Article
Biochemistry & Molecular Biology
Ryo Yamamoto, Tetsufumi Ito, Takafumi Furuyama, Munenori Ono, Nobuo Kato
Summary: Accumulating evidence suggests that the serotonergic system in the amygdala plays a significant role in affective states. This study aimed to identify the specific subtype of 5-HT receptors responsible for modulating excitatory transmission in the lateral amygdala. The results show that 5-HT1B receptors are involved in the attenuation of excitatory synaptic currents in principal neurons of the lateral amygdala.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Cell Biology
Carla Budrow, Kayla Elder, Michael Coyle, Ashley Centner, Natalie Lipari, Sophie Cohen, John Glinski, N'Senga Kinzonzi, Emily Wheelis, Grace McManus, Fredric Manfredsson, Christopher Bishop
Summary: Parkinson's Disease (PD) is a neurodegenerative disorder characterized by motor symptoms caused by the loss of dopamine cells. Recent studies have shown that neuroplasticity in the serotonin system plays a role in the development and severity of drug-induced side effects in PD patients. Through experiments on sub-chronic vortioxetine treatment, we found that the dopamine transporter modulates the anti-dyskinetic effects of vortioxetine by regulating 5-HT1A/1B receptors.
Article
Clinical Neurology
Eric M. Schoenfeld, Nishant K. Gupta, Shariful A. Syed, Anna Rozenboym, Sasha L. Fulton, Andrea P. Jackowski, Tarique D. Perera, Jeremy D. Coplan
Summary: The study suggests that bonnet macaques reared under stress, carrying the ?s?-allele and having smaller adolescent hippocampal volume, exhibit reduced neurogenesis in adulthood. The positive impact of ipsilateral hippocampal volume on neurogenesis levels was observed.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Biochemistry & Molecular Biology
Alyssa M. West, Katherine M. Holleran, Sara R. Jones
Summary: The serotonin and kappa opioid receptor (KOR) systems play important roles in disorders of negative affect. In this study, the researchers investigated the effects of KOR activation and serotonin reuptake inhibition on serotonin transmission in the substantia nigra pars reticulata (SNr). They found that KOR activation reduced serotonin release and uptake, while serotonin reuptake inhibition increased serotonin release and slowed reuptake. The researchers also demonstrated that short-term activation of KOR altered serotonin responses to reuptake inhibition. These findings highlight the complex interactions between KORs and serotonin in regulating negative affect, and suggest that the KOR system may be a promising target for treating disorders such as anxiety and depression alongside traditional antidepressant treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Smriti Patodia, Alyma Somani, Joan Liu, Alice Cattaneo, Beatrice Paradiso, Maria Garcia, Muhammad Othman, Beate Diehl, Orrin Devinsky, James D. Mills, Jackie Foong, Maria Thom
Summary: Multiple lines of evidence suggest a link between deficient serotonin function and SUDEP, with chronic treatment using serotonin reuptake inhibitors shown to reduce the risk factors associated with SUDEP. Decreased medullary serotonergic neurons, which regulate respiration in response to hypercapnia, have been found in post-mortem SUDEP cases. Additionally, the high innervation of serotonergic neurons in the amygdala and hippocampus, regions involved in seizure-related respiratory dysregulation, further supports the potential involvement of altered serotonergic networks in SUDEP.
Article
Neurosciences
Nikita Deo, Gregory Redpath
Summary: This article examines the important role of endocytosis in the cellular basis of depression and anxiety. It provides a detailed explanation of the endocytic regulation of 5-HT receptors and SERT, and explores how SSRIs and hallucinogenic compounds modulate serotonin signaling through endocytosis.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Luis A. Marquez, Alfredo Meneses, Emilio J. Galvan
Summary: This study investigates the role of 5-HT6 receptors in modulating GABAergic and glutamatergic synaptic transmission. Pharmacological manipulation of 5-HT6 receptors regulates the inhibitory postsynaptic potentials and population spike in the dorsal hippocampus, as well as the magnitude of paired-pulse inhibition. The study also demonstrates that the anti-amnesic effect induced by 5-HT6 receptor blockade requires modulation of GABAergic transmission.
