Article
Clinical Neurology
Isabel C. Hostettler, Ghil Schwarz, Gareth Ambler, Duncan Wilson, Gargi Banerjee, David J. Seiffge, Clare Shakeshaft, Surabhika Lunawat, Hannah Cohen, Tarek A. Yousry, Rustam Al-Shahi Salman, Gregory Y. H. Lip, Martin M. Brown, Keith W. Muir, Henry Houlden, Hans Rolf Jager, David J. Werring
Summary: CT-based cerebral small vessel disease biomarkers are associated with 6-month functional outcome after intracerebral hemorrhage, but adding them does not significantly improve the performance of the existing ICH prediction score.
Article
Clinical Neurology
Sae-Yeon Won, Johannes Walter, Silvia Hernandez-Duran, Obada T. Alhalabi, Bedjan Behmanesh, Joshua D. Bernstock, Marcus Czabanka, Nazife Dinc, Daniel Dubinski, Charlotte Flueh, Thomas M. Freiman, Anne S. Grosch, Eva Herrmann, Young Sill Kang, Juergen Konczalla, Andreas Kramer, Felix Lehmann, Johannes Lemcke, Ruzanna Melkonian, Dorothee Mielke, Lukas Mueller, Florian Ringel, Veit Rohde, Matthias Schneider, Christian Senft, Patrick Schuss, Merih Oznur Turgut, Michael Synowitz, Joana M. Ullmann, Hartmut Vatter, Klaus Zweckberger, Fatma Kilinc, Florian Gessler
Summary: This study aims to validate the ICH and ICH-GS scores in patients with cerebellar hemorrhage and compare the outcomes of surgical management with conservative treatment. The results showed that both ICH and ICH-GS scores have good prognostic accuracy for overall mortality and functional outcomes. Surgical management was beneficial for patients with severe cerebellar hemorrhages, indicated by high ICH scores, while conservative treatment was reasonable for patients with lower ICH scores. Therefore, ICH and ICH-GS scores are useful tools for predicting survival and outcome in cerebellar ICH patients.
Article
Clinical Neurology
Steven D. Shapiro, Miryam Alkayyali, Alexandra Reynolds, Kaitlin Reilly, Magdy Selim, Neha Dangayach, J. Mocco, Christopher P. Kellner, John W. Liang
Summary: This study suggests that minimally invasive hematoma evacuation with the SCUBA technique for ICH may reduce predicted 30-day mortality, with a number needed to treat of 4 to prevent 1 mortality.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
I. Putu Eka Widyadharma, Angga Krishna, Andreas Soejitno, A. A. A. Putri Laksmidewi, Kumara Tini, I. B. Kusuma Putra, I. G. N. Budiarsa, I. A. Sri Indrayani
Summary: The modified ICH (mICH) score was found to be more accurate and effective in predicting 30-day mortality and good outcome for non-traumatic ICH patients compared to the original ICH score (oICH).
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Article
Clinical Neurology
Wen-Song Yang, Yi-Qing Shen, Xiao Wei, Li-Bo Zhao, Qing-Jun Liu, Xiong-Fei Xie, Zhi-Wei Zhang, Lan Deng, Xin-Ni Lv, Shu-Qiang Zhang, Xin-Hui Li, Qi Li, Peng Xie
Summary: The study developed the dynamic ICH (dICH) score and ultra-early ICH (uICH) score to improve the prediction of functional outcomes in patients with ICH by incorporating hematoma expansion, IVH growth, and independent non-contrast CT markers. Compared to the original ICH score, these new scores exhibited better performance in predicting poor functional outcomes.
FRONTIERS IN NEUROLOGY
(2021)
Article
Critical Care Medicine
David Lin, Michael Minyetty, Magdy Selim, Sarah Marchina, Filipa Carvalho, Elizabeth Heistand, Gogia Bhanu, Saad Hasan, Sandeep Kumar
Summary: The study externally validated the GRAVo score for predicting PEG tube placement after intracerebral hemorrhages (ICH) and found that it was valid but less accurate compared to the derivation cohort. The inclusion of race as a variable did not significantly affect the model's performance.
