Article
Cell Biology
Yuuki Shikaya, Yuta Takase, Ryosuke Tadokoro, Ryo Nakamura, Masafumi Inaba, Yoshiko Takahashi
Summary: Gut peristaltic movements are crucial for effective transportation and digestion/absorption of ingested materials. The cellular functions underlying these movements along the gut axis during development are largely unexplored. By studying chicken embryonic gut, we found that peristaltic movements start from the posterior duodenum and become confined to specific regions during development. Manipulations of the enteric nervous system disrupted the distribution patterns of peristaltic waves and affected the transportation of ingested material. We also discovered a functional coupling between the hindgut and cloaca.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Julia Doroszkiewicz, Magdalena Groblewska, Barbara Mroczko
Summary: The interaction between the gut microbiome and the brain plays a significant role in the development of neurological disorders, including neurodegenerative diseases and neuropsychological disorders. Balanced gut microbiota composition presents new potential opportunities for therapeutic interventions in these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Bharathi N. Palanisamy, Souvarish Sarkar, Emir Malovic, Manikandan Samidurai, Adhithiya Charli, Gary Zenitsky, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G. Kanthasamy
Summary: Exposure to environmental neurotoxic pesticides impairs mitochondrial bioenergetics and activates inflammatory pathways in enteric glial cells (EGCs), leading to gut dysfunction.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Review
Developmental Biology
Yi-Ning Kang, Candice Fung, Pieter Vanden Berghe
Summary: This review focuses on the innervation of the gut during embryonic development, highlighting the importance of intrinsic and extrinsic nerves in ensuring proper gut function. The three-dimensional architecture of innervation and the differences in development along the longitudinal and circumferential axes of the gut are discussed. In addition, the formation of intrinsic and extrinsic innervation, as well as the potential influences of external microbial and nutritional cues or neuroimmune interactions on gut innervation development, are reviewed.
Review
Neurosciences
Steven Fried, Eve Wemelle, Patrice D. Cani, Claude Knauf
Summary: This article discusses the interaction between gut microbiota and the brain, focusing on the enteric nervous system as an intermediate partner, and proposes the impact of microbes on the whole body. Research suggests that microbes may influence brain function through the gut-brain axis, affecting neurodegenerative and metabolic disorders.
Review
Allergy
Laura R. Dowling, Michael R. Strazzari, Simon Keely, Gerard E. Kaiko
Summary: The gut-brain axis refers to the bidirectional interaction between the intestinal environment, including the epithelium, immune system, microbiota, and the enteric nervous system. This interaction plays a crucial role in linking environmental stimuli and nervous system function, as well as providing feedback from the brain to intestinal activities. The gut microbiota has a profound influence on these processes, which has not been extensively studied. Disruption of the gut microbiota is associated with both gut diseases and brain symptoms such as neurodegenerative and behavioral disorders.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Marine Mantel, Pascal Derkinderen, Kalyane Bach-Ngohou, Michel Neunlist, Malvyne Rolli-Derkinderen
Summary: The enteric nervous system (ENS) is able to integrate signals to accurately regulate digestive functions. The ENS produces n-6 oxylipins, derived from arachidonic acid, which play a major role in various physiological processes. The study of these oxylipins on digestive functions and their interaction with the ENS is expanding.
FRONTIERS IN MEDICINE
(2023)
Review
Geriatrics & Gerontology
Zi-Han Geng
Summary: The GI tract plays a crucial role in maintaining the stable intestinal microenvironment and its microbiota may have potential impacts on neurological diseases. However, the causal relationship between microbial changes and neurological disorders remains inconclusive at present.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Zhixin Li, Elly Sau-Wai Ngan
Summary: With the rapid development of single-cell sequencing technologies, the use of single-cell multimodal sequencing has become a powerful strategy in discovering rare cells and understanding biological processes. This article summarizes recent findings in single-cell multimodal sequencing, particularly focusing on single-cell RNA sequencing (scRNA-seq) in the enteric nervous system (ENS). The studies have revealed the heterogeneity of ENS cells at different developmental stages and identified novel cell types. The application of single-cell multimodal omics techniques in profiling disease mechanisms and cellular drug responses is expected to revolutionize biomedical research.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Review
Medicine, General & Internal
Marvin Bubeck, Christoph Becker, Jay V. Patankar
Summary: The intestinal mucosal surface, which is in direct contact with the environment, plays a crucial role in maintaining homeostasis through the coordinated actions of immune, epithelial, and neuronal cells. The enteric nervous system has been found to have important functions in regulating and maintaining the integrity of the epithelial barrier. This review provides a comprehensive understanding of the neuro-immune-epithelial mechanisms ensuring intestinal barrier integrity and maintenance of intestinal homeostasis.
