Article
Neurosciences
Veronica T. Cheli, Diara A. Santiago Gonzalez, Rensheng Wan, Shaina L. Rosenblum, Giancarlo E. Denaroso, Christina G. Angeliu, Zachary Smith, Congying Wang, Pablo M. Paez
Summary: By disrupting the expression of the Tf receptor gene in oligodendrocyte progenitor cells, researchers found that the Tf cycle is uniquely important for the development and function of oligodendrocytes. Deleting the Tfr gene resulted in impaired iron absorption and hypomyelination in mice. The Tf cycle plays a crucial role in iron homeostasis and energy production in oligodendrocyte progenitor cells.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Oncology
Fengping Yao, Xiaohong Cui, Ying Zhang, Zhuchun Bei, Hongquan Wang, Dongxu Zhao, Hong Wang, Yongfei Yang
Summary: Iron regulatory protein IRP1 plays an essential role in ferroptosis induced by erastin and RSL3, regulating iron homeostasis and affecting the survival and death of melanoma cells.
Article
Nutrition & Dietetics
Laura Tarancon-Diez, Miguel Genebat, Manuela Roman-Enry, Elena Vazquez-Alejo, Maria de la Sierra Espinar-Buitrago, Manuel Leal, Ma Angeles Munoz-Fernandez
Summary: This study aimed to determine a clinically relevant ferritin threshold to define absolute iron deficiency. The findings suggest that serum ferritin levels below 50 ng/mL are indicative of early iron deficiency.
Article
Nutrition & Dietetics
Seok-Hui Kang, Bo-Yeon Kim, Eun-Jung Son, Gui-Ok Kim, Jun-Young Do
Summary: The aim of this study was to evaluate the survival rates of patients on maintenance hemodialysis (HD) according to their iron status. The study analyzed data from the National HD Quality Assessment Program and claims data (n = 42,390). The patients were divided into four groups based on their transferrin saturation rate and serum ferritin levels. The results showed that patients with normal iron status had the highest survival rates, while there were minimal differences in survival rates among the groups with abnormal iron status. Subgroup analyses based on age, hemoglobin, or serum albumin levels showed different trends.
Article
Neurosciences
Veronica T. Cheli, Diara A. Santiago Gonzalez, Qiuchen Wan, Giancarlo Denaroso, Rensheng Wan, Shaina L. Rosenblum, Pablo M. Paez
Summary: The storage of iron by astrocytes, particularly the Fth protein, is crucial for the early development of oligodendrocytes and the remyelination of the central nervous system. Knocking out Fth in astrocytes led to delays in oligodendrocyte development and myelin synthesis, as well as a decrease in the number of myelinating oligodendrocytes and the percentage of myelinated axons. These findings suggest that astrocytic iron storage plays a vital role in the myelination process and repair of myelin damage.
Article
Biochemistry & Molecular Biology
Ewa Skarzynska, Monika Wrobel, Hanna Zborowska, Mateusz Franciszek Kolek, Grzegorz Manka, Mariusz Kiecka, Michal Lipa, Damian Warzecha, Robert Spaczynski, Piotr Piekarski, Beata Banaszewska, Artur Jakimiuk, Tadeusz Issat, Wojciech Rokita, Jakub Mlodawski, Maria Szubert, Piotr Sieroszewski, Grzegorz Raba, Kamil Szczupak, Tomasz Kluz, Marek Kluza, Miroslaw Wielgos, Barbara Lisowska-Myjak, Piotr Laudanski
Summary: The aim of this study was to investigate the relationship between lactoferrin and iron and its binding proteins in women with endometriosis. The results showed differences in lactoferrin, transferrin, ferritin, and iron levels between plasma and peritoneal fluid. Lactoferrin levels in plasma were associated with iron and transferrin in endometriosis, while lactoferrin in peritoneal fluid correlated with lactoferrin, iron, and transferrin in patients without endometriosis. The study suggests that assessing iron metabolism may be useful in diagnosing and monitoring endometriosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Laura Tarancon-Diez, Marianela Iriarte-Gahete, Pilar Sanchez-Mingo, Guillermo Perez-Cabeza, Fernando Romero-Candau, Yolanda M. Pacheco, Manuel Leal, Maria Angeles Munoz-Fernandez
Summary: The study evaluated the safety and effectiveness of a generic intravenous iron treatment in Spanish patients with absolute iron deficiency. The results showed improvements in iron-related biomarkers, anemia, and ferritin levels. The recurrence of iron deficiency was associated with baseline iron stores depletion and sTfR/hepcidin ratio.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Nutrition & Dietetics
Jiaqi Qiu, Fuzhi Lian, Xuexian Fang
Summary: This study used a two-sample Mendelian randomization analysis and found that higher iron status is associated with a detrimental effect on depression and psychogenic disorder, while it may have a potential protective role on gender identity disorders.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Ben Schoettker, Xin Gao, Eugene H. J. M. Jansen, Hermann Brenner
Summary: This study found a significant positive association between ferritin levels and red/processed meat consumption, as well as between hs-CRP levels and obesity. Transferrin saturation showed a strong positive association with both overall and advanced CRA cases. The SHP concentration was significantly inversely associated with advanced CRA.
