Review
Endocrinology & Metabolism
Jody A. Rusch, Brian T. Layden, Lara R. Dugas
Summary: Cognitive function in humans relies on the complex interplay between multiple body systems, including the HPA axis. The gut microbiota, which outnumbers human cells and has a greater genetic potential, plays a crucial role through the MGB axis, a bidirectional communication pathway. Stress can affect the MGB axis through the HPA axis and other pathways, and animal research has contributed to a paradigm shift in understanding the influence of microbiota on human health and disease. Preclinical and human trials are currently investigating the applicability of these findings in humans.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Ali S. Alzahrani, Noha Mukhtar, Abeer Aljomaiah, Hadeel Aljamei, Abdulmohsen Bakhsh, Nada Alsudani, Tarek Elsayed, Nahlah Alrashidi, Roqayh Fadel, Eman Alqahtani, Hussein Raef, Muhammad Imran Butt, Othman Sulaiman
Summary: This study aimed to investigate the adrenocortical response to COVID-19 infection. The results revealed that patients with more severe disease had lower cortisol and ACTH levels, indicating a direct link between COVID-19 infection and impaired glucocorticoid response.
ENDOCRINE PRACTICE
(2021)
Article
Allergy
Wisdom Alemya Akurugu, Carel Jacobus Van Heerden, Nicola Mulder, Ekkehard Werner Zollner
Summary: This study found that some SNPs of the CRHR1 and NR3C1 genes are associated with HPAS in asthmatic children, with the C allele of rs41423247 potentially having a protective effect on HPAS, and the CC genotype being associated with the highest PMTP ACTH response.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Mojca Jensterle, Rok Herman, Andrej Janez, Wael Al Mahmeed, Khalid Al-Rasadi, Kamila Al-Alawi, Maciej Banach, Yajnavalka Banerjee, Antonio Ceriello, Mustafa Cesur, Francesco Cosentino, Massimo Galia, Su-Yen Goh, Sanjay Kalra, Peter Kempler, Nader Lessan, Paulo Lotufo, Nikolaos Papanas, Ali A. Rizvi, Raul D. Santos, Anca P. Stoian, Peter P. Toth, Vijay Viswanathan, Manfredi Rizzo
Summary: The article reviews the rationale for glucocorticoid use in COVID-19 and emphasizes the need to be cautious about glucocorticoid-induced adrenal insufficiency. The authors also discuss other mechanisms that may affect HPA axis function and the increased risk and severity of COVID-19 in patients with pre-existing HPA axis disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pediatrics
Cynthia R. Rovnaghi, Joseph Rigdon, Jean-Michel Roue, Monica O. Ruiz, Victor G. Carrion, Kanwaljeet J. S. Anand
Summary: This study aimed to identify children at risk for altered HPA-axis function due to early life stress by examining longitudinal trajectories of hair cortisol concentrations. The results revealed different classes of children with distinct HCC profiles, suggesting varying impacts of ELS on HPA-axis function.
FRONTIERS IN PEDIATRICS
(2021)
Article
Endocrinology & Metabolism
Jacinda C. Li, Molly A. Hall, Idan Shalev, Hannah M. C. Schreier, Tomas Gonzalez Zarzar, Isabel Marcovici, Frank W. Putnam, Jennie G. Noll
Summary: This study suggests a mechanistic association between HPA axis attenuation and obesity, with the attenuated cortisol growth rate mediating the effects of childhood sexual abuse on accelerated BMI accumulation and elevated adulthood obesity rates.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Psychology, Multidisciplinary
Qian Liu, Jianhui Wu, Liang Zhang, Xiaofang Sun, Qing Guan, Zhuxi Yao
Summary: This study found that, for the same level of stress, the subjective perceived level of control in young adults can influence the activation of the hypothalamic-pituitary-adrenal axis.
