Article
Gastroenterology & Hepatology
D. F. Altomare, A. Picciariello, A. Di Ciaula, M. Rinaldi, M. De Fazio, P. Portincasa
Summary: Temporary sacral nerve stimulation (SNS) did not have any effect on upper/lower gastrointestinal motility and transit in patients with severe constipation.
TECHNIQUES IN COLOPROCTOLOGY
(2021)
Article
Multidisciplinary Sciences
Agata Furgala, Katarzyna Ciesielczyk, Magdalena Przybylska-Felus, Konrad Jablonski, Krzysztof Gil, Malgorzata Zwolinska-Wcislo
Summary: This study aimed to assess the postprandial response, including gut peptide secretion and gastric myoelectric activity, in patients with constipation-predominant irritable bowel syndrome (IBS-C). The results showed that IBS-C patients had significantly elevated preprandial levels of gastrin and insulin, while VIP and ghrelin levels were decreased. Moreover, the gastric motility was impaired in IBS-C patients. These findings suggest that disturbances in the postprandial concentration of gut peptides may contribute to abnormal gastric function and intestinal motility, leading to exacerbation of clinical symptoms in IBS patients.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Chethan Ramprasad, Lucy Norcliffe-Kaufmann, Jose-Alberto Palma, Joseph Levy, Yian Zhang, Christy L. Spalink, Abraham Khan, Scott Smukalla, Horacio Kaufmann, Lea Ann Chen
Summary: Patients with familial dysautonomia (FD) exhibit higher prevalence of gastrointestinal symptoms compared to the general US adult population, but these symptoms are less severe in FD patients. Caregivers reported similar burden of symptoms as patients.
CLINICAL AUTONOMIC RESEARCH
(2021)
Article
Medicine, General & Internal
Vinni Faber Rasmussen, Mathilde Thrysoe, Pall Karlsson, Esben Thyssen Vestergaard, Kurt Kristensen, Ann-Margrethe Ronholt Christensen, Jens Randel Nyengaard, Astrid Juhl Terkelsen, Christina Brock, Klaus Krogh
Summary: This study aimed to assess the prevalence of objective signs of gastrointestinal autonomic neuropathy (AN) in adolescents with type 1 diabetes (T1D). The results showed that adolescents with T1D had higher colonic motility index and peak pressure, and GI symptoms were associated with low gastric and colonic motility. Early interventions are needed for high-risk patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Ditte S. Kornum, Astrid J. Terkelsen, Davide Bertoli, Mette W. Klinge, Katrine L. Hoyer, Huda H. A. Kufaishi, Per Borghammer, Asbjorn M. Drewes, Christina Brock, Klaus Krogh
Summary: The autonomic nervous system regulates the function of target organs, including the gastrointestinal tract. Nerve lesions or pathologies may cause autonomic dysfunction, with common causes being diabetes mellitus and Parkinson's disease. While widespread dysmotility in the gastrointestinal tract is common in autonomic dysfunction, there is currently no commercially available method for direct verification of enteric dysfunction. Assessing segmental enteric physiological function is recommended for diagnostic and treatment guidance.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Surgery
Louise Ladebo, Pernille V. Pedersen, Grzegorz J. Pacyk, Jens Peter Kroustrup, Asbjorn M. Drewes, Christina Brock, Anne E. Olesen
Summary: This study found that in patients with RYGB, the gastric pH was high, motility index was high, and transit time was short, while the colonic transit time was long.
Article
Medicine, General & Internal
Dag A. Sangnes, Georg Dimcevski, Jakub Frey, Eirik Softeland
Summary: Chronic diarrhoea is a common but poorly investigated complication of diabetes. This study aimed to investigate the association between diabetic diarrhoea and alterations in gastrointestinal motility, pH levels, and autonomic function using new diagnostic methods. Results showed that patients with diabetic diarrhoea had altered gastrointestinal transit and intraluminal pH levels, but minimal changes in autonomic function.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Biophysics
Nipuni D. Nagahawatte, Niranchan Paskaranandavadivel, Timothy R. Angeli-Gordon, Leo K. Cheng, Recep Avci
Summary: This study successfully captured and quantified the bioelectrical activity across the wall of the GI tract using a needle-based microelectrode array. Differences in slow wave characteristics between transmural and serosal layers were observed in terms of period, amplitude, and signal to noise ratio. Additionally, four different slow wave morphologies were identified across the transmural layers, with Type 1 and Type 2 being the most prevalent.
