Article
Clinical Neurology
Alba Trislan-Noguero, Eva Borras, Marta Molero-Luis, Tessa Wassenberg, Tessa Peters, Marcel M. Verbeek, Michel Willemsen, Thomas Opladen, Kathrin Jeltsch, Roser Pons, Beat Thony, Gabriella Horvath, Zuhal Yapici, Jennifer Friedman, Keith Hyland, Guillermo E. Agosta, Eduardo Lopez-Laso, Rafael Artuch, Eduard Sabido, Angels Garcia-Cazorla
Summary: This study conducted proteomic studies in cerebrospinal fluid samples of patients with monoamine defects and identified 4 novel biomarkers, shedding new light on the consequences of early dopaminergic deprivation in the developing brain.
MOVEMENT DISORDERS
(2021)
Article
Endocrinology & Metabolism
Huimin Jiang, Chen Zhou, Huimin Wei, Yan Wu, Yifan Zhou, Xuechun Xiao, Lu Liu, Ming Li, Jiangang Duan, Ran Meng, Xunming Ji
Summary: In this study, metabolomic analysis was performed on plasma samples from acute CVT patients and healthy controls to identify specific biomarkers with high predictive ability for the diagnosis of acute CVT. The results showed that the caffeine metabolism pathway and the biosynthesis pathway for the BCAAs valine, leucine, and isoleucine were significant pathways between the CVT and healthy cohorts. The concentrations of BCAAs demonstrated good diagnostic efficacy for differentiating patients with acute CVT from the control cohort.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Immunology
Jing Xie, Ying Wang, Qi Zhong, Shun-jie Bai, Chan-juan Zhou, Tian Tian, Jian-jun Chen
Summary: This study investigated the relationships between microbial metabolites in feces and neurotransmitters in the prefrontal cortex of depressed mice using targeted metabolomics. The results identified differential microbial metabolites and neurotransmitters and found significant correlations between them. The study suggests that disturbances in microbial metabolites, especially amino acids, may affect neurotransmitter levels and contribute to the onset of depression.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hugo Alarcan, Romane Chaumond, Patrick Emond, Isabelle Benz-De Bretagne, Antoine Lefevre, Salah-eddine Bakkouche, Charlotte Veyrat-Durebex, Patrick Vourc'h, Christian Andres, Philippe Corcia, Helene Blasco
Summary: This study aimed to evaluate the kynurenine pathway and amino acids profile in the cerebrospinal fluid of ALS patients, revealing some metabolites involved in group discrimination and identifying common discriminant metabolites for disease evolution criteria. The findings suggest a possible impairment of the kynurenine pathway towards neurotoxicity in ALS patients and highlight the need for further exploration of these pathways during disease evolution.
Article
Multidisciplinary Sciences
Florian Krach, Judith Stemick, Tom Boerstler, Alexander Weiss, Ioannis Lingos, Stephanie Reischl, Holger Meixner, Sonja Ploetz, Michaela Farrell, Ute Hehr, Zacharias Kohl, Beate Winner, Juergen Winkler
Summary: This study investigates the molecular mechanism of Branaplam, a modulator of alternative splicing, in Huntington's disease. The drug effectively lowers mutant HTT protein levels and improves alternative splicing pathology in patient-derived cellular models. These findings demonstrate the potential of splicing modulators in treating CAG repeat disorders.
NATURE COMMUNICATIONS
(2022)
Review
Clinical Neurology
Wing Mann Ho, Franziska A. Schmidt, Claudius Thome, Ondra Petr
Summary: This mini review focuses on discussing the application and potential value of metabolomics in aneurysmal subarachnoid hemorrhage (aSAH). It is shown that patients' microdialysis enables the detection of biochemical changes in brain tissue. However, the pathophysiology and factors for poor outcome in aSAH patients are not completely understood yet. Routine use of biomarkers in cerebrospinal fluid, particularly in aSAH patients, is still lacking.
ACTA NEUROLOGICA BELGICA
(2023)
Article
Geriatrics & Gerontology
Roberto Aquilani, Matteo Cotta Ramusino, Roberto Maestri, Paolo Iadarola, Mirella Boselli, Giulia Perini, Federica Boschi, Maurizia Dossena, Anna Bellini, Daniela Buonocore, Enrico Doria, Alfredo Costa, Manuela Verri
Summary: This study aimed to investigate the changes in neurotransmitter synthesis, energy production, and oxidative stress in different dementia subtypes and MCI. The results showed that demented patients and MCI subjects exhibited reductions in amino acid precursors of neurotransmitter synthesis, impairment in energy production, and an increase in oxidative stress. These metabolic alterations may negatively affect synaptic plasticity and activity.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Benneth Ben-Azu, Christian Uruaka, Abayomi M. Ajayi, Thiophilus Aghogho Jarikre, Kingsley E. Nwangwa, Kingsley C. Chilaka, Bienose S. Chijioke, Marymagdalene G. Omonyeme, Chineye B. Ozege, Emmanuella C. Ofili, Ebidenara B. Warekoromor, Nwanneka L. Edigbue, Ufoma Esiekpe, Dabrechi E. Akaenyi, Gladys O. Agu
Summary: Schizophrenia is a severe neuropsychiatric disorder caused by complex neurobiological changes. Taurine has shown potential in reducing symptoms and protecting against schizophrenia through modulation of neurochemicals and neurotrophic factors, and inhibition of inflammatory cytokines.
