Article
Biochemistry & Molecular Biology
Tae-Kyeong Lee, Myoung Cheol Shin, Ji Hyeon Ahn, Dae Won Kim, Bora Kim, Hyejin Sim, Jae-Chul Lee, Jun Hwi Cho, Joon Ha Park, Young-Myeong Kim, Moo-Ho Won, Choong-Hyun Lee
Summary: This study investigated the time-dependent changes in CD200 expression in the hippocampus after transient forebrain ischemia in gerbils. The results showed that transient ischemia led to specific and selective neuronal death in the CA1 field, with CD200 expression changing over time. Interestingly, treatment with risperidone did not alter CD200 expression, indicating protection of CA1 pyramidal neurons from ischemic injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Tae-Kyeong Lee, Dae Won Kim, Hyejin Sim, Jae-Chul Lee, Hyung Il Kim, Myoung Cheol Shin, Jun Hwi Cho, Joon Ha Park, Choong-Hyun Lee, Moo-Ho Won, Ji Hyeon Ahn
Summary: According to this study, different subfields of the hippocampus (CA1 to CA3) have different vulnerabilities to ischemia. Hyperthermia exacerbates neuronal death and decreases the expression of HIF-1 alpha, while normothermia does not have the same effects.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Biology
Lingjun Ding, Giuseppe Balsamo, Hongbiao Chen, Eduardo Blanco-Hernandez, Ioannis S. Zouridis, Robert Naumann, Patricia Preston-Ferrer, Andrea Burgalossi
Summary: Neural circuits are composed of diverse neuronal cell types, and this diversity plays a crucial role in brain function during natural behavior. In this study, the combination of juxtacellular recording, labeling, and optogenetics enabled the investigation of molecularly defined cell classes in freely moving mice, revealing the weaker spatial modulation and information transmission of Calbindin-positive CA1 pyramidal cells.
Article
Biochemistry & Molecular Biology
Laurel Watkins de Jong, Mohammadreza Mohagheghi Nejad, Euisik Yoon, Sen Cheng, Kamran Diba
Summary: Recurrent connectivity and feedback inhibition from inhibitory neurons play crucial roles in determining the dynamics and computational properties of neuronal circuits. Through optogenetic manipulations and large-scale unit recordings, paradoxical responses were observed in both CA1 and CA3 regions of the hippocampus, where subsets of cells increased firing during photoinhibition while others decreased firing during photoexcitation. These paradoxical responses were more prominent in CA3 and simulations confirmed that both CA1 and CA3 hippocampal regions exhibit inhibition-stabilized networks with strong recurrent excitation.
Article
Biochemistry & Molecular Biology
Hyejin Sim, Tae-Kyeong Lee, Yeon Ho Yoo, Ji Hyeon Ahn, Dae Won Kim, Bora Kim, Jae-Chul Lee, Joon Ha Park, Soon-Sung Lim, Jung-Seok Park, Il Jun Kang, Young-Myeong Kim, Myoung Cheol Shin, Jun Hwi Cho, Yoonsoo Park, Moo-Ho Won
Summary: This study found that intermittent fasting for three months increased the expression of CB in hippocampal CA1 pyramidal neurons in gerbils, but did not protect them from transient forebrain ischemia. Gliosis gradually increased over time after ischemic insults in both groups, indicating a failure in neuroprotection possibly due to blood-brain barrier disruption.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Ying Zhang, Hai-Yan Yin, Patrizia Rubini, Peter Illes, Yong Tang
Summary: There is a dispute about whether CNS neurons possess ATP-sensitive P2X7 receptors. By genetically deleting P2X7 receptors in astrocytes and oligodendrocytes, it was found that these receptors indirectly modulate the neuronal input to neighboring neurons.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Pablo Vergara, Gabriela Pino, Jorge Vera, Felipe Arancibia, Magdalena Sanhueza
Summary: Prolonged changes in neural activity trigger homeostatic synaptic plasticity, allowing neuronal networks to operate within functional ranges. Deafferentation causes rapid and diverse compensations, which may contribute to understanding homeostatic or pathological events after brain injury.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Yueyang Liu, Xiaohang Che, Haotian Zhang, Xiaoxiao Fu, Yang Yao, Jun Luo, Yu Yang, Ruiping Cai, Xiangnan Yu, Jingyu Yang, Ming-Sheng Zhou
Summary: The study demonstrates that CAPN1 activation impairs lysosomal function and suppresses autophagosome formation, leading to accumulation of substrates and aggravating neuronal cell damage in cerebral ischemia. The findings highlight the crucial role of CAPN1 in regulating autophagy-lysosomal pathway defects and neuronal damage in the context of cerebral ischemia.
