Article
Biochemistry & Molecular Biology
Xudong Yi, Rui Cai, Weike Shaoyong, Guoyan Wang, Wenyong Yan, Ri Li, Mingkun Chao, Tiantian Zhao, Lu Deng, Gongshe Yang, Weijun Pang
Summary: Gut health is crucial for perinatal and early weaned mammals, and melatonin may play a role in maintaining gut health through its impact on the gut microbiome. However, more research is needed to fully understand the effects of melatonin on the gut microbiota and its role in mediating gut health.
Article
Biochemistry & Molecular Biology
Marina Ushio, Toshiki Ishikawa, Takakazu Matsuura, Izumi C. Mori, Maki Kawai-Yamada, Yoichiro Fukao, Minoru Nagano
Summary: In this study, the functions of MHP1 and MHL in Arabidopsis were investigated. The results showed that MHP1 and MHL are involved in synthesizing OCFAs and regulating immune responses in plants.
Article
Biochemistry & Molecular Biology
Chongyang Huang, Wenjun Deng, Huan-zhou Xu, Chen Zhou, Fan Zhang, Junfei Chen, Qinjia Bao, Xin Zhou, Maili Liu, Jing Li, Chaoyang Liu
Summary: Short-chain fatty acids (SCFAs) have anticancer activity in colon cancer. Acetate, propionate, and butyrate are the major SCFAs produced from dietary fiber by gut microbiota fermentation and have beneficial effects on human health. This study systematically analyzed the effects of acetate, propionate, and butyrate on ROS levels and metabolic and transcriptomic signatures in human colorectal adenocarcinoma cells, showing elevated levels of ROS and regulated signatures in pathways related to ROS production.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Chemistry, Applied
Giuseppina Maria Fiorino, Ali Zein Alabiden Tlais, Ilario Losito, Pasquale Filannino, Marco Gobbetti, Raffaella Di Cagno
Summary: This study demonstrates that lactic fermentation using selected starters can increase the presence of hydroxy- and oxo-fatty acids in plant matrices. The behavior of 31 strains of lactic acid bacteria during the fermentation of Persian walnuts was investigated, with a focus on the increase of certain fatty acids and the release of hydroxy- and epoxy-fatty acids. The study identified various bacteria strains, including Weissella cibaria, Leuconostoc mesenteroides, and Enterococcus faecalis, with notable lipolytic activities and the ability to produce hydroxy- and epoxy-fatty acids during walnut fermentation.
Article
Biochemistry & Molecular Biology
Fang Li, Zhuoran Kang, Xiaojuan Wu, Wei Wu
Summary: Dietary protein plays a crucial role in body growth and shaping the gut microbiota. This study found that oxidation of rice bran protein (RBP) altered the composition of the gut microbiota, improved intestinal barrier function, but had limited effects on short-chain fatty acid production.
Article
Plant Sciences
Fuyou Xiang, Wen-Cheng Liu, Xin Liu, Yuwei Song, Yu Zhang, Xiaojing Zhu, Pengtao Wang, Siyi Guo, Chun-Peng Song
Summary: During seed germination, plants utilize the CYP77A4 gene to catalyze the epoxidation of unsaturated fatty acids, balancing energy supply and reactive oxygen species (ROS) production to prevent oxidative damage.
Article
Immunology
Ming-min Zhou, Di-wen Li, Liao Xu, Bin Kong, Xi Wang, Yan-hong Tang, He Huang, Yu Liu
Summary: Propionate administration in early stage after myocardial infarction can alleviate cardiac dysfunction and remodeling by modulating macrophages polarization and pro-inflammatory cytokine production.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Ling-Jun Li, Ruochen Du, Marion Ouidir, Ruijin Lu, Zhen Chen, Natalie L. Weir, Michael Y. Tsai, Paul S. Albert, Cuilin Zhang
Summary: Saturated fatty acids (SFAs) during pregnancy have an impact on metabolic programming and fetal growth. In this study, plasma phospholipid SFAs were measured in early pregnancy and fetal growth was monitored. It was found that even-chain and very long even-chain SFAs were negatively associated, while odd-chain SFAs were positively associated with fetal weight and size. Pentadecanoic acid (15:0) in the highest tertile showed a greater fetal weight and size compared to the lowest tertile. These findings suggest the potential use of an alternative high-fat diet rich in odd-chain SFAs for optimal fetal growth.
