Article
Gastroenterology & Hepatology
Charlotte Desprez, Audrey Grange, Guillaume Gourcerol, Alexis Deperrois, Oriane Garconnet, Clemence Leroux, Gregory Mosni, Laurence Poux, Justine Breemeersch, Cecile Goblot, Sebastien Kepka, Julie Ruillon, Margot Vannier, Valerie Bridoux, Anne-Marie Leroi
Summary: Regular follow-up and reprogramming of stimulation parameters in patients with implanted SNM devices can optimize the efficacy of treatment for fecal incontinence.
COLORECTAL DISEASE
(2022)
Article
Gastroenterology & Hepatology
Anthony Y. Lin, Chris Varghese, Niranchan Paskaranandavadivel, Sean Seo, Peng Du, Phil Dinning, Ian P. Bissett, Greg O'Grady
Summary: The rectosigmoid brake was suppressed in patients with faecal incontinence, and sacral neuromodulation (SNM) may exert a therapeutic effect by modulating this rectosigmoid brake.
COLORECTAL DISEASE
(2022)
Article
Gastroenterology & Hepatology
K. Ong, L. Bordeianou, M. Brunner, S. Buntzen, M. H. S. Collie, A. Hanly, C. W. Hunt, K. E. Matzel, P. R. O'Connell, M. Rydningen, L. Savitt, A. Totaro, C. J. Vaizey, Y. Maeda
Summary: This study aimed to determine whether the paradigm of surgical intervention for faecal incontinence has changed between 2000 and 2013. The results showed an increasing use of sacral neuromodulation over time, indicating a shift in the surgical intervention paradigm for faecal incontinence.
COLORECTAL DISEASE
(2021)
Article
Gastroenterology & Hepatology
C. Seifarth, N. Slavova, C. Degro, K. S. Lehmann, M. E. Kreis, B. Weixler
Summary: This study evaluated the use of sacral nerve stimulation (SNS) in patients with high stool frequency or fecal incontinence after proctocolectomy with IPAA. The results showed that SNS improved symptoms in over two-thirds of patients, suggesting its feasibility as a therapeutic option in this patient population.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Article
Pediatrics
Stephen Trinidad, Amanda Jensen, Monica Holder, Allison Elsner, Nelson Rosen, Aaron Garrison, Beth Rymeski, Jason S. Frischer
Summary: This study evaluated the outcomes of sacral nerve stimulation (SNS) in patients with medically refractory fecal incontinence or severe constipation. A retrospective cohort study was conducted on patients who underwent SNS placement after failed medical management at a single center. The rates of involuntary bowel movements were compared pre- and post-SNS using a bowel severity score questionnaire.
JOURNAL OF PEDIATRIC SURGERY
(2023)
Article
Clinical Neurology
Luigi Valentino Berra, Daniele Armocida, Mauro Palmieri, Valerio Di Norcia, Luca D'Angelo, Massimo Mongardini, Massimo Vigliotta, Edoardo Maccari, Antonio Santoro
Summary: Reconstructing sacrificed nerves during sacral tumor removal has been proven effective in restoring sphincter and sexual function, offering promising potential to significantly enhance patients' quality of life.
Article
Gastroenterology & Hepatology
Mario de Miguel J. Valencia, Juan Cabases M. Hita, Eduardo Sanchez Iriso, Fabiola Oteiza Martinez, Inaki Alberdi Ibanez, Alfonso Alvarez Lopez, Hector Ortiz Hurtado, Mario J. de Miguel J. Velasco
Summary: The aim of this study was to evaluate the long-term cost-effectiveness of sacral neuromodulation in the treatment of severe faecal incontinence as compared with symptomatic management. The results showed that sacral neuromodulation may be considered a cost-effective technique in the long-term treatment of severe faecal incontinence from the societal and health care sector perspectives, with incremental cost-effectiveness ratios of 14347euro/QALY and 28523euro/QALY, respectively.
COLORECTAL DISEASE
(2023)
Article
Surgery
Luigi Brusciano, Antonio Brillantino, Gianluca Pellino, Franco Marinello, Coen I. M. Baeten, Alex Digesu, Gabriele Naldini, Claudio Gambardella, Francesco Saverio Lucido, Alessandro Sturiale, Giorgia Gualtieri, Stefan Riss, Ludovico Docimo
Summary: Sacral nerve modulation is a safe and effective treatment for fecal and double incontinence, improving symptoms, quality of life, and sexual function in the long term.
