Review
Pharmacology & Pharmacy
Hae Jin Kee, Inkyeom Kim, Myung Ho Jeong
Summary: This article provides an overview of the pathogenesis of hypertension, current anti-hypertensive drugs, and the need for novel drugs. It focuses on the role and regulatory mechanisms of HDACs in hypertension and discusses the progress in developing HDAC inhibitors as potential therapeutic targets.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biology
Anna S. Berezovskaya, Sergey A. Tyganov, Svetlana D. Nikolaeva, Alexandra A. Naumova, Boris S. Shenkman, Margarita V. Glazova
Summary: Research shows that simulated microgravity environment leads to a decrease in hippocampal neurogenesis, while dynamic foot stimulation can restore the number of neural progenitor cells. In addition, the microgravity environment inhibits signaling pathways related to neurogenesis, while dynamic foot stimulation can prevent this inhibition.
Article
Neurosciences
Shawn F. Sorrells, Mercedes F. Paredes, Zhuangzhi Zhang, Gugene Kang, Oier Pastor-Alonso, Sean Biagiotti, Chloe E. Page, Kadellyn Sandoval, Anthony Knox, Andrew Connolly, Eric J. Huang, Jose Manuel Garcia-Verdugo, Michael C. Oldham, Zhengang Yang, Arturo Alvarez-Buylla
Summary: Adult hippocampal neurogenesis was initially discovered in rodents, with subsequent studies identifying adult neural stem cells and their links to plasticity, behavior, and disease. The debate continues as to whether new neurons are produced in the human dentate gyrus during healthy aging. Recent research has shown conflicting results regarding the presence of dividing neuronal precursors in the adult human brain.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Marco Ghibaudi, Alessia Amenta, Miriam Agosti, Marco Riva, Jean-Marie Graic, Francesco Bifari, Luca Bonfanti
Summary: Recently, a population of immature neurons generated prenatally, retaining immaturity for long periods and finally integrating in adult circuits has been described in the cerebral cortex. Comparative studies revealed differences in occurrence/rate of different forms of neurogenic plasticity across mammals, with gyrencephalic species having more immature neurons. To extend experimentation to large-brained mammals, including humans, it is important to detect cell markers of neurogenic plasticity in brain tissues obtained through different procedures. However, the variability in fixation methods and antibody specificity makes comparison difficult.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Svetlana Demyanenko, Valentina Dzreyan, Svetlana Sharifulina
Summary: Cerebral ischemia is the second leading cause of death worldwide, requiring multimodal stroke therapy. Histone deacetylase inhibitors have shown to be effective in protecting the brain from ischemic damage by inducing neurogenesis and angiogenesis in damaged brain areas, promoting functional recovery after stroke.
Article
Neurosciences
Sarah E. Latchney, Brayan R. Ruiz Lopez, Paige D. Womble, Katherine J. Blandin, Joaquin N. Lugo
Summary: This study provides a comprehensive understanding of how conditional deletion of Pten regulates the genesis of adult neural stem/progenitor cells in the dentate gyrus and subventricular zone. The results demonstrate that Pten deletion leads to successive increases in cell proliferation and immaturity, with the increase spreading to non-neurogenic areas as mice age. The study also reveals region-specific increases in apoptotic cells that parallel the increases in proliferating cells.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Agricultural Engineering
Xuefeng Lu, Tae Kyung Hyun
Summary: Post-translational histone modifications, such as histone acetylation, play key roles in regulating gene expression in plant growth, development, and stress responses. The research found that HDAC inhibitors led to hyperacetylation of histone H3, enhancing MeJA-induced ginsenoside production in ginseng adventitious roots. Additionally, the study identified specific PgHDACs that may serve as crucial factors in controlling MeJA-induced ginsenoside production.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Review
Oncology
Amandine Badie, Christian Gaiddon, Georg Mellitzer
Summary: Our understanding of the identity of many cancers has greatly increased in recent years, leading to progress in early detection and treatment options. However, gastric cancer remains poorly treated with low survival rates. The lack of possibilities for early detection and the variations between tumors of gastric cancer patients are major challenges. Histone Deacetylases (HDACs) have been identified to be potentially related to gastric cancer. In this review, we summarize the current knowledge on the role of HDACs in gastric cancer development and their potential as early detection markers and targets for new treatment options.