Article
Geriatrics & Gerontology
Lum Kastrati, Dion Groothof, Hugo G. Quezada-Pinedo, Hamidreza Raeisi-Dehkordi, Lia Bally, Martin H. De Borst, Stephan J. L. Bakker, Pedro-Marques Vidal, Michele F. Eisenga, Taulant Muka
Summary: The study aimed to examine the association between iron biomarkers and menopausal status and assess whether these biomarkers can help differentiate menopausal status beyond age. The results showed that iron biomarkers were significantly associated with menopausal status in both cohorts and modestly improved a model with age alone for differentiating menopause status.
Review
Cardiac & Cardiovascular Systems
Milton Packer
Summary: SGLT2 inhibitors can increase cytosolic Fe2+ levels, promoting heme synthesis in erythroid precursors and ATP synthesis in cardiomyocytes by alleviating inflammation and oxidative stress.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Article
Genetics & Heredity
Miriam Sandnes, Marta Vorland, Rune J. Ulvik, Hakon Reikvam
Summary: HFE hemochromatosis is primarily associated with the C282Y variant, but the H63D variant can also affect disease manifestation. There is a complex relationship between HFE genotype and biochemical findings in patients, with non-C282Y homozygotes potentially presenting with hyperferritinemia that may have been overlooked in clinical practice.
Article
Biochemistry & Molecular Biology
Anja Reinert, Tilo Reinert, Thomas Arendt, Markus Morawski
Summary: A subpopulation of neurons, characterized by a special extracellular matrix composition forming a perineuronal net (PN) with a high affinity to iron, is less vulnerable to iron-induced oxidative stress and neurodegeneration. These PN+ neurons have higher intracellular iron concentrations and increased levels of iron proteins, with the iron concentration of the PN itself not being increased. The properties of these resilient pacemaker neurons with bustling iron metabolism and outstanding iron handling capabilities contribute to their low vulnerability to iron-induced oxidative stress and degeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Ippei Inoue, Mayumi Chiba, Kenichiro Ito, Yoriko Okamatsu, Yasuyo Suga, Yoshiro Kitahara, Yuichi Nakahara, Yuta Endo, Kazutoshi Takahashi, Uno Tagami, Naofumi Okamoto
Summary: A novel, high-yield method for preparing high drug-loaded ferritin nanomedicine has been established, allowing for the successful introduction of various types of drug molecules into ferritin nano-cages. By incubating ferritin with a target drug at an appropriate pH, a complex is formed which enables efficient drug loading and higher drug recovery rates. This simple one-step method shows promise as a powerful production process for constructing drug-loaded ferritin carriers for drug delivery systems.
Article
Nutrition & Dietetics
Sixtus Aguree, Arthur Owora, Misty Hawkins, Manju B. Reddy
Summary: Obesity is associated with health and nutritional problems, including impaired iron metabolism leading to anemia. We conducted a study to determine the prevalence of anemia, iron deficiency (ID), and iron deficiency anemia (IDA) in women aged 20-49 years based on body mass index (BMI). Analysis of data from the National Health and Nutrition Examination Survey (NHANES) showed higher levels of certain iron measures and lower levels of others in obese women compared to those with normal weight. The prevalence rates of ID and anemia (and IDA) were generally higher in obese women, but the choice of iron indices impacted the estimates.
