Article
Neuroimaging
Tobias Mantel, Angela Jochim, Tobias Meindl, Jonas Deppe, Claus Zimmer, Yong Li, Bernhard Haslinger
Summary: Through diffusion imaging study of patients with blepharospasm and healthy controls, we found abnormal brain connectivity in patients, especially in connections related to vision and movement. The cerebellum may also contribute to the occurrence of this disease.
NEUROIMAGE-CLINICAL
(2022)
Article
Anatomy & Morphology
Hua-Jun Chen, Xiao-Hong Zhang, Jia-Yan Shi, Shao-Fan Jiang, Yi-Fan Sun, Ling Zhang, Dan Li, Rong Chen
Summary: The study revealed disrupted thalamic structural connections in cirrhotic patients with MHE, which worsened from NHE to MHE and were correlated with neurocognitive performance. The moderate classification accuracy using CS and MD measurements suggests that thalamic connections could serve as potential biomarkers for diagnosing and monitoring MHE. Further research is recommended to explore structural alterations in other white matter pathways in MHE.
FRONTIERS IN NEUROANATOMY
(2021)
Article
Neurosciences
Weihao Zheng, Leilei Zhao, Zhiyong Zhao, Tingting Liu, Bin Hu, Dan Wu
Summary: In this study, the development of the thalamus in pre-term and full-term infants was investigated using high-angular resolution diffusion MRI data. The results showed that the lateral thalamus exhibited greater expansion and fiber integrity compared to the medial part. The development of thalamic connections to the frontal cortex was found to be delayed compared to other thalamocortical connections, and functional partitions of thalamic subdivisions developed in a lateral-to-medial pattern. These findings provide insights into the developmental characteristics of the thalamus during the perinatal period.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Psychiatry
Guowei Wu, Lena Palaniyappan, Manqi Zhang, Jie Yang, Chang Xi, Zhening Liu, Zhimin Xue, Xuan Ouyang, Haojuan Tao, Jinqiang Zhang, Qiang Luo, Weidan Pu
Summary: The study found that patients with schizophrenia exhibit thalamic hyperconnectivity with sensorimotor cortices and hypoconnectivity with prefrontal-cerebellar regions during both rest and task engagement, which is related to working memory performance.
SCHIZOPHRENIA BULLETIN
(2022)
Article
Psychology, Clinical
Gabor Csukly, Adam Szabo, Patricia Polgar, Kinga Farkas, Gyula Gyebnar, Lajos R. Kozak, Gabor Stefanics
Summary: The study revealed altered effective and structural connectivity within the ACC-thalamus network in SZ patients, with decreased coupling strength and increased inhibitory intrinsic connectivity in certain regions. These changes suggest imbalanced fronto-thalamic coupling may contribute to positive symptoms in SZ.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Neurosciences
Stefano Delli Pizzi, Piero Chiacchiaretta, Carlo Sestieri, Antonio Ferretti, Maria Giulia Tullo, Stefania Della Penna, Giovanni Martinotti, Marco Onofrj, Leor Roseman, Christopher Timmermann, David J. Nutt, Robin L. Carhart-Harris, Stefano L. Sensi
Summary: The study found that LSD intake selectively changes the functional connectivity between the thalamus and cortex, including the ventral complex, pulvinar, and non-specific nuclei. These nuclei showed increased functional coupling with sensory cortices and parts of the associative cortex dense in serotonin type 2A receptors. LSD also affected the subcortical connectivity.
Article
Neurosciences
Yachin Chen, Nicholas Fallon, Barbara A. K. Kreilkamp, Christine Denby, Martyn Bracewell, Kumar Das, Emily Pegg, Rajiv Mohanraj, Anthony G. Marson, Simon S. Keller
Summary: This study found significant volume reduction of the left and right anterior thalamic nuclei only in patients with refractory idiopathic generalised epilepsy (IGE), compared to those with non-refractory IGE. Both refractory and non-refractory IGE patients showed significant alterations of functional connectivity between the centromedian nucleus and cortex, with only refractory patients showing altered cortical connectivity with the ventral lateral nuclear group. Refractory IGE patients had increased functional connectivity between the left and right ventral lateral posterior nuclei and cortical regions compared to non-refractory IGE patients, mainly in the frontal lobe.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Zafer Keser, Erin L. Meier, Melissa D. Stockbridge, Bonnie L. Breining, Rajani Sebastian, Argye E. Hillis
Summary: This study found that after left hemispheric stroke, the microstructural integrity of nonlesioned thalamic nuclei and thalamocortical pathways shows rightward lateralization, which is associated with poorer naming abilities.
