Review
Surgery
Dolores T. T. Mueller, Brett Parker, Reid Fletcher, Ahmed Sharata, Daniel Davila Bradley, Steven R. R. DeMeester, Kevin M. M. Reavis, Lee L. L. Swanstrom, Christy M. M. Dunst
Summary: The aim of this study was to provide a complete set of HRM data for patients with a normally functioning fundoplication. The results showed that the addition of a fundoplication significantly increased the values of the lower esophageal sphincter. The previously accepted upper limit defining esophageal outflow obstruction may not be clinically applicable after fundoplication.
Article
Gastroenterology & Hepatology
Hui Su, Amanda J. Krause, Melina Masihi, Jacqueline Prescott, Alex Decorrevont, Emma Germond, Dave Karasik, Wenjun Kou, John E. Pandolfino, Dustin A. Carlson
Summary: This study investigated a comprehensive HRM testing protocol on 30 healthy asymptomatic volunteers, reporting normal values and findings. Isolated abnormalities of IRP and contractile parameters were observed in 80% of subjects, while all subjects also displayed normal features.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Rahul Deshmukh, Akash Shukla, Sanjay Chandnani, Pravin M. Rathi, Pratik Tibdewal, Shubham Jain, Nitin Ramani, Parmeshwar Junare, Partha Debnath, Leela Shinde, Asif Bagwan, Megha Meshram
Summary: This study provides normal data for high-resolution anorectal manometry (HRAM) in a healthy Indian population and evaluates the impact of gender, age, and body mass index (BMI) on anorectal functions. The results indicate that there is no significant difference in anal pressures between males and females, but rectal pressure and anal pressure during simulated evacuation without rectal distention are higher in males. Additionally, females have a lower threshold for the first sensation, and subjects under the age of 40 have higher anal residual pressure. Moreover, individuals with a BMI below 23 kg/m(2) have higher maximum anal squeeze pressure and maximum rectal pressure during push.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Gastroenterology & Hepatology
Le Manh Cuong, Ha Van Quyet, Tran Manh Hung, Nguyen Ngoc Anh, Tran Thu Ha, Vu Van Du, Do Van Loi, Ha Huu Hoang Khai, Vu Duy Kien
Summary: This study identified normal HRAM values for healthy young adults in Vietnam and found that sex may influence anal pressure and first rectal sensation values in this cohort. Further research is needed to improve the quality of HRAM normal values and confirm the effects of sex.
BMC GASTROENTEROLOGY
(2021)
Article
Medicine, General & Internal
Serkan Bilgin, Ahmet Kayali, Adnan Yamanoglu, Huseyin Acar, Zeynep Karakaya, Firdevs Topal, Elif Saritas Yuksel, Fatih Esad Topal
Summary: In patients with dysphagia and normal CM, over 40% were completely asymptomatic at follow-up, while less than half reported significant symptoms, with the remaining responders admitting to moderate to mild symptoms.
Article
Surgery
Shahin Ayazi, Andrew D. Grubic, Ping Zheng, Ali H. Zaidi, Katrin Schwameis, Adam C. Alleyne, Brittney M. Myers, Ashten N. Omstead, Blair A. Jobe
Summary: This study aimed to measure the outflow resistance caused by magnetic sphincter augmentation (MSA) in patients free of postoperative dysphagia using high-resolution impedance manometry. The results show an increased esophagogastric junction outflow resistance measured by intrabolus pressure (iBP) after MSA, with a significant correlation between iBP and incomplete bolus clearance percentage.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Gastroenterology & Hepatology
Apichet Sirinawasatien, Pallop Sakulthongthawin
Summary: Jackhammer esophagus is a rare esophageal motility disorder that can cause symptoms like dysphagia. High-resolution manometry and upper gastrointestinal endoscopy are key in diagnosis, with treatment options including calcium channel blockers and proton pump inhibitors.
