Article
Behavioral Sciences
Amina Nasri, Mouna Ben Djebara, Ikram Sghaier, Saloua Mrabet, Sabrina Zidi, Amina Gargouri, Imen Kacem, Riadh Gouider
Summary: This study explored the epidemiological features of atypical parkinsonian syndromes (APS) in a Tunisian population, showing a hospital prevalence of 20.6% with dementia with Lewy bodies (DLB) as the most common subtype. Age of onset proved to be a decisive factor for differential diagnosis, with males predominating in all subgroups except for multiple system atrophy (MSA).
BRAIN AND BEHAVIOR
(2021)
Article
Clinical Neurology
Andrea Mancini, Erik Stoops, Leentje Demeyer, Giovanni Bellomo, Federico Paolini Paoletti, Lorenzo Gaetani, Massimiliano Di Filippo, Lucilla Parnetti
Summary: This study retrospectively investigated the levels of LRRK2 in the cerebrospinal fluid (CSF) of Parkinson's disease (PD) patients and other parkinsonian disorders using a novel highly sensitive immunoassay, and correlated them with cognitive impairment. The results showed that PD with dementia had significantly higher levels of total and pS1292 LRRK2 compared to PD with mild cognitive impairment and PD, and these levels were also correlated with cognitive performance.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Nils Schroeter, Thilo van Eimeren, Joseph Classen, Johannes Levin, Christoph Redecker, Martin Wolz, Lars Toenges
Summary: The clinical presentation of Parkinson's disease and atypical Parkinsonian syndromes is heterogeneous. Additional diagnostic procedures and clinical evaluation are necessary to achieve a high diagnostic standard.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Review
Biochemistry & Molecular Biology
Olga Buneeva, Alexei Medvedev
Summary: Ubiquitination is a major post-translational modification of proteins, and atypical ubiquitination plays a crucial role in the development of Parkinson's disease, targeting proteins involved in the disease mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Theodora Ntetsika, Paraskevi-Evita Papathoma, Ioanna Markaki
Summary: Parkinson's disease is the second most common neurodegenerative disease globally, with treatment options currently limited to symptom relief without halting or reversing disease progression. Large biomarker development programs are being carried out to improve patient selection and clinical trial outcome assessment. Research on Parkinson's disease mechanisms and ongoing clinical trials are crucial for future perspectives in the field.
MOLECULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Yuiko Inaba, Masaaki Yamamoto, Shin Urai, Masaki Suzuki, Seiji Nishikage, Maki Kanzawa, Yayoi Aoyama, Tomonori Kanda, Katsumi Shigemura, Hironori Bando, Genzo Iguchi, Yasuhiro Nakamura, Masato Fujisawa, Akihisa Imagawa, Hidenori Fukuoka, Wataru Ogawa
Summary: This study investigates the presence of bilateral uptake in adrenal incidentalomas and its association with adrenal medullary hyperplasia. The clinical features of these cases mainly include symptoms related to catecholamine excess and hypertension. Half of the cases have unilateral adrenal tumors. Adrenocortical adenomas may be associated with adrenal medullary hyperplasia.
SCIENTIFIC REPORTS
(2022)
Review
Pharmacology & Pharmacy
Komal Latif, Aman Ullah, Anastasiia D. Shkodina, Dmytro I. Boiko, Zakia Rafique, Badrah S. Alghamdi, Mohamed A. Alfaleh, Ghulam Md. Ashraf
Summary: Drug repurposing is an attractive approach for pharmaceutical development, as it allows the use of existing drugs to treat different diseases. In the case of Parkinson's disease, a neurodegenerative condition, drug repurposing strategies can be applied effectively.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Hsiuying Wang
Summary: Parkinson's disease (PD) and Diabetes Mellitus (DM) have been shown to have a connection in recent studies. This link has been discussed in the literature in relation to different mechanisms. miRNAs play a crucial role in regulating insulin pathways, glucose absorption, and PD-related genes, making them a potential therapeutic target for both diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Medicinal
Thais Barreto Santos, Leonardo Gomes Cavalieri de Moraes, Paulo Anastacio Furtado Pacheco, Douglas Galdino dos Santos, Rafaella Machado de Assis Cabral Ribeiro, Caroline dos Santos Moreira, David Rodrigues da Rocha
Summary: This review provides an overview of neuroprotective naphthoquinones, such as shikonin, plumbagin, and vitamin K, which have been found to prevent oxidative stress and exhibit neuroprotective effects through various mechanisms. Synthetic naphthoquinones with inhibitory activity on the P2X7 receptor have also shown neuroprotective effects on Neuro-2a cells. Naphthazarin has been identified as an inhibitor of the MAO-B enzyme, and vitamin K and synthetic naphthoquinones derivatives have demonstrated inhibition of alpha-synuclein aggregation. Synthetic derivatives of juglone and naphthazarin have also been shown to protect Neuro-2a cells against neurodegenerative effects. The review also discusses routes for producing synthetic derivatives, highlighting the potential of 1,4-naphthoquinones as a promising class in the treatment of Parkinson's disease.
