Article
Clinical Neurology
Lena Ruehl, Joji B. Kuramatsu, Jochen A. Sembill, Bernd Kallmuenzer, Dominik Madzar, Stefan T. Gerner, Antje Giede-Jeppe, Stefanie Balk, Tamara Mueller, Jakob Jaeger, Stefan Schwab, Hagen B. Huttner, Maximilian Spruegel
Summary: This study found that amantadine treatment can improve consciousness in patients with non-traumatic brain injury. However, there may be an increased risk of epileptic seizures after treatment initiation. Further randomized controlled trials are needed to confirm these findings.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
L. Llull, G. Maya, R. Torne, R. Mellado-Artigas, A. Renu, A. Lopez-Rueda, C. Laredo, D. Culebras, C. Ferrando, J. Blasco, S. Amaro, A. Chamorro
Summary: Admitting patients with low-grade aSAH to a dedicated stroke unit may be a better alternative than initial admission to the ICU, with similar rates of in-hospital complications, length of stay, and long-term poor outcomes observed between the two groups.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Neurosciences
Hanxiao Chang, Chao Lin, Zheng Li, Yuqi Shen, Guangjian Zhang, Lei Mao, Chencheng Ma, Ning Liu, Hua Lu
Summary: In this study, it was found that T3 treatment after subarachnoid haemorrhage (SAH) can suppress neuronal apoptosis by reducing the release of reactive oxygen species (ROS) and improve neuroinflammation by promoting mitophagy, thus exerting a protective effect on neurons after SAH via the PINK 1/PARKIN pathway.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Surgery
Courtney J. Pokrzywa, Abdul Hafiz Al Tannir, Rodney Sparapani, Mackenzie S. Rabas, Daniel Holena, Patrick B. Murphy, Claire J. Creutzfeldt, Lewis Somberg, Ann Nattinger, Rachel S. Morris
Summary: The decision to withdraw life sustaining treatment in older adults with traumatic brain injury varies widely and is influenced by patient and hospital factors.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Medicine, General & Internal
Piotr Defort, Natalia Retkowska-Tomaszewska, Marcin Kot, Pawel Jarmuzek, Anna Tylutka, Agnieszka Zembron-Lacny
Summary: This study aimed to evaluate the relationship between neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), systemic inflammation index (SII), and Glasgow Coma Scale (GCS) score in patients with traumatic intracerebral haemorrhage (TICH). The results showed that NLR and SII were significantly related to GCS scores and could serve as promising predictors of clinical prognosis in TICH patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Yujie Chen, Ian Galea, R. Loch Macdonald, George Kwok Chu Wong, John H. Zhang
Summary: Neurological researchers have made progress in understanding the pathophysiological mechanisms associated with subarachnoid haemorrhage (SAH) which contribute to morbidity and mortality. The current dilemma in SAH management requires a reconsideration of the nature of the insult in SAH and a focus on identifying precise pathophysiological processes and potential therapeutic strategies. Normalizing cerebrospinal fluid circulation and brain-blood interface physiology is crucial in alleviating early brain injury and delayed neurological deterioration after SAH.
Article
Clinical Neurology
Hugo Gonzalez Gomez, Jude P. J. Savarraj, Atzhiry S. Paz, Xuefang Ren, Hua Chen, Louise D. McCullough, Huimahn A. Choi, Aaron M. Gusdon
Summary: This study found that an increase in peripheral eosinophil counts after non-traumatic subarachnoid hemorrhage (SAH) is associated with worse clinical outcomes. The study suggests that a delayed increase in eosinophil counts after SAH may impact patients' functional outcomes.
FRONTIERS IN NEUROLOGY
(2023)
Article
Critical Care Medicine
Raphael Cinotti, Julio Cesar Mijangos, Paolo Pelosi, Matthias Haenggi, Mohan Gurjar, Marcus J. Schultz, Callum Kaye, Daniel Agustin Godoy, Pablo Alvarez, Aikaterini Ioakeimidou, Yoshitoyo Ueno, Rafael Badenes, Abdurrahmaan Ali Suei Elbuzidi, Michael Piagnerelli, Muhammed Elhadi, Syed Tariq Reza, Mohammed Atef Azab, Victoria McCredie, Robert D. Stevens, Jean Catherine Digitale, Nicholas Fong, Karim Asehnoune
Summary: Neurocritical care patients who receive prolonged invasive mechanical ventilation have a high rate of extubation failure, which is associated with unfavorable outcomes. This study establishes a scoring system that can predict the success of extubation in multiple settings.