BRAIN CONNECTIVITY
(2021)
Article
Clinical Neurology
Yupeng Guo, Yun Chen, Yan Shao, Sifan Hu, Guangyuan Zou, Jie Chen, Yuezhen Li, Xuejiao Gao, Jiayi Liu, Ping Yao, Shuqin Zhou, Jing Xu, Jia-Hong Gao, Qihong Zou, Hongqiang Sun
Summary: This study found that there was a decreased connectivity between the left thalamus and the left cerebellum in patients with insomnia disorder (ID) during the wakefulness after sleep onset (WASO) condition, compared to healthy controls. Furthermore, the thalamic connectivity with the cerebellum was negatively correlated with Fatigue Severity Scale scores. These findings highlight the link between insomnia-related daytime fatigue and the altered thalamic network after sleep onset and suggest the potential of targeting this neural pathway for fatigue mitigation.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Min-Chien Tu, Sheng-Min Huang, Yen-Hsuan Hsu, Jir-Jei Yang, Chien-Yuan Lin, Li-Wei Kuo
Summary: The study found that DKI metrics may be more sensitive than DTI metrics in reflecting microstructural changes within the gray matter, providing complementary information for the pathogenesis of SIVD and AD.
HUMAN BRAIN MAPPING
(2021)
Article
Gastroenterology & Hepatology
Zhida Zhang, Yang Hu, Ganggang Lv, Jia Wang, Yang He, Lei Zhang, Hao Li, Karen M. von Deneen, Huaning Wang, Shijun Duan, Junwang Zhang, Qiuqiu Hou, Yanan Pan, Yu Zhao, Kuanrong Mao, Fan Wang, Yi Zhang, Guangbin Cui, Yongzhan Nie
Summary: Functional constipation is associated with abnormal structural connectivity between thalamus and limbic/parietal cortex, indicating a potential neurobiological basis for the symptoms of constipation.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Neurosciences
Gianpaolo Antonio Basile, Salvatore Bertino, Alessia Bramanti, Rosella Ciurleo, Giuseppe Pio Anastasi, Demetrio Milardi, Alberto Cacciola
Summary: Novel imaging techniques have been developed for precise delineation of thalamic nuclei, allowing for reliable identification of up to 13 distinct nuclei bilaterally. These high-resolution imaging methods have potential implications for studying thalamic connectivity, basic research, and presurgical planning.
Article
Behavioral Sciences
Aurore Menegaux, Chun Meng, Josef G. Baeuml, Maria T. Berndt, Dennis M. Hedderich, Benita Schmitz-Koep, Sebastian Schneider, Rachel Nuttall, Juliana Zimmermann, Marcel Daamen, Claus Zimmer, Henning Boecker, Peter Bartmann, Dieter Wolke, Christian Sorg
Summary: The study found aberrant cortico-thalamic structural connectivity in very premature-born adults, which is linked with impairments in verbal cognitive abilities and related to the degree of prematurity. These changes may persist into adulthood after premature birth, based on corresponding findings in infants.
Article
Neurosciences
Andrew Gaddis, Daniel E. Lidstone, Mary Beth Nebel, Roland R. Griffiths, Stewart H. Mostofsky, Amanda F. Mejia, Frederick S. Barrett
Summary: This study used a novel analysis method to investigate the effects of psilocybin on thalamic functional organization and connectivity. The results showed that psilocybin primarily affected the mediodorsal and pulvinar nuclei in the thalamus, leading to decreased connectivity with visual and default mode networks.
Article
Neurosciences
Inhan Kang, Matthew Galdo, Brandon M. Turner
Summary: This article proposes a two-step pipeline to explore task-dependent functional coactivations of brain clusters with constraints imposed from structural connectivity networks. The pipeline combines nonparametric Bayesian clustering and factor analysis methods to obtain cluster assignments and correlations between brain regions of interest, providing insights into the functional network of the brain.
NETWORK NEUROSCIENCE
(2022)
Article
Neurosciences
Philip J. Broser, Thomas Middelmann, Davide Sometti, Christoph Braun
Summary: This study aimed to analyze the signal conduction in muscular fibres by studying the spatio-temporal dynamics of the magnetic field generated by the propagating muscle action potential (MAP). The results showed that the combined electric and magnetic dipole model could explain the recorded magnetic activity generated by the activity of the intrinsic foot muscles. This non-invasive approach using Optically Pumped Magnetometers (OPMs) has the potential to become a promising diagnostic tool in peripheral neurological motor impairments.