Article
Multidisciplinary Sciences
Kristin J. Skaarud, Johannes R. Hov, Simen H. Hansen, Martin Kummen, Jorgen Valeur, Ingebjorg Seljeflot, Asta Bye, Vemund Paulsen, Knut E. A. Lundin, Marius Troseid, Geir E. Tjonnfjord, Per Ole Iversen
Summary: After allo-HSCT, gut microbiota and short-chain fatty acids were significantly reduced, with no significant differences between the intervention group and controls in investigated parameters. Patients with low microbial diversity at 3 weeks post-HSCT had significantly higher mortality rates, while those with higher abundance of Blautia genus were more likely to survive.
SCIENTIFIC REPORTS
(2021)
Article
Food Science & Technology
Lisa F. M. Lee Nen That, Baojun Xu, Jessica Pandohee
Summary: The maturation of omics technologies and bioinformatics tools has greatly advanced prebiotics research. Prebiotics are no longer limited to oligosaccharides, but include various compounds that have been proven to have prebiotic characteristics. The discovery of novel prebiotics requires further understanding of their roles in the microbiota and the host. The relationship between the gut microbiota and the host is crucial for health, and dysbiosis can result in severe illnesses.
CURRENT OPINION IN FOOD SCIENCE
(2022)
Article
Chemistry, Applied
Azemina Bajramova, Peter Spegel
Summary: This study compares the nutritional value of the fatty acid profiles of superfruits (goji berry, white mulberry, and cranberry) and common fruits (banana, apple, and strawberry). The findings suggest that cranberries and apples have the most beneficial lipid profiles, while superfruits do not show a common and beneficial lipid profile.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Article
Environmental Sciences
Quan Zhang, Sijia Gu, Yan Wang, Shitao Hu, Siqing Yue, Cui Wang
Summary: The study reveals that alpha-CYP causes weight loss, hepatic glycogen accumulation, and hyperlipemia in rats, while theta-CYP induces systemic inflammation. The gut microbiome composition differs significantly in the alpha-CYP-treated group, with lower levels of Firmicutes and higher levels of Verrucomicrobia. Short-chain fatty acids (SCFAs) are associated with blood glucose and Verrucomicrobia, which may explain the differential effects of alpha-CYP and theta-CYP.
JOURNAL OF ENVIRONMENTAL SCIENCES
(2023)
Article
Environmental Sciences
Quan Zhang, Sijia Gu, Yan Wang, Shitao Hu, Siqing Yue, Cui Wang
Summary: This study revealed that the alpha isomer of Cypermethrin (CYP) caused significant weight loss and hepatic glycogen accumulation in rats. It also found a correlation between changes in gut microbiome and CYP toxicity.
JOURNAL OF ENVIRONMENTAL SCIENCES
(2023)
Article
Medicine, General & Internal
Maaike E. Straat, Lucas Jurado-Fasoli, Zhixiong Ying, Kimberly J. Nahon, Laura G. M. Janssen, Mariette R. Boon, Gernot F. Grabner, Sander Kooijman, Robert Zimmermann, Martin Giera, Patrick C. N. Rensen, Borja Martinez-Telleza
Summary: The application of cold exposure has shown to enhance lipid catabolism in the human body. However, the effect of cold exposure on the lipidome varies depending on the intensity and duration of exposure. Through sequential lipidomic profiling, this study found that cold exposure gradually increased circulating free fatty acids in humans, while temporarily decreasing total triacylglycerols (TAGs) at 30 minutes. Different TAG species showed varying responses, with the initial decrease in unsaturated and polyunsaturated TAG species with <= 5 double bonds, followed by a significant increase in polyunsaturated TAG species with >= 6 double bonds after 120 minutes. A mechanistic study in mice revealed that the increase in polyunsaturated TAGs induced by cold exposure was largely prevented by blocking adipose triglyceride lipase. These findings suggest that cold exposure promotes the utilization of TAG-derived fatty acids for thermogenesis, resulting in a decrease in circulating TAG species and an increased production of polyunsaturated TAG species by the liver.
