Article
Neurosciences
Shunsuke Sugiyama, Tomoya Taniguchi, Tomoaki Kinukawa, Nobuyuki Takeuchi, Kazutaka Ohi, Toshiki Shioiri, Makoto Nishihara, Koji Inui
Summary: This study used magnetoencephalography to investigate the effects of 40 Hz auditory stimulation on brain activity and revealed the specific neural circuit activation mechanism underlying the 40 Hz ASSR. These findings are of great importance for understanding oscillatory abnormalities in neuropsychiatric disorders such as schizophrenia.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Kyung-min An, Jeong Hyun Shim, Hyukchan Kwon, Yong-Ho Lee, Kwon-Kyu Yu, Moonyoung Kwon, WooYoung Chun, Tetsu Hirosawa, Chiaki Hasegawa, Sumie Iwasaki, Mitsuru Kikuchi, Kiwoong Kim
Summary: Magnetoencephalography (MEG) is a noninvasive functional neuroimaging technique that detects brain magnetic field. Traditional MEG uses superconducting quantum interference devices (SQUIDs), while miniature optically pumped magnetometers (OPMs) have recently been developed as an alternative. The study suggests that OPM sensors have comparable performance to conventional SQUID-MEG sensors, showing the feasibility of using OPM sensors for functional neuroimaging and brain-computer interface applications.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Oskar Hougaard Jefsen, Yury Shtyrov, Kit Melissa Larsen, Martin J. Dietz
Summary: This study explored the evidence of 40-Hz ASSR deficits in patients with bipolar disorder, and found consistent reductions in 40-Hz ASSR evoked power and inter-trial phase coherence compared with healthy controls. Further large-scale studies are needed to link 40-Hz ASSR deficits to clinical features and developmental trajectories.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Clinical Neurology
Vardan Arutiunian, Giorgio Arcara, Irina Buyanova, Elizaveta Davydova, Darya Pereverzeva, Alexander Sorokin, Svetlana Tyushkevich, Uliana Mamokhina, Kamilla Danilina, Olga Dragoy
Summary: Language impairment is common in children with Autism Spectrum Disorder (ASD), and the neural mechanisms behind it are not well understood. This study investigates the relationship between a specific auditory response (40 Hz ASSR) and language abilities in children with ASD using MEG and individual brain models. The results show reduced 40 Hz ASSR in the right auditory cortex of children with ASD and an association between 40 Hz ASSR in the left auditory cortex and language comprehension.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Psychiatry
Tetsu Hirosawa, Daiki Soma, Yoshiaki Miyagishi, Naoki Furutani, Yuko Yoshimura, Masafumi Kameya, Yohei Yamaguchi, Ken Yaoi, Masuhiko Sano, Koji Kitamura, Tetsuya Takahashi, Mitsuru Kikuchi
Summary: This study used graph theory to evaluate the effect of tDCS on the brain network of 40 Hz ASSR and found that tDCS can significantly improve the functional integration of the whole-brain network of 40 Hz ASSR. In addition, the study also found that individuals with lower initial functional integration showed a more pronounced effect after receiving tDCS.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Neurosciences
Vardan Arutiunian, Giorgio Arcara, Irina Buyanova, Militina Gomozova, Olga Dragoy
Summary: Recent studies have found that gamma-band oscillations and transient evoked potentials in children may change with age, potentially related to the maturation of the GABAergic neurotransmission system and the balance between excitation and inhibition in neural circuits. In this study, using magnetoencephalography (MEG), researchers investigated the relationship between 40 Hz auditory steady-state gamma response (ASSR) and sustained event-related field (ERF) response to the same periodic stimuli in a group of 30 typically developing children aged 7 to 12 years. The results showed a strong association between the strength of 40 Hz ASSR and the amplitude of ERF, with age-related changes observed in both responses.
HUMAN BRAIN MAPPING
(2022)
Article
Audiology & Speech-Language Pathology
Wouter David, Elise Verwaerde, Robin Gransier, Jan Wouters
Summary: This study investigated the effects of early response buildup on the measurement outcomes of electrically evoked auditory steady-state responses (eASSRs) in adult cochlear implant (CI) users. The researchers found that including the first 300 ms in the analysis window led to overestimation of response amplitude and underestimation of response phase. However, the response signal-to-noise ratio (SNR) and pairwise phase consistency (PPC) were not affected by the inclusion of the first 300 ms. The optimal stimulus duration for efficient and reliable eASSR measurements was found to be around 800 ms for 100% dynamic range stimulation level.