JOURNAL OF ELECTROMYOGRAPHY AND KINESIOLOGY
(2021)
Article
Neurosciences
Philip J. Broser, Justus Marquetand, Thomas Middelmann, Davide Sometti, Christoph Braun
Summary: This study aimed to simultaneously record the magnetic and electric components of the propagating muscular action potential by comparing the magnetic and electric fields through modeling of the muscular anatomy. Results showed that MMG signals can reliably be recorded following the stimulation of the monosynaptic stretch reflex, providing insights into muscle physiology from the propagating muscular action potential to the activation of the contractile apparatus. The development of high-resolution magnetic cameras based on OPM technology will enable precise imaging of the biomagnetic field of skeletal muscles, with potential applications in clinical medicine and sports science.
JOURNAL OF ELECTROMYOGRAPHY AND KINESIOLOGY
(2021)
Article
Clinical Neurology
Philip Broser, Jurg Lutschg
Summary: This overview presents the complementary diagnostic roles of clinical neurophysiological methods and ultrasonography in various neuropathies, including hereditary neuropathies, Friedreich ataxia, acquired neuropathies, and traumatic nerve lesions. The combination of these methods provides important diagnostic information for different types of nerve conditions.
KLINISCHE NEUROPHYSIOLOGIE
(2021)
Article
Pediatrics
Christina T. Ruesch, Ursula Knirsch, Daniel M. Weber, Marianne Rohrbach, Andre Eichenberger, Juerg Luetschg, Kirsten Weber, Philip J. Broser, Georg M. Stettner
Summary: Carpal tunnel syndrome in childhood is rare and primarily caused by underlying disorders, with mucopolysaccharidosis being the most common underlying condition. Thorough evaluation and search for causative conditions are recommended for pediatric patients with CTS.
Article
Clinical Neurology
Justus Marquetand, Thomas Middelmann, Juergen Dax, Sangyeob Baek, Davide Sometti, Alexander Grimm, Holger Lerche, Pascal Martin, Cornelius Kronlage, Markus Siegel, Christoph Braun, Philip Broser
Summary: This study demonstrated that fasciculations could be detected non-invasively using optically pumped magnetometers (OPM), but other forms of spontaneous muscle activity were not detectable with current OPM technology. Further technical solutions are proposed to improve detection of other forms of spontaneous activity.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
Justus Marquetand, Thomas Middelmann, Davide Sometti, Christoph Braun, Philip J. Broser
Summary: The muscle action potential, measured using MMG, overcomes physical limitations with the development of OPM technology, allowing for spatial visualization, contactless and reference-free measurements. Studying muscle action potential after triggering muscle reflexes with MMG reveals new signals potentially related to muscle contraction.
KLINISCHE NEUROPHYSIOLOGIE
(2021)
Article
Neurosciences
Nathalie Alexander, Philip Julian Broser
Summary: This study compared counter-movement jump performance between children with CMT1a and typically developing children (TDC), revealing that children with CMT1a showed significantly lower peak force, net vertical impulse, and jump height values. The correlation between jump height and net vertical impulse was significant in both groups.
Article
Pediatrics
Philip Broser, Ursula von Mengershausen, Katrin Heldt, Deborah Bartholdi, Dominique Braun, Christine Wolf, Min Ae Lee-Kirsch
Summary: This study reports a case of SGMRT1 in a nine-year-old child who showed improvement upon treatment with the Janus kinase inhibitor ruxolitinib. The findings suggest that JAK inhibition is a valuable therapeutic option for SGMRT1 and personalized treatment approaches based on pathogenic insight have potential.
PEDIATRIC RHEUMATOLOGY
(2022)
Article
Clinical Neurology
Niall J. Bourke, Celia Demarchi, Sara De Simoni, Ravjeet Samra, Maneesh C. Patel, Adam Kuczynski, Quen Mok, Neil Wimalasundera, Fareneh Vargha-Khadem, David J. Sharp
Summary: Long-term outcomes of paediatric traumatic brain injury are difficult to predict. Traumatic brain injury can lead to reductions in brain volume and is associated with cognitive, emotional, and behavioral impairments. This study investigates the impact of brain injury on healthy brain development and shows that volumetric abnormalities are common after moderate/severe traumatic brain injury in both grey and white matter regions.
