Article
Pharmacology & Pharmacy
Weijian Chen, Yaozhong Zhao, Yongzhao Dai, Ke Nie
Summary: Chemotherapy-induced nausea and vomiting (CINV) is a common side effect of cancer patients receiving chemotherapy. The role of gastrointestinal (GI) inflammation in CINV is crucial, and drugs used for CINV prophylaxis have shown anti-inflammatory effects. Understanding the mechanisms of GI inflammation and CINV can lead to the discovery of novel antiemetic drugs.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Wei Gao, Linzhong Zhang, Xuechang Han, Lai Wei, Jie Fang, Xiaqing Zhang, Jiaqiang Zhang, Haiyun Wang, Qi Zhou, Chenggang Wang, Wenting Chen, Xinli Ni, Lan Yang, Ruini Du, Ge Wang, Bingyu Liu, Yajuan Li, Shanshan Zhang, Qiang Wang
Summary: The study found that TEAS can effectively reduce the incidence and severity of PONV in high-risk surgical patients, potentially providing clinical value in preventing PONV.
FRONTIERS IN MEDICINE
(2022)
Review
Neurosciences
Heithem Soliman, Guillaume Gourcerol
Summary: Gastric electrical stimulation (GES) is used as an alternative treatment for gastroparesis, with the aim of accelerating gastric motility and relieving symptoms. Although high-frequency stimulation - low energy stimulation did not accelerate gastric emptying, this technique has shown clinical impact in reducing nausea and vomiting in gastroparesis patients.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Nutrition & Dietetics
Devanshi Gala, Hattie H. Wright, Bekhinkosi Zigori, Skye Marshall, Megan Crichton
Summary: The study suggests that CINV-specific nutrition education and support from health professionals can improve CINV. Non-restrictive dietary patterns, particularly those including adequate energy and macronutrient intakes, ginger, and Mediterranean diet concepts, may benefit CINV.
CLINICAL NUTRITION
(2022)
Review
Gastroenterology & Hepatology
Matthew Heckroth, Robert T. Luckett, Chris Moser, Dipendra Parajuli, Thomas L. Abell
Summary: Nausea and vomiting are common symptoms in medicine with various treatment options including pharmacotherapy, new immunotherapies, bioelectrical neuromodulation, and surgical therapies. Emerging understandings of the pathophysiology are leading to improved therapies.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2021)
Review
Medicine, General & Internal
June Tome, Amrit K. Kamboj, Seth Sweetser
Summary: Nausea and vomiting are common symptoms in both outpatient and inpatient settings, and they can significantly impact quality of life. Clinical evaluation and treatment of these symptoms can be complex due to various underlying causes and treatment options. This concise review presents a practical 5-step approach for clinical evaluation and treatment, suitable for primary care and subspecialty settings.
MAYO CLINIC PROCEEDINGS
(2022)
Review
Gastroenterology & Hepatology
Daniel A. Carson, Sameer Bhat, Tommy C. L. Hayes, Armen A. Gharibans, Christopher N. Andrews, Gregory O'Grady, Chris Varghese
Summary: The presence of gastric slow wave abnormalities is common in patients with NVS, suggesting that gastric dysrhythmia may play a significant role in the pathophysiology of NVS.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Jouko Levijoki, Lasse Saloranta, Johanna Tuunainen, Janne Kaskinoro, Sari Pappinen, Sandra Nourry, Anne-Marie Betat, Anne Maurin, Maarit Pakarinen, Sari Hakkinen, Johanna Tervapuro, Hertta Pihlasvaara, Christophe Drieu La Rochelle, Heikki Joensuu
Summary: Ocular administration of palonosetron as eye drops can effectively prevent and treat nausea and vomiting. This method provides a quick and convenient way to deliver the medication when intravenous administration is not possible.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Danielle K. Orsagh-Yentis, Kelsey Ryan, Nicole Hurwitz, Karen A. Diefenbach, Steven Teich, Hayat Mousa, Neetu Bali, Karla Vaz, Desale Yacob, Carlo Di Lorenzo, Peter L. Lu
Summary: The study showed that children with severe nausea and vomiting treated with GES experienced significant improvement in symptoms and were able to tolerate oral nutrition better. Although there were some complications during treatment, the majority of patients were satisfied with the treatment outcomes.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Medicine, General & Internal
De-Shen Wang, Ming-Tao Hu, Zhi-Qiang Wang, Chao Ren, Miao-Zhen Qiu, Hui-Yan Luo, Ying Jin, William Pat Fong, Shu-bin Wang, Jie-wen Peng, Qing-feng Zou, Qiong Tan, Feng-Hua Wang, Yu-Hong Li
Summary: This study aimed to evaluate the efficacy and safety of adding aprepitant to palonosetron and dexamethasone for women with gastrointestinal cancer undergoing FOLFIRI or FOLFOX chemotherapy regimens. The results showed a significantly higher CR rate in the aprepitant group compared to the control group, with similar safety profiles.
Article
Gastroenterology & Hepatology
Guillaume Gourcerol, Benoit Coffin, Bruno Bonaz, Helene Hanaire, Stanislas Bruley Des Varannes, Frank Zerbib, Robert Caiazzo, Jean Charles Grimaud, Francois Mion, Samy Hadjadj, Paul Valensi, Lucine Vuitton, Guillaume Charpentier, Alain Ropert, Romain Altwegg, Philippe Pouderoux, Etienne Dorval, Michel Dapoigny, Henri Duboc, Pierre Yves Benhamou, Aurelie Schmidt, Nathalie Donnadieu, Philippe Ducrotte, Bruno Guerci
Summary: The study aimed to evaluate the efficacy, safety, and medico-economic impact of Enterra therapy for chronic medically refractory nausea and vomiting. The results showed that Enterra therapy significantly improved the gastrointestinal quality of life index score and reduced vomiting frequency. It also decreased healthcare costs and resulted in savings for the patients.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Nutrition & Dietetics
Jihee Choi, Jounghee Lee, Kijoon Kim, Hyo-Kyoung Choi, Se-A Lee, Hae-Jeung Lee
Summary: The study aimed to evaluate the effect of ginger supplementation as an adjuvant treatment for alleviating chemotherapy-induced nausea and vomiting. The results showed that ginger supplementation may reduce the incidence of acute chemotherapy-induced vomiting.
Review
Chemistry, Medicinal
Reza Rajabalizadeh, Mahboobeh Ghasemzadeh Rahbardar, Hossein Hosseinzadeh
Summary: This article reviews the potential effects of several herbal medicines and their preparations on reducing chemotherapy-induced nausea and vomiting (CINV) and calls for further high-quality research to confirm their clinical effectiveness and safety.
PHYTOTHERAPY RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Yao-Zhong Zhao, Yong-Zhao Dai, Ke Nie
Summary: Chemotherapy-induced nausea and vomiting significantly affects the quality of life in cancer patients. Traditional Chinese medicine has been recognized for its potential in treating these side effects, leading to increased research attention.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Rudolph Navari, Gary Binder, Alex Molasiotis, Jorn Herrstedt, Eric J. Roeland, Kathryn J. Ruddy, Thomas W. LeBlanc, Dwight D. Kloth, Kelsey A. Klute, Eros Papademetriou, Luke Schmerold, Lee Schwartzberg
Summary: The relationship between the duration and recurrence of chemotherapy-induced nausea and vomiting (CINV) has not been well studied. This study found that patients who experienced CINV in their first cycle of chemotherapy were more likely to have CINV recurrence in later cycles, and the duration of CINV could predict the increased risk of recurrence.