Article
Biochemistry & Molecular Biology
Zhiqiang Zhang, Qi Li, Yongxiong Huang, Zhou Xu, Xinjin Chen, Baijian Jiang, Yu Huang, Jichang Jian
Summary: This study identified and characterized the VIP precursor gene and its receptor gene in Nile tilapia, and investigated their roles in immune modulation and protection against bacterial infection. The results showed that both genes were highly expressed in the intestine and induced by Streptococcus agalatiae. In vitro and in vivo experiments demonstrated immune functions of VIP, including inflammation suppression and promotion of apoptosis and pyroptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Kotaro Sakamoto, Satoshi Asano, Yukio Ago, Takatsugu Hirokawa
Summary: In this study, the binding mechanism between VIPR2 and KS-133 was elucidated through the construction of models and simulations. The study also discovered the functional significance of the S-S bond formation between Cys residues in VIPR2.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Oncology
Sanam Shahid, Brian H. Kushner, Shakeel Modak, Ellen M. Basu, Elyssa M. Rubin, Gunes Gundem, Elli Papaemmanuil, Stephen S. Roberts
Summary: In rare cases of high-risk neuroblastoma (HR-NB), vasoactive intestinal peptide-related diarrhea (VIP-D) can be effectively treated with BRAF and MEK inhibitors, resolving symptoms associated with BRAF V600E mutations. This therapeutic strategy allows continued conventional tumor-directed treatment in HR-NB patients, reducing the severity of complications caused by VIP-D.
PEDIATRIC BLOOD & CANCER
(2021)
Review
Endocrinology & Metabolism
Xintong Hou, Dan Yang, Guimei Yang, Mengnan Li, Jian Zhang, Jiaxin Zhang, Yi Zhang, Yunfeng Liu
Summary: This review summarizes the physiological significance of vasoactive intestinal peptide (VIP) in glucose homeostasis and the potential therapeutic value of VPAC2-selective agonists in type 2 diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Xiaofan Song, Shanyao Pi, Yueming Gao, Fengxia Zhou, Shuqi Yan, Yue Chen, Lei Qiao, Xina Dou, Dongyan Shao, Chunlan Xu
Summary: The study demonstrated that VIP pretreatment inhibited the activation of mast cells and the release of certain enzymes. The protective effect of L. casei ATCC 393 on ETEC K88-induced intestinal mucosal immune barrier dysfunction was abolished by aVIP.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Raul Villanueva-Romero, Alicia Cabrera-Martin, Emigdio alvarez-Corrales, Mar Carrion, Selene Perez-Garcia, Amalia Lamana, David Castro-Vazquez, Carmen Martinez, Rosa P. Gomariz, Irene Gutierrez-Canas, Yasmina Juarranz
Summary: This study investigates the behavior of human CD4(+)CD45RA(+) T cells after in vitro activation and the role of the VIP system in this process. The findings show that without polarizing conditions, these T cells mainly differentiate into pathogenic Th17 subset and an unpaired Treg subset. The study also confirms the important immunomodulatory role of VIP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Evgeny Privalov, Matthias Zenkel, Ursula Schloetzer-Schrehardt, Stefanie Kuerten, Antonio Bergua, Bettina Hohberger
Summary: The purpose of this study was to investigate the level of choroidal VIP (VIPchor) in the presence of an increased atmospheric pressure in a chicken model. The results showed that VIPchor level was significantly increased at 40 mmHg compared to the ambient pressure. This finding suggests that the accumulation of VIP within the neurons would decrease vasodilation and choroidal thickness.
Article
Immunology
Yusheng Li, Hengzhen Li, Lijie Wang, Wenqing Xie, Dongliang Yuan, Zeqin Wen, Tiancheng Zhang, Jieyu Lai, Zixuan Xiong, Yunhan Shan, Wei Jiang
Summary: Targeting inflammatory pathways is important in treating osteoarthritis (OA), however, the role and mechanism of VIP in OA is unclear. This study found that the p65-LOC727924-miR-26a/KPNA3-p65 regulatory loop modulates various phenotypes in OA chondrocytes, including cell apoptosis, ROS accumulation, extracellular matrix deposition, and inflammatory response.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Xiaoxi Xie, Chong Geng, Xiao Li, Juan Liao, Yanni Li, Yaoyu Guo, Chunhui Wang
Summary: The intestinal barrier is a dynamic multilayer system that prevents the passage of harmful substances into the body and maintains the normal development of the gut barrier and the immune system. Gut barrier damage is associated with various intestinal and extraintestinal diseases. Gastrointestinal peptides, such as somatostatin and vasoactive intestinal peptide, play a crucial role in regulating the intestinal barrier by enhancing epithelial barrier activity and restoring gut barrier function.
