Article
Clinical Neurology
Omar H. Butt, Karin L. Meeker, Julie K. Wisch, Suzanne E. Schindler, Anne M. Fagan, Tammie L. S. Benzinger, Carlos Cruchaga, David M. Holtzman, John C. Morris, Beau M. Ances
Summary: It has been found that cognitively normal APOE ε4 carriers with subthreshold amyloid accumulation may have network reorganization associated with tau.
ALZHEIMERS & DEMENTIA
(2022)
Article
Clinical Neurology
Andrea Vergallo, Pablo Lemercier, Enrica Cavedo, Simone Lista, Eugeen Vanmechelen, Ann De Vos, Henrik Zetterberg, Kaj Blennow, Marie-Odile Habert, Marie-Claude Potier, Bruno Dubois, Stefan Teipel, Harald Hampel
Summary: The study identified a positive correlation between plasma BACE1 protein concentrations and AD biomarkers of neurodegeneration, suggesting a potential role of BACE1 in Alzheimer's disease progression.
ALZHEIMERS & DEMENTIA
(2021)
Article
Neurosciences
Esther M. Blessing, Ankit Parekh, Rebecca A. Betensky, James Babb, Natalie Saba, Ludovic Debure, Andrew W. Varga, Indu Ayappa, David M. Rapoport, Tracy A. Butler, Mony J. de Leon, Thomas Wisniewski, Brian J. Lopresti, Ricardo S. Osorio
Summary: This study found that lower body temperature is associated with increased tau pathology in cognitively normal older adults, suggesting that temperature may play an important role in the development of Alzheimer's disease.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Ophthalmology
Min Soo Byun, Sung Wook Park, Jun Ho Lee, Dahyun Yi, So Yeon Jeon, Hyo Jung Choi, Haejung Joung, Un Hyung Ghim, Un Chul Park, Yu Kyeong Kim, Seong A. Shin, Hyeong Gon Yu, Dong Young Lee
Summary: In this study, retinal biomarkers were found to be potentially useful for early detection of in vivo AD pathologic abnormalities in cognitively normal older adults. The functional and structural alterations of the retina measured by multifocal electroretinogram and SS-OCT could serve as valuable tools for screening preclinical AD.
JAMA OPHTHALMOLOGY
(2021)
Article
Computer Science, Artificial Intelligence
Pradnya Borkar, Vishal Ashok Wankhede, Deepak T. Mane, Suresh Limkar, J. V. N. Ramesh, Samir N. Ajani
Summary: Alzheimer's patients experience cognitive decline, hindering daily activities, but it is uncertain if the condition can be treated. Early detection is crucial. Invasive and expensive diagnostic procedures are currently used. This study aims to develop a noninvasive and cost-effective method using deep learning to detect Alzheimer's disease in healthy individuals.
Article
Geriatrics & Gerontology
Li Lin, Yu Sun, Xiaoqi Wang, Li Su, Xiaoni Wang, Ying Han
Summary: This study aimed to define resilience metrics for cognitive decline based on plasma and cerebrospinal fluid amyloid-beta levels and to explore the factors associated with individual differences in resilience metrics. The findings revealed that resilience metrics were linked to cognition and brain volumes, different types of resilience could predict cognitive decline, shedding light on individual susceptibility to Alzheimer's disease.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Clinical Neurology
Seunghoon Lee, Min Soo Byun, Dahyun Yi, Min Jung Kim, Joon Hyung Jung, Nayeong Kong, Gijung Jung, Hyejin Ahn, Jun-Young Lee, Koung Mi Kang, Chul-Ho Sohn, Yun-Sang Lee, Yu Kyeong Kim, Dong Young Lee
Summary: Low BMI in late-life may predict or contribute to the progression of tau pathology over the subsequent years in cognitively unimpaired older adults.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Clinical Neurology
Anna E. Mullins, Masrai K. Williams, Korey Kam, Ankit Parekh, Omonigho M. Bubu, Bresne Castillo, Zachary J. Roberts, David M. Rapoport, Indu Ayappa, Ricardo S. Osorio, Andrew W. Varga
Summary: The study found that untreated OSA affects the morning spatial navigation performance of older adults, independent of a deleterious effect on morning vigilance or evening navigation performance. Relative frontal slow wave activity is associated with overnight maze performance improvement in older participants with OSA.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2021)
Article
Geriatrics & Gerontology
Andrew C. Robinson, Federico Roncaroli, Yvonne S. Davidson, James Minshull, Calvin Heal, Daniela Montaldi, Antony Payton, Michael A. Horan, Neil Pendleton, David M. A. Mann
Summary: Early diagnosis of Alzheimer's disease is crucial for intervention, and symptoms of depression may be an indicator of early stages of the disease. This study aimed to investigate the relationship between depression scores, cognitive impairment, and AD pathology at death. The findings suggest that there is an association between GDS scores collected 20 years prior to death and cognitive status and AD pathology at death, indicating that raised GDS scores may serve as an early diagnostic marker for AD.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Neurosciences
