Journal
NEUROCHEMISTRY INTERNATIONAL
Volume 56, Issue 2, Pages 318-328Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2009.10.015
Keywords
alpha-Synuclein; Parkinson disease; Oxidative stress; Docosahexaenoic acid; Fatty acids
Categories
Funding
- Spanish Ministry of Education and Science [BFU2009-11879/BFI]
- Spanish Ministry of Health (ISCIII, Red de Envejecimiento y Fragilidad) [RD06/0013/0012]
- Generalitat of Catalunya [2009SGR735]
- Spanish Ministry of Health [05-2241, 08-1843, 08-582]
- La Caixa Foundation
- Spanish Ministry of Industry
Ask authors/readers for more resources
Transgenic mice expressing both wild mouse a-synuclein and the Parkinson's disease associated A53T mutated human alpha-synuclein were subjected to long-term diets impoverished in n-3 or diets impoverished in n-3 and supplemented with docosahexaenoic acid (DHA) for 6 months. Transgenic mice evidenced mild phenotype characterized by increased total alpha-synuclein expression, truncated alpha-synuclein forms, and abnormal solubility and aggregation, in the absence of Lewy bodies and neurites, and lack of apparent neuronal loss, astrocytosis and microgliosis. These diets produced a reduction in the content of linolenic, n-3 docosapentaenoic and total polyunsaturated fatty acids, leading to significantly lower double bond and peroxidizability indexes as well as to lower protein oxidative damage, with no effects in alpha-synuclein expression and with no modifications in the number of cortical astrocytes and microglial cells. The present results show that diets may modify brain lipid composition and susceptibility to oxidative damage that do not interfere with phenotype in models with a genetic susceptibility to develop alpha-synucleinopathy. (C) 2009 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available