Article
Gastroenterology & Hepatology
Dustin A. Carlson, Christina Shehata, Nirmala Gonsalves, Ikuo Hirano, Stephanie Peterson, Jacqueline Prescott, Domenico A. Farina, Jacob M. Schauer, Wenjun Kou, Peter J. Kahrilas, John E. Pandolfino
Summary: This study evaluated the characteristics of secondary peristalsis in patients with EoE and found that abnormal esophageal contractions were associated with disease severity.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Dustin A. Carlson, Alexandra J. Baumann, Jacqueline E. Prescott, Jacob M. Schauer, Amanda Krause, Erica N. Donnan, Wenjun Kou, Peter J. Kahrilas, John E. Pandolfino
Summary: The study compared HRM and FLIP panometry in predicting esophageal retention, with FLIP panometry showing superior performance over HRM. However, a complementary evaluation involving FLIP panometry, HRM, and TBE may be necessary for accurate diagnosis of esophageal motility disorders.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Hisashi Fukuda, Hiroki Sato, Yusuke Fujiyoshi, Hirofumi Abe, Hiroki Okada, Junya Shiota, Chiaki Sato, Hiroyuki Sakae, Masaki Ominami, Yoshitaka Hata, Ryo Ogawa, Jun Nakamura, Tetsuya Tatsuta, Yuichiro Ikebuchi, Hiroshi Yokomichi, Hironori Yamamoto, Haruhiro Inoue
Summary: This study aimed to investigate the etiology of chest pain in achalasia-related esophageal motility disorders and the frequency of persistent chest pain after POEM. The results showed that age, sex, disease duration, and prior treatment were related to the prevalence and severity of chest pain. POEM had satisfactory efficacy, but residual pain was often observed.
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Gastroenterology & Hepatology
Shiko Kuribayashi, Junichi Akiyama, Haruo Ikeda, Kazue Nagai, Hiroko Hosaka, Mariko Hamada, Manabu Onimaru, Noriyuki Kawami, Kunihiko Hayashi, Katsuhiko Iwakiri, Haruhiro Inoue, Motoyasu Kusano, Toshio Uraoka
Summary: This study aimed to evaluate the accuracy of a new automated diagnostic program for HREM, which showed high diagnostic accuracy and time-saving benefits in clinical practice.
JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Stefano Siboni, Ivan Kristo, Benjamin D. Rogers, Nicola De Bortoli, Anthony Hobson, Brian Louie, Yeong Yeh Lee, Vincent Tee, Salvatore Tolone, Elisa Marabotto, Pierfrancesco Visaggi, Jordan Haworth, Megan Ivy, Garrett Greenan, Chiara Facchini, Takahiro Masuda, Fumiaki Yano, Kyle Perry, Gokulakrishnan Balasubramanian, Dimitrios Theodorou, Tania Triantafyollu, Lorenzo Cusmai, Sara Boveri, Sebastian F. Schoppmann, C. Prakash Gyawali, Luigi Bonavina
Summary: The straight leg raise maneuver during high-resolution manometry can predict abnormal esophageal acid exposure time, increasing the diagnostic value of HRM when GERD is suspected.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Chemistry, Analytical
Zoltan Czako, Teodora Surdea-Blaga, Gheorghe Sebestyen, Anca Hangan, Dan Lucian Dumitrascu, Liliana David, Giuseppe Chiarioni, Edoardo Savarino, Stefan Lucian Popa
Summary: This study aims to develop a machine learning-based solution to detect probe positioning failure in esophageal manometry and automatically determine the normal range of IRP based solely on raw images. By preprocessing the images, resizing and rescaling them, and using a deep learning model for classification, the accuracy is improved and human intervention is reduced.
