Journal
NEUROCHEMISTRY INTERNATIONAL
Volume 52, Issue 1-2, Pages 31-33Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2007.07.021
Keywords
extrasynaptic communication; volume transmission; spillover; GABA; glutamate; astrocytes; information processing
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Brain functions such as information processing, learning and memory are commonly associated with changes in synaptic strength, the synaptic plasticity. Extrasynaptic diffusion of transmitters thought to mediate only a modulatory effect. Here I suggest a hypothesis that concentration profile of signaling molecules in the extracellular space can form a diffuse guiding template for signal propagation through neuronal network. Such template can be potentially involved in information processing and storage. This hypothesis requires further experimental investigation and, thus, provides a framework for future studies in the field of non-synaptic transmission in the brain. (C) 2007 Elsevier Ltd. All rights reserved.
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