PHYSIOLOGICAL MEASUREMENT
(2021)
Review
Neurosciences
Leo K. Cheng, Nipuni D. Nagahawatte, Recep Avci, Peng Du, Zhongming Liu, Niranchan Paskaranandavadivel
Summary: This review discusses the use of gastric pacing and stimulation strategies in treating motility disorders, as well as targeting nerves in the stomach to modulate stomach function. The article summarizes effective parameters and limitations in existing studies, and explores the use of mathematical models to refine pacing and stimulation protocols. Additionally, future directions and challenges in this field are also discussed.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Integrative & Complementary Medicine
Guotong Qiu, Tao Huang, Yang Lu, Lipeng Zhang, Yajie Zhao, Yong Yuan, Hu Ren, Jun An, Jincao Zhou, Rongjun Li, Yongxing Du, Tuoran Wang, Peng Wang, Fang He, Yunqing Ding, Jianwei Zhang, Bin Han, Zhongmin Lan, Shulan Qi, Zongze Li, Jianyong Gao, Zongting Gu, Yuemin Sun, Xiaofeng Bai, Saderbieke Aimaiti, Yunmian Chu, Chengfeng Wang
Summary: The study found that perioperative acupuncture could accelerate postoperative gastrointestinal function recovery, with significant effects observed in pancreatectomy and gastrectomy (Billroth-II), while evidence for other types of gastrectomy was limited.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Review
Medicine, General & Internal
Piero Portincasa, Leonilde Bonfrate, David Q. -H. Wang, Gema Fruhbeck, Gabriella Garruti, Agostino Di Ciaula
Summary: Type 2 and type 1 diabetes are common endocrine disorders that are associated with gastrointestinal dysfunction and increased cancer risk. Metabolic alterations and gastrointestinal dysfunction can lead to symptoms in the upper and/or lower gastrointestinal tract, affecting a significant percentage of diabetic patients. Therefore, a comprehensive assessment of gastrointestinal function is important in the management of diabetes.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Oncology
Meng Gao, Wuliang Yang
Summary: Citrus aurantium L. has positive influences on gastrointestinal motility and gastric cancer proliferation in normal mice, and can reverse the problems caused by gastrointestinal motility dysfunction.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2023)
Article
Pharmacology & Pharmacy
Nele Steenackers, Tim Vanuytsel, Patrick Augustijns, Ellen Deleus, Wies Deckers, Christophe M. Deroose, Gwen Falony, Matthias Lannoo, Ann Mertens, Raf Mols, Roman Vangoitsenhoven, Lucas Wauters, Bart Van der Schueren, Christophe Matthys
Summary: This study investigated the effects of sleeve gastrectomy and Roux-en-Y gastric bypass on gastrointestinal motility, pH, and bile acid concentration. The findings showed that both surgeries increased pouch emptying and gastric emptying, and also led to higher pH levels and bile acid concentrations in the intestines. These results highlight the significant impact of these surgeries on gastrointestinal physiology.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Nutrition & Dietetics
Toshihiro Ohtsu, Ken Haruma, Yumiko Ide, Atsushi Takagi
Summary: This study evaluated the effect of the Lactobacillus gasseri OLL2716 (LG21 strain) on mild to moderate delayed gastric emptying. After 12 weeks of ingesting yogurt containing the LG21 strain, participants showed a 4.1 odds ratio of improvement in delayed gastric emptying compared to the placebo group, along with a significant decrease in salivary amylase concentrations. Further research with a larger sample size may provide more insight into the potential impact of the LG21 strain on delayed gastric emptying.
Article
Engineering, Biomedical
Saeed Alighaleh, Leo K. Cheng, Timothy R. Angeli-Gordon, Zahra Aghababaie, Gregory O'Grady, Niranchan Paskaranandavadivel
Summary: The study developed new flexible surface-contact pacing electrodes (SPE) for gastric pacing and simultaneous mapping of slow-wave activity. Results showed that SPE had a higher rate of entrainment and lower entrainment threshold compared to temporary cardiac pacing electrodes (CPE), but had lower tissue lead contact quality over time.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2021)
Letter
Gastroenterology & Hepatology
Gao-Jue Wu, Jiande D. Z. Chen
NEUROGASTROENTEROLOGY AND MOTILITY
(2019)
Article
Gastroenterology & Hepatology
Hanaa S. Sallam, Petri Urvil, Tor C. Savidge, Jiande D. Z. Chen
NEUROGASTROENTEROLOGY AND MOTILITY
(2020)
Article
Surgery
Elisabeth R. M. Heremans, Amy S. Chen, Ximeng Wang, Jiafei Cheng, Feng Xu, Agustin E. Martinez, Georgios Lazaridis, Sabine Van Huffel, Jiande D. Z. Chen
Article
Surgery
Fei Dai, Jieyun Yin, Jiande D. Z. Chen
Article
Gastroenterology & Hepatology
Ximeng Wang, Shengai Zhang, Pankaj J. Pasricha, Jiande D. Z. Chen
NEUROGASTROENTEROLOGY AND MOTILITY
(2020)
Article
Gastroenterology & Hepatology
Lei Tu, Payam Gharibani, Jieyun Yin, Jiande D. Z. Chen
NEUROGASTROENTEROLOGY AND MOTILITY
(2020)
Article
Medicine, Research & Experimental
Yan Dong, Jieyun Yin, Yiling Zhang, Jiande D. Z. Chen
Summary: This study optimized the parameters of intestinal electrical stimulation (IES) to reduce blood glucose in diabetic rats, and found that the ameliorating effect of IES on hyperglycemia is attributed to the enhanced release of GLP-1, showing its potential for treating diabetes.
