Article
Biochemistry & Molecular Biology
Cheng-Wei Lu, Yu-Chen Huang, Kuan-Ming Chiu, Ming-Yi Lee, Tzu-Yu Lin, Su-Jane Wang
Summary: The study showed that enmein inhibited glutamate release in cortical nerve terminals by suppressing Ca2+ influx and PKC, and also reduced hippocampal neuronal death induced by KA by increasing glutamate uptake.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Hyun-Bum Kim, Jacqueline Morris, Kevin Miyashiro, Tonis Lehto, Ulo Langel, James Eberwine, Jai-Yoon Sul
Summary: The research found that astrocytes can generate a stronger calcium signal response after acute ethanol exposure, primarily influenced by neuronally-derived purinergic signaling. Astrocytes adapt to the effects of ethanol by modulating the activity of adenylyl cyclase and phospholipase C, highlighting their important role in shaping the overall physiological responsiveness to ethanol.
Article
Biochemistry & Molecular Biology
Keisuke Shimizu, Takeshi Takeuchi, Lumi Negishi, Hitoshi Kurumizaka, Isao Kuriyama, Kazuyoshi Endo, Michio Suzuki
Summary: This study investigates the evolutionary process of shell matrix proteins in mollusks and reveals the different expression locations of various proteins related to shell formation.
MOLECULAR BIOLOGY AND EVOLUTION
(2022)
Article
Cell Biology
Camille S. Wang, Lisa M. Monteggia, Ege T. Kavalali
Summary: Calcium (Ca2+) signaling is tightly regulated within a presynaptic bouton, involving evoked, spontaneous, and baseline signals derived from multiple sources. These signals have non-overlapping domains within the synapse and interact through synaptic vesicle turnover.
Article
Environmental Sciences
Laura Yesenia Castillo, Jorge Rios-Carrillo, Juan Carlos Gonzalez-Orozco, Ignacio Camacho-Arroyo, Jean-Pascal Morin, Rossana C. Zepeda, Gabriel Roldan-Roldan
Summary: This study found that male rats are more susceptible to anxiety induced by BPA exposure during puberty compared to female rats, as evidenced by an increase in passive-coping behaviors and changes in brain gene expression. These findings highlight the importance of considering sex differences in peripubertal behavioral toxicology studies.
Article
Neurosciences
Kuan-Ming Chiu, Tzu-Yu Lin, Ming-Yi Lee, Cheng-Wei Lu, Su-Jane Wang
Summary: The diterpenoid alkaloid lappaconitine found in Aconitum species has been shown to reduce the excessive release of glutamate in the brain, providing a potential therapeutic option for neurodegenerative disorders. Lappaconitine inhibits glutamate release by reducing Ca2+ influx through R-type Ca2+ channels and suppressing the protein kinase A cascade in rat cerebral cortex nerve terminals.
Article
Chemistry, Medicinal
Yi Chang, Chi Feng Hung, Horng Huey Ko, Su Jane Wang
Summary: The study found that albanin A reduces glutamate release by inhibiting Ca2+/calmodulin/AC1 activation in synaptosomes, which shows neuroprotective effects against neuronal damage induced by kainic acid in rats.
JOURNAL OF MEDICINAL FOOD
(2021)
Article
Multidisciplinary Sciences
Austin M. Ramsey, Ai-Hui Tang, Tara A. LeGates, Xu-Zhuo Gou, Beatrice E. Carbone, Scott M. Thompson, Thomas Biederer, Thomas A. Blanpied
Summary: Recent evidence suggests that nano-organization of proteins within synapses may control the strength of communication between neurons in the brain. Targeting LRRTM2, a key transsynaptic adhesion molecule, and disrupting its extracellular domain quickly led to nanoscale declustering of AMPARs, resulting in significant deficits in evoked postsynaptic receptor activation but not spontaneous activation. This indicates that adhesion molecules may acutely position receptors to dynamically control synaptic strength.
