobin, Adrian M. Owen, Penny A. Macdonald
Summary: Humor comprehension and appreciation are cognitive processes involving different brain regions. The dorsal striatum is important for humor comprehension, while the ventral striatum plays a critical role in humor appreciation.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Xiaoxue Gao, Hongbo Yu, Lu Peng, Xiaoliang Gong, Yang Xiang, Changjun Jiang, Xiaolin Zhou
Summary: In this study, researchers used a social interactive game and fMRI technology to investigate the emotional responses of transgressors after being forgiven or blamed by victims. The findings suggest that the victim's attitude and the severity of harm interactively modulate the transgressor's social emotions, with expectation violation serving as a mediator.
Article
Neurosciences
Nicole E. Keller, Augustin C. Hennings, Emily K. Leiker, Jarrod A. Lewis-Peacock, Joseph E. Dunsmoor
Summary: Neurobiological evidence suggests that incorporating reward associations with an extinction memory may be an effective strategy to attenuate threat responses. This study compared rewarded extinction to standard extinction in both short-term and long-term retrieval tests and found that rewarded extinction was more effective in reducing arousal and threat expectancy. The study also identified different patterns of brain activity and connectivity between reward-associated extinction and standard extinction.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Yimeng Zeng, Fuxiang Tao, Zaixu Cui, Liyun Wu, Jiahua Xu, Wenshan Dong, Chao Liu, Zhi Yang, Shaozheng Qin
Summary: The study identified two distinct dynamic states of intrinsic connectivity patterns based on BLA and CMA using fMRI and K-means clustering in two groups of young healthy individuals. Higher skin conductance level was found in the integration state compared to the segregation state in another dataset. Additionally, machine learning analysis revealed that the time-varying BLA and CMA intrinsic connectivity patterns had higher predictive values for fluctuations in skin conductance level in the integration state.
Article
Neurosciences
Cristian B. Calderon, Esther De Loof, Kate Ergo, Anna Snoeck, Carsten N. Boehler, Tom Verguts
Summary: Behavioral evidence suggests that reward prediction errors play a key role in episodic memory acquisition. In a novel task where RPEs were manipulated, fMRI results confirmed that signed RPEs are encoded in the ventral striatum and mediate their effects on episodic memory accuracy. Connectivity between processing areas and the hippocampus and ventral striatum increased with RPE value, supporting their central role in episodic memory formation.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Katherine W. Scangos, Ghassan S. Makhoul, Leo P. Sugrue, Edward F. Chang, Andrew D. Krystal
Summary: Deep brain stimulation shows promise in treating severe depression, but questions about anatomical targeting remain. A study implanting intracranial electrodes in a depressed patient found rapid, reproducible emotional responses that were context and state dependent, providing proof of concept for personalized, circuit-specific medicine in psychiatry.
Article
Behavioral Sciences
Filip Grill, Lars Nyberg, Anna Rieckmann
Summary: The study suggests that the fMRI response to rewards in the ventral striatum reflects a mixture of component processes of reward, with an inferior ventral striatal component and hippocampus being involved in reward-based processing during gambling. The more superior ventral striatal component is linked to networks associated with executive functioning and responds to both reward and cognitive control demands.
BRAIN AND BEHAVIOR
(2021)
Article
Psychology, Clinical
Jason Smucny, Tyler A. A. Lesh, Tara A. A. Niendam, J. Daniel Ragland, Laura M. M. Tully, Cameron S. S. Carter
Summary: This study found that in individuals with recent onset schizophrenia, deficits in reward anticipation can be reversed after one year of coordinated specialty care treatment, and this improvement is associated with a reduction in positive symptoms of the illness.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Kun Il Kim, Wi Hoon Jung, Choong-Wan Woo, Hackjin Kim
Summary: This study investigates the individual variability in context-dependent facial expression estimation and its neural circuitry, providing novel insights into the predictive accounts of affective states.
