Journal
NEUROIMAGE
Volume 42, Issue 2, Pages 850-857Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2008.05.009
Keywords
brain imaging; mood; PET; position emission tomography; serotonin synthesis; 5-HT1A receptors
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Serotonin (5-HT) is one of the major neurotransmitters and has been implicated in a wide variety of cerebral functions. Several lines of evidence indicate that 5HT(1A) receptors exert a negative feedback in the synthesis and release of serotonin. While most of what is known about serotonin comes from studies in animals, much less empirical evidence exists about the serotonergic system in the living human brain. This study aims to assess the correlation between serotonin synthesis and 5-HT1A receptor binding using positron emission tomography (PET) in humans. Six healthy male volunteers underwent 2 PET scans in the same day: one measuring alpha-[C-11] MT K* [ml/g/min] trapping constant (a measure of serotonin synthesis) and one measuring 5-HT1A receptor binding potential BPND with [F-18]MPPF. Volumes of interest (VOIs) selected a priori included: anterior cingulate cortex (ACC), anterior insula, hippocampus, amygdala, thalamus, hypothalamus and midbrain raphe nuclei. Correlation analyses were Conducted voxel-by-voxel and with manually traced VOIs. A significant negative correlation between serotonin synthesis and 5-HT1A binding potential was found bilaterally in hippocampus and anterior insula and in the left ACC. The combination of [F-18]MPPF and alpha-[C-11]MT PET offers a means to investigate key determinants of 5-HT neurotransmission Under physiological and psychopathological conditions in the human brain in vivo. (C) 2008 Elsevier Inc. All rights reserved.
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