Review
Pharmacology & Pharmacy
Pinyi Liu, Yanbing Wang, Ge Yang, Qihe Zhang, Lingbin Meng, Ying Xin, Xin Jiang
Summary: Short-chain fatty acids (SCFAs), produced during bacterial fermentation of dietary fiber, play crucial roles in regulating inflammation, carcinogenesis, intestinal barrier function, and oxidative stress. Their signaling mechanisms involve histone acetylation promotion and activation of G-protein-coupled receptors. SCFAs have a wide range of positive effects and show high therapeutic potential in human-related diseases.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Cell Biology
Mateus Grings, Moacir Wajner, Guilhian Leipnitz
Summary: Ethylmalonic encephalopathy is a severe intoxication disorder caused by mutations in the ETHE1 gene. Disruption of mitochondrial and redox homeostasis, as well as oxidative stress, are important pathomechanisms in tissue damage. Current treatment does not effectively prevent encephalopathy.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Medicine, General & Internal
Hugo Monteiro, Fernando Tavares, Joao Reis, Gustavo Ferreira, M. Jose Campos, Sergio Costa, Laura Carvalho, Joao Carvalho, Isabel Pedroto, Jose Soares, Rui Henrique, Maria Jose Bento, Cesare Hassan, Mario Dinis-Ribeiro
Summary: In the first year of implementing the colorectal cancer screening program in Northern Portugal, the adherence rate was 29%, with a positivity rate of 5% for the faecal immunochemical test and a compliance rate of 60% for colonoscopy. The detection rate of advanced neoplasia in the faecal immunochemical test was 0.35/1000 subjects.
ACTA MEDICA PORTUGUESA
(2022)
Article
Surgery
Luis Gustavo Modelli de Andrade, Taina Veras de Sandes-Freitas, Lucio R. Requiao-Moura, Laila Almeida Viana, Marina Pontello Cristelli, Valter Duro Garcia, Aline Lima Cunha Alcantara, Ronaldo de Matos Esmeraldo, Mario Abbud Filho, Alvaro Pacheco-Silva, Erika Cristina Ribeiro de Lima Carneiro, Roberto Ceratti Manfro, Kellen Micheline Alves Henrique Costa, Denise Rodrigues Simao, Marcos Vinicius de Sousa, Viviane Brandao Bandeira de Mello Santana, Irene L. Noronha, Elen Almeida Romao, Juliana Aparecida Zanocco, Gustavo Guilherme Queiroz Arimatea, Deise De Boni Monteiro de Carvalho, Helio Tedesco-Silva, Jose Medina-Pestana
Summary: This study used data from the Brazilian kidney transplant COVID-19 study to develop a prediction score for stratifying COVID-19 risk in kidney transplant recipients. The prediction score included factors such as age, hypertension, cardiovascular disease, body mass index, symptoms, and medication use.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Review
Dentistry, Oral Surgery & Medicine
Carolina Ferrairo Danieletto-Zanna, Gustavo Zanna Ferreira, Osny Ferreira Junior, Angelo Jose Pavan, Edevaldo Tadeu Camarini
Summary: This paper reports a case of infected silicone chin implant due to the nonideal placement of dental implants. The removal of mobile dental implants and silicone implant, along with imaging exams, revealed other complications. The study emphasizes the importance of precise imaging exams for diagnosis and treatment planning.