Article
Behavioral Sciences
Neeraj Kumar, Amit Jaiswal, Dipanjan Roy, Arpan Banerjee
Summary: This study characterizes the large-scale directed information flow among cortical sources of 40 Hz auditory steady-state responses (ASSR) entrained by external signals. The results confirm the right hemispheric dominance of ASSR during both monaural and binaural conditions. Moreover, bidirectional interactions involving the right superior temporal gyrus and inferior frontal gyrus underlie this dominance.
Article
Clinical Neurology
Brian J. Roach, Yoji Hirano, Judith M. Ford, Kevin M. Spencer, Daniel H. Mathalon
Summary: This study reanalyzed EEG data and found that patients with schizophrenia showed phase delay in the left hemisphere in the 40-Hz ASSR. This finding supports previous studies showing abnormal auditory cortex function in the left hemisphere in patients with schizophrenia.
CLINICAL EEG AND NEUROSCIENCE
(2023)
Article
Neurosciences
Shunsuke Sugiyama, Tomoya Taniguchi, Tomoaki Kinukawa, Nobuyuki Takeuchi, Kazutaka Ohi, Toshiki Shioiri, Makoto Nishihara, Koji Inui
Summary: This study used magnetoencephalography to analyze brain oscillations in response to auditory stimuli at different frequencies. The results revealed interactions between gamma oscillations in different frequency bands, specifically the suppression of low-gamma oscillations during 40 Hz stimulation. The study also found distinct dipoles for auditory steady-state response and suppressed low-frequency gamma oscillations. Furthermore, analysis of all sensors showed that the area of suppression surrounded the center of the 40 Hz response, suggesting specific inhibitory innervation from the 40 Hz oscillation circuit to the low-gamma circuit.
Article
Engineering, Biomedical
Ludan Zhang, Shuang Liu, Xiaoya Liu, Bo Zhang, Xingwei An, Dong Ming
Summary: Emotions play a significant role in auditory processing, as negative emotions can improve auditory perception in healthy subjects while individuals with depression exhibit deficits in this area. Arousal and valence interact to modulate auditory perception, with positive emotions enhancing brain responses to auditory stimuli.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2021)
Article
Clinical Neurology
Shaobing Li, Ruxin Hu, Huiming Yan, Lijun Chu, Yuying Qiu, Ying Gao, Meijuan Li, Jie Li
Summary: This study investigates the relationship between 40 Hz ASSR impairment and persistent auditory verbal hallucinations (pAVHs) in schizophrenia (SCZ) patients. The findings suggest that the 40 Hz ASSR can be used as a marker to detect and assess the severity of pAVHs in SCZ patients.
PSYCHIATRY RESEARCH-NEUROIMAGING
(2023)
Article
Engineering, Biomedical
Christian Bech Christensen, Thomas Lunner, James Michael Harte, Mike Lind Rank, Preben Kidmose
Summary: This study investigated the spatial distribution of the auditory steady-state response (ASSR) to broadband chirp stimuli at different repetition rates on the scalp and in the ears, and found that the ASSR amplitude and phase were dependent on the repetition rate on the scalp, but independent of the repetition rate in the ears. The use of high repetition rates for chirp stimuli was advantageous for ASSR recording in both clinical practice and mobile real-life applications.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Article
Psychology, Biological
Malina Szychowska, Stefan Wiens
Summary: This study examined the effects of different levels of visual load on auditory steady-state responses (ASSRs) and found that visual load did not affect auditory processing, implying that attentional resources are modality specific and that the attentional filter of auditory processing does not vary with visual task demands.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Biochemistry & Molecular Biology
Anastasia K. Neklyudova, Galina V. Portnova, Anna B. Rebreikina, Victoria Yu Voinova, Svetlana G. Vorsanova, Ivan Y. Iourov, Olga V. Sysoeva
Summary: SH01 is a 15-year-old girl with a duplication in the SHANK3 gene, exhibiting mild mental retardation, learning disabilities, and smaller vocabulary compared to typically developing children. Despite mild autistic symptoms and microcephaly, she did not meet the criteria for ASD diagnosis. The absence of 40-Hz ASSR in patients with SHANK3 gene duplication suggests deficient temporal resolution of the auditory system, potentially contributing to language problems.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Jose Sanchez-Bornot, Roberto C. Sotero, J. A. Scott Kelso, Ozguer Simsek, Damien Coyle
Summary: This study proposes a multi-penalized state-space model for analyzing unobserved dynamics, using a data-driven regularization method. Novel algorithms are developed to solve the model, and a cross-validation method is introduced to evaluate regularization parameters. The effectiveness of this method is validated through simulations and real data analysis, enabling a more accurate exploration of cognitive brain functions.