NEUROCHEMICAL RESEARCH
(2023)
Article
Neurosciences
Kate J. Russin, K. Sreekumaran Nair, Thomas J. Montine, Laura D. Baker, Suzanne Craft
Summary: This study aimed to investigate the impact of diets with different nutrient compositions on cerebrospinal fluid amino acid levels, finding that a high saturated fat/glycemic index diet can lead to changes in amino acid levels in individuals with mild cognitive impairment. The response to diet intervention varies according to cognitive status.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Grazyna Galezowska, Joanna Ratajczyk, Lidia Wolska
Summary: Amino acid quantitation and qualification are commonly used in clinical and epidemiological studies to monitor compounds in human fluids and prevent diseases. Recent scientific interest in evaluating these compounds has led to the development of new analytical techniques. Despite the time-consuming sample preparation, various techniques are used for amino acid separation and determination, with attention to different sample types like urine, blood, and cerebrospinal fluid.
Article
Plant Sciences
Chu Wu, Yun Wang, Honggang Sun
Summary: In this study, targeted and untargeted metabolomics analysis were conducted to evaluate the drought tolerance of Pinus taeda seedlings. The results showed that certain sugars, phytohormones, and amino acids increased significantly in the roots and needles of water-stressed seedlings. Additionally, specific metabolites and biosynthesis pathways were found, providing insights for breeding drought-tolerant P. taeda cultivars.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Multidisciplinary Sciences
Chae Gyu Park, Min Kyung Chu
Summary: Glutamate is implicated in migraine pathogenesis, and altered plasma glutamate levels have been noted in migraine patients. Chronic migraine is associated with higher levels of central sensitization and pain transmission compared to episodic migraine. This study found significantly higher plasma glutamate levels in both episodic and chronic migraine patients compared to controls, with no significant difference between the two migraine subtypes.
SCIENTIFIC REPORTS
(2022)
Article
Biochemical Research Methods
Jiajia Shen, He Wang, Haoran Huang, Haofeng Li, Changjian Li, Caixia Yan, Tengjie Yu, Huimin Guo, Kangrui Hu, Yisha Du, Hong Sun, Lin Xie, Pingfei Fang, Yan Liang
Summary: The study proposed an all-in-one liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay for efficiently analyzing neurotransmitters and amino acids. Through research on absorption solvents and Collision Energy Defect strategy, the study achieved quantitative results with high sensitivity, accuracy, and noticeable recovery effects.
JOURNAL OF CHROMATOGRAPHY A
(2021)
Article
Multidisciplinary Sciences
Kornelia Laichinger, Paula Bombach, Jutta Duenschede, Christoph Ruschil, Maria-Ioanna Stefanou, Evelyn Dubois, Sven Poli, Katharina Feil, Ulf Ziemann, Markus Kowarik, Annerose Mengel
Summary: In this study, the prevalence of intrathecal IgG synthesis and B cell activation in AIS patients was determined. It was found that 5.7% of patients had intrathecal IgG synthesis, and one third of these patients had concurrent chronic inflammatory CNS disease. No significant correlation was found with stroke characteristics.
Article
Biochemistry & Molecular Biology
Jose Luis Trillo-Contreras, Juan Jose Toledo-Aral, Javier Villadiego, Miriam Echevarria
Summary: Aquaporin-4 (AQP4) is the principal water channel in the brain, playing a crucial role in cerebrospinal fluid (CSF) homeostasis and hydrocephalus. The study found that alterations associated with hydrocephalic state may not be permanent, as some symptoms can be reversed by reexposure to normoxia, but deficits in CSF outflow and ventricular distensibility persist.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Rehabilitation
Sarah Dewilde, Lieven Annemans, Andre Peeters, Dimitri Hemelsoet, Yves Vandermeeren, Philippe Desfontaines, Raf Brouns, Geert Vanhooren, Patrick Cras, Boudewijn Michielsens, Patricia Redondo, Vincent Thijs
DISABILITY AND REHABILITATION
(2020)
Article
Multidisciplinary Sciences
Rene A. J. Crans, Jana Janssens, Sofie Daelemans, Elise Wouters, Robrecht Raedt, Debby Van Dam, Peter P. De Deyn, Kathleen Van Craenenbroeck, Christophe P. Stove
Article
Pharmacology & Pharmacy
Ammar Kurdi, Lynn Roth, Bieke Van der Veken, Debby Van Dam, Peter P. De Deyn, Mireille De Doncker, Hugo Neels, Guido R. Y. De Meyer, Wim Martinet
VASCULAR PHARMACOLOGY
(2019)
Article
Pharmacology & Pharmacy
Lynn Roth, Carole Van der Donckt, Besa Emini Veseli, Debby Van Dam, Peter P. De Deyn, Wim Martinet, Arnold G. Herman, Guido R. Y. De Meyer
VASCULAR PHARMACOLOGY
(2019)
Article
Behavioral Sciences
Jan Van Erum, Debby Van Dam, Peter Paul De Deyn
EPILEPSY & BEHAVIOR
(2019)
Editorial Material
Pharmacology & Pharmacy
Debby Van Dam, Peter Paul De Deyn
EXPERT OPINION ON DRUG DISCOVERY
(2020)
Article
Medicine, Research & Experimental
Lisa Goudman, Raf Brouns, Bengt Linderoth, Maarten Moens
Summary: The study aimed to evaluate the reliability of the wearable device Polar V800 in measuring RR intervals in FBSS patients, and found that the wearable device and 2-lead ECG have similar capabilities in capturing treatment responses. This suggests that a wearable heart rate monitor might be a reliable tool for detecting changes in chronic pain patients undergoing spinal cord stimulation therapy.
