Article
Clinical Neurology
Vittoria Borgonetti, Elisabetta Meacci, Federica Pierucci, Maria Novella Romanelli, Nicoletta Galeotti
Summary: Studies have shown that the combination of HDAC and BET inhibitors can have synergistic effects in neuropathic pain treatment. The new dual HDAC/BRD4 inhibitors, SUM52 and SUM35, administered through intranasal administration, can alleviate thermal and mechanical hypersensitivity and reduce inflammation and pro-inflammatory cytokines.
Article
Pharmacology & Pharmacy
Mohammad Abbas Sheikholeslami, Shiva Ghafghazi, Siavash Parvardeh, Sheida Koohsari, Saeed Haji Aghajani, Ramin Pouriran, Leila Alipour Vaezi
Summary: Cuminic alcohol exhibits significant analgesic effects and can alleviate nociceptive and neuropathic pain through multiple pathways, including involvement of opioid receptors, the L-arginine/NO/cGMP pathway, and anti-inflammatory functions.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ming-Feng Liao, Kwok-Tung Lu, Jung-Lung Hsu, Chih-Hong Lee, Mei-Yun Cheng, Long-Sun Ro
Summary: Recent studies have shown that both autophagic and apoptotic activities play important roles in the neural changes after nerve damage. Enhancing autophagic activities while suppressing apoptotic activities can effectively treat neuropathic pain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Xiaojuan Jiang, Ruihao Zhou, Yujun Zhang, Tao Zhu, Qian Li, Weiyi Zhang
Summary: Chronic pain is a clinical challenge and a major health problem with varying impacts on quality of life. Opioids are currently used as the first-line therapy, but they often come with unwanted psychoactive side effects. Therefore, there is an urgent need for new and effective treatments for chronic pain.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Fabiolla Rocha Santos Passos, Erik W. M. Pereira, Luana Heimfarth, Brenda S. Monteiro, Yasmim Maria Barbosa Gomes de Carvalho, Pollyana S. Siqueira-Lima, Henrique Douglas Melo Coutinho, Adriano Antunes de Souza Araujo, Jackson Roberto Guedes da Silva Almeida, Rosana S. S. Barreto, Laurent Picot, Lucindo J. Quintans-Junior, Jullyana S. S. Quintans
Summary: Neuropathic pain arises from damage to the somatosensory system, impacting quality of life. Hecogenin acetate (HA), a steroidal sapogenin with anti-inflammatory and antinociceptive properties, has low water solubility affecting bioavailability. Both pure and complexed HA/I3CD demonstrated anti-hyperalgesic activity in animal models.
Review
Biochemistry & Molecular Biology
Nikolaos Machairiotis, Sofia Vasilakaki, Nikolaos Thomakos
Summary: Inflammatory mediators play a crucial role in inducing pain in endometriosis. Inhibition of the synthesis of these mediators may provide an effective treatment for inflammation-induced pain in endometriosis. Identifying and targeting these mediators could lead to the development of novel treatments for chronic pelvic pain in endometriosis patients.