FRONTIERS IN PSYCHOLOGY
(2021)
Review
Immunology
Juan P. Sanabria-Mazo, Ariadna Colomer-Carbonell, Meritxell Carmona-Cervello, Albert Feliu-Soler, Xavier Borras, Mar Grasa, Montserrat Esteve, Michael Maes, Silvia Edo, Antoni Sanz, Juan V. Luciano
Summary: This systematic review identified preliminary evidence of increased levels of certain immune-inflammatory and HPA axis biomarkers in individuals with NSLBP, but also noted inconsistent results for some biomarkers. Additionally, insufficient evidence was found for IL-6, TNF-alpha, and CRP levels in NSLBP when compared exclusively with healthy controls. The dysregulated functioning of cortisol in NSLBP patients further adds complexity to the understanding of the immune-inflammatory and HPA axis biomarkers in this population.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Skand Shekhar, Raven McGlotten, Sunyoung Auh, Kristina Rother, Lynnette K. Nieman
Summary: The study revealed that abnormal thyroid function, likely mediated by subnormal nocturnal TSH levels, is prevalent in patients with Cushing syndrome. This abnormality can be reversed after cure.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Endocrinology & Metabolism
Yehan Bian, Heidi Hahn, Anja Uhmann
Summary: Hedgehog signaling plays essential roles in embryonic development, adult homeostasis, and tumorigenesis. Despite its close connection with pituitary embryonic development, the engagement of Hedgehog signaling in the pituitary gland has been underestimated. Dysfunction of this signaling pathway during pituitary development leads to gland malformation. Recent research also suggests a regulatory role of Hedgehog signaling in the adult pituitary, affecting homeostasis, hormone production, and possibly formation of neoplasms. Targeting this pathway with therapeutic strategies shows promise in treating pituitary diseases.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Jessica L. Irwin, Amy L. Meyering, Gage Peterson, Laura M. Glynn, Curt A. Sandman, Laurel M. Hicks, Elysia Poggi Davis
Summary: The study investigated the relationship between maternal prenatal cortisol levels and infant cortisol reactivity during inoculation. The results showed that elevated prenatal cortisol levels in mothers are associated with a larger cortisol response in infants at 6 and 12 months when faced with a challenging event.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Martin Werdermann, Ilona Berger, Laura D. Scriba, Alice Santambrogio, Pia Schlinkert, Heike Brendel, Henning Morawietz, Andreas Schedl, Mirko Peitzsch, Aileen J. F. King, Cynthia L. Andoniadou, Stefan R. Bornstein, Charlotte Steenblock
Summary: This study investigated the impact of metabolic diseases on progenitor cells in the hypothalamic-pituitary-adrenal axis, showing that insulin enhances proliferation and differentiation of these cells, while chronic metabolic stress leads to hyperactivation of the axis. This suggests a potential link between early life stress and the development of metabolic syndrome in adulthood.
MOLECULAR METABOLISM
(2021)
Article
Endocrinology & Metabolism
Raphael Hirtz, Lars Libuda, Anke Hinney, Manuel Foecker, Judith Buehlmeier, Jochen Antel, Paul-Martin Holterhus, Alexandra Kulle, Cordula Kiewert, Johannes Hebebrand, Corinna Grasemann
Summary: In adolescents with major depressive disorder (MDD), dysfunction of the hypothalamus-pituitary-adrenal (HPA) and the hypothalamus-pituitary-thyroid (HPT) axis is common, but the function of these two axes is only loosely related. This differs from findings in adults and suggests age-related maturational adjustments in the regulation of the HPA and HPT axis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Pediatrics
Elanur Uzuntas, Peter Schuermann, Thomas Rothaemel, Thilo Doerk, Michael Klintschar
Summary: The study found that single nucleotide polymorphisms relevant to the hypothalamic-pituitary-adrenal (HPA) axis, which regulates the stress hormone cortisol, are associated with sudden infant death syndrome (SIDS). These variants appear to decrease cortisol concentration and impair stress response.