BMC GASTROENTEROLOGY
(2021)
Article
Pediatrics
Anna Maria Caruso, Denisia Bommarito, Vincenza Girgenti, Glenda Amato, Adele Figuccia, Alessandra Casuccio, Annalisa Ferlisi, Rosaria Genuardi, Sabrina La Fata, Rosalia Mattei, Mario Pietro Marcello Milazzo, Maria Rita Di Pace
Summary: This study analyzed swallowing functions in neurologically impaired (NI) children using esophageal high-resolution manometry (HRM) and established swallow parameters identifying inhalation risk. The results showed alterations in swallowing functions in NI children, which could predispose them to increased inhalation risk.
Article
Otorhinolaryngology
Shumon Dhar, Nogah Nativ-Zeltzer, Omid B. Mehdizadeh, Apoorva T. Ramaswamy, Yuval Nachalon, Peter C. Belafsky
Summary: The results of this pilot study demonstrate that pyridostigmine acutely improves esophageal contractile vigor in patients suffering from dysphagia with esophageal dysmotility. Further investigation with larger sample size, longer follow-up, side effect profile, and patient-reported outcome measures is still needed to determine the clinical usefulness of pyridostigmine in specific disorders of esophageal motility.
Article
Gastroenterology & Hepatology
Alexandra J. Baumann, Erica N. Donnan, Joseph R. Triggs, Wenjun Kou, Jacqueline Prescott, Alex Decorrevont, Emily Dorian, Peter J. Kahrilas, John E. Pandolfino, Dustin A. Carlson
Summary: This study found that patients with normal FLIP panometry results generally did not exhibit major esophageal motor disorders, and HRM results that were abnormal were often considered false positives. In some cases, normal FLIP panometry results could potentially eliminate the need for HRM to diagnose esophageal motility disorders.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Yang Won Min, Kee Wook Jung, Kyoungwon Jung, Yu Kyung Cho, Moo In Park
Summary: This study investigates the characteristics and treatment outcomes of hypercontractile esophagus (HE). The results show that 61% of patients diagnosed with HE based on high-resolution manometry meet the criteria for CC v4.0. Chest pain and regurgitation are common symptoms. Medical treatment showed moderate efficacy, with 47.1% showing moderate improvement and 29.4% showing significant improvement.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Corinne Delbaen, Paraskevas Gkolfakis, Jacques Deviere, Daniel Blero, Hubert Louis
Summary: This study retrospectively analyzed the failure rate of esophagogastric junction (EGJ) insertion during high-resolution manometry (HRM) and reported the use of guidewire-assisted procedures. The results showed that insertion of a water-perfused HRM probe using an endoscopically-placed nasogastric guidewire allowed successful assessment of EGJ and esophageal peristalsis in cases where EGJ traversal was not possible.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Gastroenterology & Hepatology
Mate Gergely, Michael D. Mello, Arvind Rengarajan, C. Prakash Gyawali
Summary: Pseudoachalasia is characterized by a shorter history, greater weight loss, and incomplete high-resolution manometry patterns compared to achalasia.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Chamara Basnayake, Sawangpong Jandee, Annelies Geeraerts, Hannelore Geysen, Ans Pauwels, Lien Timmermans, Tim Vanuytsel, Nathalie Rommel, Jan Tack
Summary: This study aimed to investigate the impact of position, different volumes and consistencies of swallows, and perception of bolus passage on high-resolution esophageal manometry (HRM) metrics. The results showed significant differences in HRM metrics with different positions, volumes, and consistencies of swallows. Interpretation of HRM studies should consider normative values specific to position and bolus type.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Surgery
Yazmin Johari, Kenny Budiman, William Catchlove, Cheryl Laurie, Geoffrey Hebbard, Sam Norden, Wendy A. Brown, Paul Burton
Summary: This study describes the expected endoscopic and histological changes at the gastro-esophageal junction (GEJ) and defines diagnostic paradigms for Barrett esophagus (BE) post-sleeve gastrectomy (SG).
Article
Gastroenterology & Hepatology
Jeroen M. Schuitenmaker, Froukje B. van Hoeij, Marlies P. Schijven, Jan Tack, Jose M. Conchillo, Eric J. Hazebroek, Andre J. P. M. Smout, Albert J. Bredenoord
Summary: The study results indicate that pneumatic dilation with a 35 mm balloon is not superior to sham dilation for the treatment of persistent dysphagia after fundoplication.