Yi-Ming Zheng, Yang-Yang Zhao, Ting Zhang, Xiao-He Hou, Yan-Lin Bi, Ya-Hui Ma, Wei Xu, Xue-Ning Shen, Qiang Dong, Lan Tan, Jin-Tai Yu
Summary: Our study revealed associations between low LVEF and AD pathology, especially prominent in females and middle-aged individuals. These findings may offer new insights into AD prevention through maintaining cardiac function.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hangwei Zhuang, Junghun Cho, Gloria Chia-Yi Chiang, Ilhami Kovanlikaya, Linda Anne Heier, Jonathan P. Dyke, Yi Wang
Summary: This study investigates brain tissue viability and oxygen metabolism in NPH patients using imaging. It finds that low oxygen extraction fraction (OEF) in certain regions is significantly correlated with large ventricular volumes. This suggests decreased tissue oxygen metabolism with increased NPH severity.
Article
Geriatrics & Gerontology
Qingwei Ruan, Feng Xiao, Ke Gong, Weibin Zhang, Min Zhang, Jian Ruan, Xuefeng Zhang, Qingru Chen, Zhuowei Yu
Summary: This study aimed to develop a useful Z score calculator for assessing cognitive performance in elderly Chinese individuals, taking into account adjustments based on sex, age, and education. The study established preliminary norms for objective assessment of cognition function based on regression models.
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
(2021)
Review
Neurosciences
Shefali Chaudhary, Simon Zhornitsky, Herta H. Chao, Christopher H. van Dyck, Chiang-Shan R. Li
Summary: This study aimed to identify the neuroanatomical correlates of apathy associated with Alzheimer's disease (AD). The findings suggested that atrophy in the putamen, middle temporal gyrus (MTG), and inferior frontal gyrus (IFG) were implicated in AD-associated apathy, potentially independent of cognitive impairment and depression.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Review
Neurosciences
Shigeki Yamada, Masatsune Ishikawa, Kazuhiko Nozaki
Summary: Idiopathic normal pressure hydrocephalus (iNPH) is a chronic communicating hydrocephalus associated with cerebrospinal fluid (CSF) dynamics, with potential aetiology factors including genetic mutations, environmental factors like alcohol consumption and medical conditions like sleep apnea, diabetes, and hypertension. These factors can lead to ventricle dilatation in iNPH.
FLUIDS AND BARRIERS OF THE CNS
(2021)
Article
Geriatrics & Gerontology
Hajime Takechi, Hiroshi Yoshino
Summary: The study utilized the CogEvo computerized cognitive assessment and training tool to distinguish patients with mild Alzheimer's disease and mild cognitive impairment from cognitively normal older people. The results indicated that CogEvo showed good correlation and was able to differentiate between the three groups effectively. Further research is needed to assess the effectiveness of CogEvo as a combined assessment and training tool for early-stage cognitive impairment.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2021)
Article
Transplantation
Roel Bijkerk, Marije H. Kallenberg, Laurien E. Zijlstra, Bernard M. van den Berg, Jeroen de Bresser, Sebastiaan Hammer, Esther E. Bron, Hakim Achterberg, Mark A. van Buchem, Noeleen C. Berkhout-Byrne, Willem Jan W. Bos, Diana van Heemst, Ton J. Rabelink, Anton Jan van Zonneveld, Marjolijn van Buren, Simon Mooijaart
Summary: This study focused on the association between levels of angiopoietin and cognitive impairment in ESRD patients, revealing an unfavorable angiogenic profile in these patients and identifying certain miRNAs associated with different cognitive domains. These novel angiogenic markers may help to identify cognitive decline in older ESRD patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Clinical Neurology
Ingeborg Rasing, Sabine Voigt, Emma A. Koemans, Erik van Zwet, Paul C. de Kruijff, Thijs W. van Harten, Ellis S. van Etten, Sanneke van Rooden, Louise van der Weerd, Mark A. van Buchem, Matthias J. P. van Osch, Steven M. Greenberg, Marianne A. A. van Walderveen, Gisela M. Terwindt, Marieke J. H. Wermer
Summary: Cortical calcifications are common in Dutch-type hereditary CAA (D-CAA) but rare in sporadic CAA. These calcifications are associated with the development of intracerebral hemorrhage (ICH) and may serve as a marker for advanced CAA. Additionally, there seems to be a link between cortical calcifications on computed tomography and the striped occipital cortex on 7T-magnetic resonance imaging.