INTENSIVE CARE MEDICINE
(2022)
Review
Critical Care Medicine
Carlos A. Santacruz, Jean-Louis Vincent, Andres Bader, Luis A. Rincon-Gutierrez, Claudia Dominguez-Curell, David Communi, Fabio S. Taccone
Summary: Studies suggest that altered CSF concentrations of protein biomarkers related to cytoskeletal damage, inflammation, apoptosis, and oxidative stress may predict worse neurological outcomes in patients with acute brain injuries.
Article
Geriatrics & Gerontology
Y. Launey, A. Coquet, S. Lasocki, C. Dahyot-Fizelier, O. Huet, E. Le Pabic, A. Roquilly, P. Seguin
Summary: This study evaluated the outcomes of ICU patients over 65 years of age with TBI. The results showed that age, sex, baseline Glasgow coma scale score, injury severity score, and use of osmotherapy were predictors of unfavourable neurological outcome.
Article
Critical Care Medicine
Naomi Ketharanathan, Maayke A. W. Hunfeld, Marcus C. de Jong, Lineke J. van der Zanden, Jochem K. H. Spoor, Enno D. Wildschut, Matthijs de Hoog, Dick Tibboel, Corinne M. P. Buysse
Summary: Neuroprognostication in severe traumatic brain injury (sTBI) is challenging and lacking formal pediatric guidelines. This study investigated withdrawal of life-sustaining therapies (WLST) and outcomes in pediatric sTBI. WLST decision was multi-disciplinary and based on specific clinical features and diagnostic modalities. Two-thirds of PICU mortality was due to WLST, with early occurrence. The majority of survivors had poor outcomes at discharge but showed improvement at one year post-sTBI.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Medicine, General & Internal
Min Li, Rui Wang, Qi-Xing Fang, Yi-Xuan He, Ying-Wu Shi, Shun-Nan Ge, Rui-Na Ma, Yan Qu
Summary: This retrospective study investigates the association between the severity of traumatic subarachnoid hemorrhage (tSAH) and acute respiratory failure (ARF) in patients with moderate-to-severe traumatic brain injury (M-STBI). The study findings suggest that high Fisher grade tSAH on admission is associated with ARF in M-STBI patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Critical Care Medicine
Keita Shibahashi, Hiroyuki Ohbe, Hideo Yasunaga
Summary: There is no significant association between ICU admission practices and outcomes in patients with isolated tSAH, but higher ICU admission rates are associated with significantly higher hospitalization costs.
NEUROCRITICAL CARE
(2022)
Review
Biochemistry & Molecular Biology
Wiley Gillam, Nikhil Godbole, Shourya Sangam, Alyssa Detommaso, Marco Foreman, Brandon Lucke-Wold
Summary: This review aimed to explore how neurologic injury can lead to Post-Traumatic Stress Disorder (PTSD), focusing on traumatic brain injury, subarachnoid hemorrhage, and stroke as common neurologic injuries. The altered activity in the limbic system may be associated with characteristic symptoms of PTSD. However, early diagnosis and appropriate treatment are lacking in these patients.
Article
Critical Care Medicine
Cecilia A. Akerlund, Anders Holst, Nino Stocchetti, Ewout W. Steyerberg, David K. Menon, Ari Ercole, David W. Nelson
Summary: Using data-driven clustering analysis, we identified six stable clinical subtypes of traumatic brain injury with distinct neurological and systemic metabolic stress profiles, which were associated with outcomes.
