Article
Pharmacology & Pharmacy
Lin Lu, Jianjian Huang, Xia Xue, Ting Wang, Zhouqing Huang, Jianmin Li
Summary: Elevated expression of P2X7R and decreased levels of miR150-5p were observed in oxLDL-induced macrophages. Inhibition of AMPK-alpha and MAPK signaling pathways reversed the upregulation of EMMPRIN and MMP-9 expression mediated by P2X7R. Berberine treatment resulted in increased miR150-5p levels, downregulated P2X7R expression, and decreased levels of MMP-9 and EMMPRIN by suppressing AMPK-alpha and MAPK signaling.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yabin Ji, Qiang Gao, Yinzhong Ma, Fang Wang, Xixi Tan, Dengpan Song, Ruby L. C. Hoo, Zening Wang, Xin Ge, Hongjie Han, Fuyou Guo, Junlei Chang
Summary: A human IgG monoclonal antibody called L13 showed potential as a therapeutic approach for both ischemic and hemorrhagic stroke by selectively inhibiting MMP-9 activity and reducing brain tissue injury. Treatment with L13 improved neurological outcomes and attenuated BBB breakdown in mouse stroke models. The antibody also neutralized MMP-9 activity in stroke patients' sera and brain tissues, suggesting its clinical application.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Xiaowei Zheng, Chongke Zhong, Zhengbao Zhu, Kaixin Zhang, Hao Peng, Tian Xu, Xiaoqing Bu, Bizhong Che, Tan Xu, Aili Wang, Jing Chen, Yonghong Zhang, Jiang He
Summary: This study found that the prognostic value of MMP-9 in ischemic stroke patients is modified by the patients' dyslipidemia status, suggesting that increased MMP-9 is associated with poor prognosis only in patients with dyslipidemia. Further research is needed to confirm these findings and explore potential mechanisms.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Oncology
Hannah K. K. Jackson, Christine Mitoko, Franziska Linke, Donald Macarthur, Ian D. D. Kerr, Beth Coyle
Summary: Through investigation and experimentation, it has been determined that metastatic medulloblastoma cells release significantly more extracellular vesicles, including exosomes rich in active MMP-2, which enhance the migration and invasiveness of primary medulloblastoma cells. This study demonstrates the crucial role of exosomes in medulloblastoma metastasis.
Article
Clinical Neurology
Hanming Ge, Xiaojuan Ma, Jiachen Wang, Xiaobo Zhang, Yu Zhang, Qi Zhang, Wu Li, Jie Liu, Jinwei Duan, Wenzhen Shi, Ye Tian
Summary: This study investigates the relationship between MMP-9 gene polymorphisms and susceptibility to ischemic stroke. Genotyping of 700 ischemic stroke patients and 700 healthy controls revealed a significant association between rs2250889 polymorphism and susceptibility to ischemic stroke. Multifactor dimensionality reduction analysis identified rs2250889 as the best model for predicting the risk of ischemic stroke.
FRONTIERS IN NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jacek Kudelski, Anna Tokarzewicz, Monika Gudowska-Sawczuk, Barbara Mroczko, Piotr Chlosta, Marta Bruczko-Goralewska, Przemyslaw Mitura, Grzegorz Mlynarczyk
Summary: This study aimed to evaluate the expression and activity of matrix metalloproteinase 2 and 9 (MMP-2 and MMP-9) in urinary bladder cancer at different stages. The results showed that the content and activity of MMP-9 were higher than MMP-2, especially in high-grade cancer tissue. MMP-9 may have higher clinical utility as a potential therapeutic option and a diagnostic biomarker for urinary bladder cancer.
Article
Materials Science, Biomaterials
Yu Cai, Shou Leng, Yuanyuan Ma, Tingting Xu, Di Chang, Shenghong Ju
Summary: Type 2 diabetes mellitus is closely related to an increased risk of stroke and poor outcomes, especially in diabetic ischemic stroke. Matrix metalloproteinase-9 (MMP-9) is believed to play a role in the poor prognosis of diabetic stroke. The study introduces a fast and highly sensitive optical imaging probe (MMP-P12) to visualize MMP-9 expression in diabetic strokes, and demonstrates the potential therapeutic effect of CD28 SA in reducing MMP-9 expression.