UPDATES IN SURGERY
(2023)
Article
Gastroenterology & Hepatology
M. Bosch-Ramirez, L. Sanchez-Guillen, M. J. Alcaide-Quiros, M. M. Aguilar-Martinez, M. Bellon-Lopez, A. Lopez Delgado, F. Lopez-Rodriguez-Arias, A. Munoz-Duyos, X. Barber-Valles, A. Arroyo
Summary: This study evaluated the long-term efficacy of percutaneous tibial nerve stimulation (PTNS) for patients with refractory faecal incontinence (FI), and found that after 1 year of treatment, the majority of patients achieved optimal responses, and even those who initially had only partial responses maintained long-term continence after 3 years.
TECHNIQUES IN COLOPROCTOLOGY
(2023)
Article
Gastroenterology & Hepatology
Judith Evers, P. Ronan O'Connell, James F. X. Jones
Summary: This study investigated the changes in the transmission of sensory anorectal stimuli in a rodent model of fecal incontinence and the effects of sacral nerve stimulation on defecation behavior. The results showed that chronic sacral nerve stimulation using miniature telemetric devices is feasible in rats and can improve fecal incontinence symptoms. The amplitude of anorectal evoked potentials was found to be negatively correlated with the behavioral signs of fecal incontinence.
DISEASES OF THE COLON & RECTUM
(2022)
Article
Urology & Nephrology
Jacqueline Zillioux, Kevin C. Lewis, Daniel Hettel, Howard B. Goldman, Sandip P. Vasavada, Bradley C. Gill
Summary: This study aimed to evaluate the impact of cognitive impairment (CI) diagnoses on sacral neuromodulation (SNM) outcomes in older patients with overactive bladder (OAB). The study found that a diagnosis of CI does not affect the implantation rates of SNM therapy for refractory OAB. Therefore, patients with OAB and CI diagnoses should not be excluded from SNM therapy.
NEUROUROLOGY AND URODYNAMICS
(2023)
Article
Gastroenterology & Hepatology
Guillaume Meurette, Laurent Siproudhis, Anne-Marie Leroi, Henri Damon, David Urs Josef Keller, Jean-Luc Faucheron
Summary: This study confirms the clinical effectiveness, safety, and positive effect of sacral neuromodulation with the InterStim(TM) system for the treatment of faecal incontinence, showing significant improvements in quality of life and symptoms with high patient satisfaction. Main device-related adverse events include the need for reprogramming, infection, and surgical revision.
COLORECTAL DISEASE
(2021)
Article
Gastroenterology & Hepatology
Assia Daikh, Fabienne Reymond, Dorothee Lombardo, Caroline Thuillier, Pierrick Bedouch, Jean-Luc Faucheron
Summary: Sacral nerve neuromodulation (SNM) is a safe and effective therapy for managing fecal and/or urinary incontinence. This study evaluated the lifespan of InterStim(TM) and InterStim(TM) II generators and the long-term hospital costs associated with SNM therapy. The results showed that the lifespan of InterStim(TM) II is shorter than the first-generation device, leading to increased hospital costs over time.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Article
Gastroenterology & Hepatology
Aaron J. Dawes, Juan O. Mariscal, Peter J. White, Emily F. Midura, Anne E. Sirany, Ann C. Lowry, Christine C. Jensen, Amy J. Thorsen
Summary: This study aimed to determine whether patients with rectoanal intussusception achieve similar benefits from device implantation to patients without rectoanal intussusception. The results showed that rectoanal intussusception does not affect the clinical outcomes or quality of life after sacral nerve stimulation for fecal incontinence. Therefore, patients with fecal incontinence and rectoanal intussusception can be considered for sacral nerve stimulation placement.
