Article
Surgery
Shahin Ayazi, Katrin Schwameis, Ping Zheng, Kirsten Newhams, Brittney M. Myers, Andrew D. Grubic, Toshitaka Hoppo, Blair A. Jobe
Summary: This study evaluated the impact of MSA on the lower esophageal sphincter (LES) and esophageal body using high resolution impedance manometry. The findings showed that MSA improved LES characteristics without affecting esophageal peristaltic progression and bolus clearance.
Article
Gastroenterology & Hepatology
Anand S. Jain, Chaitanya Allamneni, Meredith Kline, Raj Dalsania, Marie Godiers, Steven Keilin, Shanthi Srinivasan, Ravinder Mittal
Summary: This study examined the relationship between distensibility index (DI) and integrated relaxation pressure (IRP), and their correlations with dysphagia symptoms in patients with achalasia and esophagogastric junction outflow obstruction (EGJOO). The study found that DI is not correlated with HRM EGJ measurements and has the strongest effect on dysphagia severity.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Gastroenterology & Hepatology
Paola Iovino, Byron Theron, Sandra Prew, Shyam Menon, Nigel Trudgill
Summary: The study found that post-prandial acid GER episodes were more common in patients with severe esophagitis or BE, and esophageal acid clearance was slower in these patients. Transient lower esophageal sphincter relaxation (TLESR) was the most common mechanism associated with reflux episodes in all subjects, and post-prandial exercise increased TLESR with acid reflux. Therefore, patients with GERD should avoid exercise immediately after a meal.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Review
Surgery
Pedro Norton, Fernando A. M. Herbella, Francisco Schlottmann, Marco G. Patti
Summary: This study reviewed the evaluation of the upper esophageal sphincter (UES) using high-resolution manometry (HRM) and found that HRM allows for more precise measurements compared to conventional manometry, but the clinical significance of these parameters still needs confirmation. Various diseases can affect UES function, including achalasia, gastroesophageal reflux disease, globus, neurologic diseases, and Zenker's diverticulum.
LANGENBECKS ARCHIVES OF SURGERY
(2021)
Article
Surgery
Matthias Paireder, Ivan Kristo, Reza Asari, Gerd Jomrich, Johannes Steindl, Erwin Rieder, Sebastian F. Schoppmann
Summary: After undergoing LES-EST treatment, patients with GERD and IEM showed significant improvement in health-related quality of life, but the normalization or significant improvement of esophageal acid exposure was limited.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Review
Gastroenterology & Hepatology
Benjamin D. Rogers, C. Prakash Gyawali
Summary: The esophagogastric junction (EGJ) is a complex barrier between the thoracic and abdominal luminal gut compartments, relaxation and muscle abnormalities at EGJ may lead to achalasia and gastroesophageal reflux disease. High resolution manometry (HRM) is the current gold standard for assessing EGJ morphology and function, with newer metrics and tests providing more comprehensive evaluation of EGJ functionality and morphology.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2021)
Article
Surgery
Gillian Lim, Yazmin Johari, Geraldine Ooi, Julie Playfair, Cheryl Laurie, Geoffrey Hebbard, Wendy Brown, Paul Burton
Summary: This study aimed to determine the discriminant factors of symptomatic reflux and establish diagnostic thresholds for GERD following SG. The results indicated that reflux score and supine acid exposure were the strongest discriminant factors for symptomatic reflux. The symptomatic cohort typically showed higher levels of acid exposure.