Article
Clinical Neurology
Yuanshu Chen, Congcong Liu, Fei Xin, Haochen Zou, Yulan Huang, Jinyu Wang, Jing Dai, Zhili Zou, Stefania Ferraro, Keith M. Kendrick, Bo Zhou, Xiaolei Xu, Benjamin Becker
Summary: Major depression (MDD) and generalized anxiety disorder (GAD) are leading causes of disability globally, with marked interpersonal and social impairments. This study used fMRI to investigate whether MDD and GAD share a neural basis during interpersonal processing. Results suggest that the dlPFC is involved in emotion-specific alteration during interpersonal processing, with depression symptom load positively associated with dlPFC reactivity to sad facial expressions. Dysregulated communication between the amygdala and salience network may be specific to depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Neurosciences
Natasha Duell, Michael T. Perino, Ethan M. McCormick, Eva H. Telzer
Summary: The present study investigated the differences in risky decision-making between delinquent and non-delinquent youth. Behavioral results showed that delinquent youth took fewer risks and earned fewer rewards compared to non-delinquent youth. Neural analyses revealed that delinquent youth exhibited greater neural tracking of reward outcomes, suggesting a preference for immediate rewards. These findings provide important insights into differential decision-making processes between delinquent and non-delinquent youth.
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2023)
Article
Psychology, Multidisciplinary
Katja Koelkebeck, Jochen Bauer, Thomas Suslow, Patricia Ohrmann
Summary: This case report describes a male patient with right amygdala damage and an ASD. He displayed a non-response of the amygdala to fearful faces and tended to misinterpret fearful expressions. Moreover, a non-reactivity of both amygdalae to emotional facial expressions at an implicit processing level was revealed.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Immunology
Johnna R. Swartz, Angelica F. Carranza, Annchen R. Knodt, Michael R. Irwin, Camelia E. Hostinar
Summary: This study examined the association between peripheral inflammation and amygdala activity and connectivity in adolescents. The results showed that peripheral inflammation was associated with increased amygdala activity to emotional face stimuli and reduced connectivity with occipital and parietal regions. These findings enhance our understanding of the relationship between peripheral inflammation and neural response to emotional faces in adolescents.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Medicine, Research & Experimental
Hasan Cagin Lenk, Robert Lovsletten Smith, Kevin S. O'Connell, Marin M. Jukic, Marianne Kristiansen Kringen, Ole A. Andreassen, Magnus Ingelman-Sundberg, Espen Molden
Summary: This study found that genetic variants in CYP1A and NFIB have a significant impact on the dose requirements and clinical response of clozapine, especially in smokers. Smokers carrying these genetic variants may require higher doses to achieve therapeutic effects.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Article
Psychiatry
Nora R. Bakken, Laurie J. Hannigan, Alexey Shadrin, Guy Hindley, Helga Ask, Ted Reichborn-Kjennerud, Martin Tesli, Ole A. Andreassen, Alexandra Havdahl
Summary: This study examines the association between childhood temperamental traits, emotional and behavioral problems, and adolescent mood and anxiety disorders. The findings show a consistent and increasing relationship between negative emotionality, behavioral and emotional problems in early to middle childhood, and mood and anxiety disorders in adolescence.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Biochemistry & Molecular Biology
Claudia Barth, Sinead Kelly, Stener Nerland, Neda Jahanshad, Clara Alloza, Sonia Ambrogi, Ole A. Andreassen, Dimitrios Andreou, Celso Arango, Inmaculada Baeza, Nerisa Banaj, Carrie E. Bearden, Michael Berk, Hannes Bohman, Josefina Castro-Fornieles, Yann Chye, Benedicto Crespo-Facorro, Elena de la Serna, Covadonga M. Diaz-Caneja, Tiril P. Gurholt, Catherine E. Hegarty, Anthony James, Joost Janssen, Cecilie Johannessen, Erik G. Joensson, Katherine H. Karlsgodt, Peter Kochunov, Noemi G. Lois, Mathias Lundberg, Anne M. Myhre, Sauel Pascual-Diaz, Fabrizio Piras, Runar E. Smelror, Gianfranco Spalletta, Therese S. Stokkan, Gisela Sugranyes, Chao Suo, Sophia I. Thomopoulos, Diana Tordesillas-Gutierrez, Daniela Vecchio, Kirsten Wedervang-Resell, Laura A. Wortinger, Paul M. Thompson, Ingrid Agartz
Summary: Emerging evidence suggests that adolescents with early-onset psychosis (EOP) exhibit altered white matter microstructure in the brain. This study used a large sample size and standardized data processing protocols to compare white matter microstructure between EOP individuals and healthy controls. The results showed widespread white matter alterations in EOP individuals, particularly in male individuals with early-onset schizophrenia and individuals with a shorter duration of illness.