DISEASES OF THE COLON & RECTUM
(2023)
Article
Gastroenterology & Hepatology
Ye Xiao, Feng Xu, Lin Lin, Jiande D. Z. Chen
Summary: This study found that transcutaneous electrical acustimulation (TEA) at acupuncture point ST36 has positive effects on constipation and reduced rectal sensation. TEA can increase spontaneous bowel movements, reduce constipation symptoms, and improve quality of life. It can also decrease the sensation threshold for rectal distention and increase parasympathetic activity.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Emma V. Carrington, Henriette Heinrich, Charles H. Knowles, Mark Fox, Satish Rao, Donato F. Altomare, Adil E. Bharucha, Rebecca Burgell, William D. Chey, Guiseppe Chiarioni, Philip Dinning, Anton Emmanuel, Ridzuan Farouk, Richelle J. F. Felt-Bersma, Kee Wook Jung, Anthony Lembo, Allison Malcolm, Ravinder K. Mittal, Francois Mion, Seung-Jae Myung, P. Ronan O'Connell, Christian Pehl, Jose Maria Remes Troche, R. Matthew Reveille, Carolynne J. Vaizey, Veronique Vitton, William E. Whitehead, Reuben K. Wong, S. Mark Scott
NEUROGASTROENTEROLOGY AND MOTILITY
(2020)
Article
Gastroenterology & Hepatology
Celia Gouynou, Francois Philit, Francois Mion, Francois Tronc, Agathe Senechal, Joris Giai, Anne-Marie Rabain, Jean-Francois Mornex, Sabine Roman
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2020)
Article
Gastroenterology & Hepatology
Wei-Yi Lei, C. Prakash Gyawali, Wei-Chuan Chang, Sabine Roman, Ming Wun Wong, Chih-Hsun Yi, Tso-Tsai Liu, Jui-Sheng Hung, Shu-Wei Liang, Chien-Lin Chen
Summary: The study showed that performing water swallows during straight leg raise can improve esophageal peristaltic performance and predict esophageal contraction reserve.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Jan Tack, Ans Pauwels, Sabine Roman, Edoardo Savarino, Andre Smout
Summary: A European consensus was developed on the clinical application of esophageal high-resolution manometry (HRM), providing guidance on when to consider HRM, how to perform it, and how to interpret the results. Areas of uncertainty and lack of consensus were identified, particularly in terms of treatment implications, highlighting the need for future research in this area.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Isis K. Araujo, Sabine Roman, Marie Napoleon, Francois Mion
Summary: The study found that using solid food swallows (SFS) during esophageal motility assessment can improve diagnostic accuracy and is important for diagnosing clinically relevant disorders. The application of solid food swallows in HRM has a significant impact on changing diagnoses and can be widely used in daily clinical practice.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Frank Zerbib, Albert J. Bredenoord, Ronnie Fass, Peter J. Kahrilas, Sabine Roman, Edoardo Savarino, Daniel Sifrim, Michael Vaezi, Rena Yadlapati, C. Prakash Gyawali
Summary: The term refractory GERD is not as clear-cut as it may seem, with distinctions needed between different types of symptoms and objective evidence of GERD. Objective evaluation, including endoscopy and esophageal physiologic testing, is essential for understanding mechanisms of symptom generation and true refractory GERD. Attention should also be paid to potential contributors such as supragastric belching and rumination syndrome.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Rena Yadlapati, Peter J. Kahrilas, Mark R. Fox, Albert J. Bredenoord, C. Prakash Gyawali, Sabine Roman, Arash Babaei, Ravinder K. Mittal, Nathalie Rommel, Edoardo Savarino, Daniel Sifrim, Andre Smout, Michael F. Vaezi, Frank Zerbib, Junichi Akiyama, Shobna Bhatia, Serhat Bor, Dustin A. Carlson, Joan W. Chen, Daniel Cisternas, Charles Cock, Enrique Coss-Adame, Nicola de Bortoli, Claudia Defilippi, Ronnie Fass, Uday C. Ghoshal, Sutep Gonlachanvit, Albis Hani, Geoffrey S. Hebbard, Kee Wook Jung, Philip Katz, David A. Katzka, Abraham Khan, Geoffrey Paul Kohn, Adriana Lazarescu, Johannes Lengliner, Sumeet K. Mittal, Taher Omari, Moo In Park, Roberto Penagini, Daniel Pohl, Joel E. Richter, Jordi Serra, Rami Sweis, Jan Tack, Roger P. Tatum, Radu Tutuian, Marcelo F. Vela, Reuben K. Wong, Justin C. Wu, Yinglian Xiao, John E. Pandolfino