NEUROCRITICAL CARE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuanliang Xie, Faxiang Chen, Yan Wu, Hua Fu, Qing Zhong, Jun Chen, Xiang Wang, Hui Li
Summary: The study found that radiomic analysis based on initial NCCT scans can predict the outcomes of patients with intracerebral hemorrhage (ICH), and the clinical-radiomics model has better accuracy in predicting poor outcomes and 30-day mortality following ICH.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Neurosciences
Adrian Balasa, Dana Ghiga, Razvan-Sebastian Andone, Ancuta Elena Zahan, Ioan Alexandru Florian, Rares Chinezu
Summary: This study found that surgical treatment may be beneficial for ICH patients with volumes between 30 to 50 mL and GCS scores of 10 points or higher, but did not significantly improve overall mortality rates.
Article
Clinical Neurology
Shen Wang, Xuxu Xu, Qiang Yu, Haicheng Hu, Chao Han, Ruhai Wang
Summary: This study aimed to evaluate the relationship between modified Graeb Score (mGS) at admission and clinical outcomes of spontaneous intracerebral hemorrhage (sICH), and investigate if combining ICH score could improve outcome prediction accuracy. The results showed that mGS was an independent risk factor for poor outcome and combining ICH score with mGS improved the ability to predict postoperative outcome.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Sukwoo Hong, Keisuke Maruyama, Akio Noguchi, Teruyuki Hirano, Motoo Nagane, Yoshiaki Shiokawa
Summary: The actual 30-day mortality rate of surgically treated ICH patients was significantly lower than predicted, with anisocoria and preoperative Glasgow Coma Scale < 7 being the only two factors predicting mortality and morbidity. The ICH and SwICH scores were more valid in predicting morbidity rather than mortality after surgical intervention for ICH.
NEUROSURGICAL REVIEW
(2021)
Article
Clinical Neurology
Craig I. Coleman, Mauricio Concha, Bruce Koch, Belinda Lovelace, Mary J. Christoph, Alexander T. Cohen
Summary: The aim of this study was to develop a composite score for predicting functional outcome post-intracerebral hemorrhage (ICeH) using proxy measures that can be assessed retrospectively. Data from the ERICH study were analyzed to derive the SAVED(2) score and its discriminative ability was measured using the area under the curve (AUC). External validation was performed in the ATACH-2 trial. The SAVED(2) score showed good predictive ability for unfavorable 90-day modified Rankin scale (mRS) score in ICeH patients.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Amber Y. Dorn, Philip Y. Sun, Nerses Sanossian, Peggy L. Nguyen, Benjamin A. Emanuel, May A. Kim-Tenser, Sebina F. Bulic
Summary: A retrospective analysis of 506 patients with intracerebral hemorrhage showed that elevated admission glycemic gap (AGG) was associated with worse Glasgow Coma Scale and ICH scores on admission, need for mechanical ventilation, in-hospital mortality, and poor discharge status, although it was not an independent predictor of poor outcome.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Article
Clinical Neurology
G. Schwarz, B. Kanber, F. Prados, S. Browning, R. Simister, H. R. Jager, G. Ambler, C. A. M. Gandini Wheeler-Kingshott, D. J. Werring
Summary: This study found that small vessel disease is the most common cause of spontaneous intracerebral hemorrhage and is associated with widespread microstructural brain tissue disruption, which can be quantified using diffusion tensor imaging metrics. The study found that whole-brain microstructural alterations are associated with functional outcome after intracerebral hemorrhage and have better predictive ability than existing hemorrhage scores.
