Review
Multidisciplinary Sciences
Amanda J. Krause, Erin H. Walsh, Philip A. Weissbrod, Tiffany H. Taft, Rena Yadlapati
Summary: Laryngopharyngeal reflux (LPR) is a syndrome caused by the reflux of gastric contents into the pharynx or larynx, leading to a variety of symptoms. Treatment options for LPR include medical therapies such as proton pump inhibitors and noninvasive treatment options like lifestyle therapy. Due to the complexity of patients with LPR, a treatment algorithm is proposed to assist clinicians in diagnosing and treating patients effectively.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Review
Medicine, Research & Experimental
Bettina Julia Wolf, Kathrin Kusch, Victoria Hunniford, Barbara Vona, Robert Kuhler, Daniel Keppeler, Nicola Strenzke, Tobias Moser
Summary: Hearing impairment is a common sensory deficit affecting millions of people worldwide, and there is a lack of effective treatment. Collaboration with cochlear implant users and the development of new therapies offer potential solutions for improving hearing restoration. Gene therapy and major innovations in cochlear implants are likely to be clinically translated within this decade.
EMBO MOLECULAR MEDICINE
(2022)
Article
Environmental Sciences
Manasa Reddy, Mohammad Heidarinejad, Brent Stephens, Israel Rubinstein
Summary: Indoor air quality in nursing homes often exceeds outdoor levels, which may adversely affect the health of elderly residents who are more susceptible to air pollutants. Regular monitoring and improvement of indoor air quality in nursing homes can reduce medical expenditures and improve residents' quality of life.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Medicine, Research & Experimental
Jerome R. Lechien, Jacqueline E. Allen, Maria R. Barillari, Petros D. Karkos, Huan Jia, Fabio P. Ceccon, Rui Imamura, Osama Metwaly, Carlos M. Chiesa-Estomba, Jonathan M. Bock, Thomas L. Carroll, Sven Saussez, Lee M. Akst
Summary: Global practices of otolaryngologists in managing laryngopharyngeal reflux (LPR) vary significantly, from definitions and prevalence to diagnosis and treatment. International guidelines are needed to improve knowledge and management of LPR worldwide.
Review
Pharmacology & Pharmacy
Lena K. Schramm, Nadejda Monsefi, Joerg Hueser, Hubert Truebel, Thomas Mondritzki
Summary: The article introduces an evaluation method that combines expert assessment and literature search to assess unmet medical needs and support portfolio management decisions.
DRUG DISCOVERY TODAY
(2022)
Article
Health Care Sciences & Services
Denis Horgan, Bettina Borisch, Bogi Eliasen, Peter Kapitein, Andrew V. Biankin, Stefan Gijssels, Michael Zaiac, Marie-Helene Fandel, Jonathan A. Lal, Marta Kozaric, Barbara Moss, Ruggero De Maria, Marius Geanta, Frederique Nowak, Antoni Montserrat-Moliner, Olaf Riess
Summary: This article discusses the measures taken by the European Union to address unmet medical needs and evaluates the current approach. The paper points out that a rigid or restrictive legislative approach may hinder innovation and the development of valuable new treatments. It calls for reflection and suggests formulating legislation that allows for rapid adaptation to unexpected circumstances.