JOURNAL OF ORAL IMPLANTOLOGY
(2022)
Article
Neurosciences
Leticia Barbieri Caus, Mayara Vendramin Pasquetti, Bianca Seminotti, Michael Woontner, Moacir Wajner, Maria Elisa Calcagnotto
Summary: This study investigated the impact of quinolinic acid on the neurological features of GA-I, finding that Gcdh(-/-)-Lys mice showed increased susceptibility to quinolinic acid-induced seizures and enduring alterations in brain oscillation patterns.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Nutrition & Dietetics
Andrey Vinicios S. Carvalho, Rafael T. Ribeiro, Luz Elena Duran-Carabali, Ana Paula R. Martini, Eduarda Hoeper, Eduardo F. Sanches, Eduardo Luis Konrath, Carla Dalmaz, Moacir Wajner, Carlos Alexandre Netto
Summary: This study demonstrates that the Plinia trunciflora fruit extract (PTE) has a neuroprotective role in neonatal rats with experimental brain hypoxia-ischemia (HI). PTE effectively prevents oxidative stress and inflammatory response induced by HI, as evidenced by reduced lipoperoxidation levels and interleukin-1 beta levels. PTE also prevents neuronal loss, astrocyte reactivity, anxiety-like behavior, spatial memory impairment, and neural tissue loss caused by HI.
Article
Pharmacology & Pharmacy
Nevton Teixeira da Rosa-Junior, Belisa Parmeggiani, Nicolas Manzke Glanzel, Leonardo de Moura Alvorcem, Morgana Brondani, Renata Britto, Mateus Grings, Vanessa Duarte Ortiz, Patrick Turck, Alex Sander da Rosa Araujo, Moacir Wajner, Guilhian Leipnitz
Summary: Barth syndrome and dilated cardiomyopathy with ataxia syndrome are characterized by high levels of 3-methylglutaric acid in urine and plasma. This study found that 3-methylglutaric acid induced lipid peroxidation, altered antioxidant defenses and reduced mitochondrial function in rat heart. It also affected signaling pathways and mitochondrial biogenesis. Vascular reactivity in the aorta was further disturbed by 3-methylglutaric acid. Pretreatment with bezafibrate mitigated most of these effects but did not prevent vascular reactivity disturbances.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Cell Biology
Julia Pramio, Mateus Grings, Amanda Gasparin da Rosa, Rafael Teixeira Ribeiro, Nicolas Manzke Glanzel, Marian Flores Signori, Manuela Bianchin Marcuzzo, Larissa Daniele Bobermin, Angela T. S. Wyse, Andre Quincozes-Santos, Moacir Wajner, Guilhian Leipnitz
Summary: Isolated sulfite oxidase (ISOD) and molybdenum cofactor (MoCD) deficiencies are genetic diseases characterized by the accumulation of toxic sulfite in the brain tissues, leading to neurological dysfunction and brain abnormalities in newborns. This study found that sulfite administration caused redox imbalance, mitochondrial dysfunction, and altered signaling proteins in the cerebral cortex of rat pups, which may contribute to the neuropathology of ISOD and MoCD.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Warley Luciano Fonseca Tavares, Ana Cecilia Diniz Viana, Marcus Vinicius Lucas Ferreira, Gabriela da Costa Ferreira, Isabella da Costa Ferreira, Ricardo Alves de Mesquita, Rodrigo Rodrigues Amaral
Summary: External cervical resorption (ECR) is a type of dental resorption that occurs when the cementum's protective layer is lost, leading to the invasion of clastic cells and tooth resorption. This case report examines the use of guided tissue regeneration (GTR) with xenogenic material and polydioxanone membrane to treat class IV ECR. The successful outcome highlights the importance of correct diagnosis and treatment planning, including thorough debridement and restoration with biodentine, as well as the use of GTR for stabilizing periodontal tissues.
JOURNAL OF ENDODONTICS
(2023)
Article
Communication
Marcelo Kischinhevsky, Gustavo Ferreira, Itala Maduell Vieira
Summary: This article discusses the role of serendipity in music streaming platforms and radio, emphasizing the connection between discovery, memory, and recognition. It explores the impact of serendipitous discovery on building bonds and fostering music innovation. The article also highlights the importance of considering the listeners' sociocultural background in creating serendipitous experiences, rather than relying solely on computer algorithms. Ultimately, it argues that understanding the complexity of serendipity is crucial for addressing critical issues in the music industry amidst the rise of platformization.
NEW MEDIA & SOCIETY
(2023)
Article
Mathematics
Gustavo Rodrigues Ferreira
Summary: Since the 1980s, significant advances have been made in determining the shared Julia sets of functions. While the polynomial case has been completely solved in 1995 using the symmetries of the Julia set, the rational case remains more complex. This study extends Beardon's results on the symmetry group of Julia sets and explores their application to singularly perturbed maps.