Review
Medicine, General & Internal
Emanuele Sinagra, Gaia Pellegatta, Marcello Maida, Francesca Rossi, Giuseppe Conoscenti, Socrate Pallio, Rita Alloro, Dario Raimondo, Andrea Anderloni
Summary: CIIPO is a disease characterized by symptoms of small bowel obstruction in the absence of mechanical obstruction, with a hypothesis that various viruses localized in the intestine may play a role in its pathogenesis. This review aims to summarize new perspectives in the etiology and pathophysiology of CIIPO.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Developmental Biology
Kevin M. Goff, Ethan M. Goldberg
Summary: VIP-INs in the cerebral cortex play a crucial role in regulating network dynamics and normal circuit development, with implications in sensory input, development, and behavior. Underexplored disease-associated genes highly expressed in VIP-INs may broadly implicate them in autism spectrum disorder and intellectual disability. Further cell type-specific investigations and targeted therapeutics are discussed in the context of genomic diagnosis.
DEVELOPMENTAL NEUROSCIENCE
(2021)
Article
Endocrinology & Metabolism
Liu Shi, Yang Liu, Zhengmeng Yang, Tianyi Wu, Hiu Tung Lo, Jia Xu, Jiajun Zhang, Weiping Lin, Jinfang Zhang, Lu Feng, Gang Li
Summary: Vasoactive intestinal peptide (VIP) plays a significant role in modulating bone homeostasis and promoting fracture healing. Study on sympathectomized mice models showed that VIP treatment can rescue the inhibitory effects of sympathetic nervous system disorder on bone structure and fracture healing, leading to improved bone quality and mechanical properties. VIP administration inhibits bone resorption and enhances osteogenesis marker expression, suggesting VIP as a potential alternative treatment for fracture healing.
CALCIFIED TISSUE INTERNATIONAL
(2021)
Review
Medicine, Research & Experimental
Hong-Lin Zhong, Pei-Ze Li, Di Li, Cha-Xiang Guan, Yong Zhou
Summary: This review discusses the function of VIP in various lung diseases and outlines its limitations as a potential medication, as well as provides information on extended-release formulations and VIP analogues.
Article
Biochemistry & Molecular Biology
Hatice Deniz Ilhan, Betul Unal, Yusuf Ayaz, Nuray Erin
Summary: This study found a close association between the recurrence of pterygium and increased levels of Substance P and Vasoactive Intestinal Peptide (VIP) in TRPV1-positive nerve fibers. Changes in TRPV1 expression were also observed in recurrent cases. These findings suggest a potential role of TRPV1 in pterygium recurrence and indicate that inhibiting TRPV1 activity may help prevent pterygium recurrence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Jia-Xi Duan, Xin-Xin Guan, Hui-Hui Yang, Wen-Xiu Mei, Ping Chen, Jia-Hao Tao, Qing Li, Yong Zhou
Summary: The study demonstrates that VIP attenuates bleomycin-induced pulmonary fibrosis in mice through restoring autophagy in alveolar epithelial cells, with anti-epithelial-mesenchymal transition (EMT) effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Clinical Neurology
Massimiliano Pau, Micaela Porta, Gabriella Spinicci, Jessica Frau, Lorena Lorefice, Giancarlo Coghe, Eleonora Cocco
Summary: Nabiximols treatment improves spasticity symptoms and upper limb motor function in patients with multiple sclerosis, as confirmed by clinical tests and kinematic analysis.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Massimiliano Pau, Micaela Porta, Rita Bertoni, Fabiola Giovanna Mestanza Mattos, Eleonora Cocco, Davide Cattaneo
Summary: This study investigated the effectiveness of fully immersive VR-based treatments on upper limb motor function in people with Multiple Sclerosis (PwMS). The results showed that immersive VR training improved the speed and stability of hand-to-mouth movement in PwMS.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Review
Genetics & Heredity
Lorefice Lorena, Pitzalis Maristella, Murgia Federica, Fenu Giuseppe, Atzori Luigi, Cocco Eleonora
Summary: From the perspective of precision medicine, the challenge for the future is to improve the accuracy of diagnosis, prognosis, and prediction of therapeutic responses through the identification of biomarkers. Omics sciences provide innovative approaches for exploring the complexity and heterogeneity of multiple sclerosis (MS). This review examines the current evidence on the application of omics sciences to MS and focuses on biomarkers associated with disease state, exposure to disease-modifying treatments (DMTs), and drug efficacies and safety profiles.
