Cell Signaling Abnormalities May Drive Neurodegeneration in Familial Alzheimer Disease

Cellular mechanisms of γ-secretase substrate selection, processing and toxicity

(2012) Gael Barthet et al.   PROGRESS IN NEUROBIOLOGY

Presenilin-Dependent Receptor Processing Is Required for Axon Guidance

(2011) Ge Bai et al.   CELL

Inhibitors of γ-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates

(2011) Gael Barthet et al.   FASEB JOURNAL

What Can Be Inferred from the Interruption of the Semagacestat Trial for Treatment of Alzheimer's Disease?

(2010) Jeffrey Cummings   BIOLOGICAL PSYCHIATRY

Mechanisms of AD neurodegeneration may be independent of Aβ and its derivatives

(2010) Nikolaos K. Robakis   NEUROBIOLOGY OF AGING

Alzheimer's-related endosome dysfunction in Down syndrome is A -independent but requires APP and is reversed by BACE-1 inhibition

(2009) Y. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early-Onset Alzheimer Disease in an Italian Family With Presenilin-1 Double Mutation E318G and G394V

(2008) Sara Batelli et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Wild-Type But Not FAD Mutant Presenilin-1 Prevents Neuronal Degeneration by Promoting Phosphatidylinositol 3-Kinase Neuroprotective Signaling

(2008) L. Baki et al.   JOURNAL OF NEUROSCIENCE

Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

(2008) Clive Holmes et al.   LANCET