Review
Oncology
Fengyi Guo, Hongjing Wang
Summary: This review summarizes the classification and mechanisms of action of histone deacetylase and the clinical application of their inhibitors in ovarian cancer. Histone deacetylase inhibitors show promising potential as anti-cancer drugs, and combination therapy with other anticancer drugs for synergistic effects can improve efficacy.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Robert Jenke, Nina Ressing, Finn K. Hansen, Achim Aigner, Thomas Buch
Summary: Epigenetic changes can drive cancer malignancy, while histone deacetylase inhibitors (HDACis) hold promise as anticancer drugs due to their ability to target multiple pathways relevant to the disease.
Article
Biology
John Darby Cole, Jacobo Sarabia Del Castillo, Gabriele Gut, Daniel Gonzalez-Bohorquez, Lucas Pelkmans, Sebastian Jessberger
Summary: Advancing age leads to decreased hippocampal neurogenesis, which is associated with age-related cognitive decline. The reorganization of the dentate gyrus (DG) niche and changes in the cell-type contributions to the blood-brain barrier and microenvironments surrounding neural stem cells (NSCs) play a pivotal role in maintaining neurogenic permissiveness.
Article
Nutrition & Dietetics
Marta Portero-Tresserra, Neus Galofre-Lopez, Elisabet Pallares, Claudia Gimenez-Montes, Carlos Barcia, Roser Granero, Divka Rojic-Becker, Anna Vale-Martinez, Margarita Marti-Nicolovius, Gemma Guillazo-Blanch
Summary: Age-related changes in the brain significantly impact hippocampal structure and function, leading to cognitive impairments such as deteriorating spatial object recognition (SOR) memory. Both intrinsic factors like neuroinflammation and lifestyle factors like diet can influence aging-related brain function and cognitive performance. This study aimed to evaluate the effects of caloric restriction (CR) on SOR memory, hippocampal neuron loss, neurogenesis, and inflammation in aged male rats. The results showed that CR attenuated the decline in SOR memory, hippocampal neuron loss, and microglial activation associated with aging, while also reducing neurogenesis in the dentate gyrus.
Article
Nutrition & Dietetics
Gemma Huguet, Irene Puig-Parnau, Jose C. E. Serrano, Meritxell Martin-Gari, Maria Rodriguez-Palmero, Jose Antonio Moreno-Munoz, Joan Tibau, Elisabet Kadar
Summary: Childhood obesity, caused by a diet rich in sugars and fatty acids, can lead to cognitive impairment and reduced neuroplasticity. A study on young female pigs found that a diet enriched with Bifidobacterium breve and omega-3 fatty acids can enhance neuroplasticity in prepubertal female pigs on a high-fat diet.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Immunology
Martina Mazzocchi, Susan R. Goulding, Noelia Morales-Prieto, Tara Foley, Louise M. Collins, Aideen M. Sullivan, Gerard W. O'Keeffe
Summary: The peripheral administration of Class IIa-specific HDIs may have neuroprotective effects in Parkinson's disease.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Review
Cell Biology
Bingyi Zhou, Deliang Liu, Yuyong Tan
Summary: Cancer is the second leading cause of death worldwide, with digestive system cancers being a primary contributor. Acetylation and deacetylation play crucial roles in cancer development, with HDAC6 being a widely studied enzyme that is upregulated in various tumors and associated with clinicopathological characteristics. There is ongoing research on HDAC6 inhibitors and their potential in inhibiting tumor growth.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)