Article
Clinical Neurology
Letizia Squarcina, Susanna Lucini Paioni, Marcella Bellani, Maria Gloria Rossetti, Josselin Houenou, Mircea Polosan, Mary L. Phillips, Michele Wessa, Paolo Brambilla
Summary: In this study, the state of white matter structures in bipolar disorder patients was investigated using TBSS and FD analyses. The results showed diffusion abnormalities primarily located in the temporo-parietal network, while no significant differences were found in the morphological complexity of white matter structures. Individual patients showed localized significant deviations in fractal dimension values.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Neurosciences
Yuchao Jiang, Mingjun Duan, Xiangkui Li, Huan Huang, Guocheng Zhao, Xuan Li, Shicai Li, Xufeng Song, Hui He, Dezhong Yao, Cheng Luo
Summary: This study reveals a reversed pattern of structure and function in frontotemporal tracts in schizophrenia, with negative associations between structural deficits and functional disturbances in patients, exacerbated by long illness duration and severe negative symptoms. Additionally, white matter activations are significantly related to cognition and emotion.
HUMAN BRAIN MAPPING
(2021)
Article
Medicine, General & Internal
Jing Jing, Yijun Zhou, Yuesong Pan, Xueli Cai, Wanlin Zhu, Zhe Zhang, Zixiao Li, Chang Liu, Xia Meng, Jian Cheng, Yilong Wang, Hao Li, Zhenzhou Wu, Suying Wang, Haijun Niu, Wei Wen, Tao Liu, Tiemin Wei, Yongjun Wang, Perminder S. Sachdev
Summary: This study investigated the white matter integrity in prediabetes and diabetes and found that microstructural abnormalities in white matter are already present in the prediabetes stage with impaired fasting glucose/ impaired glucose tolerance and are associated with higher glucose measures.
Article
Nutrition & Dietetics
Lisa M. Hortensius, Els Janson, Pauline E. van Beek, Floris Groenendaal, Nathalie H. P. Claessens, Henriette F. N. Swanenburg de Veye, Maria J. C. Eijsermans, Corine Koopman-Esseboom, Jeroen Dudink, Ruurd M. van Elburg, Manon J. N. L. Benders, Maria Luisa Tataranno, Niek E. van der Aa
Summary: The study found that higher postnatal protein intake is important for white matter development in extremely preterm born infants, but may not necessarily improve long-term cognitive and motor development. While higher protein intake was associated with higher white matter integrity, it was also linked to lower motor scores at 2 years corrected age. However, these differences were not sustained at 5.9 years.
Article
Neurosciences
Jing Chen, Anyan Ge, Ying Zhou, Yuanyuan Ma, Shaoping Zhong, Caizhong Chen, Weibin Shi, Jing Ding, Xin Wang
Summary: The study examined the relationships between cognitive function and white matter hyperintensity volume (WMHV) in patients with silent cerebrovascular disease, and found that impaired white matter integrity mediates the impact of WMHV on cognitive function. The findings suggest the importance of white matter integrity in cognitive rehabilitation strategies for patients with silent cerebrovascular diseases.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Geriatrics & Gerontology
Ciara J. Molloy, Sinead Nugent, Arun L. W. Bokde
Summary: This study characterized age-related white matter changes by evaluating patterns of overlap between diffusion measures, showing different overlapping patterns reflecting underlying biological changes with aging. Results indicated that cognitively healthy aging adults had low WMH load, emphasizing the importance of considering WMH impact in aging studies of white matter.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Review
Oncology
Aiman Abdul Manan, Noorazrul Azmie Yahya, Nur Hartini Mohd Taib, Zamzuri Idris, Hanani Abdul Manan
Summary: Diffusion tensor imaging is a non-invasive neuroimaging tool used to visualize the white matter tract of the brain. This study aims to assess the characteristics and criteria of white matter tract microstructure integrity changes in brain tumor patients.
Article
Clinical Neurology
Martin Domin, Brenton Hordacre, Pavel Hok, Lara A. Boyd, Adriana B. Conforto, Justin W. Andrushko, Michael R. Borich, Richard C. Craddock, Miranda R. Donnelly, Adrienne N. Dula, Steven J. Warach, Steven A. Kautz, Bethany P. Lo, Christian Schranz, Na Jin Seo, Shraddha Srivastava, Kristin A. Wong, Artemis Zavaliangos-Petropulu, Paul M. Thompson, Sook-Lei Liew, Martin Lotze
Summary: The study found that stroke patients with severe CST damage rely on residual pathways for better upper limb function recovery.