Review
Anesthesiology
Pierre Squara, Thomas W. L. Scheeren, Hollmann D. Aya, Jan Bakker, Maurizio Cecconi, Sharon Einav, Manu L. N. G. Malbrain, Xavier Monnet, Daniel A. Reuter, Iwan C. C. van der Horst, Bernd Saugel
Summary: Any measurement is always accompanied by a certain degree of uncertainty. It is crucial to have a correct understanding of the different types of uncertainty and their definitions for the appropriate use of measuring instruments, especially in perioperative and intensive care medicine. The metrological requirements for measuring instruments in these fields are often poorly defined and can be misused, highlighting the importance of establishing standards and uniform understandings among clinicians and scientists.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2021)
Review
Anesthesiology
Pierre Squara, Thomas W. L. Scheeren, Hollmann D. Aya, Jan Bakker, Maurizio Cecconi, Sharon Einav, Manu L. N. G. Malbrain, Xavier Monnet, Daniel A. Reuter, Iwan C. C. van der Horst, Bernd Saugel
Summary: Measurement is always influenced by uncertainty, and understanding different types of uncertainty is crucial for appropriate use of measuring instruments. In perioperative and intensive care medicine, the metrological requirements for measuring instruments are often unclear, emphasizing the importance of using metrological terms correctly and establishing standards.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2021)
Article
Critical Care Medicine
Esther N. van der Zee, Jelle L. Epker, Jan Bakker, Dominique D. Benoit, Erwin J. O. Kompanje
Summary: This study found that patients with an active malignancy are more likely to have written TLDs during their ICU stay, while patients with complete remission are not at risk of having more written TLDs. Age, SOFA score at ICU admission, and malignancy status are associated with the occurrence of TLDs.
JOURNAL OF INTENSIVE CARE MEDICINE
(2021)
Article
Critical Care Medicine
John C. Greenwood, David H. Jang, Audrey E. Spelde, Jacob T. Gutsche, Jiri Horak, Michael A. Acker, Todd J. Kilbaugh, Frances S. Shofer, John G. T. Augoustides, Jan Bakker, Benjamin S. Abella
Summary: This study found that low perfused vessel density and high microcirculatory heterogeneity are associated with an increased intensity and duration of lactic acidosis after cardiac surgery with cardiopulmonary bypass.
Article
Anesthesiology
Loek P. B. Meijs, Joris van Houte, Bente C. M. Conjaerts, Alexander J. G. H. Bindels, Arthur Bouwman, Saskia Houterman, Jan Bakker
Summary: Pmsa calculated by a computer algorithm shows high agreement with Pms-Insp derived from inspiratory holds in cardiac surgery patients, demonstrating interchangeability. Pmsa is a straightforward, non-interventional, continuous bedside option compared to the interventional and offline nature of Pms-Insp. Further studies are needed to determine the role of Pmsa in circulatory management of critically ill patients.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2022)
Review
Critical Care Medicine
Jan Bakker, Eduardo Kattan, Djillali Annane, Ricardo Castro, Maurizio Cecconi, Daniel de Backer, Arnaldo Dubin, Laura Evans, Michelle Ng Gong, Olfa Hamzaoui, Can Ince, Bruno Levy, Xavier Monnet, Gustavo A. Ospina Tascon, Marlies Ostermann, Michal R. Pinsky, James A. Russell, Bernd Saugel, Thomas W. L. Scheeren, Jean-Louis Teboul, Antoine Vieillard Baron, Jean-Louis Vincent, Fernando G. Zampieri, Glenn Hernandez
Summary: Clinical and pathophysiological understanding of septic shock has advanced significantly in recent decades, leading to a gradual reduction in morbidity and mortality. While large randomized controlled trials have addressed key aspects of septic shock resuscitation, there are still many unanswered questions. This review focuses on current standards of septic shock resuscitation and evolving concepts, providing insights into potential research opportunities.
INTENSIVE CARE MEDICINE
(2022)
Article
Critical Care Medicine
W. H. van der Ven, J. Schuurmans, J. Schenk, S. Roerhorst, T. G. Cherpanath, W. K. Lagrand, P. Thoral, P. W. G. Elbers, P. R. Tuinman, T. W. L. Scheeren, J. Bakker, B. F. Geerts, D. P. Veelo, F. Paulus, A. P. J. Vlaar
Summary: Hypotension is common in ICU settings and believed to be underdiagnosed and preventable. Nurses monitor blood pressure changes while physicians are responsible for treatment, using fluids, inotropes, vasopressors, and positional maneuvers. Most ICUs lack specific hypotension treatment guidelines, but there is a desire for one among the majority of respondents.
JOURNAL OF CRITICAL CARE
(2022)
Article
Hematology
Sanne de Bruin, Dorus Eggermont, Robin van Bruggen, Dirk de Korte, Thomas W. L. Scheeren, Jan Bakker, Alexander P. J. Vlaar
Summary: Transfusion practices in ICU vary, with the study finding that the transfusion practice for massively bleeding critically ill patients is largely influenced by the presence of massive transfusion protocol (MTP), while general non-massively bleeding patients tend to have restrictive transfusion triggers.