BIOMATERIALS SCIENCE
(2021)
Article
Clinical Neurology
Junlin Lu, Jingyi Wang, Zhidong Lin, Guangchao Shi, Rong Wang, Yahui Zhao, Yuanli Zhao, Jizong Zhao
Summary: The study investigated the association between MMP-9 levels and phenotypes of moyamoya disease (MMD). Higher MMP-9 expression was found in adult MMD patients, especially in hemorrhagic-onset cases. Elevated serum MMP-9 level (>1,011 ng/ml) may serve as an independent risk predictor for hemorrhagic strokes in adult MMD patients.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Arno Kirchhain, Asta Zubriene, Visvaldas Kairys, Federico Vivaldi, Andrea Bonini, Denise Biagini, Delio Santalucia, Daumantas Matulis, Fabio Di Francesco
Summary: Matrix metalloproteinases play a crucial role in cancer progression and metastasis, and molecular probes have been successfully used to study their activity. In this study, a series of MMP-2 and MMP-9 binding probes were synthesized, showing high selectivity against MMP-2 and potential for sensor fabrication. The experimental results were confirmed by molecular modeling, indicating the potential application of these probes for targeted enzyme detection.
BIOORGANIC CHEMISTRY
(2021)
Article
Oncology
Mikiko Aoki, Toshiyuki Tsunoda, Kaori Koga, Kazuki Nabeshima, Makoto Hamasaki
Summary: This study investigated the importance of CD73 expression in fibroblasts and cancer cells for cancer invasion. The results showed that CD73 on fibroblasts acts as a receptor for emmprin on tumor cells, forming a complex that increases MMP-2 production and possibly leading to increased invasiveness. CD73 suppression also reduced tumor invasion by decreasing MMP-2 production at the transcription level.
ANTICANCER RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Zainab Ahmed Rashid, Sanaa K. Bardaweel
Summary: Matrix metalloproteinases (MMPs), especially MMP-9, play a significant role in cancer pathogenesis and progression. However, no effective MMP-9 inhibitor has been approved by the FDA. This review focuses on exploring the strategies for designing MMP-9 inhibitors and their anticancer effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Maria Isabel Santos, Ana Lima, Joana Mota, Patricia Rebelo, Ricardo Boavida Ferreira, Laurentina Pedroso, Maria Adelia Ferreira, Isabel Sousa
Summary: This study found that fermentation with specific lactic acid bacteria produced peptides with antibacterial activity, one of which derived from beat casein. This peptide showed effectiveness against various pathogens, inhibited metalloproteases, and reduced cancer cell migration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Joana Mota, Rosa Direito, Joao Rocha, Joao Fernandes, Bruno Sepodes, Maria Eduardo Figueira, Anabela Raymundo, Ana Lima, Ricardo Boavida Ferreira
Summary: The study isolated and characterized an MMP-2 and -9 inhibitor from Lupinus albus, showing its efficacy in inhibiting MMP-9 activity in colon cancer cells and significantly reducing colitis symptoms in a mouse model. This novel type of MMP inhibitor in lupine, edible and proteinaceous in nature, holds high potential for application as a nutraceutical or functional food targeting pathologies related to high MMP-9 activity in the digestive system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Xinying Zhou, Linmiao Lie, Yao Liang, Hui Xu, Bo Zhu, Yingqi Huang, Lijie Zhang, Zelin Zhang, Qianna Li, Qi Wang, Zhenyu Han, Yulan Huang, Honglin Liu, Shengfeng Hu, Chaoying Zhou, Qian Wen, Li Ma
Summary: This study reveals the significant role of GSK-3alpha/beta pathway in regulating immune response of macrophages to Mycobacterium tuberculosis infection. It also demonstrates that PKC-delta and mTOR can influence the activation of GSK-3alpha/beta and subsequently regulate the expression of MMP-1/9. These findings provide new insights into the immune escape mechanism of tuberculosis and the crosstalk between critical signaling pathways.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Orthopedics
M. Bollmann, K. Pinno, L. I. Ehnold, N. Martens, A. Maertson, T. Pap, C. Staerke, C. H. Lohmann, J. Bertrand
Summary: The shedding of Sdc4 in synovial fluid is increased in OA patients and can predict OA severity. MMP-9 appears to be the relevant enzyme for Sdc4 shedding under OA conditions. Increased Sdc4 shedding leads to reduced phosphorylation of ERK in response to IL-1 beta stimulation.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Clinical Neurology
Zixiao Yang, Xin Zhang, Jianping Song, Wei Zhu
Summary: The video showcases a rare case of cavernous malformation in the subcallosal gyrus successfully cured using a contralateral anterior interhemispheric approach. This case offers new insights into anatomical knowledge and surgical techniques for subcallosal lesions.