Article
Clinical Neurology
Juho Dahl, Olli Tenovuo, Jussi P. Posti, Jussi Hirvonen, Ari J. Katila, Janek Frantzen, Henna-Riikka Maanpaa, Riikka Takala, Eliisa Loyttyniemi, Jussi Tallus, Virginia Newcombe, David K. Menon, Peter J. Hutchinson, Mehrbod Mohammadian
Summary: Cerebral microbleeds are associated with the clinical severity of traumatic brain injury but have a weaker association with white matter integrity.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Melanie A. Matyi, Jeffrey M. Spielberg
Summary: Deficits in negative emotion differentiation are associated with mental health outcomes, but the processes underlying individual differences in negative emotion differentiation are poorly understood. This study examines the relationship between white matter microstructure and negative emotion differentiation, providing insights into its component processes and its link to brain structure.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Yingrong Xie, Kelong Cai, Jingang Dai, Gaoxia Wei
Summary: Tai Chi Chuan (TCC) is a popular mind-body practice with potential cognitive benefits, but the underlying neurobiological mechanisms are largely unknown. This study used diffusion tensor imaging (DTI) and the attention network test (ANT) to compare TCC practitioners and healthy controls, and found significant differences in white matter microstructure between the two groups, specifically in the corticospinal tract, fornix/stria terminalis, and cerebral peduncle. The study also found a significant correlation between improved white matter microstructure and ANT performance in TCC practitioners, suggesting the potential for cognitive improvement and clinical applications in neurological rehabilitation.
Article
Geriatrics & Gerontology
Yi-Ping Chao, Po-Ting Bertram Liu, Pei-Ning Wang, Chia-Hsiung Cheng
Summary: This study investigated the white matter integrity in patients with subjective cognitive decline (SCD) using diffusion tensor imaging (DTI). The results showed that SCD patients exhibited alterations in diffusion properties in the left superior frontal gyrus, right anterior cingulate cortex, and left lingual gyrus. These findings suggest that detectable changes in white matter tracts occur in SCD patients before the onset of objective cognitive deficits.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
Jeonghwan Lee, Gawon Ju, Jung-Woo Son, Chul-Jin Shin, Sang Ick Lee, Hyemi Park, Siekyeong Kim
Summary: This study investigated the impact of chronic alcohol consumption on white matter pathways using probabilistic tractography. Although no significant difference was found in diffusion parameters between alcohol-dependent men and healthy drinkers, findings indicated a positive correlation between axial diffusivity in the right cingulum-angular bundle and alcohol abstinence period, suggesting resilience in white matter of patients with alcohol dependence. Additional longitudinal studies with multimodal methods and neuropsychological tests may further enhance understanding of changes in white matter pathways in patients with alcohol dependence.
Article
Geriatrics & Gerontology
Benjamin Yeske, Jiancheng Hou, Nagesh Adluru, Veena A. Nair, Vivek Prabhakaran
Summary: This study revealed significant structural differences in white matter regions associated with language production in young adults, compared to older adults who showed significant correlations between language production and MD values. This suggests that white matter structures play a crucial role in age-related changes in language production.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Geriatrics & Gerontology
Ryan A. Mace, David A. Gansler, Kayle S. Sawyer, Michael Suvak
Summary: The study found a significant relationship between cardiovascular fitness and white matter microstructure, particularly in older individuals. However, this relationship was weaker in younger adults. Aerobic exercise plays a crucial role in maintaining brain health into old age.
NEUROBIOLOGY OF AGING
(2021)
Article
Biochemistry & Molecular Biology
Feng Liu, Jiayuan Xu, Lining Guo, Wen Qin, Meng Liang, Gunter Schumann, Chunshui Yu
Summary: Individual differences in human brain structure, function, and behavior can be explained by genetic variations, environmental exposures, and their interactions. While genetic variants associated with brain imaging phenotypes have been identified, the environmental exposures related to these phenotypes are largely unknown. This study proposes that research in environmental neuroscience should focus on understanding the associations between lifetime environmental exposures and brain imaging phenotypes, as well as identifying cumulative environmental effects and their vulnerable age windows.