Editorial Material
Gastroenterology & Hepatology
Albert J. Bredenoord
Article
Gastroenterology & Hepatology
Emily Taillieu, Chloe De Witte, Heiko De Schepper, Wouter Van Moerkercke, Sophie Rutten, Stijn Michiels, Yuna Arnst, Sofie De Bruyckere, Sven Francque, Frauke van Aert, Christophe George, Emma Callewaert, Tiene Callewaert, Glenn Vanneste, Erik Vanderstraeten, Nina Van Heddegem, Margaux Vansteelant, Koen Chiers, Freddy Haesebrouck, Christophe Van Steenkiste
Summary: This study reveals that gastric non-Helicobacter pylori Helicobacter (NHPH) species naturally associated with animals are linked with gastric disease in human patients. The findings suggest that routine PCR testing for zoonotic gastric NHPHs should be conducted on patients with gastric complaints to diagnose potential pathogens.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Nikita Hanning, Rosanne Verboven, Joris G. De Man, Hannah Ceuleers, Heiko U. De Schepper, Annemieke Smet, Benedicte Y. De Winter
Summary: This study showed that single-day or multi-day orogastric gavages do not have a significant effect on gut physiology in mice. However, multi-day gavages result in a slight increase in stress levels and altered gastrointestinal motor function. Despite this, the intestinal barrier function remains unaffected.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2023)
Article
Cell Biology
Samuel Van Remoortel, Lana Lambeets, Heiko De Schepper, Jean-Pierre Timmermans
Summary: In recent years, it has been discovered that the family of Mas-related G protein-coupled receptors (MRGPRs) plays a crucial role in neuro-immune communication in the skin. However, the expression of MRGPRs at other mucosal surfaces remains poorly understood. This study aimed to investigate the expression of MRGPRs in mucosal biopsies of the human gastrointestinal (GI) tract. The results showed that MRGPRF mRNA was the only detectable member of the MRGPR family expressed in human mucosal biopsies of the terminal ileum and sigmoid colon. Immunohistochemical analysis revealed that MRGPRF was specifically expressed in mucosal entero-endocrine cells (EECs).
CELL AND TISSUE RESEARCH
(2023)
Review
Obstetrics & Gynecology
Sylvie van den Broeck, Sara Nullens, Yves Jacquemyn, Heiko De Schepper, Alexandra Vermandel, Niels Komen
Summary: The objective of this study is to review available devices for perineal support during defecation in patients with obstructive defecation syndrome (ODS) and posterior pelvic organ prolapse (POP). A total of 10 studies were included for review. The devices can be categorized into three groups: pessaries, vaginal stent, and external support device. The meta-analysis showed that the pessaries significantly improved Colorectal-Anal Distress Inventory (CRADI-8) and Impact Questionnaire (CRAI-Q-7), while the vaginal stent decreased ODS significantly.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Jeroen M. Schuitenmaker, Thijs Kuipers, Marlies P. Schijven, Andre J. P. M. Smout, Paul Fockens, Albert J. Bredenoord
Summary: This study evaluated the effect of an electronic positional therapy wearable device on nocturnal gastroesophageal reflux. The results showed that the device improved reflux symptoms, reduced the number of reflux episodes, and promoted left lateral decubitus sleep position, leading to improvement in reflux parameters.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Sudharshan Achalu, Rani Berry, Justin Zhuo, Albert J. Bredenoord, John O. Clarke, Ronnie Fass, C. Prakash Gyawali, Peter J. Kahrilas, David A. Katzka, Benson T. Massey, Roberto Penagini, Sabine Roman, Edoardo Savarino, Marcelo F. Vela, Afrin N. Kamal
Summary: This study aimed to develop a dysphagia-specific question prompt list (QPL) to improve patient-physician communication. A two-round Delphi method and survey were used to generate a QPL consisting of 40 questions, incorporating both expert and patient perspectives.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Microbiology
Baptiste Oosterlinck, Hannah Ceuleers, Wout Arras, Joris G. De Man, Karen Geboes, Heiko De Schepper, Marc Peeters, Sarah Lebeer, Jurgita Skieceviciene, Georgina L. Hold, Juozas Kupcinskas, Alexander Link, Benedicte Y. De Winter, Annemieke Smet
Summary: This study identified the mucin-microbiome signatures in gastric adenocarcinomas and their impact on clinical outcomes. The findings showed that intestinal mucin phenotype and high-level MUC13 expression were associated with poor survival, while gastric MUC5AC or MUC6 abundance was associated with a more favorable outcome. Furthermore, oral bacteria such as Neisseria, Prevotella, and Veillonella were found to play a potential role in MUC13 signaling and were associated with intestinal and mixed mucin phenotype tumors.