ACTA NEUROCHIRURGICA
(2022)
Article
Clinical Neurology
Kangmin He, M. H. S. Alriashy, Zhen Fan, Nidan Qiao, Yujun Liao, Qingzhu An, Bin Xu, Jianping Song, Xin Zhang, Wei Zhu, Liang Chen, Ying Mao
Summary: This study aimed to explore a treatment protocol for patients with mesial temporal cerebral cavernoma (MTC)-associated epilepsy. Through analyzing the patients admitted to their center, the research team found that comprehensive preoperative and intraoperative assessments could help patients choose a suitable surgical time and maximize the benefits between seizure control and cognition protection.
WORLD NEUROSURGERY
(2022)
Review
Oncology
Xin Zhang, Wei Hua, Kai Quan, Guo Yu, Zunguo Du, Zixiao Yang, Xiaowen Wang, Jianping Song, Liang Chen, Wei Zhu
Summary: This study presented a series of 6 consecutive intraorbital tumors that were treated with endonasal endoscopic resection. The neuroendoscopic endonasal approach proved to be a suitable method for selected pathological conditions and was effective in achieving gross total resection with improved visual outcomes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Neuroimaging
Zhiyuan Fan, Zhen Fan, Tianming Qiu, Liuxun Hu, Yuan Shi, Yunman Xia, Xiaoyi Sun, Yingjun Liu, Sichen Li, Mingrui Xia, Wei Zhu
Summary: The study found that there are differences in the topological organization of functional brain connectomes between patients with right-sided unilateral hearing loss (RUHL) and left-sided unilateral hearing loss (LUHL), indicating different pathophysiological mechanisms between the two conditions.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Clinical Neurology
Zixiao Yang, Jianping Song, Kai Quan, Peiliang Li, Qingzhu An, Yuan Shi, Peixi Liu, Guo Yu, Yanlong Tian, Liangfu Zhou, Wei Zhu
Summary: This study reports a tailored approach to posterior inferior cerebellar artery (PICA) aneurysms based on angioarchitecture and high-resolution vessel wall MRI (HR-VW MRI) findings. The results demonstrate successful treatment of various types of PICA aneurysms with different surgical strategies, and the potential of HR-VW MRI in predicting aneurysmal atherosclerosis.
STROKE AND VASCULAR NEUROLOGY
(2022)
Article
Clinical Neurology
Peixi Liu, Yingjun Liu, Yuan Shi, Qingzhu An, Wei Zhu, Yingtao Liu, Peiliang Li, Yanlong Tian
Summary: This study retrospectively analyzed the clinical data of 64 patients with cavernous sinus dural arteriovenous fistula who underwent endovascular embolization, and summarized the treatment approach selection and outcome. The study found that the vascular architecture is closely related to the selection of treatment approach and the outcome of the treatment.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Yuan Shi, Peixi Liu, Yingtao Liu, Kai Quan, Peiliang Li, Zongze Li, Wei Zhu, Yanlong Tian
Summary: In this report, the authors illustrate the endovascular treatment of scalp arteriovenous malformations (AVM) using a direct percutaneous puncture approach when traditional arterial and venous approaches were not available. The technique involves occluding draining veins, fistulous connections, and feeders using Onyx-18 injected through a microcatheter inserted into draining veins directly. At a 1-year follow-up, no procedure-related complications and evidence of recurrence were observed.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Kai Quan, Yingjun Liu, Yun Wang, Yanlong Tian, Bin Xu, Peiliang Li, Peixi Liu, Yuan Shi, Liuxun Hu, Geng Xu, Jianfeng Luo, Jianping Song, Wei Zhu
Summary: The study found that one-stop hybrid treatment in a hybrid operating room is safe and effective for patients with high-grade brain arteriovenous malformations (BAVMs), especially those with complex angioarchitecture. Preoperative embolization can effectively reduce blood flow and preserve motor and language function while avoiding causing neurological injury with the combined application of functional magnetic resonance imaging, electrophysiological monitoring, and awake craniotomy.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Article
Clinical Neurology
Wei Hua, Hao Xu, Xin Zhang, Guo Yu, Xiaowen Wang, Jinsen Zhang, Zhiguang Pan, Wei Zhu
Summary: The objective of this study was to evaluate the effectiveness of neuroendoscopic resection via supracerebellar infratentorial (SCIT) approach for pineal region tumors. The study reviewed the clinical and radiological data of four patients who underwent pure endoscopic tumor resection using this approach, and also reviewed related literature on fully endoscopic pineal region tumor resection.