Article
Multidisciplinary Sciences
Hongmei Yang, Chang-ki Oh, Haitham Amal, John S. Wishnok, Sarah Lewis, Emily Schahrer, Dorit Trudler, Tomohiro Nakamura, Steven R. Tannenbaum, Stuart A. Lipton
Summary: Protein S-nitrosylation plays a crucial role in various processes in health and disease, and it is implicated in synaptic damage in Alzheimer's disease. By studying SNO proteins in AD brains, we found that the formation of SNO-C3 is sex-dependent and may contribute to cognitive decline through increased synaptic phagocytosis.
Article
Neurosciences
Daniel Batora, Aron Zsigmond, Istvan Z. Lorincz, Gabor Szegvari, Mate Varga, Andras Malnasi-Csizmadia
Summary: Researchers have discovered distinct dynamics of neurons in zebrafish, revealing how they regulate behavioral responses through modulation of excitatory inputs to specific regions of the nerve cells.
FRONTIERS IN NEURAL CIRCUITS
(2021)
Article
Plant Sciences
Xiangyang Li, Linru Chen, Xiaoyue Zeng, Kaixin Wu, Jiayu Huang, Mengmeng Liao, Yue Xi, Guohui Zhu, Xiuying Zeng, Xuewen Hou, Zhisheng Zhang, Xinxiang Peng
Summary: When a single plant tissue detects environmental challenges, systemic signaling is activated to adjust the plant's physiology and morphology for better survival and reproduction. This study reveals that local wounding induces changes in H2O2 levels and NADPH oxidase-derived apoplastic H2O2 release, both of which rely on Ca2+ signaling through glutamate-receptor-like Ca2+ channels. Furthermore, peroxisomal Ca2+ regulates H2O2 levels by modulating the GC switch states, providing insights into the functions of plant systemic acclimation and optimized H2O2 signaling through interplay between the GC switch and NADPH oxidases.
Article
Cell Biology
Faten Abdelli, Karim Jellali, Estefania Anguita, Maria Gonzalez-Munoz, Eduardo Villalobo, Ivan Madronal, Juan Alcalde, Mamdouh Ben Ali, Jihene Elloumi-Mseddi, Ikram Jemel, Francesc Tebar, Carlos Enrich, Sami Aifa, Antonio Villalobo
Summary: The study shows that EGFR with CaM-BD and CaM-LD domains affects the receptor's TK activity. Different EGFR mutants exhibit varying abilities to bind EGF, localize to the plasma membrane, and undergo ligand-dependent internalization.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yi-Chieh Hung, Yi-Hsiu Kuo, Pei-Wen Hsieh, Ting-Yang Hsieh, Jinn-Rung Kuo, Su-Jane Wang
Summary: The study found that chlorogenic acid (CGA) can inhibit glutamate release in cortical nerve terminals by suppressing P/Q-type Ca2+ channels and CaMKII/synapsin I pathways, thereby preventing excitotoxic damage to cortical neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Tzu-Kang Lin, Chi-Feng Hung, Jing-Ru Weng, Ting-Yang Hsieh, Su-Jane Wang
Summary: This study found that Kaempferol 3-rhamnoside (KR) can inhibit 4-aminopyridine (4-AP)-evoked glutamate release. The inhibitory effect of KR is linked to the omission of external Ca2+ or the depletion of glutamate in synaptic vesicles, as well as the suppression of P/Q-type Ca2+ channel activity. Additionally, KR reduces the increase in Ca2+ concentration and the phosphorylation of CaMKII and its substrate synapsin I.
Article
Genetics & Heredity
Xin Liu, Kaiqing Liu, Danyao Nie, Jing Zhang, Liyun Zhang, Xinhua Liu, Jiantao Wang
Summary: In this study, we investigated the effects of cysteine mutations in different domains of fibrillin-1 on protein stability and found that mutations in the EGF domain have a greater impact on proteolytic sensitivity and thermostability compared to mutations in the cbEGF domain. Furthermore, cysteine mutations can result in the exposure or alteration of enzymatic sites. These results suggest that cysteine mutations in fibrillin-1 may play a significant role in the pathogenesis of diseases such as Marfan syndrome.
FRONTIERS IN GENETICS
(2022)