Review
Biochemistry & Molecular Biology
Kazunori Kageyama, Yasumasa Iwasaki, Makoto Daimon
Summary: This review focuses on the molecular mechanisms of CRF regulation in the hypothalamus during stress and stress resilience, highlighting the central role of CRF in regulating the stress response. The involvement of ACTH, glucocorticoids, various regulatory factors, and different CRF receptors in stress resilience are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Michael T. Bardo, Lindsey R. Hammerslag, Samantha G. Malone
Summary: Early life adversity can increase vulnerability to drug abuse by influencing neurobiological factors, with CRF and OT systems playing key roles in mediating the link between early life stressors and drug abuse vulnerability.
Article
Biology
Alessandra Caruso, Alessandra Gaetano, Sergio Scaccianoce
Summary: CRH plays a role in regulating multiple biological systems, and is also associated with reproduction, neuropsychiatric, gastrointestinal, immune disorders, and tumor development. Further research on the physiological functions of CRH will help determine its role in human diseases and may serve as novel therapeutic targets.
Article
Medicine, General & Internal
Lei Guo, Yang-Jian Qi, Hong Tan, Dan Dai, Rawien Balesar, Arja Sluiter, Joop van Heerikhuize, Shao-Hua Hu, Dick F. Swaab, Ai -Min Bao
Summary: Increased expression of OXT in PVN and OXTR in DLPFC are characteristic for male BD patients. Stimulation of PVN-OXT neurons induced mood changes in mice, in a pattern different from BD.
Review
Cell Biology
Mirmohammadali Mirramezani Alizamini, Mojdeh Fattahi, Fatemeh Sayehmiri, Abbas Haghparast, Jing Liang
Summary: Stress plays a significant role in psychiatric disorders, particularly depression. Impairment of the prefrontal cortex (PFC) is associated with cognitive and executive deficits caused by stress. This review examines the potential use of the corticotropin-releasing factor (CRF) system within the PFC as a treatment for stress-induced depression. The results suggest that modulating CRF receptors within the PFC can regulate depression caused by stress, but further research is needed to determine the most effective treatment.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yukiomi Nakade, Rena Kitano, Taeko Yamauchi, Satoshi Kimoto, Kazumasa Sakamoto, Tadahisa Inoue, Yuji Kobayashi, Tomohiko Ohashi, Yoshio Sumida, Kiyoaki Ito, Masashi Yoneda
Summary: The study showed that central corticotropin-releasing factor (CRF) affects hepatic de novo lipogenesis and inflammation-related gene expression in rats through the sympathetic-noradrenergic nervous system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Mirmohammadali Mirramezani Alizamini, Xing Chen, Lina Nie, Zhonghua Dai, Ying Liu, Abbas Haghparast, Ning Wu, Jianjun Zhang, Fang Shen, Nan Sui, Jing Liang
Summary: Chronic stress can lead to a bias towards habitual behavioral strategies, and it is still unclear which neuronal system modulates stress-induced behavioral abnormalities during decision making. This study found that the corticotropin-releasing factor (CRF) system in the medial prefrontal cortex (mPFC) plays a critical role in governing strategy choice and stress response. Antagonists of CRF receptor 1 (CRFR1) can alleviate stress-induced behavioral abnormalities, suggesting that CRFR1 may be a potential target for treating chronic stress-altered behavior.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Mizuki Tasso, Kazunori Kageyama, Yasumasa Iwasaki, Yutaka Watanuki, Kanako Niioka, Shinobu Takayasu, Makoto Daimon
Summary: This study investigated the regulatory role of GDF15 in Crf gene expression in hypothalamic cells under stressful conditions. The results demonstrated that GDF15 increased Crf promoter activity and mRNA levels through activating GFRAL protein and subsequent activation of AKT and cAMP signaling pathways.