Article
Critical Care Medicine
Esther N. van der Zee, Fabian Termorshuizen, Dominique D. Benoit, Nicolette F. de Keizer, Jan Bakker, Erwin J. O. Kompanje, Wim J. R. Rietdijk, Jelle L. Epker
Summary: The study found that the 1-year mortality of cancer patients (hematological and solid) with an unplanned ICU admission was higher than that of patients without cancer, with about one-third of cancer patients surviving their hospital admission dying within 1 year. The 1-year mortality decreased until 2011 in hematological patients and stabilized, while there was no significant change in solid cancer patients.
JOURNAL OF INTENSIVE CARE MEDICINE
(2022)
Review
Infectious Diseases
Prashant Nasa, Elie Azoulay, Arunaloke Chakrabarti, Jigeeshu Divatia, Ravi Jain, Camilla Rodrigues, Victor Rosenthal, Waleed Alhazzani, Yaseen M. Arabi, Jan Bakker, Matteo Bassetti, Jan De Waele, George Dimopoulos, Bin Du, Sharon Einav, Laura Evans, Simon Finfer, Claude Guerin, Naomi E. Hammond, Samir Jaber, Ruth M. Kleinpell, Younsuck Koh, Marin Kollef, Mitchell M. Levy, Flavia R. Machado, Jordi Mancebo, Ignacio Martin-Loeches, Mervyn Mer, Michael S. Niederman, Paolo Pelosi, Anders Perner, John Peter, Jason Phua, Lise Piquilloud, Mathias W. Pletz, Andrew Rhodes, Marcus J. Schultz, Mervyn Singer, Jean-Francois Timsit, Balasubramanian Venkatesh, Jean-Louis Vincent, Tobias Welte, Sheila Myatra
Summary: There is a wide variation in the clinical practice of infection control and prevention for SARS-CoV-2 in ICU. International experts have developed consensus statements on infection control, including 25 clinical practice statements. However, consensus has not been reached on the optimal return to work criteria for healthcare workers infected with SARS-CoV-2 or the acceptable disinfection strategy for heat-sensitive instruments used for airway management of patients with SARS-CoV-2 infection. Further research is needed to address these uncertainties.
LANCET INFECTIOUS DISEASES
(2022)
Article
Health Care Sciences & Services
Maike Hiller, Maria Wittmann, Hendrik Bracht, Jan Bakker
Summary: Making discharge decisions in ICU patients is often challenging, as there are no established guidelines and decisions are often based on subjective judgements. Premature discharge puts patients at risk of readmission, while delayed discharge wastes resources and leads to suboptimal patient flow. Objective decision support is needed to assess both the patient's readiness for discharge and the capabilities of the receiving unit.
BMC HEALTH SERVICES RESEARCH
(2022)
Article
Multidisciplinary Sciences
John C. Greenwood, Fatima M. Talebi, David H. Jang, Audrey E. Spelde, Joseph E. Tonna, Jacob T. Gutsche, Jiri Horak, Michael A. Acker, Todd J. Kilbaugh, Frances S. Shofer, John G. T. Augoustides, Jan Bakker, Jacob S. Brenner, Vladimir R. Muzykantov, Benjamin S. Abella
Summary: This study evaluated the microcirculatory function in patients with circulatory shock after cardiac surgery using a low-dose topical nitroglycerin solution and handheld videomicroscopy. The results showed that patients with shock had persistent and irreversible abnormalities in microcirculatory function, and a topical nitroglycerin challenge was able to assess the localized recruitment of microcirculatory blood flow and identify nitroglycerin responsiveness.
SCIENTIFIC REPORTS
(2022)
Meeting Abstract
Critical Care Medicine
L. Ramadan, J. Kaidbey, J. Bakker
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Critical Care Medicine
Cheyenne Snavely, Leena Ramadan, Sam Kozloff, Gustavo Ospina-Tascon, David Kaufman, Jan Bakker
CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Critical Care Medicine
John Greenwood, Fatima Talebi, David Jang, Audrey Spelde, Jiri Horak, Jacob Gutsche, John Augoustides, Todd Kilbaugh, Nuala Meyer, Jan Bakker, Benjamin Abella
CRITICAL CARE MEDICINE
(2022)