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Jingchun Liu, Caihong Wang, Wen Qin, Hao Ding, Yanmin Peng, Jun Guo, Tong Han, Jingliang Cheng, Chunshui Yu
Summary: Subcortical ischemic stroke can cause long-lasting changes in the cerebral cortex. This study investigated the relationship between cortical structural changes, motor recovery, lesion location, and early impairment of specific subsets of fibers in the corticospinal tract (CST) in patients with subcortical stroke. The findings revealed different patterns of cortical structural changes in patients with partial and complete recovery, which were associated with lesion location and impairment of specific CST fiber subsets.
HUMAN BRAIN MAPPING
(2023)
Article
Endocrinology & Metabolism
Tsubasa Tomoto, Aryan Verma, Kayla Kostroske, Takashi Tarumi, Neena R. Patel, Evan P. Pasha, Jonathan Riley, Cynthia D. Tinajero, Linda S. Hynan, Karen M. Rodrigue, Kristen M. Kennedy, Denise C. Park, Rong Zhang
Summary: This study found that one-year progressive, moderate-to-vigorous aerobic exercise training has positive effects on cerebral blood flow, central arterial stiffness, and cognitive performance. In cognitively normal older adults, aerobic exercise training increased cerebral blood flow, decreased carotid arterial stiffness and cerebrovascular resistance, and was associated with improved memory function.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Retraction
Neurosciences
Nianming Zuo, Tianyu Hu, Hao Liu, Jing Sui, Yong Liu, Tianzi Jiang
NEUROSCIENCE BULLETIN
(2023)
Editorial Material
Neurosciences
Yongbin Wei, Han Zhang, Yong Liu
NEUROSCIENCE BULLETIN
(2023)
Letter
Neurosciences
Nianming Zuo, Tianyu Hu, Hao Liu, Jing Sui, Yong Liu, Tianzi Jiang
NEUROSCIENCE BULLETIN
(2023)
Article
Computer Science, Information Systems
Xiaoqi Sheng, Jiazhou Chen, Yong Liu, Bin Hu, Hongmin Cai
Summary: Numerous studies have shown that accurate analysis of neurological disorders contributes to the early diagnosis of brain disorders and provides a window to diagnose psychiatric disorders due to brain atrophy. The emergence of geometric deep learning approaches provides a new way to characterize geometric variations on brain networks. However, brain network data suffer from high heterogeneity and noise, resulting in poor diagnostic accuracy for complex brain networks. This paper presents a dual-attention deep manifold harmonic discrimination (DA-DMHD) method that aims to enhance the identification of discriminative features for early diagnosis of neurodegenerative diseases. The proposed method achieves excellent classifying performance in terms of accuracy and robustness, outperforming existing state-of-the-art methods.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2023)
Article
Psychiatry
Yuqing Sun, Yuxin Zhao, Ke Hu, Meng Wang, Yong Liu, Bing Liu
Summary: We investigated the relationship between amyloid deposition and Alzheimer's disease (AD) profiles in cognitively normal (CN) individuals and those with mild cognitive impairment (MCI). Using amyloid-PET data, we identified and validated two subtypes with distinct regional patterns of progression, genetic, clinical, and biomarker characteristics. Our findings suggest that the spatiotemporal variants of amyloid deposition are closely associated with disease trajectories, providing insight into disease monitoring and therapeutic trials in AD.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Computer Science, Artificial Intelligence
Xiao Zhang, Yun He, Zhigang Xu, Zainan Jiang, Yong Liu, Wenbo Feng, Junwu Wu
Summary: In traditional spacecraft semi-physical docking tests, the evaluation of docking and separation performance relies on specific equipment. This paper proposes a novel docking test platform using a general-purpose industrial manipulator and 3-D force and 3-D torque sensors. The platform is well-assembled, cost-effective, and introduces an actuation delay compensation method to improve performance. Simulation results demonstrate promising actuation delay compensation performance of the novel method.
FRONTIERS IN NEUROROBOTICS
(2023)
Article
Clinical Neurology
M. Yuan, Kristen M. Kennedy
Summary: This study used geospatial tools and landmarks to assess environmental complexity and predict cognitive status. The results showed that street length, circuity, and points of interest were associated with dementia. Therefore, environmental complexity plays an important role in the development of Alzheimer's disease.