Article
Medicine, Research & Experimental
Mats De Jaeger, Lisa Goudman, Raf Brouns, Ann De Smedt, Bengt Linderoth, Sam Eldabe, Maarten Moens
Summary: This study aimed to evaluate the effectiveness of HD-SCS after conversion from standard SCS and develop a model for predicting the long-term response of HD-SCS after unsatisfactory standard SCS. Results showed significant time effects for both low back and leg pain responders after conversion to HD-SCS. Logistic regression models highlighted the importance of pain intensity scores, medication use, paresthesia coverage (for back pain), and EQ5D (for leg pain) as predictors of being a responder after 12 months of HD-SCS.
Article
Neurosciences
Jan R. Detrez, Ines R. H. Ben-Nejma, Kristof Van Kolen, Debby Van Dam, Peter Paul De Deyn, Erik Fransen, Marleen Verhoye, Jean-Pierre Timmermans, Rony Nuydens, Annemie Van der Linden, Georgios A. Keliris, Winnok H. De Vos
NEUROBIOLOGY OF DISEASE
(2020)
Review
Biochemistry & Molecular Biology
Jhana O. Hendrickx, Wim Martinet, Debby Van Dam, Guido R. Y. De Meyer
Summary: The average age of the world's elderly population is increasing, leading to a rise in age-related disorders such as cardiovascular disease and neurodegeneration. Recent interest has focused on the potential interplay between cardiovascular diseases and neurodegenerative syndromes, with arterial stiffness identified as a common risk factor for both types of conditions. In this review, various inflammaging-related disease mechanisms are discussed, highlighting how they may contribute to the proposed synergism between arterial stiffness and Alzheimer's disease.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Chemistry, Medicinal
Annelies Heylen, Yannick Vermeiren, Ido P. Kema, Martijn van Faassen, Claude van der Ley, Debby Van Dam, Peter P. De Deyn
Summary: Despite distinct clinical profiles, ALS and FTD patients share pathological features, with a substantial percentage of patients displaying a mixed disease phenotype. Kynurenine metabolism plays a role in dementia-associated neuroinflammation and has been linked to both diseases. Kynurenine pathway metabolite levels were significantly lower in ALS patients compared to FTD, EOAD, and control subjects in multiple brain regions. This suggests that the contribution of kynurenine metabolism in neuroinflammation is lower in ALS than in FTD or EOAD, possibly due to differences in age of onset.
Article
Biology
Debby Van Dam, Femke Valkenburg, Kristof Van Kolen, Isabel Pintelon, Jean-Pierre Timmermans, Peter Paul De Deyn
Summary: The tau protein dysfunction is a core feature of neurodegenerative diseases, and mouse models expressing mutated tau protein associated with FTDP-17 can mimic some aspects of the disease. Our study demonstrates the validity of these models in replicating the pathology and symptoms of FTDP-17.
Article
Neurosciences
F. J. H. Sorgdrager, C. P. van Der Ley, M. van Faassen, E. Calus, E. A. Nollen, I. P. Kema, D. van Dam, P. P. De Deyn
INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH
(2020)
Article
Cell Biology
Andre Marreiro, Kristof Van Kolen, Cristiano Sousa, Liesbet Temmerman, Bruno Vasconcelos, Rosa Crespo-Rodriguez, Jan R. T. van Weering, Debby Van Dam, Peter P. De Deyn, Adrian Apetri, Liliane Schoofs, Marc H. Mercken
BMC MOLECULAR AND CELL BIOLOGY
(2020)
Article
Neurosciences
Jan Van Erum, Femke Valkenburg, Debby Van Dam, Peter Paul De Deyn
Article
Biochemistry & Molecular Biology
Hui-Ting Huang, Shun-Fen Tzeng
Summary: Our study demonstrates the role of interleukin-33 (IL-33) in a demyelinating mouse model induced by cuprizone (CPZ), showing that IL-33 can alleviate the reduction of APC+ OLs and the decline of IL-33 levels in the corpus callosum, and promote the expression of myelin basic protein (MBP).
NEUROCHEMISTRY INTERNATIONAL
(2024)