FRONTIERS IN GENETICS
(2023)
Article
Immunology
Martina Kunkl, Carola Amormino, Francesco Spallotta, Silvana Caristi, Maria Teresa Fiorillo, Alessandro Paiardini, Raymond Kaempfer, Loretta Tuosto
Summary: Staphylococcus aureus superantigens (SAgs) like staphylococcal enterotoxin A (SEA) and B (SEB) can cause toxic shock and sepsis by stimulating T cells to produce excessive inflammatory cytokines. Using an AI-based algorithm, we have discovered a new mechanism of action for SAgs, showing that SEA and SEB can bind to TCR and CD28 independently of MHC class II- and B7-expressing antigen presenting cells, leading to inflammatory signal activation and massive cytokine secretion.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Massimiliano Pau, Eleonora Cocco, Federico Arippa, Giulia Casu, Micaela Porta, Shay Menascu, Anat Achiron, Alon Kalron
Summary: Rehabilitation through VR training tools allows safe and controlled repetitive practice for patients with upper-limb dysfunction. A novel immersive VR kitchen system was developed and tested on individuals with multiple sclerosis. The system demonstrated feasibility, safety, and high satisfaction among the participants.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Federica Murgia, Lorena Lorefice, Antonio Noto, Martina Spada, Jessica Frau, Giuseppe Fenu, Giancarlo Coghe, Antonella Gagliano, Luigi Atzori, Eleonora Cocco
Summary: Current treatment for Multiple Sclerosis (MS) involves multidisciplinary approach and disease-modifying therapies. Metabolomics is used to identify biomarkers/predictors of treatment response. This study evaluated metabolic changes in MS patients starting Fingolimod treatment, finding specific metabolomic features that predict therapeutic response and potential side effects. The results showed that Fingolimod influences aminoacidic and energy metabolisms and reduces oxidative stress and immune system activity, characteristic of MS.
Review
Biology
Jessica Frau, Giancarlo Coghe, Lorena Lorefice, Giuseppe Fenu, Eleonora Cocco
Summary: Multiple sclerosis (MS), neuromyelitis optica (NMO) and myelin oligodendrocyte glycoprotein antibody disease (MOGAD) are inflammatory diseases of the central nervous system (CNS) with a multifactorial aetiology. Microorganisms, such as Epstein-Barr virus (EBV) and Helicobacter pylori, play a role in the development and progression of these diseases. Molecular mimicry, epitope spreading, bystander activation, and the dual cell receptor theory are some of the mechanisms involved in their pathogenesis. Understanding the involvement of infectious factors in these diseases is crucial for their prevention and treatment.
Article
Health Care Sciences & Services
Andrea Giordano, Silvia Testa, Marta Bassi, Sabina Cilia, Antonio Bertolotto, Maria Esmeralda Quartuccio, Erika Pietrolongo, Monica Falautano, Monica Grobberio, Claudia Niccolai, Beatrice Allegri, Rosa Gemma Viterbo, Paolo Confalonieri, Ambra Mara Giovannetti, Eleonora Cocco, Maria Grazia Grasso, Alessandra Lugaresi, Elisa Ferriani, Ugo Nocentini, Mauro Zaffaroni, Alysha De Livera, George Jelinek, Alessandra Solari, Rosalba Rosato
Summary: This study evaluated the performance of MCAT on the MSQOL-54 and found that it had satisfactory performance in assessing the quality of life of patients with multiple sclerosis. Compared to the full-length MSQOL-54, the simulated MCAT required fewer items without losing precision for the general HRQOL factor.
