Journal
NEUROCHEMISTRY INTERNATIONAL
Volume 58, Issue 7, Pages 820-825Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2011.03.010
Keywords
Alzheimer's disease; AMPA receptors; GluA2; Mixed dementia; Neocortex; Subcortical ischemic vascular dementia
Categories
Funding
- Singapore National Medical Research Council (NMRC) [R-184-003-184-511, R-711-000-017-101]
- Life Sciences Institute, National University of Singapore
- NIHR Biomedical Research Centre, Oxford
Ask authors/readers for more resources
Glutamatergic AMPA receptors are of clinical significance in dementia because of their roles in mediating fast excitatory neurotransmission and other synaptic events relevant to cognition. Reductions in the AMPA receptor GluR2 subunit are well-established in Alzheimer's disease (AD), but the status of GluR2 in subcortical ischemic vascular dementia (SIVD) and mixed AD/SIVD (MIX) has not been investigated. In this study we measured GluR2 immunoreactivity and mRNA levels in the postmortem neocortex of a longitudinally assessed cohort of SIVD and MIX, together with age-matched controls. We found that GluR2 immunoreactivity and mRNA were up-regulated in SIVD, but remained unchanged in MIX. Furthermore, higher GluR2 immunoreactivity was associated with milder cognitive impairment and lower concentrations of A beta 42 peptide and phosphorylated tau. Our study suggests that GluR2 upregulation may be an adaptive process in SIVD, and that this process is repressed in the presence of concomitant AD in mixed dementia. (C) 2011 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available