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
(2023)
Article
Neurosciences
Huaigui Liu, Wei Li, Nana Liu, Jie Tang, Lixin Sun, Jiayuan Xu, Yuan Ji, Yingying Xie, Hao Ding, Zhaoxiang Ye, Chunshui Yu, Wen Qin
Summary: Evidence suggests that dysregulation of the dopamine (DA) system and dysfunction of the prefrontal cortex (PFC) may contribute to the development of schizophrenia. However, the relationship between DA genes, PFC morphology, and schizophrenia is still not fully understood. In this study, we analyzed brain gene expression data and structural magnetic resonance imaging data to identify specific PFC subregions that are associated with the expression profiles of DA genes. We found that some PFC subregions showed abnormal increases in gray matter volume covariance with other brain regions in schizophrenia patients. Furthermore, our analysis of postmortem expression data revealed reduced coexpression of DA genes between the middle frontal gyrus and hippocampus in schizophrenia patients, with these genes being implicated in brain functions related to working memory, reward processing, speech production, and episodic memory.
Article
Neurosciences
Wenshuang Zhu, Feng Liu, Jilian Fu, Wen Qin, Kaizhong Xue, Jie Tang, Yong Zhang, Chunshui Yu
Summary: This study identified 903 clinically sensitive genes and 633 clinically insensitive genes associated with ALFF alterations in MDD. The sensitive genes were enriched for cell differentiation and development, while the insensitive genes were enriched for ion transport and synaptic signaling.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Stephan A. Muller, Merav D. Shmueli, Xiao Feng, Johanna Tushaus, Neele Schumacher, Ryan Clark, Brad E. Smith, An Chi, Stefan Rose-John, Matthew E. Kennedy, Stefan F. Lichtenthaler
Summary: In this study, the researchers identified SEZ6 and gp130/IL6ST as physiological substrates of BACE1 in non-human-primate cerebrospinal fluid. They also found a reduction of gp130 in human CSF from a clinical trial with a BACE inhibitor and in plasma of BACE1-deficient mice. These findings provide insights into the relationship between BACE1 and gp130 in neuronal signaling and survival.
MOLECULAR NEURODEGENERATION
(2023)
Article
Neurosciences
Yida Qu, Pan Wang, Hongxiang Yao, Dawei Wang, Chengyuan Song, Hongwei Yang, Zengqiang Zhang, Pindong Chen, Xiaopeng Kang, Kai Du, Lingzhong Fan, Bo Zhou, Tong Han, Chunshui Yu, Xi Zhang, Nianming Zuo, Tianzi Jiang, Yuying Zhou, Bing Liu, Ying Han, Jie Lu, Yong Liu
Summary: This study verified the utility of white matter (WM) as a neuroimaging marker in Alzheimer's disease (AD) using multisite diffusion tensor imaging datasets. The results showed significant degeneration patterns in AD and mild cognitive impairment (MCI) groups compared to normal controls (NC). Machine learning models using tract-based features were able to predict cognitive ability in AD and MCI groups.
NEUROSCIENCE BULLETIN
(2023)
Article
Neurosciences
Huiying Yu, Yanhui Ding, Yongbin Wei, Martin Dyrba, Dong Wang, Xiaopeng Kang, Weizhi Xu, Kun Zhao, Yong Liu
Summary: This study reveals significant alterations in regional mean connectivity strength in the hippocampus and medial temporal lobe of Alzheimer's disease (AD) and mild cognitive impairment (MCI) patients, which are spatially related to the expression of AD-risk genes. Additionally, the modulation of chemical synaptic transmission is identified as the most relevant biological process associated with the altered connectivity in AD.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Jose Sanchez-Bornot, Roberto C. Sotero, J. A. Scott Kelso, Ozguer Simsek, Damien Coyle
Summary: This study proposes a multi-penalized state-space model for analyzing unobserved dynamics, using a data-driven regularization method. Novel algorithms are developed to solve the model, and a cross-validation method is introduced to evaluate regularization parameters. The effectiveness of this method is validated through simulations and real data analysis, enabling a more accurate exploration of cognitive brain functions.