Review
Biochemistry & Molecular Biology
Patricia Richter, Anca Cardoneanu, Ciprian Rezus, Alexandra Maria Burlui, Elena Rezus
Summary: Cardiovascular diseases are a leading cause of high mortality in SLE patients, and traditional risk factors are insufficient in predicting their risk. Inflammation has been found to play a crucial role in the development of atherosclerosis in SLE, highlighting the need for new biomarkers to assess subclinical CVD risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Wan Ni, Xiaolan Zheng, Ling Hu, Chao Kong, Qingbang Xu
Summary: Berberine demonstrates significant analgesic effects in oxaliplatin-induced CIPNP, alleviating mechanical and cold allodynia as well as thermal hyperalgesia. This effect is associated with reduced phosphorylation of p65 and decreased levels of pro-inflammatory cytokines IL-6 and TNF-alpha.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Alessandro Leuti, Marina Fava, Niccolo Pellegrini, Mauro Maccarrone
Summary: Inflammation and neuroinflammation play critical roles in generating neuropathic pain in chronic diseases, with specialized pro-resolving mediators emerging as crucial in regulating the inflammatory cascade and onset of chronic inflammation and pain. Accumulating evidence suggests a synergy between these mediators and other signaling pathways, implying a more intricate relationship between inflammation and pain perception than initially anticipated.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Plant Sciences
Geovanna N. Quinonez-Bastidas, Andres Navarrete
Summary: Most studies on Mexican medicinal plants have focused on inflammatory experimental models for testing their anti-pain properties, with results showing lack of adverse effects and safety for consumption. However, there is still no convincing evidence on the possible mechanisms of action involved in the anti-pain properties of Mexican plants, highlighting the need for further isolation and pharmacological characterization of their compounds for future preclinical studies.
Article
Immunology
Rahim Ullah, Gowhar Ali, Abdur Rasheed, Fazal Subhan, Ajmal Khan, Sobia Ahsan Halim, Ahmed Al-Harrasi
Summary: The study evaluated the effects of 7-Hydroxyflavone on neuropathic pain and its interaction with inflammatory mediators. The results showed that 7-Hydroxyflavone has potential as an anti-nociceptive, anti-inflammatory, and anti-neuropathic agent.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Saskia Wedel, Lisa Hahnefeld, Yannick Schreiber, Christian Namendorf, Tim Heymann, Manfred Uhr, Mathias V. Schmidt, Natasja de Bruin, Felix Hausch, Dominique Thomas, Gerd Geisslinger, Marco Sisignano
Summary: In this study, the researchers investigated the effects of a novel FKBP51 inhibitor SAFit2 on paclitaxel-induced neuropathic pain. The results showed that SAFit2 could alleviate mechanical hypersensitivity caused by paclitaxel and modulate lipid levels in nervous tissue to reduce peripheral sensitization. Additionally, SAFit2 reduced the activation of astrocytes and microglia in the spinal cord, as well as the levels of pain-mediating chemokines, and increased anti-inflammatory cytokine levels in neuronal tissues, leading to resolution of neuroinflammation.
JOURNAL OF NEUROINFLAMMATION
(2023)
Review
Chemistry, Medicinal
Narges Navaei-Alipour, Mohadeseh Mastali, Gordon A. Ferns, Maryam Saberi-Karimian, Majid Ghayour-Mobarhan
Summary: Honey contains flavonoids and phenolic acids that may have important implications for human health due to their antioxidant and anti-inflammatory properties. Studies have shown that honey can inhibit the expression of pro-inflammatory factors in conditions such as cancer and neuro-inflammatory disorders. However, more high-quality research is needed to firmly establish the clinical efficacy of honey and understand the specific mechanisms of its anti-inflammatory effects.
PHYTOTHERAPY RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Ivan K. Domingo, Asna Latif, Amit P. Bhavsar
Summary: Cisplatin, a widely used chemotherapeutic drug, is effective against various solid cancers but limited by its adverse drug reactions. The most common reactions include nephrotoxicity, peripheral neuropathy, and ototoxicity. Previous studies focused on oxidative stress as the cause of these toxicities, but recent evidence suggests that inflammation may be the main driving force. This review summarizes the common and distinct inflammation characteristics among different adverse reactions, as well as current treatments targeting pro-inflammatory signaling pathways to improve the use of cisplatin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Boram Nho, Kyeong Ryang Ko, Sunyoung Kim, Junghun Lee
Summary: Hepatocyte growth factor (HGF) is a secretory protein that exhibits anti-inflammatory effects by regulating the expression of pro-inflammatory cytokines, thereby alleviating neuropathic pain. Intramuscular injection of HGF-encoding plasmid DNA has long-lasting analgesic effects, which are mediated by the c-Met receptor.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)