Article
Pediatrics
Lekshmi Sambhu Hema, Prawin Kumar, Jagdish Prasad Goyal, Varuna Vyas, Kuldeep Singh
Summary: This study aims to assess the effect of long-term use of inhaled corticosteroids (ICS) on the hypothalamic-pituitary-adrenal (HPA) axis. By measuring cortisol levels and conducting adreno-corticotropic hormone (ACTH) stimulation tests, it was found that only a few asthmatic children using ICS showed HPA axis suppression, and there was no clinical evidence supporting this suppression.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Article
Biochemistry & Molecular Biology
J. L. Cadet, C. Brannock, I. N. Krasnova, S. Jayanthi, B. Ladenheim, M. T. McCoy, D. Walther, A. Godino, M. Pirooznia, R. S. Lee
MOLECULAR PSYCHIATRY
(2017)
Article
Biochemistry & Molecular Biology
Fayaz Seifuddin, Gary Wand, Olivia Cox, Mehdi Pirooznia, Laura Moody, Xiaoju Yang, Jonathan Tai, Gretha Boersma, Kellie Tamashiro, Peter Zandi, Richard Lee
Article
Biochemistry & Molecular Biology
Jonathan B. Coulter, Hernando Lopez-Bertoni, Katherine J. Kuhns, Richard S. Lee, John Laterra, Joseph P. Bressler
Article
Neurosciences
Joan Kaufman, Nicholas F. Wymbs, Janitza L. Montalvo-Ortiz, Catherine Orr, Matthew D. Albaugh, Robert Althoff, Kerry O'Loughlin, Hannah Holbrook, Hugh Garavan, Catherine Kearney, Bao-Zhu Yang, Hongyu Zhao, Catherine Pena, Eric J. Nestler, Richard S. Lee, Stewart Mostofsky, Joel Gelernter, James Hudziak
NEUROPSYCHOPHARMACOLOGY
(2018)
Article
Endocrinology & Metabolism
Richard S. Lee, Pamela B. Mahon, Peter P. Zandi, Mary E. McCaul, Xiaoju Yang, Utsav Bali, Gary S. Wand
PSYCHONEUROENDOCRINOLOGY
(2018)
Article
Oncology
Robin Ortiz, Joshua J. Joseph, Richard Lee, Gary S. Wand, Sherita Hill Golden
CLINICAL EPIGENETICS
(2018)
Article
Multidisciplinary Sciences
Jenny L. Carey, Olivia H. Cox, Fayaz Seifuddin, Leonard Marque, Kellie L. K. Tamashiro, Peter P. Zandi, Gary S. Wand, Richard S. Lee
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2018)
Article
Genetics & Heredity
Jessica Duis, Olivia H. Cox, Yuelong Ji, Fayaz Seifuddin, Richard S. Lee, Xiaobin Wang
FRONTIERS IN GENETICS
(2018)
Article
Oncology
Ding Ma, Senquan Liu, Bachchu Lal, Shuang Wei, Shuyan Wang, Daqian Zhan, Hao Zhang, Richard S. Lee, Peisong Gao, Hernando Lopez-Bertoni, Mingyao Ying, Jian Jian Li, John Laterra, Mary Ann Wilson, Shuli Xia
Article
Genetics & Heredity
Marie E. Gaine, Fayaz Seifuddin, Sarven Sabunciyan, Richard S. Lee, Kelly S. Benke, Eric T. Monson, Peter P. Zandi, James B. Potash, Virginia L. Willour
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
(2019)
Article
Behavioral Sciences
Benjamin Rodriguez, Joao Victor Nani, Priscila G. C. Almeida, Elisa Brietzke, Richard S. Lee, Mirian A. F. Hayashi
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2020)
Article
Oncology
Tomoaki Ito, Harumi Saeki, Xin Guo, Polina Sysa-Shah, Jonathan Coulter, Kellie L. K. Tamashiro, Richard S. Lee, Hajime Orita, Koichi Sato, Shun Ishiyama, Alicia Hulbert, William E. Smith, Lisa A. Peterson, Malcolm Brock, Kathleen L. Gabrielson
Article
Clinical Neurology
Celia Maria de Araujo, James Hudziak, Deana Crocetti, Nicholas F. Wymbs, Janitza L. Montalvo-Ortiz, Catherine Orr, Matthew D. Albaugh, Robert R. Althoff, Kerry O'Loughlin, Hannah Holbrook, Hugh Garavan, Bao-Zhu Yang, Stewart Mostofsky, Andrea Jackowski, Richard S. Lee, Joel Gelernter, Joan Kaufman
PSYCHIATRY RESEARCH-NEUROIMAGING
(2020)
Article
Multidisciplinary Sciences
Andre Krumel Portella, Afroditi Papantoni, Catherine Paquet, Spencer Moore, Keri Shiels Rosch, Stewart Mostofsky, Richard S. Lee, Kimberly R. Smith, Robert Levitan, Patricia Pelufo Silveira, Susan Carnell, Laurette Dube
Article
Substance Abuse
Richard S. Lee, Lynn M. Oswald, Gary S. Wand
ALCOHOL RESEARCH-CURRENT REVIEWS
(2018)