Article
Neurosciences
Dong-Woo Ryu, Sang-Won Yoo, Yoon-Sang Oh, Kwang-Soo Lee, Seunggyun Ha, Joong- Seok Kim
Summary: According to this study, Parkinson's disease patients can be categorized into brain-predominant PD and PD with body involvement phenotypes based on the onset of cardiac sympathetic denervation (CSD). The study found that PD patients with body involvement had more severe initial symptoms and experienced faster progression of motor deterioration, indicating potentially more severe involvement of the central and peripheral nervous systems.
NEUROBIOLOGY OF DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Roberta J. Ward, David T. Dexter, Antonio Martin-Bastida, Robert R. Crichton
Summary: This review explores the iron deposition in the brains of PD patients, the role of neuroinflammation and glia cells, and the potential therapeutic effects of iron chelators. The combination of anti-inflammatory drugs with iron chelators is proposed as a better approach to enhance chelator efficacy in treating PD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Jiri Buril, Petra Burilova, Andrea Pokorna, Ingrid Kovacova, Marek Balaz
Summary: Epidemiological analysis of Parkinsonism in the Czech Republic based on data from national health registries revealed a growing number of patients with Parkinson's disease and other degenerative disorders of basal ganglia. Regional differences in prevalence of Parkinson's diagnoses and potential disparities in patient care were identified.
Review
Biochemistry & Molecular Biology
Elena Piccinin, Anna Maria Sardanelli, Peter Seibel, Antonio Moschetta, Tiziana Cocco, Gaetano Villani
Summary: Parkinson's disease is characterized by the progressive loss of dopaminergic neurons, with mitochondrial dysfunction considered central to its pathogenesis. Failure of mitochondrial quality control is a hallmark of the disease, with the PGC-1 family playing a crucial role in regulating mitochondrial biogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Wolfgang P. Ruf, Axel Freischmidt, Veselin Grozdanov, Valerie Roth, Sarah J. Brockmann, Brit Mollenhauer, Dorothea Martin, Bernhard Haslinger, Katrin Fundel-Clemens, Markus Otto, Christine von Arnim, Karlheinz Holzmann, Albert C. Ludolph, Jochen H. Weishaupt, Karin M. Danzer
Summary: Cumulative evidence suggests that microRNAs (miRNAs) play a significant role in neurodegenerative diseases, particularly with more pronounced differential expression in the serum of Parkinson's disease patients. The study indicates that miRNA-protein binding may mediate the pathogenic effects of HNF4a, suggesting a complex role for miRNAs in pathology beyond transcriptional dysregulation.