Article
Behavioral Sciences
Jacoba van der Linde, Carole Jenny, Thomas Hundsberger, Philip J. Broser
Summary: The aim of this study was to analyze the increase in diameter of the nerve roots C5 and C6 in early childhood. The results showed that the main increase in diameter occurs during the first 2 years of life, and then the growth rate decreases steadily. Additionally, the study found that the maturation of the proximal part of the nerve is comparable to the maturation of its distal segments.
BRAIN AND BEHAVIOR
(2022)
Article
Clinical Neurology
Eva Maria Wendel, Helen Sophie Thonke, Annikki Bertolini, Matthias Baumann, Astrid Blaschek, Andreas Merkenschlager, Michael Karenfort, Barbara Kornek, Christian Lechner, Daniela Pohl, Martin Pritsch, Kathrin Schanda, Mareike Schimmel, Charlotte Thiels, Stephan Waltz, Gert Wiegand, Banu Anlar, Nina Barisic, Christian Blank, Markus Breu, Philip Broser, Adela Della Marina, Katharina Diepold, Matthias Eckenweiler, Astrid Eisenkoelbl, Michael Freilinger, Ursula Gruber-Sedlmayr, Annette Hackenberg, Tobias Iff, Ellen Knierim, Johannes Koch, Georg Kutschke, Steffen Leiz, Grischa Lischetzki, Margherita Nosadini, Alexander Pschibul, Edith Reiter-Fink, Doris Rohrbach, Michela Salandin, Stefano Sartori, Jan-Ulrich Schlump, Johannes Stoffels, Jurgis Strautmanis, Daniel Tibussek, Victoria Tuengler, Norbert Utzig, Markus Reindl, Kevin Rostasy
Summary: This study assessed the relationship between MOG-IgG titers and the clinical course of MOGAD in children and found that decreasing MOG-IgG titers were associated with a reduced risk of relapse.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2022)
Article
Clinical Neurology
Nathalie Alexander, Johannes Cip, Elisabeth Mueller, Katrin Lengnick-Lampadius, Philip Julian Broser
Summary: Hemispherotomy is considered as a treatment option for children with therapy refractory epilepsy. The effect of hemispherotomy on gait pattern has been analyzed qualitatively but lacks quantitative data. In this study, two children with therapy refractory epilepsy underwent gait analysis before and after hemispherotomy, with one showing no changes and the other showing differences in gait pattern by three-dimensional analysis.
Article
Neurosciences
Lorenzo Semeia, Thomas Middelmann, Sangyeob Baek, Davide Sometti, Hui Chen, Alexander Grimm, Holger Lerche, Pascal Martin, Cornelius Kronlage, Christoph Braun, Philip Broser, Markus Siegel, Maria-Sophie Breu, Justus Marquetand
Summary: This study reports a proof-of-principle investigation on the application of optically pumped magnetometers (OPM) for magnetomyography (MMG) in patients with neuromuscular diseases. The results show that OPM-MMG can record pathologically altered voluntary muscle activity, paving the way for further exploration of its potential benefits in clinical neurophysiology.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Carole Jenny, Jacoba van der Linde, Thomas Hundsberger, Philip J. Broser
Summary: The study aimed to investigate the maturation of the peripheral nervous system by analyzing the cross-sectional area of the sciatic nerve during the first 2 years of life. Using high-resolution ultrasound imaging, the sciatic nerve of 52 children aged 0 days to 10 years was examined, and a significant correlation between age and nerve cross-sectional area was found. A logarithmic growth model was developed to describe the growth rate of the nerve. The study provides normative values for the size of the sciatic nerve in children.
BRAIN AND BEHAVIOR
(2023)
Article
Neurosciences
Rachael Elward, Jennifer Limond, Loic J. Chareyron, Janice Ethapemi, Faraneh Vargha-Khadem
Summary: This study investigates how patients with developmental amnesia (DA) utilize recognition to support semantic learning. The results show that recognition-learning is beneficial for cued recall in patients with DA. This finding has implications for the support of school-aged children with episodic memory difficulties.
NEUROPSYCHOLOGICAL REHABILITATION
(2023)
Article
Neurosciences
Jose Sanchez-Bornot, Roberto C. Sotero, J. A. Scott Kelso, Ozguer Simsek, Damien Coyle
Summary: This study proposes a multi-penalized state-space model for analyzing unobserved dynamics, using a data-driven regularization method. Novel algorithms are developed to solve the model, and a cross-validation method is introduced to evaluate regularization parameters. The effectiveness of this method is validated through simulations and real data analysis, enabling a more accurate exploration of cognitive brain functions.