FRONTIERS IN MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Richard A. Guyer, Jessica L. Mueller, Allan M. Goldstein
Summary: With the advancement of technology, single-cell sequencing has become a common tool to analyze cellular diversity and reveal cellular diversity within organs. The application of these methods in the study of the enteric nervous system has provided abundant data and biological insights. As technology continues to evolve, these methods may become commonplace in enteric nervous system research and diagnostic testing.
Article
Infectious Diseases
Giulia Bernabe, Mahmoud Elsayed Mosaad Shalata, Veronica Zatta, Massimo Bellato, Andrea Porzionato, Ignazio Castagliuolo, Paola Brun
Summary: The side effects of antibiotic treatment are directly related to intestinal dysbiosis. This study examined the long-term effects of antibiotic-induced dysbiosis on the enteric nervous system and the impact of spontaneous restoration of gut microbiota on gastrointestinal functions. Two weeks of antibiotic treatment significantly altered gut microbial composition, and some bacterial genera did not regain their abundance after six weeks of discontinuation.
Article
Cell Biology
Hailing Yao, Huiying Shi, Chen Jiang, Mengke Fan, Yurui Zhang, Wei Qian, Rong Lin
Summary: The study revealed that L-Fucose could promote neurogenesis and gliogenesis derived from ENPCs by inhibiting the SMAD2 signaling, facilitating ENS regeneration and gastrointestinal motility recovery in type 1 diabetic mice.
CELL COMMUNICATION AND SIGNALING
(2023)
Review
Neurosciences
Chang Liu, Jing Yang
Summary: Enteric glial cells (EGCs) play important roles in the gastrointestinal tract by supporting the survival and functions of enteric nervous system (ENS) neurons, and potentially participating in the immune homeostasis of the gut. This review article summarizes the potential involvement of EGCs in immunological disorders such as inflammatory bowel disease, celiac disease, and autoimmune enteropathy, and highlights key questions for future research on the immunological aspects of EGCs.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Yue Ji, Paul Kwong-Hang Tam, Clara Sze-Man Tang
Summary: The development of the enteric nervous system relies on the interaction between enteric neural crest cells and the neural stem cell niche. Defects in ENCCs may lead to ENS dysfunction. HSCR patients may have niche defects affecting ECM-cell interaction, suggesting the need for complementary therapies involving drugs and niche-based treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biophysics
Juliane Grimm, Marius Bill, Madlen Jentzsch, Stefanie Beinicke, Janine Haentschel, Karoline Goldmann, Julia Schulz, Michael Cross, Georg-Nikolaus Franke, Gerhard Behre, Vladan Vucinic, Wolfram Poenisch, Thoralf Lange, Dietger Niederwieser, Sebastian Schwind
BONE MARROW TRANSPLANTATION
(2019)
Article
Pathology
Georg-Nikolaus Franke, Jacqueline Maier, Kathrin Wildenberger, Michael Cross, Francis J. Giles, Martin C. Mueller, Andreas Hochhaus, Dietger Niederwieser, Thoralf Lange
JOURNAL OF MOLECULAR DIAGNOSTICS
(2020)
Article
Oncology
Thoralf Lange, Christian Niederwieser, Arthur Gil, Rainer Krahl, Ulrich von Gruenhagen, Haifa Kathrin Al-Ali, Kathleen Jentsch-Ullrich, Claudia Spohn, Volker Lakner, Michael Assmann, Christian Junghanss, Michael Cross, Ruediger Hehlmann, Michael Deininger, Markus Pfirrmann, Dietger Niederwieser
LEUKEMIA & LYMPHOMA
(2020)
Review
Biochemistry & Molecular Biology
Georg-Nikolaus Franke, Anne Sophie Kubasch, Michael Cross, Vladan Vucinic, Uwe Platzbecker
MOLECULAR ASPECTS OF MEDICINE
(2020)
Article
Oncology
Vladan Vucinic, Madlen Jentzsch, Sebastian Schwind, Enrica Bach, Sabine Leiblein, Yvonne Remane, Susanne Rieprecht, Sandra Otto, Anne-Sophie Kubasch, Gerhard Behre, Michael Cross, Uwe Platzbecker, Georg-Nikolaus Franke
FRONTIERS IN ONCOLOGY
(2020)
Article
Oncology
Manja Wobus, Anna Mies, Nandini Asokan, Uta Oelschlaegel, Kristin Moebus, Susann Winter, Michael Cross, Heike Weidner, Martina Rauner, Lorenz C. Hofbauer, Martin Bornhaeuser, Uwe Platzbecker
Summary: This study shows that luspatercept can restore ineffective hematopoiesis in MDS patients by modulating the functional properties of MSCs in the bone marrow microenvironment.