Article
Clinical Neurology
E. S. Hoogeveen, N. Pelzer, I. de Boer, M. A. van Buchem, G. M. Terwindt, M. C. Kruit
Summary: Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations caused by TREX1 mutations presents distinctive neuroimaging findings, such as punctate white matter lesions in younger mutation carriers and supratentorial lesions with long-term contrast enhancement and diffusion restriction in older carriers. These findings can help in early recognition and treatment of the disease manifestations.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2021)
Article
Clinical Neurology
S. Voigt, P. C. de Kruijff, E. A. Koemans, I Rasing, E. S. van Etten, G. M. Terwindt, M. J. P. van Osch, M. A. van Buchem, M. A. A. van Walderveen, M. J. H. Wermer
Summary: Superficially located asymptomatic cerebellar macrobleeds and microbleeds are common in Dutch-type hereditary CAA. Cerebellar microbleeds are already present in the presymptomatic stage and are predominantly superficially located. Despite the high frequency of cerebellar micro and macrobleeds, CAA pathology did not result in symptomatic cerebellar ICH in patients with D-CAA.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Clinical Neurology
Emma A. Koemans, Sabine Voigt, Ingeborg Rasing, Thijs W. van Harten, Wilmar M. T. Jolink, Floris H. B. M. Schreuder, Erik W. van Zwet, Mark A. van Buchem, Matthias J. P. van Osch, Gisela M. Terwindt, Catharina J. M. Klijn, Marianne A. A. van Walderveen, Marieke J. H. Wermer
Summary: This study investigated the frequency of cerebellar superficial siderosis and its relation to hemorrhagic magnetic resonance imaging markers in patients with cerebral amyloid angiopathy (CAA). The study found that cerebellar superficial siderosis may be a novel marker for CAA.
Article
Clinical Neurology
Sabine Voigt, Siham Amlal, Emma A. Koemans, Ingeborg Rasing, Ellis S. van Etten, Erik W. van Zwet, Mark A. van Buchem, Gisela M. Terwindt, Marianne A. A. van Walderveen, Marieke J. H. Wermer
Summary: The study investigated the topographical and temporal patterns of index and recurrent intracerebral hemorrhages in Dutch-type hereditary Cerebral Amyloid Angiopathy (D-CAA). Results showed a preference for occipital lobe in both index and recurrent ICHs, with no acceleration in time nor gradual increase of hematoma volume between subsequent ICHs.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Rheumatology
Francesca Inglese, Myriam G. Jaarsma-Coes, Gerda M. Steup-Beekman, Rory Monahan, Tom Huizinga, Mark A. van Buchem, Itamar Ronen, Jeroen de Bresser
Summary: Patients with neuropsychiatric manifestations of systemic lupus erythematosus (NPSLE) showed higher white matter hyperintensity (WMH) volume and more complex WMH shape compared to non-NPSLE patients, with the inflammatory phenotype exhibiting more significant findings.
Article
Clinical Neurology
Sigurdur Sigurdsson, Thor Aspelund, Olafur Kjartansson, Elias Gudmundsson, Palmi Jonsson, Mark A. van Buchem, Vilmundur Gudnason, Lenore J. Launer
Summary: This study found that the risk factors for different types of brain infarcts vary depending on the location in the brain. Small vessel disease risk factors such as hypertension and diabetes were associated with subcortical infarcts, while atherosclerotic/coronary processes were associated with cortical infarcts, and a mixed profile of factors was associated with cerebellar infarcts. Assessing risk factors based on the location of asymptomatic infarcts detected on magnetic resonance imaging may help improve preventive therapeutic approaches for stroke.