Article
Pharmacology & Pharmacy
Aline Zaparte, Angelica R. Cappellari, Caroline A. Brandao, Julia B. de Souza, Thiago J. Borges, Luiza W. Kist, Mauricio R. Bogo, Luiz F. Zerbini, Luis Felipe Ribeiro Pinto, Talita Glaser, Maria Carolina B. Goncalves, Yahaira Naaldijk, Henning Ulrich, Fernanda B. Morrone
Summary: Esophageal cancer is a global disease with two main subtypes, esophageal squamous cell carcinoma and esophageal adenocarcinoma. Research shows that P2Y(2) receptor activation in esophageal cancer cells promotes cell proliferation and colony formation, while its blockade reduces these effects. Targeting P2Y(2) receptors may have therapeutic potential for esophageal cancer treatment.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Environmental Sciences
Vitor Otacilio de Almeida, Talita Carneiro Brandao Pereira, Lilian de Souza Teodoro, Manuella Escobar, Carolina Junqueira Ordovas, Karine Batista dos Santos, Jessica Weiler, Mauricio Reis Bogo, Ivo Andre Homrich Schneider
Summary: The study found that iron ore tailings particles did not have significant harmful effects on the development and behavior of zebrafish embryos and larvae, although particle adhesion on the chorion was observed. Therefore, the particle size range and potential interactions with SiO2 content may contribute to explaining this effect.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Biochemistry & Molecular Biology
Barbara Dutra Petersen, Talita Carneiro Brandao Pereira, Stefani Altenhofen, Debora Dreher Nabinger, Pedro Maria de Abreu Ferreira, Mauricio Reis Bogo, Carla Denise Bonan
Summary: Antibiotics are widely used in human and veterinary health along with the food industry, resulting in their presence as contaminants in water bodies. This study reveals that exposure to certain antibiotics led to hyperlocomotion, cognitive decline, and exacerbated aggressive behavior in adult zebrafish, indicating a short-term impact on their behavior.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Patricia Molz, Betania Souza de Freitas, Vanise Hallas Uberti, Kesiane Mayra da Costa, Luiza Wilges Kist, Mauricio Reis Bogo, Nadja Schroder
Summary: The study found that supplementing with LA during adulthood combined with supplementation later in life can reverse age-induced cognitive dysfunction and mitochondrial DNA deletions, whereas using LA treatment only at old age has a lesser effect.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Thamiris Becker Scheffel, Liliana Rockenbach, Fernanda Fernandes Cruz, Luiza Wilges Kist, Mauricio Reis Bogo, Juliete Nathali Scholl, Fabricio Figueiro, Guido Lenz, Fernanda Bueno Morrone
Summary: This study reveals the regulatory role of extracellular ATPase activity in the cytotoxicity and migration process of malignant gliomas.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Neurosciences
Adriana Fernanda Kuckartz Vizuete, Ben Hur Mussulini, Kamila Cagliari Zenki, Suelen Baggio, Amanda Pasqualotto, Denis Broock Rosemberg, Mauricio Reis Bogo, Diogo Losch de Oliveira, Eduardo Pacheco Rico
Summary: Prolonged ethanol exposure can lead to impairment of the glutamatergic uptake system, changes in astroglial markers, increased neuroinflammation, and elevated levels of brain-derived neurotrophic factor. After 28 days of exposure, ethanol may play a modulatory role in glutamate uptake.
Article
Neurosciences
Camilo Alexandre Jablonski, Talita Carneiro Brandao Pereira, Lilian De Souza Teodoro, Stefani Altenhofen, Gabriel Rubensam, Carla Denise Bonan, Mauricio Reis Bogo
Summary: The use of pesticides has increased in recent years, leading to concerns regarding the environment and human health. This study investigated the effects of acute exposure to the insecticide methomyl on zebrafish embryos and larvae. The results showed that methomyl had lethal and sublethal effects on zebrafish, affecting their development, morphology, behavior, and enzyme activity.