Article
Medicine, Research & Experimental
Liuqin Jiang, Shengai Zhang, Nina Zhang, Jiande D. Z. Chen
Summary: The study found that tibial nerve stimulation with specific parameters can improve colonic hypersensitivity in rats by modulating autonomic and opioid mechanisms.
Article
Gastroenterology & Hepatology
Yiling Zhang, Tao Lu, Yan Dong, Yan Chen, Jiande D. Z. Chen
Summary: The study shows that aVNS can significantly increase normal GI slow waves and accelerate impaired GE and SIT caused by loperamide. Additionally, aVNS can increase plasma PP levels, decrease plasma NE levels, and promote an increase in gastric ICC.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Medicine, Research & Experimental
Yiling Zhang, Tao Lu, Yan Meng, Alimujiang Maisiyiti, Yan Dong, Shiying Li, Yan Chen, Jieyun Yin, Jiande D. Z. Chen
Summary: The study found that aVNS improves OIC by increasing colon motility and restoring enteric neural functions. This therapy acts through central and vagal efferent pathways.
Review
Medicine, General & Internal
Yan Wang, Jiande D. Z. Chen, Borko Nojkov
Summary: Gastric motility abnormalities are common in disorders of gut-brain interaction and accurate assessment of the gastric motility can help understand the underlying pathophysiology and guide effective treatment. Various diagnostic methods have been developed to objectively evaluate the presence of gastric dysmotility, including tests of gastric accommodation, antroduodenal motility, gastric emptying, and gastric myoelectrical activity. This review summarizes the advances in clinically available diagnostic methods and discusses the advantages and disadvantages of each test.
Review
Medicine, General & Internal
Md Jahangir Alam, Jiande D. Z. Chen
Summary: Abdominal pain is common in FGIDs and affects patients' quality of life. Neural circuits in the brain encode, store, and transfer pain information. Neuroimaging techniques have limitations in studying pain mechanisms due to poor temporal resolution. This review highlights important brain regions involved in pain modulation and proposes extracellular electrophysiology as a suitable method for capturing pain dynamics with high spatiotemporal resolution.
Article
Chemistry, Analytical
M. Khawar Ali, Shiyuan Gong, Borko Nojkov, Colin Burnett, Jiande D. Z. Chen
Summary: This study aimed to identify the most suitable HRV parameters for ANS activity in response to rectal distention in IBS patients. The results showed that SI and SDNN/SDNN Index were the most sensitive at assessing the autonomic response to rectal distention. Additionally, it was observed that repetitive rectal distention in IBS patients resulted in a decreased autonomic response.
Review
Medicine, General & Internal
M. Khawar Ali, Jiande D. Z. Chen
Summary: Functional gastrointestinal disorders (FGID) and gastroesophageal reflux (GERD) disease affect a large population worldwide and result in significant healthcare costs. Gut-brain communication impairment is a key factor in the development of these disorders. Autonomic dysfunction, identified through heart rate variability (HRV), may be associated with GERD and FGIDs. This article reviews the use of HRV in assessing autonomic function and dysfunction in GERD, functional dyspepsia (FD), gastroparesis, irritable bowel syndrome (IBS), and constipation. Studies indicate that GERD and FGIDs are linked to decreased parasympathetic activity and increased sympathetic nervous system activity, with a shift towards sympathetic dominance. HRV can also evaluate autonomic responses to interventions, particularly the enhancement of parasympathetic activity. In conclusion, HRV provides a noninvasive method for assessing impaired autonomic function associated with GERD and FGIDs.