Article
Biochemistry & Molecular Biology
Julia Winter, Magdalena Meyer, Ilona Berger, Melanie Royer, Marta Bianchi, Kerstin Kuffner, Sebastian Peters, Simone Stang, Dominik Langgartner, Finn Hartmann, Anna K. Schmidtner, Stefan O. Reber, Oliver J. Bosch, Anna Bludau, David A. Slattery, Erwin H. van den Burg, Benjamin Jurek, Inga D. Neumann
Summary: Chronic oxytocin treatment in rats leads to increased anxiety-like behavior, with females showing higher sensitivity, contrasting the known anxiolytic effects of acute oxytocin. The behavioral effects are linked to alternative splicing of hypothalamic corticotropin-releasing factor receptor 2 alpha (Crfr2 alpha), shifting towards the expression of the anxiogenic soluble form (sCRFR2 alpha). This alternative splicing and release of sCRFR2 alpha into the cerebrospinal fluid positively correlate with anxiety-like behavior.
MOLECULAR PSYCHIATRY
(2021)
Article
Veterinary Sciences
Ginevra Brocca, Angela Rebesco, Massimo Castagnaro, Emanuele Ricci
Summary: The study aims to find a suitable immunohistochemical marker for the assessment of suffering in Veterinary Forensic Pathology by analyzing the expression of CRF in dogs' brains. CRF is identified as a promising marker of stress in abused patients, demonstrating its significance in Veterinary Medicine.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Endocrinology & Metabolism
Lierni Ugartemendia, Rose M. De Guzman, Jing Cai, Shivakumar Rajamanickam, Zhiying Jiang, Jonathan Tao, Damian G. Zuloaga, Nicholas J. Justice
Summary: Oxytocin is crucial for successful reproduction and maternal behavior. This study reveals that a subset of oxytocin neurons express the stress neuropeptide receptor CRFR1 in reproductive females. The expression of CRFR1 increases during the postpartum period and is maintained even after breeding ceases. This finding suggests a mechanism by which stress can influence oxytocin release and promote stress resilience in mothers.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Emi Kasama, Miho Moriya, Ryuma Kamimura, Tohru Matsuki, Kenjiro Seki
Summary: The study revealed that knockdown of hypothalamic corticotropin-releasing factor enhances the induction of false fear memories, while overexpression enhances the onset of false fear memory formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yurika Hata, Takahiro Shimizu, Suo Zou, Masaki Yamamoto, Yohei Shimizu, Hideaki Ono, Takaaki Aratake, Shogo Shimizu, Youichirou Higashi, Nobutaka Shimizu, Takashi Karashima, Motoaki Saito
Summary: This study investigated the effects of central CRF on micturition and the involvement of CRF receptor subtypes and glutamatergic receptors. The results suggest that stimulation of brain CRFR1 may facilitate rat micturition via brain NMDA/AMPA receptors.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Anesthesiology
Zheng Xu, Yu Zhou, Qingchen Guo, Di Wang, Yi-Hong Gao, Wei -Nan Zhao, Hui-Mei Tang, Jun-Xia Yang, Xiaolu Yu, Hai -Lei Ding, Jun -Li Cao
Summary: PVNCRF neurons in the paraventricular nucleus of the hypothalamus play a role in isoflurane anesthesia and its modulation by acute stress. Inhibition of PVNCRF neurons can facilitate emergence from anesthesia, while activation of these neurons delays emergence.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Environmental Sciences
Xue Liu, Jiaqian Feng, Zhijing Jiang, Guangbo Zhang, Xiuwen Xu, Jixiu Wang, Jingwen Yang, Tianming Wang
Summary: In the neuroendocrine system, corticotropin-releasing hormone (CRH) activates CRHRs and plays a vital role in the HPA/HPI axis. Two CRHR1 subtypes, LcCRHR1-1 and LcCRHR1-2, were identified in Larimichthys crocea genome and were found to be highly homologous to known teleost CRHRs. These receptors were found to be localized in the cell membrane and respond to LcCRH by increasing cAMP, Ca2+ and mitogen-activated protein kinase phosphorylation. LcCRHR1s were expressed in various tissues, with high expression in the brain and ovaries, and shown to be specifically localized in ovarian follicle cells. This study suggests that the CRH/CRHR1 system may be involved in the neuroendocrine regulation of reproduction in L. crocea.
FRONTIERS IN MARINE SCIENCE
(2023)