Summary: CCv4.0 is an updated classification scheme for esophageal motility disorders using HRM, developed by fifty-two international experts in seven subgroups over two years. Key updates include a more rigorous and expansive HRM protocol, refined definition of EGJOO, stricter criteria for ineffective esophageal motility, and description of baseline EGJ metrics. These changes aim to provide more standardized criteria for disorders of peristalsis and obstruction at the EGJ.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Kelli DeLay, John E. Pandolfino, Sabine Roman, C. Prakash Gyawali, Edoardo Savarino, Michael Tye, Alexander Kaizer, Rena Yadlapati
Summary: Supragastric belching (SGB) and rumination are behavioral disorders associated with proton pump inhibitor (PPI) non-response. This pilot study compared the diagnostic yield and inter-rater agreement for SGB and rumination using multichannel intraluminal impedance-pH (MII-pH) and post-prandial high-resolution impedance manometry (PPHRIM). Results showed that diagnostic accuracy and inter-rater agreement are higher for MII-pH than PPHRIM, and behavioral disorders are more frequently identified on PPHRIM. Clinical context is essential for accurate interpretation of the studies.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Review
Gastroenterology & Hepatology
Sabine Roman, Geoff Hebbard, Kee Wook Jung, Phil Katz, Radu Tutuian, Reuben Wong, Justin Wu, Rena Yadlapati, Daniel Sifrim
Summary: Distal esophageal spasm (DES) is characterized by premature contractions in the esophagus, often causing dysphagia or non-cardiac chest pain. Treatments for DES can be challenging, with endoscopic options like botulinum toxin and peroral endoscopic myotomy currently being evaluated. Further research is needed to understand the role of contractile vigor and lower esophageal sphincter hypercontractility in DES symptoms.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Letter
Gastroenterology & Hepatology
Jamila Lenz, Berenice Rault, Sabine Roman, Mathieu Pioche, Francois Mion
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2021)
Article
Otorhinolaryngology
Sabine Roman, Livia Anna Guadagnoli, Audrey Hastier, Estelle Becam, Meredith Ruth Ann Craven, John E. Pandolfino, Marie Napoleon, Dustin A. Carlson, Francois Mion, Tiffany Taft
Summary: The study found that the esophageal dysphagia questionnaire (BEDQ) is a valid clinical assessment tool in French, accurately reflecting the frequency and intensity of dysphagia in patients, and showing good correlation with other scoring tools. For patients undergoing examination, the BEDQ score is significantly higher in the dysphagia group compared to the GERD or other symptom groups.
Article
Gastroenterology & Hepatology
Barrett Rogers, Benjamin Rogers, Marzio Frazzoni, Edoardo Savarino, Sabine Roman, Daniel Sifrim, C. Prakash Gyawali
Summary: In pH-impedance studies, acidic reflux episodes in upright position with high proximal extent and longer acid clearance times have the highest concordance for identification by expert reviewers. Reflux episode identification may be influenced by reviewer opinions despite the availability of established criteria.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Gastroenterology & Hepatology
Sabine Roman, Livia Anna Guadagnoli, Audrey Hastier, Estelle Becam, Meredith Ruth Ann Craven, Marie Napoleon, John E. Pandolfino, Dustin A. Carlson, Francois Mion, Tiffany Taft
Summary: The study validated a French version of the esophageal hypervigilance and anxiety scale (EHAS), showing good internal consistency and reliability. The EHAS score was consistent between groups, demonstrating its utility in assessing psychological processes in patients with esophageal disorders. Further research is needed to explore its application in patient management.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Pauline Riviere, Blandine Vauquelin, Emiliane Rolland, Chloe Melchior, Sabine Roman, Stanislas Bruley des Varannes, Francois Mion, Guillaume Gourcerol, Sylvie Sacher-Huvelin, Frank Zerbib
Summary: The study found that both a low FODMAP diet and usual dietary advice had similar but limited beneficial effects on symptoms in patients with PPI refractory GERD.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Morgane Sallette, Jamila Lenz, Francois Mion, Sabine Roman
Summary: This study compared the frequency of motility disorders diagnosed with CCv3.0 and CCv4.0 and evaluated the severity of symptoms. The results showed that while the diagnoses remained mainly unchanged with both versions, CCv4.0 had a lower frequency of ineffective esophageal motility (IEM) compared to CCv3.0.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)