Journal
NEUROCASE
Volume 16, Issue 4, Pages 307-316Publisher
ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
DOI: 10.1080/13554790903559671
Keywords
Autism; Asperger's Disorder; Citalopram; Celexa; Repetitive behaviors; Target detection; Oddball; Cingulate gyrus; fMRI; Functional magnetic resonance imaging
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Funding
- Dana Foundation (Dichter)
- UNC-Chapel Hill
- NIH/NCRR [K12 RR023248]
- NIMH [K23 MH081285]
- NATIONAL CENTER FOR RESEARCH RESOURCES [K12RR023248] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH073402, K23MH081285] Funding Source: NIH RePORTER
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Autism is characterized by abnormal prefrontal brain activation during cognitive control, a potential biomarker of repetitive behaviors. In this proof-of-principle study, functional magnetic resonance imaging (fMRI) was used to examine brain activity during an oddball task in two high-functioning males with autism before and after 12 weeks of treatment with citalopram, a selective serotonin reuptake inhibitor. One participant showed marked reductions in repetitive behaviors whereas the other showed mild worsening. Brain activation in relevant prefrontal regions increased in only the participant whose repetitive behavior symptoms improved. These findings suggest that fMRI may elucidate potential mechanisms of action of targeted autism interventions.
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