Article
Gastroenterology & Hepatology
Wei-Yi Lei, Taher Omari, Tso-Tsai Liu, Ming-Wun Wong, Jui-Sheng Hung, Chih-Hsun Yi, Shu-Wei Liang, Charles Cock, Chien-Lin Chen
Summary: This study measured the effect of esophageal outflow obstruction induced by a leg-lift protocol on intrabolus pressures. The results showed an increase in relaxation pressure and distal contractile integral at the esophagogastric junction, as well as increased pressures in all bolus categories. Measuring pressures within the intrabolus domain can aid in confirming a diagnosis of EGJ outflow obstruction.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Gastroenterology & Hepatology
Natalya C. B. Dias, Fernando A. M. Herbella, Leonardo M. Del Grande, Marco G. Patti
Summary: This study evaluated the role of the transdiaphragmatic pressure gradient (TPG) and lower esophageal sphincter (LES) dysfunction in the pathogenesis of gastroesophageal reflux disease (GERD). The results showed that abdominal pressure and TPG were higher in GERD-positive patients, while LES resting pressure was not different between groups. Relative LES pressure (LES retention pressure) was able to predict the presence and severity of GERD. The study concluded that TPG plays an important role in the pathophysiology of GERD, and the relative LES pressure is a reliable indicator for GERD.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Gastroenterology & Hepatology
Asad Jehangir, Zubair Malik, Henry P. Parkman
Summary: This study aimed to examine the correlation between reflux observed on esophagogastric junction (EGJ) during high-resolution esophageal manometry with impedance (HREMI) and reflux on conventional esophageal reflux monitoring studies. The results showed that about 20.5% of patients undergoing HREMI had pathologic reflux at EGJ. Patients with reflux on HREMI more frequently had gastroesophageal reflux disease (GERD) on ambulatory pH monitoring. However, reflux on HREMI had low sensitivity for GERD.
BMC GASTROENTEROLOGY
(2022)
Article
Surgery
Akira Dobashi, Jodie L. Deters, Charles A. Miller, Crystal J. Lavey, Elizabeth Rajan
Summary: This study investigated the feasibility and safety of a newly developed endotherapy for GERD using intraluminal magnets referred to as a magnet closure device (MCD). The results showed successful deployment of MCDs, increased LES pressures, and no clinically significant adverse events, suggesting a promising reversible technique for GERD therapy. Future studies are needed to improve durability and explore its potential as an attractive alternative to endoluminal GERD therapy.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Biology
Mariana Floria, Diana-Elena Iov, Daniela Maria Tanase, Oana Bogdana Barboi, Genoveva Livia Baroi, Alexandru Burlacu, Mihaela Grecu, Radu Andy Sascau, Cristian Statescu, Catalina Mihai, Vasile Liviu Drug
Summary: Patients undergoing atrial fibrillation ablation may not be at a higher risk of developing symptomatic gastroesophageal reflux disease three months after the procedure, according to a small prospective study.
Article
Gastroenterology & Hepatology
Francis O. Edeani, Mark Kern, Kenan Ulualp, Karlo Kovacic, Patrick Sanvanson, Ling Mei, Reza Shaker
Summary: The study aimed to determine the impact of various factors on deglutitive and non-deglutitive UES parameters, finding that parameters vary across different positions, sexes, ages, heights, and weights. These findings provide important information for clinical evaluation.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Gastroenterology & Hepatology
Yue-Yuan Li, Wen-Ting Lu, Jian-Xiang Liu, Li-Hong Wu, Meng Chen, Hong-Mei Jiao
Summary: This study aimed to evaluate the esophageal motility characteristics of patients with EGJOO and identify valuable parameters for confirming the diagnosis. The results showed that based on CCv4.0, patients with EGJOO had more severe esophagogastric junction dysfunction and were implicated in the proximal esophagus. Additionally, several parameters were supportive for confirming the diagnosis of EGJOO.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Surgery
Rachel Sillcox, Saurabh Khandelwal, Mary Kate Bryant, Benjamin Vierra, Roger Tatum, Robert Yates, Judy Y. Y. Chen
Summary: Patients who undergo vertical sleeve gastrectomy (VSG) are at risk of postoperative gastroesophageal reflux disease (GERD). Abnormal preoperative pH studies and esophageal motility disorders are associated with higher rates of postoperative reflux after VSG. A DeMeester score greater than 24.8 predicts the occurrence of postoperative reflux in patients with abnormal preoperative pH studies.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)