Article
Cell Biology
Tom Breugelmans, Wout Arras, Baptiste Oosterlinck, Aranzazu Jauregui-Amezaga, Michael Somers, Bart Cuypers, Kris Laukens, Joris G. De Man, Heiko U. De Schepper, Benedicte Y. De Winter, Annemieke Smet
Summary: This study investigates the role of MUC13 in disrupting epithelial barrier integrity and the involvement of MUC1 in inflammatory bowel diseases (IBD). The results demonstrate that MUC13 overexpression affects the expression of junctional proteins and barrier mediators, leading to intestinal barrier dysfunction. Furthermore, MUC13 modulates several signaling pathways, including JAK1/STAT3, SNAI1/ZEB1, and ROCK2/MAPK, in cooperation with MUC1. The findings suggest that aberrant MUC13 signaling plays an active role in inducing intestinal barrier dysfunction during inflammation.
Review
Gastroenterology & Hepatology
H. Ruymbeke, J. Geldof, D. De Looze, M. A. Denis, H. De Schepper, P. Dewint, I. Gijsen, M. Surmont, J. Wyndaele, P. Roelandt
Summary: An anal fissure is a painful tear in the sensitive skin of the anus, typically located below the dentate line. It is a common condition that significantly affects quality of life. Primary fissures are usually associated with constipation and found at the posterior midline, while secondary fissures, which account for about 1% of cases, can have atypical appearances and may be caused by underlying conditions such as Crohn's disease, malignancy, trauma or venereal infections. This manuscript aims to provide a comprehensive review of the clinical aspects, evaluation, and treatment of secondary anal fissures. (Acta gastroenterol. belg., 2023, 86, 58-67).
ACTA GASTRO-ENTEROLOGICA BELGICA
(2023)
Article
Gastroenterology & Hepatology
K. Van Malderen, J. G. De Man, B. Y. De Winter, H. U. De Schepper
Summary: This study aimed to evaluate the characteristics of a population visiting a patient-centered informative website about IBS. The study found that red flag symptoms and psychological comorbidities were common, and despite seeking medical help and receiving therapy, most patients still experienced moderate to severe symptoms with a significant impact on their quality of life. Furthermore, there was an urgent need for high-quality information and education for both healthcare professionals and patients.
ACTA GASTRO-ENTEROLOGICA BELGICA
(2023)
Editorial Material
Gastroenterology & Hepatology
N. Lanthier, S. Lefere, H. De Schepper, C. Reenaers
ACTA GASTRO-ENTEROLOGICA BELGICA
(2023)
Article
Gastroenterology & Hepatology
Albert J. Bredenoord, Evan Dellon, Ikuo Hirano, Alfredo J. Lucendo, Christoph Schlag, Xian Sun, Lila Glotfelty, Leda Mannent, Jennifer Maloney, Elizabeth Laws, Eric Mortensen, Arsalan Shabbir
Article
Gastroenterology & Hepatology
Guy Boeckxstaens, Stefanie Elsen, Ann Belmans, Vito Annese, Albert J. Bredenoord, Olivier R. Busch, Mario Costantini, Uberto Fumagalli, Andre J. P. M. Smout, Jan Tack, Tim Vanuytsel, Giovanni Zaninotto, Renato Salvador
Summary: The 10-year follow-up of the European Achalasia Trial comparing endoscopic pneumodilation (PD) with laparoscopic Heller myotomy (LHM) showed that both treatments are equally effective in treating achalasia, with limited risk of developing gastro-oesophageal reflux.