Review
Food Science & Technology
Paulina Gatarek, Joanna Kaluzna-Czaplinska
Summary: The relationship between diet and Parkinson's disease needs further exploration, as studies indicate it may have an impact on disease management and progression. Treatment options should consider both pharmaceutical approaches and holistic methods, emphasizing the importance of understanding how nutrition influences the condition.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Clinical Neurology
Jan Kassubek, Hans-Peter Mueller, Kelly Del Tredici, Dorothee Lule, Martin Gorges, Heiko Braak, Albert C. Ludolph
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2018)
Article
Clinical Neurology
Heiko Braak, Kelly Del Tredici
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2018)
Article
Clinical Neurology
Sarah K. Kaufman, Kelly Del Tredici, Talitha L. Thomas, Heiko Braak, Marc I. Diamond
ACTA NEUROPATHOLOGICA
(2018)
Article
Clinical Neurology
Martin Gorges, Barbara Kuntz, Kelly Del Tredici, Daniel G. Schmidt, Hans-Peter Mueller, Albert C. Ludolph, Luc Dupuis, Jan Kassubek
MOVEMENT DISORDERS
(2019)
Letter
Clinical Neurology
David Brenner, Angela Rosenbohm, Ruestem Yilmaz, Kathrin Mueller, Torsten Grehl, Susanne Petri, Thomas Meyer, Julian Grosskreutz, Patrick Weydt, Wolfgang Ruf, Christoph Neuwirth, Markus Weber, Susana Pinto, Kristl G. Claeys, Berthold Schrank, Berit Jordan, Antje Knehr, Kornelia Guenther, Annemarie Huebers, Daniel Zeller, Christian Kubisch, Sibylle Jablonka, Michael Sendtner, Thomas Klopstock, Mamede de Carvalho, Anne Sperfeld, Guntram Borck, Alexander E. Volk, Johannes Dorst, Joachim Weis, Markus Otto, Joachim Schuster, Kelly Del Tredici, Heiko Braak, Karin M. Danzer, Axel Freischmidt, Thomas Meitinger, Albert C. Ludolph, Peter M. Andersen, Jochen H. Weishaupt, Ute Weyen, Andreas Hermann, Juergen Winkler, Tim Hagenacker, Jan Christoph Koch, Paul Lingor, Bettina Goericke, Stephan Zierz, Petra Baum, Joachim Wolf, Andrea Winkler, Peter Young, Ulrich Bogdahn, Johannes Prudlo, Jan Kassubek
Article
Neurosciences
Martin Gorges, Martin S. Kunz, Hans-Peter Mueller, Inga Liepelt-Scarfone, Alexander Storch, Richard Dodel, Ruediger Hilker-Roggendorf, Daniela Berg, Elke Kalbe, Heiko Braak, Kelly Del Tredici, Simon Baudrexel, Hans-Juergen Huppertz, Jan Kassubek
HUMAN BRAIN MAPPING
(2020)
Article
Clinical Neurology
Heiko Braak, Kelly Del Tredici
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2020)
Article
Clinical Neurology
Kelly Del Tredici, Albert C. Ludolph, Simone Feldengut, Christian Jacob, Heinz Reichmann, Juergen R. Bohl, Heiko Braak
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2020)
Review
Neurosciences
Kelly Del Tredici, Heiko Braak
CURRENT OPINION IN NEUROBIOLOGY
(2020)
Article
Neurosciences
Deniz Yilmazer-Hanke, Theresa Mayer, Hans-Peter Mueller, Hermann Neugebauer, Alireza Abaei, Angelika Scheuerle, Joachim Weis, Karin M. E. Forsberg, Katharina Althaus, Julia Meier, Albert C. Ludolph, Kelly Del Tredici, Heiko Braak, Jan Kassubek, Volker Rasche
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2020)
Article
Neuroimaging
Hans-Peter Mueller, Martin Gorges, Kelly Del Tredici, Albert C. Ludolph, Jan Kassubek
NEUROIMAGE-CLINICAL
(2019)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
G. Winter, P. Bohn, E. Yousefzadeh-Nowshahr, K. Kneer, C. A. F. von Arnim, M. Otto, C. Solbach, G. Glatting, S. Anderl-Straub, D. Polivka, P. Fissler, V. Prasad, M. W. Riepe, H. Braak, K. Del Tredici, M. Higuchi, A. Ludolph, A. J. Beer
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2019)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
E. Yousefzadeh-Nowshahr, G. Winter, P. Bohn, K. Kneer, C. von Arnim, M. Otto, C. Solbach, S. Anderl-Straub, D. Polivka, P. Fissler, P. Kletting, V. Prasad, M. W. Riepe, H. Braak, K. Del Tredici, M. Higuchi, A. Ludolph, A. J. Beer, G. Glatting
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2019)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
E. Yousefzadeh-Nowshahr, G. Winter, P. Bohn, K. Kneer, C. von Arnim, M. Otto, C. Solbach, S. Anderl-Straub, D. Polivka, P. Fissler, V. Prasad, P. Kletting, M. W. Riepe, H. Braak, K. Del Tredici, M. Higuchi, A. Ludolph, A. J. Beer, G. Glatting
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2019)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Gordon Winter, Karl Bohn, Elham Yousefzadeh-Nowshahr, Katharina Kneer, Christine von Arnim, Markus Otto, Christoph Solbach, Gerhard Glatting, Sarah Anderl-Straub, Darte Polivka, Patrick Fissler, Vikas Prasad, Matthias Riepe, Heiko Braak, Kelly Del Tredici, Makoto Higuchi, Albert Ludolph, Ambros Beer
JOURNAL OF NUCLEAR MEDICINE
(2019)