CONFORMAL GEOMETRY AND DYNAMICS
(2023)
Review
Clinical Neurology
Francielle Joyce Fuckner Leonel, Lauana de Paula, Gustavo Cezar Raab Ferreira, Dariel Matheus dos Reis do Nascimento, Talita Gianello Gnoato Zotz, Julia Milena de Melo, Ana Carolina Brandt de Macedo
Summary: The aim of this study is to compare the effects of two suspension training protocols on pain and musculoskeletal function in women with chronic low back pain. The study will be a randomized, controlled, blinded clinical trial. Women aged 18-60 years with chronic low back pain will be selected and randomized into three groups: STG1, STG2, and control group. STG1 and STG2 will undergo training twice a week for 60 minutes for 12 weeks. It is expected to evaluate pain reduction and functionality improvement in both groups and determine the best training protocol.
Article
Neurosciences
Isadora Matias, Luan Pereira Diniz, Ana Paula Bergamo Araujo, Isabella Vivarini Damico, Pamella de Moura, Felipe Cabral-Miranda, Fabiola Diniz, Belisa Parmeggiani, Valeria de Mello Coelho, Renata E. P. Leite, Claudia K. Suemoto, Gustavo Costa Ferreira, Regina Celia Cussa Kubrusly, Flavia Carvalho Alcantara Gomes
Summary: Aging is characterized by physiological changes in the brain, including the glutamatergic system, which leads to a decline in brain function. The increased presence of senescent cells, such as glial cells, has been found to impact cognition in both animal models and human tissue during normal aging and neurodegenerative disease. The mechanisms of glutamate homeostasis in brain aging are still not well understood.
Article
Infectious Diseases
Lorena O. Fernandes-Siqueira, Bruna G. Sousa, Carlos E. Cleto, Luciana S. Wermelinger, Beatriz L. L. Caetano, Agatha R. Pacheco, Simone M. Costa, Fabio C. L. Almeida, Gustavo C. Ferreira, Didier Salmon, Ada M. B. Alves, Andrea T. Da Poian
Summary: This study aimed to evaluate the correlation between serum antibody seroconversion and neutralizing antibody titers in individuals who received a complete initial vaccination schedule. The results showed that although IgG titers were high in all individuals after vaccination, the amounts of neutralizing antibodies varied among the groups. Serum neutralizing antibody concentrations were more comparable to IgA levels, suggesting that these antibodies have a major neutralizing capacity against SARS-CoV-2.
JOURNAL OF CLINICAL VIROLOGY PLUS
(2022)
Article
Surgery
Taina Veras de Sandes-Freitas, Marina Pontello Cristelli, Lucio Roberto Requiao-Moura, Luis Gustavo Modelli de Andrade, Laila Almeida Viana, Valter Duro Garcia, Claudia Maria Costa de Oliveira, Ronaldo de Matos Esmeraldo, Paula Roberta de Lima, Ida Maria Maximina Fernandes Charpiot, Teresa Cristina Alves Ferreira, Rodrigo Fontanive Franco, Kellen Micheline Alves Henrique Costa, Denise Rodrigues Simao, Gustavo Fernandes Ferreira, Viviane Brandao Bandeira de Mello Santana, Ricardo Augusto Monteiro de Barros Almeida, Luciane Monica Deboni, Anita Leme da Rocha Saldanha, Irene de Lourdes Noronha, Livia Claudio de Oliveira, Deise De Boni Monteiro de Carvalho, Reinaldo Barreto Oria, Jose Osmar Medina-Pestana, Helio Tedesco-Silva
Summary: Data from the Brazilian Kidney Transplant COVID-19 Registry suggests that fatality rates for hospitalized patients with COVID-19 decreased over time. The decrease in fatality was associated with a lower number of comorbidities, younger age, better baseline renal function, and a decrease in the proportion of patients with dyspnea, hypoxemia, and requiring intensive care.
TRANSPLANT INTERNATIONAL
(2022)