Article
Hematology
Thomas Heinicke, Rainer Krahl, Christoph Kahl, Michael Cross, Sebastian Scholl, Hans-Heinrich Wolf, Detlev Haehling, Ute Hegenbart, Norma Peter, Antje Schulze, Axel Florschuetz, Schmidt Volker, Kolja Reifenrath, Niklas Zojer, Christian Junghanss, Herbert G. Sayer, Georg Maschmeyer, Spath Christian, Andreas Hochhaus, Thomas Fischer, Haifa Kathrin Al-Ali, Dietger Niederwieser
Summary: Relapse of acute leukemia is a common complication with uncertain outcomes, affecting both younger and older patients. Factors such as hematopoietic cell transplantation and long-term remission are beneficial, while challenges remain in the treatment and prognosis of relapse.
ANNALS OF HEMATOLOGY
(2021)
Correction
Hematology
Thomas Heinicke, Rainer Krahl, Christoph Kahl, Michael Cross, Sebastian Scholl, Hans-Heinrich Wolf, Detlev Haehling, Ute Hegenbart, Norma Peter, Antje Schulze, Axel Florschuetz, Volker Schmidt, Kolja Reifenrath, Niklas Zojer, Christian Junghanss, Herbert G. Sayer, Georg Maschmeyer, Christian Spaeth, Andreas Hochhaus, Thomas Fischer, Haifa Kathrin Al-Ali, Dietger Niederwieser
ANNALS OF HEMATOLOGY
(2021)
Article
Oncology
Kristin Gerhardt, Madlen Jentzsch, Thomas Georgi, Aleksandra Sretenovi, Michael Cross, Enrica Bach, Astrid Monecke, Sabine Leiblein, Sandra Hoffmann, Milena Todorovi, Jelena Bila, Osama Sabri, Sebastian Schwind, Georg-Nikolaus Franke, Uwe Platzbecker, Vladan Vucinic
Summary: The study reports two heavily pretreated patients with different types of lymphoma who relapsed after CAR T-cell therapy and achieved complete metabolic remission after Pola-BR therapy, followed by alloHSCT treatment and disease-free survival post-operation. The findings suggest that Pola-BR may be an effective bridging therapy before alloHSCT for patients relapsing after CAR T-cell therapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Hematology
Vladan Vucinic, Madlen Jentzsch, Sabine Leiblein, Enrica Bach, Yvonne Remane, Kai Schulze-Forster, Michael Cross, Wolfram Poenisch, Sebastian Schwind, Georg-Nikolaus Franke, Uwe Platzbecker, Dietger Niederwieser
Summary: The study found that stem cell mobilization with pegfilgrastim is a feasible and attractive option. Among the 28 related donors examined, 75% had a CD34+ count >50 cells/mu l on day four, and 89% of donors had CD34+ yields >= 4 x 10/kg body weight of the recipient. All grafts were administered without rejections.
Review
Cell Biology
Anna Stein, Uwe Platzbecker, Michael Cross
Summary: This article examines the different mechanisms of action of azanucleosides in the treatment of myeloid neoplasia and their impact on stem cell lineage commitment and neoplastic progression. It also discusses the efficacy of azanucleoside treatment in neoplasias without mutations in epigenetic regulators. Furthermore, the article summarizes recent data on the role of azacytidine-sensitive RNA methylation in lineage commitment and cellular response to stress.
Article
Biochemistry & Molecular Biology
Petra Buettner, Julia Boettner, Knut Krohn, Ronny Baber, Uwe Platzbecker, Michael Cross, Steffen Desch, Holger Thiele, Sabine Steiner, Dierk Scheinert, Klaus H. Metzeler, Daniela Branzan
Summary: In this pilot study, it was found that clonal hematopoiesis (CH)-associated mutations can be detected in both peripheral blood cells and tissues associated with atherosclerosis, suggesting a potential impact on disease physiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Hematology
Max Hansen, Lilly Stahl, Andreas Heider, Nadja Hilger, Ulrich Sack, Andreas Kirschner, Michael Cross, Stephan Fricke
Summary: This study analyzed the potential beneficial effects of syngeneic versus allogenic treatment, culture expansion of MSCs, and various MSC cell doses and time points of MSC transplantation in a murine GVHD model. The results showed that syngeneic treatment, culture-expanded cells, simultaneous administration, and high doses of UC-MSCs were more effective in reducing CD8(+) T cells, protecting mice from weight loss, and prolonging survival. This animal model of GVHD can be used for further detailed studies on the efficacy of MSCs from alternative sources.
TRANSPLANTATION AND CELLULAR THERAPY
(2021)
Article
Cell & Tissue Engineering
Waseem Nasr, Claire Fabian, Katrin Arnold, Ulrike Koehl, Ulrich Sack, Ronald Weiss, Michael Cross, Sunna Hauschildt
STEM CELL REVIEWS AND REPORTS
(2020)
Article
Hematology
Madlen Jentzsch, Marius Bill, Juliane Grimm, Julia Schulz, Stefanie Beinicke, Janine Haentschel, Karoline Goldmann, Wolfram Poenisch, Georg-Nikolaus Franke, Vladan Vucinic, Michael Cross, Gerhard Behre, Thoralf Lange, Dietger Niederwieser, Sebastian Schwind