JOURNAL OF NEUROLOGY
(2023)
Article
Biology
Yantao Xing, Hongyi Cheng, Chenxi Yang, Zhijun Xiao, Chang Yan, Feifei Chen, Jiayi Li, Yike Zhang, Chang Cui, Jianqing Li, Chengyu Liu
Summary: Classification and outcome prediction of ICH based on SKNA signals is a feasible method with high accuracy. There are significant differences in SKNA signals between healthy control subjects and ICH patients. The features of change rate and complexity can be used to characterize the difference in SKNA signals of different groups.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Review
Medicine, General & Internal
Peter B. Sporns, Marios-Nikos Psychogios, Gregoire Boulouis, Andreas Charidimou, Qi Li, Enrico Fainardi, Dar Dowlatshahi, Joshua N. Goldstein, Andrea Morotti
Summary: Intracerebral hemorrhage (ICH) accounts for 10% to 20% of all strokes worldwide and is associated with high morbidity and mortality. Neuroimaging plays a crucial role in the rapid diagnosis of ICH, identification of ICH expansion, and assessment of early hematoma expansion risk.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Robert J. Rothrock, Alexander G. Chartrain, Jacopo Scaggiante, Jonathan Pan, Rui Song, Danny Hom, Adam C. Lieber, Joshua B. Bederson, J. Mocco, Christopher P. Kellner
Summary: This study summarizes the operative nuances of endoscopic minimally invasive ICH evacuation developed at a single center over an experience of 80 procedures. The results show a significant reduction in preoperative and postoperative ICH volume, with an evacuation rate of 88.7% and a 30-day mortality rate of 8.9%. It emphasizes the importance of academic discussion of specific surgical techniques to enhance safety and efficacy as experience builds with this procedure.
OPERATIVE NEUROSURGERY
(2021)
Editorial Material
Neuroimaging
Zachary Troiani, Luis C. Ascanio, Kurt A. Yaeger, Muhammad Ali, Christopher Paul Kellner
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2021)
Article
Clinical Neurology
A. M. Mehta, J. T. Fifi, H. Shoirah, T. Shigematsu, T. J. Oxley, C. P. Kellner, R. De Leacy, J. Mocco, S. Majidi
Summary: The study aimed to characterize disparities in the use of endovascular thrombectomy in acute ischemic stroke treatment based on race and income. Data from 2006 to 2016 showed an overall increase in endovascular thrombectomy use, with less significant growth observed in black patients and those in the lowest income quartile. The highest income quartile predicted higher rates of endovascular thrombectomy use and better outcomes, while black race predicted poorer outcomes.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2021)
Review
Clinical Neurology
Christopher P. Kellner, Alexander J. Schupper, J. Mocco
Article
Clinical Neurology
Christopher P. Kellner, Rui Song, Muhammad Ali, Dominic A. Nistal, Milan Samarage, Neha S. Dangayach, John Liang, Ian McNeill, Xiangnan Zhang, Joshua B. Bederson, J. Mocco
Summary: This retrospective analysis of 90 patients undergoing minimally invasive endoscopic intracerebral hemorrhage evacuation found that younger age, absence of intraventricular hemorrhage, lobar location, and early time to evacuation were independently associated with good long-term functional outcomes. The odds ratio for time to evacuation suggests a 5% reduction in the odds of achieving a favorable outcome for each additional hour.
Article
Health Care Sciences & Services
Laura Tabacof, Jamie Wood, Nicki Mohammadi, Katherine E. Link, Jenna Tosto-Mancuso, Sophie Dewil, Erica Breyman, Leila Nasr, Christopher Kellner, David Putrino
Summary: Telehealth, particularly the Precision Recovery Program (PRP), was utilized during the COVID-19 pandemic to remotely monitor and support patients at home. A retrospective cohort study identified common factors (risk factors, vital signs, and symptoms) among patients requiring screening, triage, and hospitalization, providing valuable information for decision making. Implementing similar clinician-led remote patient monitoring programs may be beneficial for COVID-19 cohorts and other conditions at risk of rapid clinical deterioration in the home setting.