Article
Neurosciences
I Olivas-Cano, J. M. Rodriguez-Andreu, J. M. Blasco-Ibanez, C. Crespo, J. Nacher, E. Varea
Summary: Adult neurogenesis remains active during adulthood in certain brain regions, such as the subgranular zone (SGZ) of the hippocampus. Factors and CNS disorders, including major depression, can reduce adult neurogenesis. Antidepressant treatments, like chronic fluoxetine administration, can restore normal levels of adult neurogenesis. This study investigates the relevance of the serotonin receptor 3 (5-HT3) in hippocampal neurogenesis in adult rats, finding that 5-HT3 receptor activation is necessary for the increase in neurogenesis induced by fluoxetine.
NEUROSCIENCE LETTERS
(2023)
Article
Neurosciences
Pierre Lecouflet, Candice M. Roux, Brigitte Potier, Marianne Leger, Elie Brunet, Jean-Marie Billard, Pascale Schumann-Bard, Thomas Freret
Summary: Activation of the 5-HT4R has been shown to impact LTP within the hippocampal CA1 area through modulation of GABAergic neurotransmission. The study also revealed the involvement of GABA(B) receptor in this regulatory process.
Article
Biochemistry & Molecular Biology
Caroline Lahogue, Jean-Marie Billard, Thomas Freret, Valentine Bouet
Summary: The 5-HT6 receptors antagonist SB-271046 increases excitatory synaptic transmission and NMDAR activation at the CA3/CA1 hippocampal connections in mice. In male mice, this improvement is related to GABAAR antagonism, while in female mice it is not. Furthermore, the 5-HT6 receptors blockade has no significant effect on synaptic plasticity.
Article
Biochemistry & Molecular Biology
Elena Yu. Rybakova, Piotr P. Avdonin, Sergei K. Trufanov, Nikolay V. Goncharov, Pavel V. Avdonin
Summary: This study investigates the regulation of intracellular calcium concentration in human umbilical vein endothelial cells by 5-HT1B and 5-HT2B receptors. The findings suggest that simultaneous activation of both receptors leads to a synergistic increase in calcium concentration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Scheila Daiane Schmidt, Carolina Garrido Zinn, Lorena Evelyn Cavalcante, Flavia Fagundes Ferreira, Cristiane Regina Guerino Furini, Ivan Izquierdo, Jociane De Carvalho Myskiw
Summary: Social recognition, crucial for social group establishment, reproduction, and species survival, relies on the consolidation of social stimuli in long-term memory. This study reveals the involvement of specific serotonin receptors in the consolidation of social recognition memory, shedding light on the molecular mechanisms underlying this process.
Article
Chemistry, Medicinal
Dilip K. Tosh, Maggie M. Calkins, Marko S. Ivancich, Hailey A. Bock, Ryan G. Campbell, Sarah A. Lewicki, Eric Chen, Zhan-Guo Gao, John D. Mccorvy, Kenneth A. Jacobson
Summary: Derivatives of (N)-Methanocarba adenosine were modified to target 5-HT2B serotonin receptors as antagonists, showing affinity enhancement with the bicyclic ring system. Compound 43 (MRS7925) exhibited potential for anti-fibrotic therapy due to its affinity and moderate 5-HT2BR binding selectivity. The compounds also demonstrated dual action as 5-HT2B antagonists and A(1)AR agonists.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Neurosciences
Takuma Nishijo, Etsuko Suzuki, Toshihiko Momiyama
Summary: This study investigated the modulation of glutamatergic transmission onto cholinergic neurones in the rat basal forebrain slices induced by serotonin (5-HT). Results showed that 5-HT, as well as agonists of 5-HT1A or 5-HT1B receptors, inhibited EPSCs. Activation of 5-HT1A receptors decreased postsynaptic glutamate receptor sensitivity, while presynaptic activation of 5-HT1B receptors inhibited glutamate release. The different pre- and postsynaptic mechanisms underlying 5-HT1A and 5-HT1B receptor-mediated modulation of excitatory transmission were revealed.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Neurosciences
Sang Beom Jun, Stephen R. Ikeda, Jee Eun Sung, David M. Lovinger
Summary: Ethanol enhances 5-HT3-induced GABA release by modulating calcium levels and involving cAMP-mediated signaling in presynaptic terminals, resulting in long-lasting potentiation.
Article
Biochemistry & Molecular Biology
Hui-Ting Huang, Shun-Fen Tzeng
Summary: Our study demonstrates the role of interleukin-33 (IL-33) in a demyelinating mouse model induced by cuprizone (CPZ), showing that IL-33 can alleviate the reduction of APC+ OLs and the decline of IL-33 levels in the corpus callosum, and promote the expression of myelin basic protein (MBP).
NEUROCHEMISTRY INTERNATIONAL
(2024)