Article
Neurosciences
Zijuan Zhang, Hai Li, Yunfang Su, Jinlian Ma, Ye Yuan, Ziyang Yu, Ming Shi, Simai Shao, Zhenqiang Zhang, Christian Holscher
Summary: Research demonstrates that the CCK analogue has neuroprotective effects and improves locomotor function in an acute PD mouse model. It acts by restoring dopaminergic neuron count and synapse number, reducing neuroinflammation and autophagy impairment, and protecting against mitochondrial and ER damage.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Chemistry, Applied
Vincent M. Lombardo, Louise Bernier, Ming Z. Chen, William Farrell, Andrew Flick, Philippe Nuhant, Neal W. Sach, Yong Tao, John Trujillo
Summary: Chiral piperidines are commonly found in approved drugs and drug candidates, but their synthesis faces challenges of scalability and stereochemical control. This research focused on accessing stereochemically pure 3,4-disubstituted piperidines through a classical resolution method, which could have broader utility in pharmaceutical intermediates. The practical synthesis described in this work allows for the production of kilogram quantities of enantiopure precursor, enabling scale-up efforts for toxicology studies.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2021)
Article
Oncology
Jing Zhang, Bohao Sun, Jifeng Yang, Zhuo Chen, Zhengzheng Li, Nan Zhang, Hongzhi Li, Luxi Shen
Summary: This study compared the effects of rotenone and MPTP in two commonly used mouse models of chronic PD. The results showed that the MPTP model accurately reproduced the pathological features of PD, while the rotenone model was more suitable for studying mitochondrial dysfunction and Lewy body formation in PD.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Crystallography
Maya Chochkova, Rusi Rusew, Reni Kalfin, Lyubka Tancheva, Maria Lazarova, Hristina Sbirkova-Dimitrova, Andrey Popatanasov, Krasimira Tasheva, Boris Shivachev, Nejc Petek, Martin Sticha
Summary: Parkinson's disease is a common neurodegenerative disorder with severe side effects associated with current treatments. In this study, a new compound, CA(2-Me)-Am, was synthesized and shown to improve memory performance and neuromuscular coordination in an experimental model of Parkinson's disease.
Article
Pharmacology & Pharmacy
Babita Singh, Shivani Pandey, Mohammad Rumman, Shashank Kumar, Prem Prakash Kushwaha, Rajesh Verma, Abbas Ali Mahdi
Summary: The study showed that Bacopa monnieri extract has neuroprotective and neurorescue effects against MPTP-induced degeneration of dopaminergic neurons, potentially slowing down disease progression and delaying neurodegeneration in Parkinson's disease.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Eduard Bentea, Laura De Pauw, Lise Verbruggen, Lila C. Winfrey, Lauren Deneyer, Cynthia Moore, Giulia Albertini, Hideyo Sato, Ann Van Eeckhaut, Charles K. Meshul, Ann Massie
Summary: Our study revealed age-related protection against proteasome inhibition-induced nigrostriatal degeneration in xCT(-/-) mice, while xCT deletion failed to protect nigral dopaminergic neurons of aged mice against MPTP-induced toxicity. This provides new insights into the role of system x(c)(-) in mechanisms of dopaminergic cell loss and its interaction with aging.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Behavioral Sciences
Abdolvahed Narmashiri, Mojtaba Abbaszadeh, Ali Ghazizadeh
Summary: This article provides a comprehensive review and meta-analysis on the effects of MPTP on memory and motor functions in Parkinson's disease. The results show that MPTP not only significantly affects motor functions, but also various mnemonic processes. However, no systematic relationship between the MPTP injection protocol parameters and the extent of induced PD symptoms was found.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Neurosciences
Yun-Mi Kim, Su Yeon Choi, Onyou Hwang, Joo-Yong Lee
Summary: This study investigated the potential neuroprotective effects of exogenous pyruvate in a mouse model of Parkinson's disease. The results showed that sodium pyruvate administration could protect nigral DA neurons from degeneration and alleviate the associated motor deficits, indicating its therapeutic potential for PD and related neurodegenerative diseases.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Chemistry, Medicinal
Shendong Jing, Zhenhai Wang, Jun Zhang, Xianfeng Li, Ruifei Huang
Summary: Neferine was shown to have a neuroprotective effect against MPTP-induced Parkinson's in mice by reducing pro-inflammatory cytokines levels and increasing dopamine levels. This indicates that neferine could potentially be used as a drug to treat Parkinson's disease with minimal side effects, pending further trials.
PHARMACOGNOSY MAGAZINE
(2021)
Article
Pharmacology & Pharmacy
Benchi Cai, Lifan Zhong, Qitong Wang, Wendi Xu, Xi Li, Tao Chen
Summary: This study investigates the neuroprotective mechanisms of curcumin for Parkinson's disease through the microbiota-gut-brain axis, and finds that curcumin alleviates motor deficits and gut dysfunctions by regulating the gut microbiota and short-chain fatty acids.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Chuanqi Chu, Tiantian Li, Leilei Yu, Yiwen Li, Miaoyu Li, Min Guo, Jianxin Zhao, Qixiao Zhai, Fengwei Tian, Wei Chen
Summary: Dietary patterns, specifically a low-protein, high-carbohydrate (LPHC) diet, have potential protective effects on Parkinson's disease (PD) by improving motor deficits, increasing dopamine levels, and normalizing gut bacterial composition. Key mediators in this process include fibroblast growth factor 21 (FGF-21), aromatic amino acids (AAAs), microbial metabolites (TUDCA and taurine), and the gut-microbiota-brain axis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Nutrition & Dietetics
Zhili Ren, Hui Ding, Ming Zhou, Piu Chan
Summary: In this study, the neuroprotective effects of Ganoderma lucidum extract (GLE) in a Parkinson's disease (PD) model were explored. GLE was found to inhibit microglia activation and regulate abnormal cytokine expression levels. It also suppressed iNOS/NLRP3 pathway and abnormal microglial autophagy and lysosomal degradation, providing new evidence for the treatment of PD using Ganoderma lucidum.
Article
Neurosciences
Huidan Weng, Wenjing Song, Kangyue Fu, Yunqian Guan, Guoen Cai, En Huang, Xiaochun Chen, Haiqiang Zou, Qinyong Ye
Summary: This study aimed to investigate the potential mechanism and possible regulatory targets of SIRT4 in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mice. The results indicated that fatty acid binding protein 4 (FABP4) in the peroxisome proliferator-activated receptor (PPAR) signaling pathway is the most promising molecular target of SIRT4 in an MPTP-induced mouse model.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Toxicology
Yi Ren, Dan Ye, Yiping Ding, Ning Wei
Summary: This study investigated the role of RK1 in an in vitro and in vivo model of Parkinson's disease. RK1 was found to alleviate motor deficits, enhance TH expression, and protect against cell apoptosis, oxidative stress and inflammatory response. The neuroprotective effects of RK1 were mediated by the SIRT3/Nrf2/HO-1 signaling pathway.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2023)
Article
Neurosciences
Tsu-Kung Lin, Kai-Jung Lin, Hung-Yu Lin, Kai-Lieh Lin, Min-Yu Lan, Pei-Wen Wang, Tzu-Jou Wang, Feng-Sheng Wang, Po-Chin Tsai, Chia-Wei Liou, Jiin-Haur Chuang
Summary: Parkinson's disease is a common neurodegenerative disorder with no known treatments to slow its progression. Recent studies suggest that anti-diabetic drugs like GLP-1RA may have neuroprotective effects in PD by improving mitochondrial morphology balance and enhancing damaged organelle degradation.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)