NEUROTOXICOLOGY AND TERATOLOGY
(2022)
Review
Neurosciences
Jose Afonso Correa da Silva, Nadja Schroeder
Summary: It is believed that neurological diseases caused by degenerative conditions may have abnormal influx of Ca2+ through glutamate receptors. In addition to the NMDAR, AMPARs can also mediate neurotoxic Ca2+ influx, especially when the GluA2 subunit is absent or disrupted. The increase of Ca2+-permeable AMPA receptors (CP-AMPARs) is associated with behavioral changes and various neurodegenerative, neuroinflammatory, and neurotoxic conditions, suggesting a potential role in the emergence and evolution of central nervous system (CNS) pathological conditions. This article summarizes and discusses studies on changes in the composition of AMPARs and their effects, aiming to understand the therapeutic potential of CP-AMPAR in neurological diseases.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Article
Nutrition & Dietetics
Pauline S. Effting, Anand Thirupathi, Alexandre P. Muller, Barbara C. Pereira, Diane M. Sepa-Kishi, Luis F. B. Marqueze, Franciane T. F. Vasconcellos, Renata T. Nesi, Talita C. B. Pereira, Luiza W. Kist, Mauricio R. Bogo, Rolando B. Ceddia, Ricardo A. Pinho
Summary: This study found that ladder climbing, as a model of resistance exercise, can reverse the metabolic and inflammatory effects of high-fat diet-induced obesity in mice. The training reduced body weight, adipocyte size, improved glycemic control, and reduced inflammation in skeletal muscles.
Article
Biochemistry & Molecular Biology
Pedro Vargas, Thamiris Becker Scheffel, Fernando Mendonca Diz, Liliana Rockenbach, Nathalia Grave, Angelica Regina Cappellari, Luiza Wilges Kist, Mauricio Reis Bogo, Marcos Paulo Thome, Gabriel Fernandes Leal, Amanda de Fraga Dias, Fabricio Figueiro, Eduardo Cremonese Filippi-Chiela, Guido Lenz, Fernanda Bueno Morrone
Summary: This study investigated the role of the P2Y(12) receptor in the proliferation and migration of GBM cells and evaluated its expression in patients' data. The results showed that the P2Y(12) antagonist, ticagrelor, decreased the viability and proliferation of GBM cells and reduced colony formation and migration potentials. The expression of P2Y(12)R was found to be higher in glioma samples, suggesting its importance in glioma development.
PURINERGIC SIGNALLING
(2022)
Article
Biochemistry & Molecular Biology
Luiza Reali Nazario, Jessica Streb de Sousa, Francielle Schroeder de Moraes Silveira, Kesiane Mayra Costa, Giovanna Medeiros Tavares de Oliveira, Mauricio Reis Bogo, Rosane Souza da Silva
Summary: This study evaluated the effects of LPS on white blood cells, inflammatory markers, and ecto-5'-nucleotidase activity and expression in zebrafish. The results showed that inflammation did not affect ecto-5'-nucleotidase activity in most tissues, but there was a delayed increase in activity in the heart, possibly related to tissue repair.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Article
Clinical Neurology
Melissa Talita Wiprich, Stefani Altenhofen, Darlan Gusso, Rafaela da Rosa Vasques, Rodrigo Zanandrea, Luiza Wilges Kist, Mauricio Reis Bogo, Carla Denise Bonan
Summary: This study investigated the effects of acute exposure to different substances in an HD pharmacological model induced by 3-NPA in adult zebrafish. The results showed that some substances could reverse or exacerbate the bradykinesia symptoms of HD, and also reverse memory impairment. The study suggests that these substances play an important role in modulating locomotor function and memory, and may be a potential pharmacological strategy against late-stage symptoms of HD.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Review
Environmental Sciences
Kaue Pelegrini, Talita Carneiro Brandao Pereira, Thuany Garcia Maraschin, Lilian De Souza Teodoro, Nara Regina De Souza Basso, Griselda Ligia Barrera De Galland, Rosane Angelica Ligabue, Mauricio Reis Bogo
Summary: Polymeric wastes, especially microplastics (MPs) and nanoplastics (NPs), contribute to significant environmental problems and can induce toxic effects on various organisms. This review aims to summarize the current knowledge and identify literature gaps regarding the generation and toxicological effects of MPs and NPs, considering factors such as polymer type, size, source, and test organisms. The analysis of 615 publications revealed that PS was the most commonly studied polymer, and toxicity testing primarily focused on arthropods and fish. NPs were found to exhibit greater toxicity than MPs, particularly in terms of oxidative stress.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Neurosciences
Melissa Talita Wiprich, Rafaela da Rosa Vasques, Darlan Gusso, Gabriel Ruebensam, Luiza Wilges Kist, Mauricio Reis Bogo, Carla Denise Bonan
Summary: Huntington's disease is a progressive neurodegenerative disease characterized by neuropsychiatric disturbance, cognitive impairment, and locomotor dysfunction. The levels of dopamine and the expression of dopamine receptors are altered in different stages of the disease.
MOLECULAR NEUROBIOLOGY
(2023)