Article
Gastroenterology & Hepatology
Alexandra J. Baumann, Erica N. Donnan, Joseph R. Triggs, Wenjun Kou, Jacqueline Prescott, Alex Decorrevont, Emily Dorian, Peter J. Kahrilas, John E. Pandolfino, Dustin A. Carlson
Summary: This study found that patients with normal FLIP panometry results generally did not exhibit major esophageal motor disorders, and HRM results that were abnormal were often considered false positives. In some cases, normal FLIP panometry results could potentially eliminate the need for HRM to diagnose esophageal motility disorders.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Rena Yadlapati, Peter J. Kahrilas, Mark R. Fox, Albert J. Bredenoord, C. Prakash Gyawali, Sabine Roman, Arash Babaei, Ravinder K. Mittal, Nathalie Rommel, Edoardo Savarino, Daniel Sifrim, Andre Smout, Michael F. Vaezi, Frank Zerbib, Junichi Akiyama, Shobna Bhatia, Serhat Bor, Dustin A. Carlson, Joan W. Chen, Daniel Cisternas, Charles Cock, Enrique Coss-Adame, Nicola de Bortoli, Claudia Defilippi, Ronnie Fass, Uday C. Ghoshal, Sutep Gonlachanvit, Albis Hani, Geoffrey S. Hebbard, Kee Wook Jung, Philip Katz, David A. Katzka, Abraham Khan, Geoffrey Paul Kohn, Adriana Lazarescu, Johannes Lengliner, Sumeet K. Mittal, Taher Omari, Moo In Park, Roberto Penagini, Daniel Pohl, Joel E. Richter, Jordi Serra, Rami Sweis, Jan Tack, Roger P. Tatum, Radu Tutuian, Marcelo F. Vela, Reuben K. Wong, Justin C. Wu, Yinglian Xiao, John E. Pandolfino
Summary: CCv4.0 is an updated classification scheme for esophageal motility disorders using HRM, developed by fifty-two international experts in seven subgroups over two years. Key updates include a more rigorous and expansive HRM protocol, refined definition of EGJOO, stricter criteria for ineffective esophageal motility, and description of baseline EGJ metrics. These changes aim to provide more standardized criteria for disorders of peristalsis and obstruction at the EGJ.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Chien-Lin Chen, Ming-Wun Wong, Jui-Sheng Hung, Shu-Wei Liang, Tso-Tsai Liu, Chih-Hsun Yi, Lin Lin, William C. Orr, Wei-Yi Lei
Summary: The study investigated the effects of acute administration of codeine on primary and secondary peristalsis in healthy adults. Results showed that codeine increased the relaxation pressure and frequency of secondary peristalsis, while also affecting primary peristalsis by increasing relaxation pressure and shortening distal latency. This suggests that opioids like codeine can impact both primary and secondary peristalsis in the esophagus.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Ming-Wun Wong, Chih-Hsun Yi, Tso-Tsai Liu, Wei-Yi Lei, Jui-Sheng Hung, Chao-Zong Liu, Chien-Lin Chen
Summary: This study investigated the effects of sildenafil on secondary peristalsis using HRM and found that sildenafil reduces the success rate and vigor of secondary peristalsis, similar to its effects on primary peristalsis.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Roberto Penagini, Nicola de Bortoli, Edoardo Savarino, Elena Arsie, Salvatore Tolone, Garrett Greenan, Pierfrancesco Visaggi, Daria Maniero, Aurelio Mauro, Dario Consonni, C. Prakash Gyawali
Summary: RDC during high-resolution manometry is an effective surrogate for TBE in assessing esophageal emptying in treated patients with achalasia.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Apichet Sirinawasatien, Pallop Sakulthongthawin
Summary: Jackhammer esophagus is a rare esophageal motility disorder that can cause symptoms like dysphagia. High-resolution manometry and upper gastrointestinal endoscopy are key in diagnosis, with treatment options including calcium channel blockers and proton pump inhibitors.
BMC GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Asad Jehangir, Zubair Malik, Henry P. Parkman
Summary: This study aimed to examine the correlation between reflux observed on esophagogastric junction (EGJ) during high-resolution esophageal manometry with impedance (HREMI) and reflux on conventional esophageal reflux monitoring studies. The results showed that about 20.5% of patients undergoing HREMI had pathologic reflux at EGJ. Patients with reflux on HREMI more frequently had gastroesophageal reflux disease (GERD) on ambulatory pH monitoring. However, reflux on HREMI had low sensitivity for GERD.
BMC GASTROENTEROLOGY
(2022)
Review
Otorhinolaryngology
C. Prakash Gyawali, Peter J. Kahrilas
Summary: High-resolution esophageal manometry (HRM) combined with pressure topography allows simultaneous observation of the entire esophageal contractility, with advantages of easier recognition and better reproducibility of contractile patterns. Compared to conventional manometry, HRM is more sensitive in detecting impaired relaxation of the esophagogastric junction (EGJ) and subcategorizes achalasia into three clinically relevant subtypes. HRM and the CC process have revolutionized our understanding of esophageal motility and motility disorders.
Article
Gastroenterology & Hepatology
Arvind Rengarajan, Benjamin D. Rogers, Zhiqin Wong, Salvatore Tolone, Daniel Sifrim, Jordi Serra, Edoardo Savarino, Sabine Roman, Jose M. Remes-Troche, Rosa Ramos, Julio Perez de la Serna, Ans Pauwels, Ana Maria Leguizamo, Yeong Yeh Lee, Osamu Kawamura, Jamal Hayat, Albis Hani, Sutep Gonlachanvit, Daniel Cisternas, Dustin Carlson, Serhat Bor, Shobna Bhatia, Luiz Abrahao, John Pandolfino, C. Prakash Gyawali
Summary: The study aimed to investigate the prevalence of abnormal esophageal motor patterns in healthy individuals. Results showed that motor abnormalities are infrequent in healthy individuals and consist mainly of ineffective esophageal motility (IEM), with lower proportions when using stringent criteria in the supine position. Thresholds for HRM metrics varied across HRM systems and study positions.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