Review
Immunology
Jun Yuan, Jiarui Li, Ce Gao, Chun Jiang, Ze Xiang, Jian Wu
Summary: Colorectal cancer is a common malignant tumor with an increasing incidence in recent years. Immunotherapy, a hot topic in cancer therapy, has limited effectiveness on cold colorectal cancer. Researchers are focusing on developing immunotherapies to prevent colorectal cancer cells from escaping the immune system.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Otorhinolaryngology
Gui Chen, Weixing Liu, Wenjing Liao, Lijuan Song, Pingchang Yang, Xiaowen Zhang
Summary: This study found high detection rates of GERD and LPRD at the digestive endoscopy center in Guangzhou, China. Older age, BMI >= 24.0 kg/m(2), smoking, and drinking history were identified as risk factors for both GERD and LPRD. Neither GerdQ nor RSI scores included common extraesophageal symptoms.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Medicine, General & Internal
Ivan Abicic, Marina Covic, Milorad Zjalic, Marina Bakula, Ksenija Marjanovic, Anamarija Sestak, Branko Dmitrovic, Tihana Mendes, Martina Smolic, George Y. Wu, Hrvoje Mihalj, Zeljko Zubcic, Andrijana Vceva
Summary: In recent years, the prevalence of laryngopharyngeal reflux has increased, especially among pediatric patients. This study investigated the correlation between laryngeal and pharyngeal manifestations of laryngopharyngeal reflux, pepsin presence in saliva, and palatine tonsils in a pediatric population. Although no statistically significant differences were found, elevated index values consistently trended higher in the group with pepsin presence in tonsillar tissue.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Jerome R. Lechien, Stephane Hans, Francois Bobin, Christian Calvo-Henriquez, Sven Saussez, Petros D. Karkos
Summary: This study presented atypical clinical presentations of LPR in patients seen at a clinic in Europe, showcasing how LPR can manifest in various ways involving the mouth, eyes, tracheobronchial tract, nasal passages, or larynx. These atypical findings were resolved with appropriate treatment, highlighting the importance of recognizing diverse symptoms of LPR for effective management.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Eliana Barrenho, Reka Halmai, Marisa Miraldo, Ivan Tzintzun, Setti Rais Ali, Lea Toulemon, Jean-Claude K. Dupont, Lise Rochaix
Summary: This study measures the inequality and inequity in the distribution of clinical trials on cancer drug development between 1996 and 2016. The findings show disparities in clinical trial activity and research investment between rare and non-rare cancers, with differences across different stages of research and changes over time.
SOCIAL SCIENCE & MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Yannick Degboe, Remy Poupot, Mary Poupot
Summary: Monocytes and macrophages play a crucial role in the immune system, detecting and eradicating danger signals while maintaining tissue homeostasis. Imbalance in their response can lead to pathological disorders, and repolarization of these unbalanced macrophages shows promise as a therapeutic strategy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Gastroenterology & Hepatology
Joan W. Chen, Marcelo F. Vela, Kathryn A. Peterson, Dustin A. Carlson
Summary: This article provides practical advice for the clinical management of patients with suspected extraesophageal gastroesophageal reflux disease. The advice is based on available evidence from published studies, clinical trials, and clinical guidelines. It emphasizes the importance of considering extraesophageal manifestations of gastroesophageal reflux disease and the need for a multidisciplinary approach in diagnosis and treatment.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Cell Biology
Madison I. J. Honey, Yorrick R. J. Jaspers, Marc Engelen, Stephan Kemp, Irene C. Huffnagel
Summary: X-linked adrenoleukodystrophy (ALD) is a genetic disease caused by mutations in the ABCD1 gene, with no existing molecular markers available to quantify disease severity or predict clinical outcomes. Despite limitations in ALD biomarker studies, the growing number of biobanks and introduction of newborn screening provide unique opportunities for identifying and evaluating new biomarkers. The studies have generated a list of potential biomarker candidates, but further research is needed to address existing shortcomings and guide future biomarker research.
Article
Pharmacology & Pharmacy
Angelica Petrillo, Piera Federico, Gianpaolo Marte, Carlo Liguori, Andreas Seeber, Margaret Ottaviano, Andrea Tufo, Bruno Daniele
Summary: Gastric cancer is a lethal disease, and diagnosing it in young people is a significant challenge from both an individual and societal perspective. Early-onset gastric cancer accounts for around 5% of cases, with 3% being part of a hereditary syndrome and the majority being sporadic. However, the increasing number of early-onset cases in recent decades has generated increased interest and awareness in society and the scientific community. This article provides an updated overview of non-hereditary early-onset gastric cancer, which is currently an unmet clinical need, and explores future perspectives in this field.
CURRENT OPINION IN PHARMACOLOGY
(2023)