Article
Neurosciences
Sebi Rolotti, Heike Blockus, Fraser T. Sparks, James B. Priestley, Attila Losonczy
Summary: The hippocampus plays a critical role in memory consolidation, particularly during sharp-wave ripple (SWR) events. This study investigated the relationship between network state and information processing in dendrites, the primary sites of synaptic input integration and plasticity. The researchers found that immobility led to increased dendritic activity, which was concentrated during SWR events. Concurrent dendritic and somatic activity during SWRs predicted increased coupling during subsequent exploration of a novel environment. Somatic-dendritic coupling and SWR recruitment also varied based on cells' tuning distance to reward location during a goal-learning task.
Article
Biochemistry & Molecular Biology
Xuansheng Xiao, Xiaotong Wang, Ke Zhu, Lijuan Li, Ying He, Jinglan Zhang, Linying Li, Hanning Hu, Yanqiu Cui, Jianliang Zhang, Yan Zheng
Summary: BACE1 is a key enzyme involved in the production of β-amyloid, and is considered a major drug target for Alzheimer's disease. However, BACE1 inhibitors have failed in clinical trials, and may actually worsen cognitive function, suggesting that BACE1 may play a role in regulating cognition-relevant neural circuits.
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Yael Almog, Saja Fadila, Marina Brusel, Anat Mavashov, Karen Anderson, Moran Rubinstein
Summary: Dravet syndrome is a rare and severe childhood-onset epilepsy caused by mutations in the SCN1A gene. Studies on Dravet mice showed persistent reduced function in inhibitory neurons and changes in excitatory neurons during different disease stages. This suggests a complex pathophysiological mechanism with reciprocal functional changes in both excitatory and inhibitory neurons influencing the developmental trajectory of the disease.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Chemistry, Medicinal
Joon Ha Park, Tae-Kyeong Lee, Dae Won Kim, Ji Hyeon Ahn, Choong-Hyun Lee, Jong-Dai Kim, Myoung Cheol Shin, Jun Hwi Cho, Jae-Chul Lee, Moo-Ho Won, Soo Young Choi
Summary: Astaxanthin has been shown to have neuroprotective effects in transient ischemic brain injury, reducing neuronal death and oxidative damage. It also increases the expression of antioxidant enzymes.
Article
Nutrition & Dietetics
Woosuk Kim, Hyo Young Jung, Dae Young Yoo, Hyun Jung Kwon, Kyu Ri Hahn, Dae Won Kim, Yeo Sung Yoon, Soo Young Choi, In Koo Hwang
Summary: The study demonstrates that GPE-R has neuroprotective effects against ischemic damage and inflammation in the hippocampus, reducing locomotor hyperactivity and increasing neuronal survival. It also shows a decrease in pro-inflammatory cytokines and activated microglia after ischemia/reperfusion, indicating GPE-R as a potential agent for protecting neurons from ischemic damage.
Article
Plant Sciences
Zhiguo Mao, Liyu Tian, Jiao Liu, Qian Wu, Ning Wang, Guangyun Wang, Yang Wang, Saiwang Seto
Summary: This study found that LIG improves mitochondrial function by promoting PINK1/Parkin-mediated mitophagy and alleviates neuronal injury in cerebral ischemia reperfusion injury.
Article
Neurosciences
Joseph Cichon, Andrzej Z. Wasilczuk, Loren L. Looger, Diego Contreras, Max B. Kelz, Alex Proekt
Summary: This study demonstrates that ketamine can cause a switch in the active population of excitatory neurons in the cortical layers, which leads to impairments in sensory processing and dissociative-like state. These findings provide insights into how the brain can become disconnected from the environment while maintaining internal subjective experiences.
NATURE NEUROSCIENCE
(2023)