HEALTH AND QUALITY OF LIFE OUTCOMES
(2023)
Article
Biochemistry & Molecular Biology
Valentina Tedeschi, Giorgia Paldino, Josephine Alba, Emanuele Molteni, Fabiana Paladini, Rossana Scrivo, Mattia Congia, Alberto Cauli, Rosalba Caccavale, Marino Paroli, Manuela Di Franco, Loretta Tuosto, Rosa Sorrentino, Marco D'Abramo, Maria Teresa Fiorillo
Summary: The HLA-B*27 family of alleles is strongly associated with ankylosing spondylitis (AS), but some non-associated HLA-B*27 variants have been found. The quantity of presented epitopes, rather than the quality, may explain the difference. The ERAP1/2 haplotype and the B*27:05 allele play crucial roles in shaping the CD8+ T cell response to viral and self-B*27 peptides.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Clinical Neurology
L. Lorefice, P. Mellino, G. Fenu, E. Cocco
Summary: New treatment options for active progressive MS have shown potential benefits, especially in the early stages of the disease. Evaluating the response to treatment in progressive MS goes beyond the concept of NEDA-3, which was initially designed for relapsing-remitting cases. This review explores the current perspectives and limitations in assessing treatment effectiveness, defining response criteria, and evaluating MS progression and patient perception.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Clinical Neurology
Lorena Lorefice, Giuseppe Fenu, Marzia Fronza, Federica Murgia, Jessica Frau, Giancarlo Coghe, Maria Antonietta Barracciu, Luigi Atzori, Stefano Angioni, Eleonora Cocco
Summary: This study investigates the influence of menopause on multiple sclerosis (MS), showing that menopause is associated with MS progression and brain atrophy.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
Angela Sanna, Massimiliano Pau, Giuseppina Pilia, Micaela Porta, Giulia Casu, Valentina Secci, Emanuele Cartella, Alessandro Demattia, Stefano Firinu, Chiara Pau, Antonio Milia, Eleonora Cocco, Paolo Tacconi
Summary: SCA 38 is a rare genetic disorder caused by a mutation in ELOV5 gene, leading to impairments in motor and cognitive functions. The study shows that cerebellar tDCS can improve these symptoms, but further quantitative analysis is needed to assess the efficacy of the treatment.
Review
Clinical Neurology
Diego Centonze, Maria Pia Amato, Vincenzo Brescia Morra, Eleonora Cocco, Nicola De Stefano, Claudio Gasperini, Paolo Gallo, Carlo Pozzilli, Maria Trojano, Massimo Filippi
Summary: Multiple sclerosis (MS) is a chronic neurological disease characterized by inflammation, degeneration, and demyelination. Cladribine tablets have been approved as an effective treatment option for highly active relapsing-remitting MS. A group of neurologists has proposed management pathways for patients completing the approved 4-year regimen, based on response to treatment and monitoring of disease activity. Re-treatment decisions should be made based on clinical and radiological assessments, as well as patient eligibility and preference.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2023)
Article
Medicine, Research & Experimental
Federica Murgia, Maura Fiamma, Silvia Serra, Giulia Marras, Raul Argiolas, Chiara Mattana, Maria Grazia Mattu, Maria Cristina Garau, Sonia Doneddu, Sabrina Olla, Eleonora Cocco, Lorena Lorefice, Sandro Muntoni, Peppino Paffi, Stefano Porru, Marta Abis, Saverio Bellizzi, Antonello Pani, Andrea Angioi, Gabriella Simbula, Michele Mussap, Orietta Massidda, Franco Carta, Luigi Atzori
Summary: Microbial secondary infections increase the risk of mortality in severe COVID-19 patients. This study evaluated the clinical, laboratory, and microbiological data of ICU patients with severe COVID-19 to determine their significance and prognostic value. 178 ICU patients from S. Francesco Hospital in Nuoro, Italy were enrolled. Blood chemistry parameters were analyzed at three time points using statistical approaches. 74% of ICU COVID-19 patients had a negative outcome, while 26% had a favorable prognosis. There were significant differences in laboratory parameters between the two groups. Staphylococcus aureus, Enterococcus faecalis, Candida spp, Pseudomonas aeruginosa, and Klebsiella pneumoniae were the most frequently isolated microorganisms.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Andrea Tacchino, Michela Ponzio, Paolo Confalonieri, Letizia Leocani, Matilde Inglese, Diego Centonze, Eleonora Cocco, Paolo Gallo, Damiano Paolicelli, Marco Rovaris, Loredana Sabattini, Gioacchino Tedeschi, Luca Prosperini, Francesco Patti, Placido Bramanti, Elisabetta Pedrazzoli, Mario Alberto Battaglia, Giampaolo Brichetto
Summary: This paper describes the design, development, and usability testing of MS Fitness Intervention Training (MS-FIT), a Kinect-based tool implementing customized Pilates exercises for people with MS. The user-centered design approach was used to create an accessible and challenging tool for balance training. The usability testing showed that MS-FIT is a promising system for enhancing the motivation and engagement of people with MS in performing exercises.
JMIR SERIOUS GAMES
(2023)