Article
Neurosciences
Francesca Inglese, Minseon Kim, Gerda M. Steup-Beekman, Tom W. J. Huizinga, Mark A. van Buchem, Jeroen de Bresser, Dae-Shik Kim, Itamar Ronen
Summary: Self-supervised contrastive learning algorithms can be used to distinguish between NPSLE and non-NPSLE patients in SLE. This study found that common brain changes in NPSLE patients include tissue loss, local atrophy, and periventricular white matter lesions.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Suzanne E. van Dijk, Jeroen van der Grond, Jessie Lak, Annette van den Berg-Huysmans, Gerda Labadie, Gisela M. Terwindt, Marieke J. H. Wermer, M. Edip Gurol, Mark A. van Buchem, Steven M. Greenberg, Sanneke van Rooden
Summary: This study found that cerebrovascular reactivity worsens progressively in the presymptomatic phase of Dutch-type hereditary cerebral amyloid angiopathy (D-CAA). Recurrent intracerebral hemorrhage appears to be the most salient marker of progression in the symptomatic phase of the disease.
Article
Clinical Neurology
Andreas Charidimou, Gregoire Boulouis, Matthew P. Frosch, Jean-Claude Baron, Marco Pasi, Jean Francois Albucher, Gargi Banerjee, Carmen Barbato, Fabrice Bonneville, Sebastian Brandner, Lionel Calviere, Francois Caparros, Barbara Casolla, Charlotte Cordonnier, Marie-Bernadette Delisle, Vincent Deramecourt, Martin Dichgans, Elif Gokcal, Jochen Herms, Mar Hernandez-Guillamon, Hans Rolf Jager, Zane Jaunmuktane, Jennifer Linn, Sergi Martinez-Ramirez, Elena Martinez-Saez, Christian Mawrin, Joan Montaner, Solene Moulin, Jean-Marc Olivot, Fabrizio Piazza, Laurent Puy, Nicolas Raposo, Mark A. Rodrigues, Sigrun Roeber, Jose Rafael Romero, Neshika Samarasekera, Julie A. Schneider, Stefanie Schreiber, Frank Schreiber, Corentin Schwall, Colin Smith, Levente Szalardy, Pascale Varlet, Alain Viguier, Joanna M. Wardlaw, Andrew Warren, Frank A. Wollenweber, Marialuisa Zedde, Mark A. van Buchem, M. Edip Gurol, Anand Viswanathan, Rustam Al-Shahi Salman, Eric E. Smith, David J. Werring, Steven M. Greenberg
Summary: This study aimed to update and validate the Boston criteria for the diagnosis of cerebral amyloid angiopathy (CAA). The results showed that the Boston criteria version 2.0 had superior accuracy in terms of sensitivity and specificity, and incorporated new MRI markers.
Article
Neurosciences
Thijs W. van Harten, Anne Heijmans, Sanneke van Rooden, Marieke J. H. Wermer, Matthias J. P. van Osch, Hugo J. Kuijf, Susanne J. van Veluw, Steven M. Greenberg, Mark A. van Buchem, Jeroen van der Grond, Marianne A. A. van Walderveen
Summary: This study found no differences in DMV parameters between Dutch-type hereditary CAA mutation carriers and controls, and no associations between DMV parameters and MRI markers associated with D-CAA. Therefore, DMVs may not play a role in the pathogenesis of MRI markers associated with CAA.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
Jasmin Annica Keller, Sigurdur Sigurdsson, Kelly Klaassen, Lydiane Hirschler, Mark A. A. van Buchem, Lenore J. J. Launer, Matthias J. P. van Osch, Vilmundur Gudnason, Jeroen H. J. M. de Bresser
Summary: This study aimed to investigate the association between the shape and volume of white matter hyperintensity (WMH) and the long-term risk of dementia in community-dwelling older adults. The results showed that an irregular shape of periventricular/confluent WMH, higher WMH volume, and higher deep WMH volume were associated with an increased risk of dementia.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neuroimaging
Jasmin A. Keller, Ilse M. J. Kant, Arjen J. C. Slooter, Simone J. T. van Montfort, Mark A. van Buchem, Matthias J. P. van Osch, Jeroen Hendrikse, Jeroen de Bresser
Summary: This study investigated the association between cardiovascular risk factors and WMH markers in non-demented older adults. The results showed that hypertension was associated with irregular WMH shape, while diabetes was associated with WMH volume. Different cardiovascular risk factors may lead to different WMH MRI phenotypes.
NEUROIMAGE-CLINICAL
(2022)
Meeting Abstract
Clinical Neurology
R. Van Dort, I. Rasing, E. Koemans, S. Voigt, K. Kaushik, R. Van der Zwet, M. Schipper, T. Van Harten, E. Van Etten, M. Verbeek, M. Van Buchem, S. Van Rooden, J. Van der Grond, E. Van Zwet, M. Van Walderveen, M. Van Osch, G. Terwindt, M. Wermer
INTERNATIONAL JOURNAL OF STROKE
(2022)