MOLECULAR PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Aili R. Lochen, Knut K. Kolskar, Ann-Marie G. de Lange, Markus H. Sneve, Beathe Haatveit, Trine V. Lagerberg, Torill Ueland, Ingrid Melle, Ole A. Andreassen, Lars T. Westlye, Dag Alnaes
Summary: The objective of this study was to compare visual discrimination performance in patients with schizophrenia spectrum disorder or bipolar disorder with healthy controls, and investigate associations with clinical symptoms and IQ. The results showed that patients with schizophrenia spectrum or bipolar disorders exhibited higher visual discrimination thresholds than healthy controls. Furthermore, there were negative associations between IQ and discrimination threshold among healthy controls and bipolar disorder patients.
Article
Geriatrics & Gerontology
Ina S. Almdahl, Liva J. Martinussen, Olga Therese Ousdal, Miroslawa Kraus, Piotr Sowa, Ingrid Agartz, Maria S. Korsnes
Summary: This study aimed to compare the functional connectivity of large-scale brain networks during a cognitive control task with emotional stimuli in older adults with and without a history of late-life depression (LLD). The results revealed that LLD patients exhibited reduced functional connectivity between certain networks during the processing of incongruent emotional stimuli. The findings expand on the network-based LLD model and suggest the salience network as a potential target for future interventions.
AGING & MENTAL HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Stuart B. Murray, Jaroslav Rokicki, Alina M. Sartorius, Adriano Winterton, Ole A. Andreassen, Lars T. Westlye, Jason M. Nagata, Daniel S. Quintana
Summary: By analyzing the Allen Human Brain Atlas, researchers have found that genes associated with anorexia nervosa are highly expressed in the brain and have specific expression patterns, which are related to brain activity involved in processing appetitive and aversive cues.
MOLECULAR PSYCHIATRY
(2023)
Article
Psychiatry
Rune Boen, Tobias Kaufmann, Oleksandr Frei, Dennis van der Meer, Srdjan Djurovic, Ole A. Andreassen, Kaja K. Selmer, Dag Alnaes, Ida E. Sonderby
Summary: The study investigates the differences in brain morphology and ageing process between 15q11.2 BP1-BP2 CNV carriers and non-carriers. Despite the alterations in brain structure, there is no apparent effect on ageing in terms of brain structure and motor, lung, and heart function.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychiatry
Eshim S. Jami, Anke R. Hammerschlag, Hannah M. Sallis, Zhen Qiao, Ole A. Andreassen, Per M. Magnus, Pal R. Njolstad, Alexandra Havdahl, Jean-Baptiste Pingault, David M. Evans, Marcus R. Munafo, Eivind Ystrom, Meike Bartels, Christel Middeldorp
Summary: Parental genes can influence offspring psychiatric outcomes indirectly through the environment they create. This study aimed to estimate the contribution of parental genetic nurture effects on childhood psychiatric symptoms using advanced statistical genetic methods. The results suggest that parental genetic nurture effects may play a role in explaining individual differences in childhood psychiatric symptoms, but further research with larger samples is needed.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychiatry
Ragna Bugge Askeland, Laurie J. Hannigan, Kevin S. O'Connell, Elizabeth C. Corfield, Oleksandr Frei, Anita Thapar, George Davey Smith, Ted Reichborn-Kjennerud, Ole A. Andreassen, Helga Ask, Alexandra Havdahl
Summary: Knowledge on how genetic risk for bipolar disorder manifests in developmental, emotional or behavioral traits during childhood is lacking. This issue is important to address to inform early detection and intervention efforts. Our study investigated the association between polygenic risk for bipolar disorder and developmental outcomes in children, and found robust evidence for an association with conduct difficulties and oppositional defiant difficulties at 8 years. Other associations were estimated within a range close to zero, except for negative associations with activity levels and benevolence at age 5 and positive associations with motor difficulties, inattention, and hyperactivity at age 3 and 8. These findings suggest that genetic risk for bipolar disorder manifests as disruptive behaviors in childhood.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Olivia Wootton, Alexey A. Shadrin, Christine Mohn, Ezra Susser, Raj Ramesar, Ruben C. Gur, Ole A. Andreassen, Dan J. Stein, Shareefa Dalvie
Summary: This study conducted a large-scale genome-wide association study (GWAS) to identify genetic underpinnings of reaction time variability (RTV). The findings suggest that RTV is associated with genes involved in synaptic function and neural development. Additionally, RTV is genetically correlated with other neuropsychological traits. The study also demonstrated the predictive ability of a polygenic score for RTV.