NEUROLOGICAL RESEARCH
(2023)
Article
Clinical Neurology
Liuxun Hu, Kai Quan, Yuan Shi, Peixi Liu, Jianping Song, Yanlong Tian, Qingzhu An, Yingjun Liu, Sichen Li, Guo Yu, Zhiyuan Fan, Jianfeng Luo, Yuxiang Gu, Bin Xu, Wei Zhu, Ying Mao
Summary: This study evaluates the value of VWI as a predictor of surgical outcome in patients with UIAs. It found that the type of aneurysmal wall enhancement on VWI is associated with clinical outcome and the incidence of salvage anastomosis and surgical complications.
Review
Clinical Neurology
Peixi Liu, Yuan Shi, Zongze Li, Yingjun Liu, Kai Quan, Yingtao Liu, Qingzhu An, Wei Zhu
Summary: This study retrospectively reviewed the techniques and outcomes of bypass based on anterior cerebral artery (ACA) A1 donor anastomosis in patients with intracranial aneurysm. The results showed that interposition IC-IC bypass provides an effective way to achieve blood flow reconstruction in the treatment of complex aneurysms. However, perforator-related infarction was the main complication in patients with MCA M1 aneurysm location.
OPERATIVE NEUROSURGERY
(2023)
Article
Clinical Neurology
Peixi Liu, Zongze Li, Liuxun Hu, Yingjun Liu, Peiliang Li, Wei Zhu, Yanlong Tian, Ying Mao
Summary: This study evaluated the clinical features, endovascular strategy selection, and outcomes of vertebral artery dissecting aneurysms (VADAs) near the origin of the posterior inferior cerebellar artery (PICA). The results showed that young patients had a higher probability of subarachnoid hemorrhage (SAH), while elderly patients had a higher probability of posterior circulation infarction. The surgical plan selection should be based on the SAH history, VA dominant side, and PICA origin location.
JOURNAL OF NEUROSURGERY
(2023)
Article
Clinical Neurology
Peixi Liu, Yuan Shi, Peiliang Li, Wei Zhu
Summary: In this case report, we present a case of MCA M1 bifurcation aneurysm resection and reconstruction using Y fashion anastomosis. Intraoperative DSA confirmed the patency of the anastomotic stoma. The patient experienced transient ischemia but had a good recovery with a modified Rankin scale of 0 at discharge. The Y fashion anastomosis showed advantages and challenges in specific situations.
ACTA NEUROCHIRURGICA
(2023)
Article
Clinical Neurology
Peixi Liu, Yuan Shi, Qingzhu An, Wei Zhu
Summary: This case report highlights the value of distal bypass for blood flow protection in the resection and reanastomosis of MCA M1-2 dissecting aneurysm, as demonstrated by histological staining showing the pathological characteristics of the aneurysm.
ACTA NEUROCHIRURGICA
(2022)
Article
Clinical Neurology
Peixi Liu, Yuan Shi, Qingzhu An, Wei Zhu
Summary: This case report demonstrates the value of using ACA-RAG-PCA bypass in treating PCA dissecting aneurysm.
ACTA NEUROCHIRURGICA
(2022)
Article
Biochemistry & Molecular Biology
Hui-Ting Huang, Shun-Fen Tzeng
Summary: Our study demonstrates the role of interleukin-33 (IL-33) in a demyelinating mouse model induced by cuprizone (CPZ), showing that IL-33 can alleviate the reduction of APC+ OLs and the decline of IL-33 levels in the corpus callosum, and promote the expression of myelin basic protein (MBP).
NEUROCHEMISTRY INTERNATIONAL
(2024)