TELEMEDICINE AND E-HEALTH
(2022)
Article
Clinical Neurology
Emma Reford, Christopher P. Kellner
Summary: Stroke and COVID-19, both traumatic and life-changing experiences, present significant challenges during the pandemic. Investigating isolated stroke and the co-occurrence of stroke and COVID-19 is important on both medical and humanistic levels.
Review
Clinical Neurology
Dominic Nistal, Muhammad Ali, Daniel Wei, J. Mocco, Christopher Kellner
Summary: The study found that statins significantly improved behavioral outcomes in intracerebral hemorrhage (ICH), with variable results in histological outcomes. This suggests that statin therapy may be suitable for randomized clinical trials in humans, and that the STAIR criteria can be effectively modified to evaluate preclinical studies in ICH.
WORLD NEUROSURGERY
(2021)
Editorial Material
Neuroimaging
Christopher Paul Kellner, J. Mocco
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Neuroimaging
Timothy J. Kleinig, Amal Abou-Hamden, John Laidlaw, Leonid Churilov, Christopher Paul Kellner, Teddy Wu, J. Mocco, Hui Lau, Alexios Adamides, Bhadrakant Kavar, James Dimou, Jennifer Cranefield, Amy McDonald, Stephanie Plummer, Stephen Davis, Bruce C. Campbell
Summary: This study aimed to demonstrate the safety, feasibility, and promise of efficacy of early minimally invasive surgery (MIS) for intracerebral hemorrhage (ICH) using the Aurora Surgiscope and Evacuator. The results showed that MIS was feasible and safe, with positive outcomes observed in the majority of patients. Further exploration of this method is warranted.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Alexander J. Schupper, Mirhojjat Khorasanizadeh, Christina P. Rossitto, Lydia D. Foster, Christopher P. Kellner, Jose I. Suarez, Adnan I. Qureshi, Shahram Majidi
Summary: This study evaluated the impact of smoking on hematoma expansion and clinical outcome in patients with primary intracerebral hemorrhage. The results showed that smoking was associated with hematoma expansion, but had no significant effect on death and disability rates.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Health Care Sciences & Services
Tosto-Mancuso
Summary: This study demonstrated the feasibility of remote patient monitoring in patients poststroke or at immediate risk of stroke, and facilitates the triage of care when blood pressure exceeds recommended limits.
TELEMEDICINE REPORTS
(2022)
Article
Health Care Sciences & Services
Jenna M. Tosto-Mancuso, David Putrino, Jamie Wood, Laura Tabacof, Erica Breyman, Leila Nasr, Nicki Mohammadi, Neha S. Dangayach, Christopher P. Kellner
Summary: This study investigated the application of remote patient monitoring of blood pressure in patients poststroke or at immediate risk of stroke and its impact on triage and escalation of care. The study demonstrated the feasibility of using remote patient monitoring to triage care when blood pressure is elevated above recommended limits.
TELEMEDICINE REPORTS
(2022)
Article
Medicine, General & Internal
Katty Wu, Kurt A. Yaeger, Christopher Paul Kellner, Hazem Shoirah
Summary: This study presents a simultaneous bilateral thrombectomy method for acute bilateral middle cerebral artery occlusions, resulting in successful vessel recanalisation without hemorrhagic complications. However, the patient's unfavorable outcome was complicated by a history of heart failure and other cardiac-related problems, requiring maximal assistance at a skilled nursing facility.
Article
Ophthalmology
Ethan K. Sobol, Yu Sakai, Danielle Wheelwright, Carl S. Wilkins, Amanda Norchi, Michael G. Fara, Christopher Kellner, James Chelnis, J. Mocco, Richard B. Rosen, Reade A. De Leacy, Gareth M. C. Lema
Summary: TAT treatment showed significant visual improvement in central retinal artery occlusion cases, with some patients experiencing a remarkable improvement in vision. There were no statistically significant differences found based on treatment time, tPA dose, or the use of paracentesis. No major adverse events were recorded in this small study.
CLINICAL OPHTHALMOLOGY
(2021)