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Ashlea Segal, Linden Parkes, Kevin Aquino, Seyed Mostafa Kia, Thomas Wolfers, Barbara Franke, Martine Hoogman, Christian F. Beckmann, Lars T. Westlye, Ole A. Andreassen, Andrew Zalesky, Ben J. Harrison, Christopher G. Davey, Carles Soriano-Mas, Narcis Cardoner, Jeggan Tiego, Murat Yucel, Leah Braganza, Chao Suo, Michael Berk, Sue Cotton, Mark A. Bellgrove, Andre F. Marquand, Alex Fornito
Summary: Classical case-control research often overlooks the individual heterogeneity of people with mental illness. Our study provides a comprehensive multiscale characterization of gray matter volume differences in individuals diagnosed with six different mental conditions. We found that while the regional deviations in gray matter volume were highly varied, they were embedded within common functional circuits and networks.
NATURE NEUROSCIENCE
(2023)
Article
Behavioral Sciences
Max Korbmacher, Meng-Yun Wang, Rune Eikeland, Ralph Buchert, Ole A. Andreassen, Thomas Espeseth, Esten Leonardsen, Lars T. Westlye, Ivan I. Maximov, Karsten Specht
Summary: This study shows that there is a small correlation between brain age predictions and actual age, and the prediction can be influenced by factors such as field strength and scan quality. Therefore, the clinical applications of brain age models should be carefully validated and take into account potential biases in the data acquisition process.
BRAIN AND BEHAVIOR
(2023)
Article
Psychiatry
Laura A. Wortinger, Alexey A. Shadrin, Attila Szabo, Stener Nerland, Runar Elle Smelror, Kjetil Nordbo Jorgensen, Claudia Barth, Dimitrios Andreou, Marianne Thoresen, Ole A. Andreassen, Srdjan Djurovic, Gianluca Ursini, Ingrid Agartz
Summary: Placental dysfunction and birth asphyxia have an impact on fetal brain development and may increase the risk of developing schizophrenia. This study found that placental genomic risk factors associated with schizophrenia were more likely to be present in individuals with a history of birth asphyxia. Additionally, the interaction between these risk factors and birth asphyxia affected neonatal head circumference and adult intracranial volume, particularly in males.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Neurosciences
Ashlea Segal, Linden Parkes, Kevin Aquino, Seyed Mostafa Kia, Thomas Wolfers, Barbara Franke, Martine Hoogman, Christian F. Beckmann, Lars T. Westlye, Ole A. Andreassen, Andrew Zalesky, Ben J. Harrison, Christopher G. Davey, Carles Soriano-Mas, Narcis Cardoner, Jeggan Tiego, Murat Yucel, Leah Braganza, Chao Suo, Michael Berk, Sue Cotton, Mark A. Bellgrove, Andre F. Marquand, Alex Fornito
Summary: Traditional case-control research often ignores the substantial individual heterogeneity among people with mental illness. This study provides a comprehensive, multiscale characterization of gray matter volume differences in six mental disorders. The results show that individual deviations in regional gray matter volume are highly heterogeneous, but some of these deviations are embedded within common functional circuits and networks.
NATURE NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Claudia Barth, Sinead Kelly, Stener Nerland, Neda Jahanshad, Clara Alloza, Sonia Ambrogi, Ole A. Andreassen, Dimitrios Andreou, Celso Arango, Inmaculada Baeza, Nerisa Banaj, Carrie E. Bearden, Michael Berk, Hannes Bohman, Josefina Castro-Fornieles, Yann Chye, Benedicto Crespo-Facorro, Elena de la Serna, Covadonga M. Diaz-Caneja, Tiril P. Gurholt, Catherine E. Hegarty, Anthony James, Joost Janssen, Cecilie Johannessen, Erik G. Joensson, Katherine H. Karlsgodt, Peter Kochunov, Noemi G. Lois, Mathias Lundberg, Anne M. Myhre, Sauel Pascual-Diaz, Fabrizio Piras, Runar E. Smelror, Gianfranco Spalletta, Therese S. Stokkan, Gisela Sugranyes, Chao Suo, Sophia I. Thomopoulos, Diana Tordesillas-Gutierrez, Daniela Vecchio, Kirsten Wedervang-Resell, Laura A. Wortinger, Paul M. Thompson, Ingrid Agartz
Summary: This study compared white matter microstructure in adolescents with early-onset psychosis (EOP) and healthy controls using diffusion tensor imaging (DTI). The results showed widespread lower fractional anisotropy (FA) and higher radial diffusivity (RD), mean diffusivity (MD), and axial diffusivity (AD) in EOP patients. There were significant effects of diagnostic subgroup, sex, and duration of illness.
MOLECULAR PSYCHIATRY
(2023)